Effects of exercise training alone vs a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial

Although the Diabetes Prevention Program (DPP) established lifestyle changes (diet, exercise and weight loss) as the ‘gold standard’ preventive therapy for diabetes, the relative contribution of exercise alone to the overall utility of the combined diet and exercise effect of DPP is unknown; furthermore, the optimal intensity of exercise for preventing progression to diabetes remains very controversial. To establish clinical efficacy, we undertook a study (2009 to 2013) to determine: how much of the effect on measures of glucose homeostasis of a 6 month programme modelled after the first 6 months of the DPP is due to exercise alone; whether moderate- or vigorous-intensity exercise is better for improving glucose homeostasis; and to what extent amount of exercise is a contributor to improving glucose control. The primary outcome was improvement in fasting plasma glucose, with improvement in plasma glucose AUC response to an OGTT as the major secondary outcome

Intrinsic errors of the central galactic mass derived from rotation curves under the influence of a weak non-axisymmetric potential

Rotation curves are often used to estimate the mass distribution of spiral galaxies, assuming circular rotation of disks. However, non-circular motions caused by a non-axisymmetric gravitational potential, such as a stellar bar, may disturb the velocity field, resulting in errors in mass estimation, especially in the central regions of galaxies, because the line-of-sight velocity depends on the viewing angles in a non-axisymmetric flow. Observing rotation curves of edge-on galaxies in time-dependent numerical simulations from different viewing angles, we obtain errors in the estimation of galactic mass from the rotation curves. In the most extreme case, the ellipticity of gas orbits is as high as 0.8 in the central regions, even if the bar potential is weak. When rotation curves are defined as the highest velocity envelope of position-velocity diagrams, the mass estimated from the rotation curves is larger than the true mass by a factor of five for 15% of the viewing angles, and the ratio between the apparent mass and true mass is less than six for any viewing angle. The overestimation in mass occurs more frequently than the underestimation.Comment: 11 pages, 10 figures, accepted by A&

Aerobic and Resistance Training Effects on Energy Intake: The STRRIDE AT/RT Study: Exercise Training Effects on Energy Intake

Our study characterizes food and energy intake responses to long-term aerobic (AT) and resistance training (RT) during a controlled 8-month trial

Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes

GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA in persons at risk for type 2 diabetes. GlycA, fitness, and body habitus were measured in 169 sedentary adults (45–75 years) with prediabetes randomly assigned to one of four six-month exercise-based lifestyle interventions. Interventions included exercise prescription based on the amount (energy expenditure (kcal/kg weight/week (KKW)) and intensity (%VO2peak). The groups were (1) low-amount/moderate-intensity (10KKW/50%) exercise; (2) high-amount/moderate-intensity (16KKW/50%) exercise; (3) high-amount/vigorous-intensity (16KKW/75%) exercise; and (4) a Clinical Lifestyle (combined diet plus low-amount/moderate-intensity exercise) intervention. Six months of exercise training and/or diet-reduced GlycA (mean Δ: −6.8 ± 29.2 μmol/L;p=0.006) and increased VO2peak(mean Δ: 1.98 ± 2.6 mL/kg/min;p<0.001). Further, visceral (mean Δ: −21.1 ± 36.6 cm2) and subcutaneous fat (mean Δ: −24.3 ± 41.0 cm2) were reduced, while liver density (mean Δ: +2.3 ± 6.5HU) increased, allp<0.001. When including individuals in all four interventions, GlycA reductions were associated with reductions in visceral adiposity (p<0.03). Exercise-based lifestyle interventions reduced GlycA concentrations through mechanisms related to exercise-induced modulations of visceral adiposity. This trial is registered with Clinical Trial Registration Number NCT00962962

Fine-scale structure of the quasar 3c 279 measured with 1.3 mm very long baseline interferometry

Contains fulltext : 116998.pdf (preprint version ) (Open Access