Velos antiguos i modernos en los rostros de las mugeres sus con ueniençias, i daños : ilustración de la Real Premática de las Tapadas...a la señora doña María de Auellaneda...

Contiene: "Discurso geneálogico de la ilustre Casa y descendencia de Avellaneda"Sign.: [parágrafo-7parágrafo]4, 8[parágrafo]2, A-Z4, 2A-2L4, 2MHojas impresas por ambas carasPortada calcográficaDigitalización. Vitoria-Gasteiz : Fundación Sancho el Sabio, 2008Digitalización. Vitoria-Gasteiz : Archivos y Bibliotecas, Junio 1995Carton

Tablas cronológicas de los Reales Consejos Supremo y de la Cámara de las Indias Occidentales D.O.C. al Rey nuestro señor en sus dos Reales Consejos de las Indias

Copia digital : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer

DNA methylation is important for gene expression and genome stability, and its disruption is thought to play a key role in the initiation and progression of cancer and other diseases. The DLK1-DIO3 cluster has been shown to be imprinted in humans, and some of its components are relevant to diverse pathological processes. The purpose of this study was to assess the methylation patterns of the DLK1-DIO3 cluster in patients with lung cancer to study its relevance in the pathogenesis of this disease. We found a characteristic methylation pattern of this cluster in smoking associated lung cancer, as compared to normal lung tissue. This methylation profile is not patent however in lung cancer of never smokers nor in lung tissue of COPD patients. We found 3 deregulated protein-coding genes at this locus: one was hypermethylated (DIO3) and two were hypomethylated (DLK1 and RTL1). Statistically significant differences were also detected in two different families of SNORDs, two miRNA clusters and four lncRNAs (MEG3, MEG8, MEG9 and LINC00524). These findings were validated using data from the cancer genome atlas (TCGA) database. We have then showed an inverse correlation between DNA methylation and expression levels in 5 randomly selected genes. Several targets of miRNAs included in the DLK1-DIO3 cluster have been experimentally verified as tumor suppressors. All of these results suggest that the dysmethylation of the imprinted DLK1-DIO3 cluster could have a relevant role in the pathogenesis of lung cancer in current and former smokers and may be used for diagnostic and/or therapeutic purposes.Instituto de Salud Carlos III PI17/00033Junta de Andalucía PI2009-0224 y PI-0046-2012LPA fundado por Instituto de Salud Carlos III PI1102688, 1401964, R12/0036/0028 y CB16/12/00442Ministerio de Economía y Competitividad PI12/00137, PI15/00045, RTICC: RD12/0036/0028, CB16/12/00275Junta de Andalucía PI-0135-2010 y PI-0306-2012Junta de Andalucía CTS-6844 y CTS-1848Instituto de Salud Carlos III PI12/0283

Translating Christianity in an Age of Reformations

This article argues that the age of the Protestant and Catholic Reformations and the global spread of the latter brought with it the challenge that not only was it necessary to learn new languages in order to communicate the Christian message to non-European peoples encountered during the so-called ‘Age of Discovery’, but some kind of control had to be exercised over the new, global circulation of sacred images and relics. The latter facilitated the visual (and virtual) translation of such holy sites as Jerusalem and Rome and its specific holy treasures in the mental prayers of the faithful. It concludes that it was less Lamin Sanneh’s ‘triumph of [linguistic] translatability’ and more the physical translatability of the sacred that made possible the emergence of Roman Catholicism as this planet’s first world religion

Velos antiguos i modernos en los rostros de las mugeres sus con ueniençias, i daños : ilustración de la Real Premática de las Tapadas...a la señora doña María de Auellaneda... / por el Lic. Antonio de Leon-Pinelo...

Sign.: [parágrafo-7parágrafo]4, 8[parágrafo]2, A-Z4, 2A-2L4, 2MHojas impresas por ambas carasPortada calcográficaPALAU 135751CCPB 000033980-6Digitalización Vitoria-Gasteiz Archivos y Bibliotecas Junio 1995 16-22Digitalización Vitoria-Gasteiz Fundación Sancho el Sabio 2008Carton

El gran canciller de las Indias

En los párrafos que siguen, serán desgranados los motivos principales en cuyo derredor se remansó el caudal sapiente de León Pinelo. Ello facilitará la oportunidad para restituirle diversos escritos suyos que corrían emboscados en obras ajenas, exhumar una composición poética desconocida, identificar varios impresos, manuscritos y cartas procedentes de su pluma que se deploraban como perdidos, y finalmente, localizar un nutrido elenco de trabajos traspapelados.Peer reviewe

Epitome de la Biblioteca Oriental y Occidental, Nautica, y Geografica : Tomo Segundo [y Tercero]

Port. a dúas tintas: vermella e negr

Tablas cronológicas de los Reales Consejos Supremo y de la Cámara de la Indias Occidentales ...

Port. a dúas tinta