Reference values and repeatability of inspiratory capacity for men and women aged 65–85

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Numerical investigation of oil injection in a Roots blower operated as expander

The adoption of positive displacement machines as expanders in Organic Rankine Cycles (ORCs) is increasingly common, especially in the low to medium power range. At the same time, these devices often serve as compressor in Vapor-Compression Refrigeration Systems. In both cases, the application of Computation Fluid Dynamics (CFD) to optimize such machines has become an integrated tool in the design process. As a consequence, several challenges associated with the numerical simulation have to be taken into account. For example, the modeling of the gap represents a challenge for the stability of the numerical analysis. The dynamic of the process, combined with deformations of the clearances and of the working chamber has to be considered with extra care. To raise the efficiency of the machine, oil is typically injected. Its numerical modeling imply an extra challenge in the simulation of the actual operation of the machine. The present work is mainly focused on the multi-phase nature of the flow, with a particular analysis of the lubricant oil injected. In this work, a two-lobe Roots blower operated as expander has been simulated with the open-source software OpenFOAM-v1812, using the SCORG-V5.2.2. This analysis highlights the areas that are affected the most by the oil presence in order to highlight the sealing effect it provides

Biomaterial-mediated factor delivery for spinal cord injury treatment

Spinal cord injury (SCI) is an injurious process that begins with immediate physical damage to the spinal cord and associated tissues during an acute traumatic event. However, the tissue damage expands in both intensity and volume in the subsequent subacute phase. At this stage, numerous events exacerbate the pathological condition, and therein lies the main cause of post-traumatic neural degeneration, which then ends with the chronic phase. In recent years, therapeutic interventions addressing different neurodegenerative mechanisms have been proposed, but have met with limited success when translated into clinical settings. The underlying reasons for this are that the pathogenesis of SCI is a continued multifactorial disease, and the treatment of only one factor is not sufficient to curb neural degeneration and resulting paralysis. Recent advances have led to the development of biomaterials aiming to promote in situ combinatorial strategies using drugs/biomolecules to achieve a maximized multitarget approach. This review provides an overview of single and combinatorial regenerative-factor-based treatments as well as potential delivery options to treat SCIs

Seeds and oil polyphenol content of sunflower (Helianthus annuus L.) grown with different agricultural management

Using a long term experiment (20 and 11 years of organic cultivation on the same soil), sunflower was cultivated on these soils under organic management and in a different part of the same farm under conventional management. Kernels, teguments and oils were analyzed for their polyphenols content. Five caffeoylquinic acids were identified. No qualitative differences were found in the three cases, while quantitative differences have been pointed out and discussed

Experimental Performance of a Micro-ORC Energy System for Low Grade Heat Recovery

Abstract The state-of-the art of ORC energy systems is mainly dominated by large scale units in the MW range of power output, in the field of heat recovery at mid-high temperature levels (around 200-500°C), where multiple commercial realizations are available. Nevertheless, the cutting-edge niche of micro-ORC energy systems offers good solutions for low-temperature heat recovery. Many prototypes are currently under investigations, but a leading technology is not yet established. This work reports an experimental activity carried out for performance characterization of a prototypal micro-ORC energy system. In particular, the paper presents the test bench developed in the laboratories of the University of Bologna and the first obtained results in terms of thermodynamic performance and main components characteristics. The ORC system comprises a small reciprocating three-piston expander, run on R134a as operating fluid. Heat is provided to the ORC from an external source, via hot water at temperature below 100 °C, in order to simulate a low-enthalpy heat recovery process. The system rejects unused heat via a water cooled condenser. Thus, the investigated ORC is a plug and play system, requiring only to be connected to the hot and cold heat sources. The ORC system has been tested for prolonged operation at various thermal input conditions. In particular, the behavior of the key cycle parameters and performance indexes (e.g. max. and min. pressures, superheating temperature, expander isentropic efficiency, electric power output, etc.) are investigated as function of pump rotational speed (i.e. organic fluid mass flow rate), for three different set point values of the hot source (65 °C, 75 °C, 85 °C). The operating thermodynamic cycle has been completely characterized by means of a real-time measurement and acquisition tool, developed in LabVIEW environment. Performance variations of the system have been monitored: the electric power output ranges between 0.30 to 1.2 kW, with gross efficiency in the range 2.9-4.4 %, while the expander "electro-isentropic" efficiency results in the range of 35-42 %

Practical management of pleural empyema

Empyema is defined as pus in the thoracic cavity due to pleural space infection and has a multifactorial underlying cause, although the majority of cases are post-bacterial pneumonia. Despite treatment with antibiotics, patients with empyema have a considerable morbidity and mortality due at least in part to inappropriate management of the effusion. Timely diagnosis of pleural space infection and rapid initiation of effective pleural drainage represent fundamental principles for managing patients with empyema. Ultrasound is particularly useful to identify early fibrin membranes and septations in the pleural cavity conditioning treatment strategy. Empyema and large or loculated effusion with a pH<7.20 need to be drained. Thoracoscopy has largely been used in pleural effusion due to lung infection. Whereas the efficacy of video-assisted thoracic surgery (VATS) in empyema management has been evaluated in several retrospective studies showing favourable results, less is known about the role of medical thoracoscopy (MT) in pleural infection. MT, appears to be safe and successful in multiloculated empyema treatment. It is also lower in cost and in frail patients is better tolerated than VATS which requires tracheal intubation

MR imaging diagnosis of diencephalic-mesencephalic junction dysplasia in fetuses with developmental ventriculomegaly

SUMMARY: Diencephalic-mesencephalic junction dysplasia is a rare malformation characterized by a poorly defined junction between the diencephalon and the mesencephalon, associated with a characteristic butterfly-like contour of the midbrain (butterfly sign). This condition may be variably associated with other brain malformations, including callosal abnormalities and supratentorial ventricular dilation, and is a potential cause of developmental hydrocephalus. Here, we have reported 13 fetuses with second-trimester obstructive ventriculomegaly and MR features of diencephalic-mesencephalic junction dysplasia, correlating the fetal imaging with available pathology and/or postnatal data. The butterfly sign can be clearly detected on axial images on fetal MR imaging, thus allowing for the prenatal diagnosis of diencephalic-mesencephalic junction dysplasia, with possible implications for the surgical management of hydrocephalus and parental counseling

MR Imaging Diagnosis of Diencephalic-Mesencephalic Junction Dysplasia in Fetuses with Developmental Ventriculomegaly

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Experimental Investigation with Steady-State Detection in a Micro-ORC Test Bench

Abstract The exploitation of low grade thermal sources is recognized as a feasible strategy in order to pursue the primary energy saving target worldwide. This concept, adaptable to a number of different applications, is aimed at exploiting low-value heat fluxes that would be wasted otherwise; additional useful electric power can be produced locally, with ORC energy systems; this is one of the most promising heat recovery solutions. In particular, the paper refers to the test bench developed in the laboratories of the University of Bologna; a prototypal micro-ORC energy system is here investigated. The micro-ORC system presents a reciprocating three-piston expander operated with refrigerant fluid. Heat is provided to the ORC from via hot water at low temperature, in order to simulate a constant low-enthalpy heat recovery process. The system rejects unused heat via a water-cooled condenser, dependent on the external ambient conditions. The test bench layout and the real-time data acquisition system, developed in the LabVIEW environment, are here described. In particular, the paper focus is on the system steady-state detection methodology. Starting from an experimental campaign, steady-state operational points are identified through an appropriate literature approach. The measured quantities and calculated performance have been post-processed in order to evaluate the influence on steady state detection, of different hot source temperature set points. Moreover, the selected steady-state detection method is suitable for real-time implementation, due to its simple formulation and the low number of variables required to be stored at time step of acquisition

A Micro-ORC Energy System: Preliminary Performance and Test Bench Development

Abstract A large market potential for small electricity and heat generators can be identified in the domestic sector. Among the under development micro-scale power generation technologies the ORC (Organic Rankine Cycle) concept is a promising solution, already proven in the MW-range of power. There is still a prospective for smaller units for domestic users, with low temperature thermal demand. A test bench for a micro-CHP unit, currently run with a prototypal prime mover, is under development at University of Bologna. In particular, the system in study in the test facility is a micro-ORC system, rated for up to 3 kW. The ORC input heat is provided from an external source, which can be an external combustion system (a 46 kW biomass boiler will be connected to the thermal cycle) or an electric heater. The heat source delivers hot water to the bottoming ORC, currently operated with R134a as working fluid, which evolves in a recuperated cycle, with a 3-piston reciprocating expander, producing mechanical/electric power. The residual low-value heat is discharged to the environment with a water cooled condenser. The hot and cold water circuits have been realized in the lab to test the ORC performance. The micro-ORC internal layout and the external hot and cold water lines have been instrumented, implementing an acquisition and control software by means of LabVIEW software. A preliminary test campaign has been performed on the micro-ORC system, obtaining information on the actual thermodynamic cycle and the real performance under different operating conditions