Neutral Copper(II) TE1PA-based chelate for 64Cu-PET imaging: when an additional carboxyl group makes the difference

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Optimisation d’un Agent Chélatant Avancé pour la Production de Radiopharmaceutiques en Médecine Nucléaire Personnalisée

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Développement de radiopharmaceutiques à base de cyclam pour l'imagerie TEP au cuivre-64 et la thérapie des cancers

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Relevance of palladium to radiopharmaceutical development considering enhanced.

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In vivo albumin-binding of a cyclam-based platform for imaging and therapy of cancers

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A competitive chelating agent for the development of radiopharmaceuticals in personalized nuclear medicine

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Novel 64Cu/109Pd theranostic pair for a TE1PA-based trifunctional chelating agent

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Palladium(II) coordination with polyazacycloalkanes

International audienceIn view of the growing interest of palladium(II) for medical applications and the important role of polyamines in exploiting its properties, this review combines the published literature on the coordination of Pd(II) with small polyazacycloalkanes (three and four nitrogen atoms), such as 1,4,7-triazacyclononane, 1,5,9-triazacyclododecane, cyclen, cyclam, as well as their derivatives or close scaffolds such as pyclen. Finally, the rare examples of the use of aza-ligands with 103Pd and 109Pd radioisotopes for therapeutic purposes are also presented. The coordination of the Pd(II) ion is mainly square planar, often slightly distorted depending on the nature of the ligand. A few rare five-coordinated complexes with square pyramidal or trigonal bipyramidal geometries have been described in cases where the steric or topological requirements of the ligand outweigh the loss of stabilization due to geometric distortion. Considering the marked structural preference of Pd(II) for square planar coordination, this review allows us to propose hypotheses on the nature of new Pd(II) complexes whose properties could be exploited, especially in nuclear medicine

Characterization of the Peri-Membrane Fluorescence Phenomenon Allowing the Detection of Urothelial Tumor Cells in Urine

International audienceSimple Summary To detect bladder cancer (BC), urinary cytology and cystoscopy are the primary diagnostic tests used. Urine cytology is non-invasive, easy to collect, with medium sensitivity and high specificity. It is an effective way to detect high-grade BC, but it is less effective on low-grade BC because the rate of equivocal results is much higher, making them difficult to detect. Despite the implementation of new diagnostics, urinary cytology and cystoscopy remain the gold standard. Instead of looking for new diagnostics, one of the new research areas is the improvement of urinary cytology. Recently, the fluorescent properties of plasma membranes of urothelial tumor cells, called peri-membrane fluorescence, found in urinary cytology have been shown to be useful in improving the early detection of BC. The main objective of this study was to characterize the peri-membrane fluorescence allowing the detection of urothelial tumor cells in urine. Urine cytology is non-invasive, easy to collect, with medium sensitivity and a high specificity. It is an effective way to detect high-grade bladder cancer (BC), but it is less effective on low-grade BC because the rate of equivocal results is much higher. Recently, the fluorescent properties of plasma membranes of urothelial tumor cells (UTC) found in urine cytology have been shown to be useful in improving the early detection of BC. This phenomenon is called peri-membrane fluorescence (PMF). Based on previous studies that have identified the PMF on UTCs, the main objective was to characterize this phenomenon. For this study, a software was specially created to quantify the PMF of all tested cells and different treatments performed. PMF was not found to be a morphological and discriminating feature of UTCs, all cells in shape and not from urine show PMF. We were able to highlight the crucial role of plasma membrane integrity in the maintenance of PMF. Finally, it was found that the induction of a strong cellular stress induced a decrease in PMF, mimicking what was observed in non-tumor cells collected from urine. These results suggest that PMF is found in cells able to resist this stress, such as tumor cells

Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA

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