Cabin crew members’ silence: A qualitative study with cabin attendants

Silence among flight crews has been one of the significant causes of aviation incidents and/or accidents. This study aims to explore why flight attendants remain silent during flights and/or do not report errors after the end of the flight. For this purpose, semi-structured online interviews were conducted with 21 flight attendants. The data were analyzed through content analysis using the MAXQDA 22 Qualitative Analysis Program. Themes and coding related to the research question were obtained by analyzing the scripts with creative coding techniques. Nine themes were identified by the content analysis, namely poor relationship with cabin supervisors/pilots , the lack of knowledge on rules and/or procedures , the fear of punishment , feelings of futility , the fear of damaging relationships , status differences , the fear of negative label , workload , and laziness . Recommendations were provided for aviation companies to take culture-specific measures and improve the safety of flights

Breast Cancer and Flavonoids as Treatment Strategy

Breast cancer is the most prevalent cancer type among women. Despite recent progress in early detection and therapeutic strategies, the rate of mortality is increasing. Anti-estrogens or aromatase inhibitors are preferred to treat the women diagnosed with estrogen-receptor (ER) positive tumors. However, breast tumors usually show intra-tumoral heterogeneity with ER-positive and -negative cells. The advanced breast cancer cells lose the estrogen responsiveness and become aggressive by developing new strategies for rapid proliferation such as mutations in cell cycle machinery. New promising drugs are still being investigating against these types of tumors especially to overcome acquired resistance against chemotherapeutic drugs; however, a successful treatment for metastatic tumors is still unclear. Flavonoids, with various pharmacological activities, are plant or fungus secondary metabolites present in human diet. In plants, beside their role in pigmentation, they may also act as messengers, regulators and cell cycle inhibitors. Therefore, they are being tested in ovarian, cervical as well as breast cancer. Due to the positive correlation between flavonoids-rich diet and lower risk of cancer, flavonoids are referred as chemopreventive agents. The current chapter emphasizes the therapeutic potential of flavonoids and their synthetic analogues as anti-cancer agents in breast cancer providing new insights into the molecular mechanisms

Aging-Related Diseases and Autophagy

Autophagy is fundamental, evolutionary conserved physiological process at molecular level which targets long-lived cytosolic proteins and organelles to be recycled through lysosomal degradation. Diminished autophagic activity caused cellular stress in many organisms following aging, and inhibition of autophagy in model organisms causes degenerative changes and pathologic diseases observed with high incidence ratio generally in older ages. Consequently the delayed senescence or increased longevity in model organisms often stimulate autophagy, and autophagy inhibition compromises anti-aging effects. The cytoprotective function of autophagy is presented in various human diseases such as lung, liver, cardiovascular diseases, neurodegeneration, myopathies, cancer, stroke, infections and metabolic diseases which are found associated with autophagic targets. These pathologies are defined with their age-dependent characteristics, is not fully understood that how autophagy network regulates metabolism and may cause diseases in age-related manner. In this book chapter, we are going to discuss the autophagy and aging relationship in three different parts. In the first section autophagy and aging relationship is going to be presented through explaining responsible signalling network. The autophagy and age-related neurological disorders, genetic basis of age-dependent diseases and the functional role of autophagy is going to be discussed in the second and third part of the chapter

Exposure to Perchlorate in Lactating Women and Its Associations With Newborn Thyroid Stimulating Hormone

Background: Perchlorate, thiocyanate, and nitrate can block iodide transport at the sodium iodide symporter (NIS) and this can subsequently lead to decreased thyroid hormone production and hypothyroidism. NIS inhibitor exposure has been shown to reduce iodide uptake and thyroid hormone levels; therefore we hypothesized that maternal NIS inhibitor exposure will influence both maternal and newborn thyroid function.Methods: Spot urine samples were collected from 185 lactating mothers and evaluated for perchlorate, thiocyanate, and nitrate concentrations. Blood and colostrum samples were collected from the same participants in the first 48 h after delivery. Thyroid hormones and thyroid-related antibodies (TSH, fT3, fT4, anti-TPO, anti-Tg) were analyzed in maternal blood and perchlorate was analyzed in colostrum. Also, spot blood samples were collected from newborns (n = 185) between 48 and 72 postpartum hours for TSH measurement. Correlation analysis was performed to assess the effect of NIS inhibitors on thyroid hormone levels of lactating mothers and their newborns in their first 48 postpartum hours.Results: The medians of maternal urinary perchlorate (4.00 μg/g creatinine), maternal urinary thiocyanate (403 μg/g creatinine), and maternal urinary nitrate (49,117 μg/g creatinine) were determined. Higher concentrations of all three urinary NIS inhibitors (μg/g creatinine) at their 75th percentile levels were significantly correlated with newborn TSH (r = 0.21, p < 0.001). Median colostrum perchlorate level concentration of all 185 participants was 2.30 μg/L. Colostrum perchlorate was not significantly correlated with newborn TSH (p > 0.05); however, there was a significant correlation between colostrum perchlorate level and maternal TSH (r = 0.21, p < 0.01). Similarly, there was a significant positive association between colostrum perchlorate and maternal urinary creatinine adjusted perchlorate (r = 0.32, p < 0.001).Conclusion: NIS inhibitors are ubiquitous in lactating women in Turkey and are associated with increased TSH levels in newborns, thus signifying for the first time that co-exposure to maternal NIS inhibitors can have a negative effect on the newborn thyroid function

LIMPRINT study - the Turkish experience

Background: Lymphedema and chronic oedema is a major healthcare problem in both developed and non-developed countries The LIMPRINT study is an international health service based study to determine the prevalence and functional impact in adult populations of member countries of the International Lymphoedema Framework (ILF). Methods: 1051 patients from 8 centers in Turkey were recruited using the LIMPRINT study protocol. Data were collected using the core and module tools which assess the demographic and clinical properties as well as disability and QoL. Results: Most of the Turkish patients were recruited from specialist lymphedema services and were found to be female, housewives and having secondary lymphedema due to cancer treatment. The duration of lymphedema was commonly less than 5 years and most of them had ISL Grade 2 lymphedema. Cellulitis, infection and wounds were uncommon. The majority of patients did not get any treatment or advice before. Most of the patients had impaired QoL and decreased functionality, but psychological support was neglected. Although most had social health security access to Lymphedema centres nevertheless access seemed difficult due to distance and cost. Conclusion: The study has shown the current status and characteristics of lymphedema patients, treatment conditions, the unmet need for the diagnosis and treatment as well as burden of the disease in both patients and families in Turkey. National health policies are needed for the prevention, diagnosis and treatment in Turkey that utilise this informative data

Effects of Mental Shift and Stimulus Discrimination on Planning

The present study examined effects of perceptual features of the Tower of London (TOL) Test on planning performance by means of manipulating visual properties of the beads used to make planned movements. The same planning problems were used in three different versions of the TOL. That is, they were solved by exactly the same successive moves but each version had different target configurations that consisted of two dimensional (color and shape) or one dimensional (color) beads. In the two-dimensional TOL (2D-TOL test), the planning problems were solved according to either color or shape dimensions of four beads, whereas in the Tower of Conflict Test (TOC), participants were required to discriminate their four beads as two beads to be matched in shape and two in color to a problem configuration. The results revealed that performance on the TOL with one-dimensional beads significantly differed from those on the TOC and the 2D-TOL indicating that planning and execution of movements were influenced by mental shifts between two dimensions (color and shape) of the beads and stimulus discrimination processes. In addition, same problem was solved 4 times in succession by a control group, who did not shift between the two dimensions, and by a mental shift group, who were required to shift to the other dimension after solving a problem two times in succession, and trend analyses were used to examine changes due to mental shift. Polynomial contrasts revealed only a significant linear trend for the control group, while quadratic and cubic trends were observed across the repeated measures of same planning problem for the mental shift group

Metabolic side effects of new generation antipsychotics

With the introduction of atypical antipsychotics, a promising new erain the treatment of schizophrenia and psychotic disorders has begun.These drugs effect a broader range of schizophrenicpsychopathology by improving depressive symptomatology andcognitive functions. These drugs are also better tolerated andconsiderably improve the quality of life and treatment compliance ofthe patients. On the other hand, these new drugs are associated withother potentially important side effects. Three main entities amongthese side effects that may cause important complications inlong-term treatment are reviewed: diabetes mellitus, lipid profilealterations and weight gai

The role of leadership perception as a mediator between managers' self-monitoring and subordinate attitudes

Although the role of social cognition in leadership perception has been emphasized frequently in recent years, research using this approach in an organizational context is rare. This study investigated subordinates' perceptions of their managers as leaders (that is, to what extent they perceive their manager as a leader) as a potential mediating factor explaining the relationship between managers' self-monitoring and their subordinates' attitudes toward their organizations. The study was carried out with middle-level managers (N=64) and their subordinates (N=210) from various business organizations in Turkey. Results indicate that subordinates' leadership perceptions of their managers mediate the relationship between managers' self-monitoring and their subordinates' affective and normative organizational commitment. These results provide insight into some of the antecedents and outcomes of leadership perception