Explaining Veracity Predictions with Evidence Summarization: A Multi-Task Model Approach

The rapid dissemination of misinformation through social media increased the importance of automated fact-checking. Furthermore, studies on what deep neural models pay attention to when making predictions have increased in recent years. While significant progress has been made in this field, it has not yet reached a level of reasoning comparable to human reasoning. To address these gaps, we propose a multi-task explainable neural model for misinformation detection. Specifically, this work formulates an explanation generation process of the model's veracity prediction as a text summarization problem. Additionally, the performance of the proposed model is discussed on publicly available datasets and the findings are evaluated with related studies

Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

BACKGROUND: Exposure to exogenous zinc results in increased apoptosis, growth inhibition, and altered oxidative stress in cancer cells. Previous studies also suggested that zinc sensitizes some cancer cells to cytotoxic agents depending on the p53 status. Therefore, zinc supplementation may show anticancer efficacy solely and may increase docetaxel-induced cytotoxicity in non-small-cell lung cancer cells. METHODS: Here, we report the effects of several concentrations of zinc combined with docetaxel on p53-wild-type (A549) and p53-null (H1299) cells. We evaluated cellular viability, apoptosis, and cell cycle progression as well as oxidative stress parameters, including superoxide dismutase, glutathione peroxidase, and malondialdehyde levels. RESULTS: Zinc reduced the viability of A549 cells and increased the apoptotic response in both cell lines in a dose-dependent manner. Zinc also amplified the docetaxel effects and reduced its inhibitory concentration 50 (IC(50)) values. The superoxide dismutase levels increased in all treatment groups; however, glutathione peroxidase was slightly increased in the combination treatments. Zinc also caused malondialdehyde elevations at 50 μM and 100 μM. CONCLUSION: Zinc has anticancer efficacy against non-small-cell lung cancer cells in the presence of functionally active p53 and enhances docetaxel efficacy in both p53-wild-type and p53-deficient cancer cells

Neuroendocrine tumors presenting with thyroid gland metastasis: a case series

<p>Abstract</p> <p>Introduction</p> <p>Autopsy series have shown that metastasis to the thyroid gland has occurred in up to 24% of patients who have died of cancer. Neuroendocrine tumors may metastasize to thyroid gland.</p> <p>Case presentations</p> <p>Case 1 was a 17-year-old Turkish woman who was referred from our Endocrinology Department for a thyroidectomy for treatment of neuroendocrine tumor metastasis. She was treated with a bilateral total thyroidectomy. Histopathological examination results were consistent with a neuroendocrine tumor; neoplastic cells showed strong immunoreactivity to chromogranin A and synaptophysin, but the immunohistochemical profile was inconsistent with medullary thyroid carcinoma in that the tumor was negative for calcitonin, carcinoembryonic antigen, and thyroid transcription factor-1.</p> <p>Case 2 was a 54-year-old Turkish woman who presented with a 3-cm nodule on her right thyroid lobe. She had undergone surgery for a right lung mass four years previously. After a right pneumonectomy, thymectomy and lymph node dissection, a typical carcinoid tumor was diagnosed. Under ultrasonographic guidance, fine needle aspiration biopsy of her right thyroid pole nodule was performed and the biopsy was compatible with a neuroendocrine tumor metastasis. She was treated with a bilateral total thyroidectomy. Histopathological examination indicated three nodular lesions, 5 cm and 0.4 cm in diameter in her right lobe and 0.1 cm in diameter in her left lobe. The tumors were consistent with a neuroendocrine phenotype, showing strong immunoreactivity to chromogranin A and synaptophysin.</p> <p>Conclusion</p> <p>Thyroid nodules detected during follow-up of neuroendocrine tumor patients should be thoroughly investigated. A fine needle aspiration biopsy of the thyroid confirms the diagnosis in most cases and leads to appropriate management of those patients and may prevent unnecessary treatment approaches.</p

Preferred Computer Activities During School Age: Indicators of Internet Addiction

Dramatic increase in the use of the internet in recent years has led to pathological use. This study is a preliminary investigation of the extent of internet addiction in 6(th), 7(th) and 8(th) grade school children in Ankara, Turkey. 106 boys and 110 girls participated in the study. Computer use subtest of the Turkish adaptation of the Computer Attitudes Questionnaire was applied. Results showed that boys are more into computer and internet use for various purposes. As children grow old, their internet use purposes seem to change as well as their daily computer use amounts increase. 6(th) graders are more into online gaming and using internet for studying whereas 8(th) graders mainly use internet for chatting. Vast majority of the 8(th) graders spend more than 5 hours on internet each day. (C) 2010 Published by Elsevier Ltd.WoSScopu

The Bethesda system for reporting thyroid fine needle aspiration cytology: A study comparing the results of two centers from two different countries

Three thousand and forty-one cases of thyroid FNAs have been classified following the Bethesda System for reporting thyroid cytopathology. They have been collected over a 2-year period in two different university centers; one in Turkey and the other in France. Harmonization in the distribution of the diagnostic categories as well as an increasing risk of malignancy towards "benign" to "malignant" categories were shown in both of the series and were quite equivalent to the Bethesda System expected results. Furthermore, applying this terminology gives us the opportunity to make an easy comparison between our results. However, some discrepancies still exist between these two compared series for the estimated risk of malignancy per category. One reason could be the differences in application of the cytological criteria. However, close analysis of our results and comparison with already published series lead us to point out that differences between countries and institutions could also be due to factors other than the Bethesda terminology such as epidemiological factors, organized national screening and interobserver variability in histopathology. (c) 2012 Elsevier Masson SAS. All rights reserved

The Bethesda system for reporting thyroid fine needle aspiration cytology: A study comparing the results of two centers from two different countries

Three thousand and forty-one cases of thyroid FNAs have been classified following the Bethesda System for reporting thyroid cytopathology. They have been collected over a 2-year period in two different university centers; one in Turkey and the other in France. Harmonization in the distribution of the diagnostic categories as well as an increasing risk of malignancy towards "benign" to "malignant" categories were shown in both of the series and were quite equivalent to the Bethesda System expected results. Furthermore, applying this terminology gives us the opportunity to make an easy comparison between our results. However, some discrepancies still exist between these two compared series for the estimated risk of malignancy per category. One reason could be the differences in application of the cytological criteria. However, close analysis of our results and comparison with already published series lead us to point out that differences between countries and institutions could also be due to factors other than the Bethesda terminology such as epidemiological factors, organized national screening and interobserver variability in histopathology. (c) 2012 Elsevier Masson SAS. All rights reserved

Primary small cell carcinoma of the parotid: Fine needle aspiration and immunohistochemical features of a neuroendocrine variant

Salivary gland small cell carcinoma (SGSmCC) is extremely rare, accounting for less than 1% of salivary gland tumors. A 42-year-old female patient came to the outpatient clinic due to a mass localized in the left submandibular space and that had been growing since 3-4 months. The fine needle aspiration cytology (FNAC) matched with small cell carcinoma (SmCC). As no other focus was detected by computerized tomography (CT), it was accepted as a primary neoplasm of the parotid gland. The histopathological assessment of the excised material and immunohistochemical staining demonstrated a neuroendocrine differentiation of SmCC. No recurrence was observed during the 54-month follow-up period. We believe this to be the second case of SmCC with neuroendocrine differantiation of the parotid glands reported in TurkUsh medical literature and will be added to the english database as one of the favorable SmCC cases