Prediction of Smoothed Sunspot Number Using Dynamic Relations Between the Sun and Planets

Dynamic parameters of sun and planet interaction for predicting sunspot

Statistical mechanics of ecosystem assembly

We introduce a toy model of ecosystem assembly for which we are able to map out all assembly pathways generated by external invasions. The model allows to display the whole phase space in the form of an assembly graph whose nodes are communities of species and whose directed links are transitions between them induced by invasions. We characterize the process as a finite Markov chain and prove that it exhibits a unique set of recurrent states (the endstate of the process), which is therefore resistant to invasions. This also shows that the endstate is independent on the assembly history. The model shares all features with standard assembly models reported in the literature, with the advantage that all observables can be computed in an exact manner.Comment: Accepted for publication in Physical Review Letter

BCG treatment of human tumour xenografts in athymic nude mice.

Xenografts of 3 human malignant cell lines in congenitally athymic nude mice have been examined for susceptibility to BCG. Growth of all 3 tumours, a bladder carcinoma, a melanoma and a colon carcinoma, was suppressed when cells were injected in admixture with BCG. Distant injection of BCG was ineffective. Mice with progressive growths had no detectable anti-human antibody, and rejection of cells and BCG failed to confer protection against subsequent tumour challenge. These studies indicate that human malignant cells are susceptible to local BCG-activated host responses, and that athymic mouse xenografts may be a useful model for assessing the response of human tumours to such agents

Serological aspects of rat tumour xenograft growth in athymic nude mice.

The serum of athymic nude mice bearing rat tumour xenografts has been examined for tumour-specific antigen. With a sarcoma and a hepatoma, tumour-specific antigen expression continued in xenograft growths, and sera of tumour-bearing mice contained free antigen, assayed by its ability to neutralise reactivity of tumour-immune rat sera against tumour target cells in an indirect membrane-immunofluorescence test. In contrast, no anti-rat antibody was detectable in sera of mice bearing the xenografts, or rejecting cells injected in admixture with BCG

Complement-dependent cytotoxicity of anti-human osteogenic sarcoma monoclonal antibodies.

Two mouse monoclonal antibodies against the human osteogenic sarcoma 791T were examined for their capacity to exert complement-dependent cytotoxicity against a panel of human tumour cell lines. Cytotoxicity was most evident against the immunizing tumour 791T although significant reactivity was directed against other osteogenic sarcomas. In admixture, the 2 antibodies displayed synergism in their cytotoxicity although this was only demonstrable with defined ranges of antibody concentration. The cytotoxicity of these antibodies was dependent upon the use of rabbit serum as complement and no tumour-cell lysis was produced using human, guinea-pig or mouse serum complement. The more potent cytotoxic antibody failed to modify the outgrowth of 791T tumour xenografts in immunodeprived mice even though localization of antibody at the tumour site has been demonstrated (Pimm et al., 1982)

Trajectories for the 1976 - 1980 Grand Tour opportunities. Volume 3 - Trajectory data for alternate Grand Tour missions

Tabulating trajectory data for alternate Grand Tour missions from earth for period 1976 to 198