Peri-implant diseases and metabolic syndrome components: a systematic review

OBJECTIVE: Metabolic syndrome (MetS) is defined as a spectrum of conditions associated with an increased risk of developing CVD and type 2 diabetes. MetS include: hyperglycemia, hypertension, visceral obesity, dyslipidemia with elevated values of triglycerides (TG) and low levels of HDL. The aim of this review is to provide current knowledge of the relationship between MetS, its components and peri-implant diseases. MATERIALS AND METHODS: An electronic literature search was conducted in the English language in several databases. The Newcastle-Ottawa Scale was used for quality assessment of cohort and cross-sectional studies; while systematic reviews were evaluated through AMSTAR; results were reported according to the PRISMA Statement. RESULTS: A total of 272 records were identified through database searching, six studies were included for qualitative analysis. No study directly related to MetS was found, there was inconsistent and controversial evidence regarding association with cardiovascular disease. A higher risk of peri-implantitis was detected in people with hyperglycemia. CONCLUSIONS: Future research should be orientated in assessing the risk of peri-implant diseases, evaluating patient's therapeutic response, analyzing directionality of the relationship between MetS, its components and biologic implant complications. Few studies have investigated the possible relationship between systemic conditions and peri-implant diseases. The aim of this review is to present, in a systematic manner, current evidence and knowledge regarding possible association between cardiovascular disease and implant biologic complications. Out of the one-hundred-eighty-nine studies screened, just five studies were selected for qualitative analysis: three cohort studies (one prospective and two retrospectives) and two cross-sectional studies. According to their results, there is inconsistent and controversial evidence regarding association of cardiovascular disease and implant biologic complications. Future research should be orientated in conducting longitudinal studies, evaluating patients affected by cardiovascular disease rehabilitated with dental implants

The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions

C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migra- tion and proliferation, has shown differential immunostaining in various benign and malig- nant melanocytic lesions. The purpose of this study is to compare c-Kit immunostaining in benign nevi and in primary and metastatic malignant melanomas, to determine whether c-Kit can aid in the differential diagnosis of these lesions. c-Kit immunostaining was per- formed in 60 cases of pigmented lesions, including 39 benign nevi (5 blue nevi, 5 intra- dermal nevi, 3 junctional nevi, 15 cases of pri- mary compound nevus, 11 cases of Spitz nevus), 18 cases of primary malignant melanoma and 3 cases of metastatic melanoma. The vast majority of nevi and melanomas examined in this study were posi- tive for c-Kit, with minimal differences between benign and malignant lesions. C-Kit cytoplasmatic immunoreactivity in the intraepidermal proliferating nevus cells, was detected in benign pigmented lesions as well as in malignant melanoma, increasing with the age of patients (P=0.007) in both groups. The patient’s age at presentation appeared to be the variable able to cluster benign and malignant pigmented lesions. The percentage of c-Kit positive intraepidermal nevus cells was better associated with age despite other vari- ables (P=0.014). The intensity and percentage of c-Kit positivity in the proliferating nevus cells in the dermis was significantly increased in malignant melanocytic lesions (P=0.015 and P=0.008) compared to benign lesions (compound melanocytic nevi, Spitz nevi, intradermal nevi, blue nevi). Immunostaning for c-Kit in metastatic melanomas was nega- tive. Interestingly in two cases of melanoma occurring on a pre-existent nevus, the melanoma tumor cells showed strong cytoplas- matic and membranous positivity for c-kit, in contrast with the absence of any immunoreac- tivity in pre-existent intradermal nevus cells. C-Kit does not appear to be a strong immuno- histochemical marker for distinguishing melanoma from melanocytic nevi, if we consid- er c-Kit expression in intraepidermal prolifer- ating cells. The c-Kit expression in proliferat- ing melanocytes in the dermis could help in the differential diagnosis between a superfi- cial spreading melanoma (with dermis inva- sion) and a compound nevus or an intradermal nevus. Finally, c-Kit could be a good diagnostic tool for distinguishing benign compound nevi from malignant melanocytic lesions with der- mis invasion and to differentiate metastatic melanoma from primary melanoma

Amplitude analysis and the nature of the Zc(3900)

The microscopic nature of the XYZ states remains an unsettled topic. We show how a thorough amplitude analysis of the data can help constraining models of these states. Specifically, we consider the case of the Zc(3900) peak and discuss possible scenarios of a QCD state, virtual state, or a kinematical enhancement. We conclude that current data are not precise enough to distinguish between these hypotheses, however, the method we propose, when applied to the forthcoming high-statistics measurements should shed light on the nature of these exotic enhancements.Comment: 14 pages, 10 figures, 3 tables. Version accepted for publication on Phys.Lett.

On the η\eta and η′\eta' Photoproduction Beam Asymmetry at High Energies

We show that, in the Regge limit, beam asymmetries in $\eta$ and $\eta'$ photoproduction are sensitive to hidden strangeness components. Under reasonable assumptions about the couplings we estimate the contribution of the $\phi$ Regge pole, which is expected to be the dominant hidden strangeness contribution. The ratio of the asymmetries in $\eta'$ and $\eta$ production is estimated to be close to unity in the forward region $0 < -t/\text{GeV}^2 \leq 1$ at the photon energy $E_\text{lab} = 9$~GeV, relevant for the upcoming measurements at Jefferson Lab.Comment: 9 pages, 4 figure

Exclusive tensor meson photoproduction

We study tensor meson photoproduction outside of the resonance region, at beam energies of few GeVs. We build a model based on Regge theory that includes the leading vector and axial exchanges. We consider two determinations of the unknown helicity couplings, and fit to the recent a2 photoproduction data from CLAS. Both choices give a similar description of the a2 cross section, but result in different predictions for the parity asymmetries and the f2 photoproduction cross section. We conclude that new measurements of f2 photoproduction in the forward region are needed to pin down the correct production mechanism. We also extend our predictions to the 8.5 GeV beam energy, where current experiments are running.Comment: 13 pages, 7 figures, 3 tables. Version accepted for publication on Phys.Rev.

Studying the Pc(4450) resonance in J/psi photoproduction off protons

The LHCb has reported the observation of a resonancelike structure, the Pc(4450), in the J/psi p invariant masses. In our work, we discuss the feasibility of detecting this structure in J/psi photoproduction, e.g. in the measurements that have been approved for the experiments in Hall A/C and in Hall B with CLAS12 at JLab. Also the GlueX Collaboration has already reported preliminary results. We take into account the experimental resolution effects, and perform a global fit to world J/psi photoproduction data in order to study the possibility of observing the Pc(4450) signal in future JLab data. We present a first estimate of the upper limit for the branching ratio of the Pc(4450) into the J/psi p channel, and we study the angular distributions of the differential cross sections. This will shed light on the nature and couplings of the Pc(4450) structure in the future photoproduction experiments.Comment: NSTAR 2017 conference proceeding

Early wound healing outcomes after regenerative periodontal surgery with enamel matrix derivatives or guided tissue regeneration: a systematic review

Background Proper wound healing after regenerative surgical procedures is an essential issue for clinical success. Guided tissue regeneration (GTR) and application of enamel matrix derivatives (EMD) are common means to regenerate periodontal tissues. Both methods bear considerable advantages due to their special characteristics, but also go along with certain disadvantages. Today, there is no consensus in the literature whether GTR or EMD show better results regarding early wound healing, which is considered a crucial stage in periodontal regeneration. Therefore, the aim of the present systematic review was to compare the early wound healing after regenerative periodontal surgery with either EMD or GTR treatment.MethodsAn electronic literature search in PubMed was performed to identify randomized clinical trials (RCTs) or clinical trials (CTs) comparing regenerative surgery employing EMD and/or GTR in patients with chronic periodontitis. Among the finally included studies, a qualitative and quantitative data extraction regarding early wound healing parameters was performed. Primary outcome parameters were early wound healing index (EWH), flap dehiscence, membrane exposure, suppuration and abscess formation during the first 6weeks. As secondary parameters, swelling and allergic reactions were assessed.ResultsSeven studies reporting 220 intrabony periodontal defects in 199 patients were analysed.Flap dehiscence was observed in two studies in 12% of the GTR treated sites and in 10.3% of those treated with EMD. Membrane exposure was evaluated in five studies and was registered in the 28.8% of the defects, while no dehiscence was reported on the EMD group. Swelling was reported only in one study in 8/16 GTR sites and 7/16 EMD sites. Due to considerable heterogeneity of parameters no meta-analysis was possible.ConclusionsDue to considerable heterogeneity of the published studies a clear beneficial effect of the EMD on the early wound healing outcomes after surgical treatment of periodontal intrabony defects cannot be confirmed.Standardized RCT studies are needed in order to allow for proper comparison of early wound healing after both types of surgical approaches

Structure of Pion Photoproduction Amplitudes

We derive and apply the finite energy sum rules to pion photoproduction. We evaluate the low energy part of the sum rules using several state-of-the-art models. We show how the differences in the low energy side of the sum rules might originate from different quantum number assignments of baryon resonances. We interpret the observed features in the low energy side of the sum rules with the expectation from Regge theory. Finally, we present a model, in terms of a Regge-pole expansion, that matches the sum rules and the high-energy observables.Comment: 19 pages, 15 figures and 4 table

TAN: A Distributed Algorithm for Dynamic Task Assignment in WSNs

We consider the scenario of wireless sensor networks where a given application has to be deployed and each application task has to be assigned to each node in the best possible way. Approaches where decisions on task execution are taken by a single central node can avoid the exchange of data packets between task execution nodes but cannot adapt to dynamic network conditions, and suffer from computational complexity. To address this issue, in this paper, we propose an adaptive and decentralized task allocation negotiation algorithm (TAN) for cluster network topologies. It is based on noncooperative game theory, where neighboring nodes engage in negotiations to maximize their own utility functions to agree on which of them should execute single application tasks. Performance is evaluated in a city scenario, where the urban streets are equipped with different sensors and the application target is the detection of the fastest way to reach a destination, and in random WSN scenarios. Comparisons are made with three other algorithms: 1) baseline setting with no task assignment to multiple nodes; 2) centralized task assignment lifetime optimization; and 3) a dynamic distributed algorithm, DLMA. The result is that TAN outperforms these algorithms in terms of application completion time and average energy consumption. Published in

Cooperative task assignment for distributed deployment of applications in WSNs

Nodes in Wireless Sensor Networks (WSNs) are becoming more and more complex systems with the capabilities to run distributed structured applications. Which single task should be implemented by each WSN node needs to be decided by the application deployment strategy by taking into account both network lifetime and execution time requirements. In this paper, we propose an adaptive decentralised algorithm based on noncooperative game theory, where neighbouring nodes negotiate among each other to maximize their utility function. We then prove that an increment of the nodes utility corresponds to the same increment of the utility for the whole network. Simulation results show significant performance improvement with respect to existing algorithms