The Life History of a Knowledge Support System: Emerging a Change Process for Knowledge Rich Organisations

This case study traces the life history through several transformations of software used by knowledge workers in a global professional practice. The target application provides a globally operating major firm with knowledge management support for legal practitioners and provides data to support managing its relationships with clients. The research constitutes a careful longitudinal reflection using the processes and techniques of Action Research and Grounded Theory. An information systems change management process is promulgated

The life history of a knowledge support system: emerging a change process for knowledge rich organisations

This case study traces the life history through several transformations of software used by knowledge workers in a global professional practice. The target application provides a globally operating major firm with knowledge management support for legal practitioners and provides data to support managing its relationships with clients. The research constitutes a careful longitudinal reflection using the processes and techniques of Action Research and Grounded Theory. An information systems change management process is promulgated. The change process that was emerged is richer than existing change management processes with which it is compared. It is suggested that this enhanced change process may be useful particularly in organisations of knowledge rich practitioners

At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis

The development of striated muscle in vertebrates requires the assembly of contractile myofibrils, consisting of highly ordered bundles of protein filaments. Myofibril formation occurs by the stepwise addition of complex proteins, a process that is mediated by a variety of molecular chaperones and quality control factors. Most notably, myosin of the thick filament requires specialized chaperone activity during late myofibrillogenesis, including that of Hsp90 and its cofactor, Unc45b. Unc45b has been proposed to act exclusively as an adaptor molecule, stabilizing interactions between Hsp90 and myosin; however, recent discoveries in zebrafish and C. elegans suggest the possibility of an earlier role for Unc45b during myofibrillogenesis. This role may involve functional control of nonmuscle myosins during the earliest stages of myogenesis, when premyofibril scaffolds are first formed from dynamic cytoskeletal actin. This paper will outline several lines of evidence that converge to build a model for Unc45b activity during early myofibrillogenesis

Review of offshore cable reliability metrics

Reliable cable systems are essential for offshore wind operation. Industry trends have led to a large number of offshore cable connections being installed recently, with 11027 MW of offshore wind connected at the end of 2015 compared to just 2955 MW in 2010 [1]. Despite the increase in connections, the publically available reliability data in this area is almost non-existent. With several connections in planning of both similar and increasing lengths it is essential to better understand these metrics. A review of published reliability data was undertaken in order to populate a database which is presented in this paper. This data focusses on a number of connection types including both AC and DC connections across a number of cable ratings and configurations. From this database it is confirmed that reliability figures currently being used across the literature generally conform to those currently being experienced in the offshore wind industry. However it is established that failure rates taken from some reports are not accurate as the technology and environments these are calculated from are typically different from those used in offshore wind farm connections. This information is collated and converted into reliability metrics in order for comparisons to be made. Analysis of the cost of an outage experienced by a windfarm is also carried out in this paper. The results of which establish that the revenue lost from a cable failure could potentially be substantial. The findings in this paper would also suggest a greater risk of failure in the early life of a windfarm and as such a greater potential cost associated with this risk. It is important to have a better understanding of offshore renewable energy cable connections as the reliability of a cable has a significant impact on the Levelised Cost of Energy. With a greater understanding of the metrics investors can make more informed decisions with respect to the technology that is installed as well as the importance of the installation process itself, due diligence on subsequent OFTO asset purchases and the maintenance plans that have been outlined for the connection

Wavelength-Agile External-Cavity Diode Laser for DWDM

A prototype external-cavity diode laser (ECDL) has been developed for communication systems utilizing dense wavelength- division multiplexing (DWDM). This ECDL is an updated version of the ECDL reported in Wavelength-Agile External- Cavity Diode Laser (LEW-17090), NASA Tech Briefs, Vol. 25, No. 11 (November 2001), page 14a. To recapitulate: The wavelength-agile ECDL combines the stability of an external-cavity laser with the wavelength agility of a diode laser. Wavelength is modulated by modulating the injection current of the diode-laser gain element. The external cavity is a Littman-Metcalf resonator, in which the zeroth-order output from a diffraction grating is used as the laser output and the first-order-diffracted light is retro-reflected by a cavity feedback mirror, which establishes one end of the resonator. The other end of the resonator is the output surface of a Fabry-Perot resonator that constitutes the diode-laser gain element. Wavelength is selected by choosing the angle of the diffracted return beam, as determined by position of the feedback mirror. The present wavelength-agile ECDL is distinguished by design details that enable coverage of all 60 channels, separated by 100-GHz frequency intervals, that are specified in DWDM standards

#41 - A preliminary assessment of native pollinator attraction to bee hotels in northeast Georgia

Native pollinators are an essential component of ecosystems as they ensure a stable and diverse vegetation community. However, populations at local, regional and global scales are currently threatened and will potentially undergo a large-scale extinction. One of the primary challenges is the constant threat of nesting habitat degradation. These structures are especially important in well-manicured areas where there is a lack of natural debris (e.g., decaying logs, leaves). In this study, we created “Bee Hotels” to serve as pre-constructed native pollinator habitats at UNG’s Appalachian Studies Center in The Historic Vickery House gardens. We placed these structures near an open-air garden as well as an enclosed hoop house garden. Pollinators were assessed using the method established in partnership with University of Georgia Extension Great Pollinator Census. We found that pollinator species occupied both structures to an equal degree and inhabited them within three to four days following their construction. These preliminary data indicate that 1) there is a need for increased pollinator habitats across the UNG Dahlonega Campus, and 2) pollinators in open-air as well as enclosed settings utilize these structures. In the future, we will compare pollinator usage of the hotels in manicured versus unmanicured areas. Comparison of data collected prior to and after the establishment of bee hotels will indicate the effectiveness of bee hotels as a native pollinator habitat and inform conservation practices at UNG and more broadly

Dynamical Belyi maps

We study the dynamical properties of a large class of rational maps with exactly three ramification points. By constructing families of such maps, we obtain infinitely many conservative maps of degree $d$; this answers a question of Silverman. Rather precise results on the reduction of these maps yield strong information on the rational dynamics.Comment: 21 page

Valve-in-valve TAVI and risk of coronary obstruction: Validation of the VIVID classification.

BACKGROUND The Valve-in-Valve International Data (VIVID) registry proposed a simplified classification to assess the risk of coronary obstruction during valve-in-valve transcatheter aortic valve implantation (ViV-TAVI) based on preprocedural multi-detector computed tomography (MDCT). We investigated the validity of the VIVID classification in patients undergoing ViV-TAVI for degenerated bioprostheses. METHODS Patients undergoing ViV-TAVI for degenerated bioprostheses were prospectively included in this study. The risk of coronary obstruction among patients treated with stented valves was retrospectively evaluated based on anatomical assessment on pre-procedural MDCT. RESULTS Among a total of 137 patients that underwent ViV-TAVI between August 2007 and June 2021, 109 patients had stented, sutureless, or transcatheter degenerated bioprosthesis of which 96 (88%) had adequate MDCT data for risk assessment. High-risk anatomy for coronary obstruction (VIVID type IIB, IIIB, or IIIC) in either the left or right coronary artery was observed in 30 patients (31.3%). Of the 30 patients with high-risk anatomy, coronary protection using wire protection or BASILICA (bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction) was performed in 3 patients (10.0%). Three patients treated with stentless valves and one patient treated with a stented valve with externally mounted leaflets had coronary obstruction. None of the patients with high risk anatomy according to MDCT had coronary obstruction even without coronary protection. CONCLUSIONS Coronary obstruction occurred in none of the patients classified as high-risk patients according to the VIVID classification despite the absence of coronary protection. Refined tools are required to assess the risk of coronary obstruction. CLINICAL TRIAL REGISTRATION https://www. CLINICALTRIALS gov. NCT01368250

Characterizing Episodic Memory Retrieval: Electrophysiological Evidence for Diminished Familiarity following Unitization

Episodic memory relies on both recollection and familiarity; why these processes are differentially engaged during retrieval remains unclear. Traditionally, recollection has been considered necessary for tasks requiring associative retrieval, whereas familiarity supports recognition of items. Recently, however, familiarity has been shown to contribute to associative recognition if stimuli are "unitized" at encoding (a single representation is created from multiple elements)-the "benefit" of unitization. Here, we ask if there is also a "cost" of unitization; are the elements of unitized representations less accessible via familiarity? We manipulated unitization during encoding and used ERPs to index familiarity and recollection at retrieval. The data revealed a selective reduction in the neural correlate of familiarity for individual words originally encoded in unitized compared with nonunitized word pairs. This finding reveals a measurable cost of unitization, suggesting that the nature of to-be-remembered stimuli is critical in determining whether familiarity contributes to episodic memory