Inhomogeneity of donor doping in SrTiO3 substrates studied by fluorescence-lifetime imaging microscopy

Fluorescence-lifetime imaging microscopy (FLIM) was applied to investigate the donor distribution in SrTiO3 single crystals. On the surfaces of Nb- and La-doped SrTiO3, structures with different fluorescence intensities and lifetimes were found that could be related to different concentrations of Ti3+. Furthermore, the inhomogeneous distribution of donors caused a non-uniform conductivity of the surface, which complicates the production of potential electronic devices by the deposition of oxide thin films on top of doped single crystals. Hence, we propose FLIM as a convenient technique (length scale: 1 $\mu$m) for characterizing the quality of doped oxide surfaces, which could help to identify appropriate substrate materials

Consistent reductions of IIB*/M* theory and de Sitter supergravity

We construct consistent non-linear Kaluza Klein reduction ansatze for a subset of fields arising from the reduction of IIB* and M* theory on dS_5 x H^5 and dS_4 x AdS_7, respectively. These reductions yield four and five-dimensional de Sitter supergravities, albeit with wrong sign kinetic terms. We also demonstrate that the ansatze may be used to lift multi-centered de Sitter black hole solutions to ten and eleven dimensions. The lifted dS_5 black holes correspond to rotating E4-branes of IIB* theory.Comment: 27 pages, late

Effect of creatine malate supplementation on physical performance, body composition and selected hormone levels in spinters and long-distance runners

Purpose The aim of the study was to determine whether creatine malate (CML) supplementation results in similar ergogenic effect in sprinters and long-distance runners. The other goal was to compare changes in body composition, physical performance and hormone levels after six-week training in athletes, divided into subgroups supplemented with creatine malate or taking placebo. Results Six-week supplementation combined with physical training induced different effects in athletes. Significantly higher increases in relative and absolute peak power and total work (p < 0.05) were found in sprinters compared to other groups. Except for growth hormone, post-exercise venous blood serum hormone levels exhibited no statistically significant differences in athletes. After CML loading period, a significant increase in growth hormone was found in the group of sprinters. Conclusions A significant ergogenic effect was found in sprinters, which was reflected by the increase in anaerobic exercise indices and morphological indices and elevated growth hormone level, after graded exercise testing. The significant increase in the distance covered during graded test was only observed in supplemented long-distance runners, whereas no significant changes in maximal oxygen uptake, relative peak power and relative total work were noticed. This could be caused by later anaerobic threshold appearance in exercise test to exhaustion

Spectral Functions in Holographic Renormalization Group Flows

The spectrum of two-point functions in a holographic renormalization group flow from an ultraviolet (UV) to an infrared (IR) conformal fixed point is necessarily continuous. For a toy model, the spectral function does not only show the expected UV and IR behaviours, but other interesting features such as sharp peaks and oscillations in the UV. The spectral functions for the SU(3)xU(1) flow in AdS_4/CFT_3 and the SU(2)xU(1) flow in AdS_5/CFT_4 are calculated numerically. They exhibit a simple cross-over behaviour and reproduce the conformal dimensions of the dual operators in the UV and IR conformal phases.Comment: 20 pages, 6 figures v2: added referene

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability

YesEffective suppression of JAK–STAT signalling by the inducible inhibitor “suppressor of cytokine signalling 3” (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is a functionally significant SOCS3- interacting protein. Biochemical and confocal imaging demonstrate that SOCS3 localisation to the plasma membrane requires cavin-1. SOCS3 is also critical for cavin-1 stabilisation, such that deletion of SOCS3 reduces the expression of cavin-1 and caveolin-1 proteins, thereby reducing caveola abundance in endothelial cells. Moreover, the interaction of cavin-1 and SOCS3 is essential for SOCS3 function, as loss of cavin-1 enhances cytokine-stimulated STAT3 phosphorylation and abolishes SOCS3-dependent inhibition of IL-6 signalling by cyclic AMP. Together, these findings reveal a new functionally important mechanism linking SOCS3-mediated inhibition of cytokine signalling to localisation at the plasma membrane via interaction with and stabilisation of cavin-1.This work was supported by project grants to T.M.P. from the Chief Scientist Office (ETM/226), British Heart Foundation (PG12/1/ 29276, PG 14/32/30812), and a National Health Service Greater Glasgow and Clyde Research Endowment Fund (2011REFCH08). P.F.P. was supported by the National Institutes of Health grant DK097708. J.J.L.W. was supported by a doctoral training studentship from the Biotechnology and Biological Sciences Research Council Doctoral Training Programme in Biochemistry and Molecular Biology at the University of Glasgow (BB/F016735/1). N.A. was supported by a Saudi Government PhD Scholarship. This work was also supported in part by equipment grants to T.M.P. from Diabetes UK (BDA 11/0004309) and Alzheimer’s Research UK (ARUK-EG2016A-3)

String theory and the Classical Stability of Plane Waves

The presence of fields with negative mass-squared typically leads to some form of instability in standard field theories. The observation that, at least in the light-cone gauge, strings propagating in plane wave spacetimes can have worldsheet scalars with such tachyon-like masses suggests that the supergravity background may itself be unstable. To address this issue, we perform a perturbative analysis around the type IIB vacuum plane wave, the solution which most obviously generates worldsheet scalars with negative mass-squared. We argue that this background is perturbatively stable.Comment: 23 pages, no figures; v2: very minor changes, references added, version accepted by PR

Constructing Lifshitz solutions from AdS

Under general assumptions, we show that a gravitational theory in d+1 dimensions admitting an AdS solution can be reduced to a d-dimensional theory containing a Lifshitz solution with dynamical exponent z=2. Working in a d=4, N=2 supergravity setup, we prove that if the AdS background is N=2 supersymmetric, then the Lifshitz geometry preserves 1/4 of the supercharges, and we construct the corresponding Killing spinors. We illustrate these results in examples from supersymmetric consistent truncations of type IIB supergravity, enhancing the class of known 4-dimensional Lifshitz solutions of string theory. As a byproduct, we find a new AdS4 x S1 x T(1,1) solution of type IIB.Comment: 29 pages, no figures; v2 minor corrections, a reference adde

Poincare gauge invariance and gravitation in Minkowski spacetime

A formulation of Poincare symmetry as an inner symmetry of field theories defined on a fixed Minkowski spacetime is given. Local P gauge transformations and the corresponding covariant derivative with P gauge fields are introduced. The renormalization properties of scalar, spinor and vector fields in P gauge field backgrounds are determined. A minimal gauge field dynamics consistent with the renormalization constraints is given.Comment: 36 pages, latex-fil

Generalized Kaehler Potentials from Supergravity

We consider supersymmetric N=2 solutions with non-vanishing NS three-form. Building on worldsheet results, we reduce the problem to a single generalized Monge-Ampere equation on the generalized Kaehler potential K recently interpreted geometrically by Lindstrom, Rocek, Von Unge and Zabzine. One input in the procedure is a holomorphic function w that can be thought of as the effective superpotential for a D3 brane probe. The procedure is hence likely to be useful for finding gravity duals to field theories with non-vanishing abelian superpotential, such as Leigh-Strassler theories. We indeed show that a purely NS precursor of the Lunin-Maldacena dual to the beta-deformed N=4 super-Yang-Mills falls in our class.Comment: "38 pages. v3: improved exposition and minor mistakes corrected in sec. 4

Running Scaling Dimensions in Holographic Renormalization Group Flows

Holographic renormalization group flows can be interpreted in terms of effective field theory. Based on such an interpretation, a formula for the running scaling dimensions of gauge-invariant operators along such flows is proposed. The formula is checked for some simple examples from the AdS/CFT correspondence, but can be applied also in non-AdS/non-CFT cases.Comment: 14 pages, 2 figure