Assembly line balancing and activity scheduling for customised products manufacturing

Nowadays, end customers require personalized products to match their specific needs. Thus, production systems must be extremely flexible. Companies typically exploit assembly lines to manufacture produces in great volumes. The development of assembly lines distinguished by mixed or multi models increases their flexibility concerning the number of product variants able to be manufactured. However, few scientific contributions deal with customizable products, i.e., produces which can be designed and ordered requiring or not a large set of available accessories. This manuscript proposes an original two-step procedure to deal with the multi-manned assembly lines for customized product manufacturing. The first step of the procedure groups the accessories together in clusters according to a specific similarity index. The accessories belonging to a cluster are typically requested together by customers and necessitate a significant mounting time. Thus, this procedure aims to split accessories belonging to the same cluster to different assembly operators avoiding their overloads. The second procedure step consists of an innovative optimization model which defines tasks and accessory assignment to operators. Furthermore, the developed model defines the activity time schedule in compliance with the task precedencies maximizing the operator workload balance. An industrial case study is adopted to test and validate the proposed procedure. The obtained results suggest superior balancing of such assembly lines, with an average worker utilization rate greater than 90%. Furthermore, in the worst case scenario in terms of customer accessories requirement, just 4 line operators out of 16 are distinguished by a maximum workload greater than the cycle time

Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study

Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological evaluations were retrospectively enrolled in the study. PD-MCI and PDD were diagnosed according to the Movement Disorder Society criteria. Incidence rates of PD-MCI and PDD were estimated. Clinical and demographic factors predicting PD-MCI and dementia were evaluated using Cox proportional hazard model. Results: Out of 139 enrolled PD patients, 84 were classified with normal cognition (PD-NC), while 55 (39.6%) fulfilled the diagnosis of PD-MCI at baseline. At follow-up (mean follow-up 23.5 ± 10.3 months) 28 (33.3%) of the 84 PD-NC at baseline developed MCI and 4 (4.8%) converted to PDD. The incidence rate of PD-MCI was 184.0/1000 pyar (95% CI 124.7-262.3). At multivariate analysis a negative association between education and MCI development at follow-up was observed (HR 0.37, 95% CI 0.15-0.89; p = 0.03). The incidence rate of dementia was 24.3/1000 pyar (95% CI 7.7-58.5). Out of 55 PD-MCI patients at baseline, 14 (25.4%) converted to PDD, giving an incidence rate of 123.5/1000 pyar (95% CI 70.3-202.2). A five time increased risk of PDD was found in PD patients with MCI at baseline (RR 5.09, 95% CI 1.60-21.4). Conclusion: Our study supports the relevant role of PD-MCI in predicting PDD and underlines the importance of education in reducing the risk of cognitive impairment

Physical States in Canonically Quantized Supergravity

We discuss the canonical quantization of $N=1$ supergravity in the functional Schrodinger representation. Although the form of the supersymmetry constraints suggests that there are solutions of definite order $n$ in the fermion fields, we show that there are no such states for any finite $n$. For $n=0$, a simple scaling argument definitively excludes the purely bosonic states discussed by D'Eath. For $n>0$, the argument is based on a mode expansion of the gravitino field on the quantization 3-surface. It is thus suggested that physical states in supergravity have infinite Grassmann number. This is confirmed for the free spin-3/2 field, for which we find that states satisfying the gauge constraints contain an infinite product of fermion mode operators.Comment: 36 pages (uses jnl.tex), CTP #227

Metastability in spin polarised Fermi gases and quasiparticle decays

We investigate the metastability associated with the first order transition from normal to superfluid phases in the phase diagram of two-component polarised Fermi gases.We begin by detailing the dominant decay processes of single quasiparticles.Having determined the momentum thresholds of each process and calculated their rates, we apply this understanding to a Fermi sea of polarons by linking its metastability to the stability of individual polarons, and predicting a region of metastability for the normal partially polarised phase. In the limit of a single impurity, this region extends from the interaction strength at which a polarised phase of molecules becomes the groundstate, to the one at which the single quasiparticle groundstate changes character from polaronic to molecular. Our argument in terms of a Fermi sea of polarons naturally suggests their use as an experimental probe. We propose experiments to observe the threshold of the predicted region of metastability, the interaction strength at which the quasiparticle groundstate changes character, and the decay rate of polarons

Slave boson model for two-dimensional trapped Bose-Einstein condensate

A system of N bosons in a two-dimensional harmonic trap is considered. The system is treated in term of the slave boson representation for hard-core bosons which is valid in the arbitrary density regimes. I discuss the consequences of higher order interactions on the density profiles by mapping the slave boson equation to the known Kohn-Sham type equation within the density functional scheme.Comment: 12 pages, 3 figures. Submitted to J. Phys. B : At. mol. opt. phy

Variations on the Seventh Route to Relativity

As motivated in the full abstract, this paper further investigates Barbour, Foster and O Murchadha (BFO)'s 3-space formulation of GR. This is based on best-matched lapse-eliminated actions and gives rise to several theories including GR and a conformal gravity theory. We study the simplicity postulates assumed in BFO's work and how to weaken them, so as to permit the inclusion of the full set of matter fields known to occur in nature. We study the configuration spaces of gravity-matter systems upon which BFO's formulation leans. In further developments the lapse-eliminated actions used by BFO become impractical and require generalization. We circumvent many of these problems by the equivalent use of lapse-uneliminated actions, which furthermore permit us to interpret BFO's formulation within Kuchar's generally covariant hypersurface framework. This viewpoint provides alternative reasons to BFO's as to why the inclusion of bosonic fields in the 3-space approach gives rise to minimally-coupled scalar fields, electromagnetism and Yang--Mills theory. This viewpoint also permits us to quickly exhibit further GR-matter theories admitted by the 3-space formulation. In particular, we show that the spin-1/2 fermions of the theories of Dirac, Maxwell--Dirac and Yang--Mills--Dirac, all coupled to GR, are admitted by the generalized 3-space formulation we present. Thus all the known fundamental matter fields can be accommodated. This corresponds to being able to pick actions for all these theories which have less kinematics than suggested by the generally covariant hypersurface framework. For all these theories, Wheeler's thin sandwich conjecture may be posed, rendering them timeless in Barbour's sense.Comment: Revtex version; Journal-ref adde

Corta meromixis en un lago somero de la región semiárida pampeana

Los lagos meromícticos son aquellos que no se mezclan en su totalidad debido a un fuerte gradiente salino que separa el mixolimnion (superficial, menos salino) del monimolimnion (profundo, más salino). La laguna Este de la Reserva Provincial Parque Luro (La Pampa) es una típica laguna hipersalina (salitral) que luego de una lluvia excepcional mostró una corta meromixis. El objetivo del presente trabajo fue determinar los cambios en las características físico-químicas y en las comunidades planctónicas durante la meromixis, la cual duró al menos 7 meses. En comparación con el monimolimnion, el mixolimnion se caracterizó por tener menor salinidad y nutrientes; sin embargo, tuvo mayor pH, oxígeno disuelto, clorofila, y sólidos orgánicos. La escasa profundidad de esta laguna y la acción de los vientos ocasionaron el fin de la meromixis. El fitoplancton estuvo dominado casi exclusivamente por Dunaliella salina y durante la meromixis no se observaron diferencias en la densidad o en la biomasa en su distribución vertical. El zooplancton (generalmente dominado por Artemia persimilis) redujo su riqueza con el aumento de salinidad. Mientras duró la meromixis, esta especie coexistió con Boeckella poopoensis, y ambas presentaron altas densidades de juveniles en el mixolimnion respecto del monimolimnion. El episodio de una corta meromixis, como el descripto en este estudio, permitió observar diversas condiciones limnológicas y el desarrollo de un mayor número de especies de zooplancton, algunas de ellas endémicas de la región. Estos atributos, transforman a este lago somero en un sitio de particular interés para su conservación

Transcranial random noise stimulation over the primary motor cortex in PD-MCI patients: a crossover, randomized, sham-controlled study

Mild cognitive impairment (MCI) is a very common non-motor feature of Parkinson’s disease (PD) and the non-amnestic single-domain is the most frequent subtype. Transcranial random noise stimulation (tRNS) is a non-invasive technique, which is capable of enhancing cortical excitability. As the main contributor to voluntary movement control, the primary motor cortex (M1) has been recently reported to be involved in higher cognitive functioning. The aim of this study is to evaluate the effects of tRNS applied over M1 in PD-MCI patients in cognitive and motor tasks. Ten PD-MCI patients, diagnosed according to the Movement Disorder Society, Level II criteria for MCI, underwent active (real) and placebo (sham) tRNS single sessions, at least 1 week apart. Patients underwent cognitive (Digit Span Forward and Backward, Digit Symbol, Visual Search, Letter Fluency, Stroop Test) and motor assessments (Unified Parkinson’s Disease Rating Scale [UPDRS-ME], specific timed trials for bradykinesia, 10-m walk and Timed up and go tests) before and after each session. A significant improvement in motor ability (UPDRS-ME and lateralized scores, ps from 0.049 to 0.003) was observed after real versus sham tRNS. On the contrary, no significant differences were found in other motor tasks and cognitive assessment both after real and sham stimulations. These results confirm that tRNS is a safe and effective tool for improving motor functioning in PD-MCI. Future studies using a multisession tRNS applied over multitargeted brain areas (i.e., dorsolateral prefrontal cortex and M1) are required to clarify the role of tRNS regarding rehabilitative intervention in PD

Fluorine-induced J-aggregation enhances emissive properties of a new NLO push–pull chromophore

A new fluorinated push–pull chromophore with good second-order NLO properties even in concentrated solution shows solid state intermolecular aryl–fluoroaryl interactions leading to J-aggregates with intense solid state luminescence