Un guttus inédito procedente de Rusaddir

Study and analysis of an unpublished glass (guttus) from the necropolis of Cerro de san Lorenzo, in the archaeological context of Rusaddir, (Melilla), preparing an examination of this piece, both descriptive and iconographic, and its possible symbolic, religious and funerary meaning.Estudio y análisis de un vaso (guttus) inédito procedente de la necrópolis del Cerro de san Lorenzo, en el contexto arqueológico de Rusaddir, (Melilla) elaborando un examen de esta pieza tanto descriptivo e iconográfico como su posible significado simbólico, religioso y funerario.

Docencia de la asignatura Modelos Abstractos de Cálculo

En este trabajo presentamos nuestro enfoque de la asignatura Modelos Abstractos de Cálculo, que introduce a los estudiantes de las titulaciones de Informática en la Teoría de la Computabilidad. Hacemos especial énfasis en la adaptación de los contenidos teóricos a los conocimientos y habilidades de dichos estudiantes

Nanoarchitectures Based on Layered Titanosilicates Supported on Glass Fibers: Application to Hydrogen Storage

This work reports on the synthesis of nanosheets of layered titanosilicate JDF-L1 supported on commercial E-type glass fibers with the aim of developing novel nanoarchitectures useful as robust and easy to handle hydrogen adsorbents. The preparation of those materials is carried out by hydrothermal reaction from the corresponding gel precursor in the presence of the glass support. Because of the basic character of the synthesis media, silica from the silicate-based glass fibers can be involved in the reaction, cementing its associated titanosilicate and giving rise to strong linkages on the support with the result of very stable heterostructures. The nanoarchitectures built up by this approach promote the growth and disposition of the titanosilicate nanosheets as a house-of-cards radially distributed around the fiber axis. Such an open arrangement represents suitable geometry for potential uses in adsorption and catalytic applications where the active surface has to be available. The content of the titanosilicate crystalline phase in the system represents about 12 wt %, and this percentage of the adsorbent fraction can achieve, at 298 K and 20 MPa, 0.14 wt % hydrogen adsorption with respect to the total mass of the system. Following postsynthesis treatments, small amounts of Pd (<0.1 wt %) have been incorporated into the resulting nanoarchitectures in order to improve their hydrogen adsorption capacity. In this way, Pd-layered titanosilicate supported on glass fibers has been tested as a hydrogen adsorbent at diverse pressures and temperatures, giving rise to values around 0.46 wt % at 298 K and 20 MPa. A mechanism of hydrogen spillover involving the titanosilicate framework and the Pd nanoparticules has been proposed to explain the high increase in the hydrogen uptake capacity after the incorporation of Pd into the nanoarchitecture.We thank the CICYT (Spain, projects MAT2009-09960 and MAT2012-31759), Obra Social la Caixa, Aragon Government (GA-LC-019/2011), ESF, Generalitat Valenciana, and FEDER (PROMETEO/2009/047) for financial support. J.P.-C. is grateful for a Ph.D. grant (FPI, BES-2010-038410) from the Spanish Ministerio de Ciencia e Innovación

Docencia de la informática en las titulaciones de Económicas

En el presente artículo se presenta un estudio de las materias de Informática que se imparten en las Licenciaturas de Economía y Administración de Empresas. Nos centramos en la Universidad de Alicante, detallando el contenido de la asignatura Microinformática e incluyendo un estudio estadístico del grupo destinatario de la asignatura

Instrucción en estrategias de comprensión lectora mediante enseñanza recíproca: Efectos del agrupamiento de los estudiantes.

El objetivo de este estudio es comparar el efecto que dos formatos de agrupamiento de los estudiantes tiene sobre la comprensión lectora. La instrucción en comprensión lectora empleó la Enseñanza Recíproca (ER) que es un procedimiento que enseña a los estudiantes estrategias cognitivas para incrementar la comprensión lectora. Participaron 43 alumnos de 4º de E.P.: 18 fueron instruidos mediante ER en el aula ordinaria (GG); 8 mediante ER en pequeño grupo (PG) y 17 recibieron la enseñanza tradicional. Se emplearon dos tipos de medidas: medidas de efectos específicos (idea principal y supervisión y regulación) y medidas de generalización (test estandarizado, significado implícito y recuerdo). Los resultados demuestran que los dos grupos instruidos mediante ER fueron superiores en las medidas de efectos específicos y en las de generalización al grupo de comparación. Además, el grupo instruido en pequeño grupo (PG) fue superior al GG y GC en la mayoría de las medidas de efectos específicos y de generalización

Innovando en la Gestión académica: La incorporación de protocolos y herramientas digitales en los Grados de la Facultad de Ciencias Políticas y Sociología

Proyecto de Innovación en la Gestión Académica que tiene como objetivos principales incorporar protocolos y herramientas para la mejora en la Calidad de la gestión académica de los Grados. Principalmente aplicables a la coordinación docente de los Grados, la organización académica de los Trabajos Fin de Grado, la difusión e información de los estudios de Grado, el mantenimiento de la información web de los Grados, el reconocimiento de Créditos, y, la acogida, tutela y asesoramiento de los estudiantes de los Grados

GREDIQ-RIMA: The evolution of a teaching project of experimentation in chemistry

Authors of this project belong to the Resources Chemistry Teaching Group (GReDiQ) involved in RIMA (Research and innovation in learning methodologies). The audiovisual and multimedia material productions realized have been grouped into three themes: Basic Techniques of Experimentation in Chemistry, Safety in Chemistry Laboratories and Advanced Techniques of Experimentation in Chemistry. This work has been awarded a prize of the Universitat Politècnica de Catalunya (UPC–BARCELONATECH), one of the Autonomous Region of Catalunya and another one of a State scopePostprint (author’s final draft

Molecular characterization of new FBXL4 mutations in patients with mtDNA depletion syndrome

Encephalomyopathic mitochondrial DNA (mtDNA) depletion syndrome 13 (MTDPS13) is a rare genetic disorder caused by defects in F-box leucine-rich repeat protein 4 (FBXL4). Although FBXL4 is essential for the bioenergetic homeostasis of the cell, the precise role of the protein remains unknown. In this study, we report two cases of unrelated patients presenting in the neonatal period with hyperlactacidemia and generalized hypotonia. Severe mtDNA depletion was detected in muscle biopsy in both patients. Genetic analysis showed one patient as having in compound heterozygosis a splice site variant c.858+5G>C and a missense variant c.1510T>C (p.Cys504Arg) in FBXL4. The second patient harbored a frameshift novel variant c.851delC (p.Pro284LeufsTer7) in homozygosis. To validate the pathogenicity of these variants, molecular and biochemical analyses were performed using skin-derived fibroblasts. We observed that the mtDNA depletion was less severe in fibroblasts than in muscle. Interestingly, the cells harboring a nonsense variant in homozygosis showed normal mtDNA copy number. Both patient fibroblasts, however, demonstrated reduced mitochondrial transcript quantity leading to diminished steady state levels of respiratory complex subunits, decreased respiratory complex IV (CIV) activity, and finally, low mitochondrial ATP levels. Both patients also revealed citrate synthase deficiency. Genetic complementation assays established that the deficient phenotype was rescued by the canonical version of FBXL4, confirming the pathological nature of the variants. Further analysis of fibroblasts allowed to establish that increased mitochondrial mass, mitochondrial fragmentation, and augmented autophagy are associated with FBXL4 deficiency in cells, but are probably secondary to a primary metabolic defect affecting oxidative phosphorylation

ceritinib plus nivolumab in patients with advanced alk rearranged non small cell lung cancer results of an open label multicenter phase 1b study

Abstract Introduction Induction of programmed death ligand 1 (PD-L1) expression due to constitutive oncogenic signaling has been reported in NSCLC models harboring echinoderm microtubule associated protein like 4 gene (EML4)–ALK receptor tyrosine kinase gene (ALK) rearrangements. We assessed the safety and activity of ceritinib plus nivolumab in these patients. Methods In this open-label, phase 1B, multicenter, dose escalation and expansion study, previously treated (with ALK receptor tyrosine kinase [ALK] inhibitor [ALKI]/chemotherapy) or treatment-naive patients with stage IIIB or IV ALK-rearranged NSCLC received nivolumab, 3 mg/kg intravenously every 2 weeks, plus ceritinib, 450 mg/300 mg daily, with a low-fat meal. Results In total, 36 patients were treated (a 450-mg cohort [n=14] and a 300-mg cohort [n=22]). In the 450-mg cohort, four patients experienced dose-limiting toxicities. In the 300-mg cohort, two patients experienced dose-limiting toxicities. Among ALKI-naive patients, the overall response rate (ORR) was 83% (95% confidence interval [CI]: 35.9–99.6) in the 450-mg cohort and 60% (95% CI: 26.2–87.8) in the 300-mg cohort. Among ALKI-pretreated patients, the ORR was 50% (95% CI: 15.7–84.3) in the 450-mg cohort and 25% (95% CI: 5.5–57.2) in the 300-mg cohort. The ORR point estimate was observed to be greater in patients who were positive for PD-L1 than in those who were negative for PD-L1, with overlapping CIs (e.g., at a cutoff ≥1% PD-L1, 64% of patients [95% CI: 35.1–87.2] had confirmed responses as compared with those with negative PD-L1 staining (31% [95% CI: 11.0–58.7]). The most frequently reported grade 3 or 4 adverse events were increased alanine aminotransferase level (25%), increased gamma-glutamyl transferase level (22%), increased amylase level (14%), increased lipase level (11%), and maculopapular rash (11%). The incidence of all-grade rash (grouped term) was 64% in both cohorts; grade 3 rash was reported in 29% and 14% of patients in the 450-mg and 300-mg cohorts, respectively; no grade 4 rash was reported. Conclusion Ceritinib plus nivolumab has activity; ORR appears to correlate with PD-L1 at baseline. Toxicity, especially rash, is more common than with either single agent