Is there an interplay between adherence to mediterranean diet, antioxidant status, and vascular disease in atrial fibrillation patients?

Mediterranean Diet (Med-Diet) is associated with reduced incidence of vascular events (VEs) in atrial fibrillation (AF), but the mechanism accounting for its beneficial effect is only partially known. We hypothesized that Med-Diet may reduce VEs by improving antioxidant status, as assessed by glutathione peroxidase 3 (GPx3) and superoxide dismutase (SOD). We performed a prospective cohort study investigating the relationship between adherence to Med-Diet, serum baseline GPx3 and SOD activities, and the occurrence of VEs in 690 AF patients. GPx3 activity was directly associated with Med-Diet score (B = 0.192, p < 0.001) and inversely with age (B = −0.124, p = 0.001), after adjustment for potential confounders; Med-Diet weakly affected SOD levels. During a mean follow-up of 46.1 ± 28.2 months, 89 VEs were recorded; patients with VEs had lower GPx3 levels compared with those without VEs (p = 0.002); and no differences regarding SOD activity were found. Multivariable Cox regression analysis showed that age (Hazard ratio [HR]:1.065, p < 0.001), logGPx3 (above median, HR: 0.629, p < 0.05), and Med-Diet score (HR: 0.547, p < 0.05) predicted VEs. Med-Diet favorably modulates antioxidant activity of GPx3 in AF, resulting in reduced VEs rate. We hypothesize that the modulation of GPx3 levels by Med-Diet could represent an additional nutritional strategy to prevent VEs in AF patients

Direct Experimental Evidence for Differing Reactivity Alterations of Minerals following Irradiation: The Case of Calcite and Quartz

Concrete, a mixture formed by mixing cement, water, and fine and coarse mineral aggregates is used in the construction of nuclear power plants (NPPs), e.g., to construct the reactor cavity concrete that encases the reactor pressure vessel, etc. In such environments, concrete may be exposed to radiation (e.g., neutrons) emanating from the reactor core. Until recently, concrete has been assumed relatively immune to radiation exposure. Direct evidence acquired on Ar$^+$-ion irradiated calcite and quartz indicates, on the contrary, that, such minerals, which constitute aggregates in concrete, may be significantly altered by irradiation. Specifically, while quartz undergoes disordering of its atomic structure resulting in a near complete lack of periodicity, i.e., similar to glassy silica, calcite only experiences random rotations, and distortions of its carbonate groups. As a result, irradiated quartz shows a reduction in density of around 15%, and an increase in chemical reactivity, described by its dissolution rate, similar to a glassy silica; i.e., an increase of around 3 orders of magnitude. Calcite however, shows little change in dissolution rates - although its density noted to reduce by around 9%. These differences are correlated with the nature of bonds in these minerals, i.e., being dominantly ionic or covalent, and the rigidity of the mineral's atomic network that is characterized by the number of topological constraints (n$_c$) that are imposed on the atoms in the network. The outcomes are discussed within the context of the durability of concrete structural elements formed with calcitic/quartzitic aggregates in nuclear power plants

Is there an interplay between adherence to mediterranean diet, antioxidant status, and vascular disease in atrial fibrillation patients?

Mediterranean Diet (Med-Diet) is associated with reduced incidence of vascular events (VEs) in atrial fibrillation (AF), but the mechanism accounting for its beneficial effect is only partially known. We hypothesized that Med-Diet may reduce VEs by improving antioxidant status, as assessed by glutathione peroxidase 3 (GPx3) and superoxide dismutase (SOD). We performed a prospective cohort study investigating the relationship between adherence to Med-Diet, serum baseline GPx3 and SOD activities, and the occurrence of VEs in 690 AF patients. GPx3 activity was directly associated with Med-Diet score (B = 0.192, p < 0.001) and inversely with age (B = −0.124, p = 0.001), after adjustment for potential confounders; Med-Diet weakly affected SOD levels. During a mean follow-up of 46.1 ± 28.2 months, 89 VEs were recorded; patients with VEs had lower GPx3 levels compared with those without VEs (p = 0.002); and no differences regarding SOD activity were found. Multivariable Cox regression analysis showed that age (Hazard ratio [HR]:1.065, p < 0.001), logGPx3 (above median, HR: 0.629, p < 0.05), and Med-Diet score (HR: 0.547, p < 0.05) predicted VEs. Med-Diet favorably modulates antioxidant activity of GPx3 in AF, resulting in reduced VEs rate. We hypothesize that the modulation of GPx3 levels by Med-Diet could represent an additional nutritional strategy to prevent VEs in AF patients

A Dissolution-Precipitation Mechanism is at the Origin of Concrete Creep in Moist Environments

Long-term creep (i.e., deformation under sustained load) is a significant material response that needs to be accounted for in concrete structural design. However, the nature and origin of concrete creep remain poorly understood and controversial. Here, we propose that concrete creep at relative humidity ≥ 50%, but fixed moisture content (i.e., basic creep), arises from a dissolution-precipitation mechanism, active at nanoscale grain contacts, as has been extensively observed in a geological context, e.g., when rocks are exposed to sustained loads, in liquid-bearing environments. Based on micro-indentation and vertical scanning interferometry data and molecular dynamics simulations carried out on calcium-silicate-hydrate (C-S-H), the major binding phase in concrete, of different compositions, we show that creep rates are correlated with dissolution rates - an observation which suggests a dissolution-precipitation mechanism as being at the origin of concrete creep. C-S-H compositions featuring high resistance to dissolution, and, hence, creep are identified. Analyses of the atomic networks of such C-S-H compositions using topological constraint theory indicate that these compositions present limited relaxation modes on account of their optimally connected (i.e., constrained) atomic networks

Location data for buildings related energy efficiency policies

Based on the priority currently given by the European Union to the energy efficiency topic through its Energy Union Package, this feasibility study has focused on the role of location data in support of energy efficiency policies, taking into account the requirements of INSPIRE, EPBD and EED Directives, as well as the CoM initiative. The EU Member States are already due to implement such Directives according to different roadmaps, but there are benefits to be gained from a coherent and consistent approach. Moreover, data is not always available in consistent form and with good quality. The monitoring and reporting requirements set by the CoM need real data and models, that can be used and that should work consistently across different administrative levels. The analysis reported in this document support these statement, showing that there is lack of data quality and reliability. These aspects might hinder the effective application of the energy efficiency policies at the municipal, district and national level. Geospatial technologies in general and accurate location data in particular can support this field, because they can significantly support efficient processes related to data collection, elaboration and communication to be executed in all the phases of energy efficiency policies life cycle; and effective decision-making. INSPIRE has a role to play as it can provide common data models and common data access rules adopted by all EU MS and a roadmap to provide interoperable datasets of high relevance with energy efficiency. The study has identified areas of development and analysis that can be useful to fill the recognised “data gap”, and proposed an initial pilot activity as a start-up project to investigate concretely these ideas with a limited number of pilot citiesJRC.H.6-Digital Earth and Reference Dat

EULF Energy Pilot - Final Report Phase 1

The European Union is giving more and more emphasis to its energy policies, reinforcing a political commitment to very high energy savings, with the aim to achieve a more competitive, secure and sustainable European energy system. Increased energy efficiency is vital to achieve the challenging goals set for the future and energy efficiency constitutes one of the five dimensions of the European Commission's Energy Union Package, designed to enhance energy security, sustainability and competitiveness. Within this policy context, this report focused on the 2010/31/EU Directive on the Energy Performance of Buildings and the 2012/27/EU Directive on Energy Efficiency, describing an initial set of pilot activities undertaken to enable and test the use of geospatial technologies in Digital Government processes and services related to energy efficiency EU policies, aiming to show, through a set of use cases, that accurate and interoperable location-based information can lower the barriers faced by government, companies and citizens involved in the energy efficiency policies’ lifecycle. The approach adopted is based on the INSPIRE Directive 2007/2/EC, establishing an infrastructure for spatial information in Europe to support Community environmental policies, and policies or activities which may have an impact on the environment, such as energy policies. The enabling role played by INSPIRE consists in the provision of common data models and common data access rules adopted by all EU MS and a roadmap to provide interoperable datasets of high relevance with energy efficiency. The report has identified a series of next steps to be undertaken to achieve the expected benefits deriving from the use of interoperable location-based information within the analysed energy policy instruments and to solve the issues encountered.JRC.B.6-Digital Econom

Methodologies for energy performance assessment based on location data: Proceedings of the workshop, Ispra, 12-14 September 2016

This expert workshop is one of a series covering the following topics: energy, buildings, location, assessment methods and data in relation to European Directives on Energy Efficiency (EED), Energy Performance of Buildings (EPBD), INSPIRE, establishing an Infrastructure for Spatial Information in Europe and the Covenant of Mayors (CoM) initiative. These workshops are jointly organised by the EC DG JRC project on Energy and Location and the European Union Location Framework (EULF) action of the EC ISA Programme (Interoperability Solutions for Public Administration) . So far the JRC team has produced a feasibility study and started a dedicated pilot project on location data for buildings related energy efficiency policies . The first event organised was the workshop on “Spatial data for modelling building stock energy needs” held at JRC in Ispra 23-25 November 2015 . The aim of this second workshop was to discuss different approaches and methodologies to assess energy efficiency measures as well as energy usage and monitoring of energy flows at building, urban and regional level, representing an opportunity to share information, integrate stakeholders’ views and set the ground for mutual collaboration. Eleven invited leading organisations and EU projects were invited to take part in this workshop sending experts to present their projects and discuss how to assess synergies and how to arrive to a coherent approach for assessment of energy use in the built environment. Another twelve people from JRC, experts on energy efficiency, energy performance, geospatial data modelling and processing participated to the workshop. From the discussions, it has emerged that a holistic approach would give more evidence of the needs for measures to reduce energy consumption. This is a bit in contrast to what the EU policy requests by the present energy related Directives. More and more it becomes evident that the target should be reducing emissions and not necessarily reducing energy consumption. Integration of energy technologies are playing an important role at a higher level than the building only (i.e. at the EPBD–level). The energy market (gas and electricity) is able to provide an enormous buffer in storing energy virtually and the buildings itself should be much better balanced in energy terms to the thermal needs, e.g. heating and cooling. At the same time the energy network requires buildings for balancing. INSPIRE could be very relevant for energy assessment in the built environment and for this reason the Energy Pilot initiated under the “Energy and Location” and “European Union Location Framework” projects will be continued over the next years. Main objectives of the pilot project will be to continue to work on Use Cases already outlined, to be further elaborated based on the information gathered at the workshop. The JRC will seek to develop partnerships to implement the defined use cases with the selected partners.JRC.B.6-Digital Econom

Does a dissolution-precipitation mechanism explain concrete creep in moist environments?

Long-term creep (i.e., deformation under sustained load) is a significant material response that needs to be accounted for in concrete structural design. However, the nature and origin of creep remains poorly understood, and controversial. Here, we propose that concrete creep at RH (relative humidity) > 50%, but fixed moisture-contents (i.e., basic creep), arises from a dissolution-precipitation mechanism, active at nanoscale grain contacts, as is often observed in a geological context, e.g., when rocks are exposed to sustained loads, in moist environments. Based on micro-indentation and vertical scanning interferometry experiments, and molecular dynamics simulations carried out on calcium-silicate-hydrates (C-S-H's), the major binding phase in concrete, of different compositions, we show that creep rates are well correlated to dissolution rates - an observation which supports the dissolution-precipitation mechanism as the origin of concrete creep. C-S-H compositions featuring high resistance to dissolution, and hence creep are identified - analysis of which, using topological constraint theory, indicates that these compositions present limited relaxation modes on account of their optimally connected (i.e., constrained) atomic networks