High Reynolds Number tests of the NASA SC(2)-0012 airfoil in the Langley 0.3-meter transonic cryogenic tunnel

A wind-tunnel investigation of the NASA SC(2)-0012 airfoil has been conducted in the Langley 0.3-Meter Transonic Cryogenic Tunnel. This investigation supplements the two-dimensional airfoil studies of the Advanced Technology Airfoil Test Program. The Mach number was varied from 0.60 to 0.84. The stagnation temperature and pressure were varied to provide a Reynolds number range from 6 to 40 x 10 to the 6th power based on a 6.0-in. (15.24-cm) airfoil chord. No corrections for wind-tunnel wall interference have been made to the data. The aerodynamic results are presented as integrated force and moment coefficients and pressure distributions without any analysis

Detection of sequential polyubiquitylation on a millisecond timescale

The pathway by which ubiquitin chains are generated on substrate through a cascade of enzymes consisting of an E1, E2 and E3 remains unclear. Multiple distinct models involving chain assembly on E2 or substrate have been proposed. However, the speed and complexity of the reaction have precluded direct experimental tests to distinguish between potential pathways. Here we introduce new theoretical and experimental methodologies to address both limitations. A quantitative framework based on product distribution predicts that the really interesting new gene (RING) E3 enzymes SCF^(Cdc4) and SCF^(β-TrCP) work with the E2 Cdc34 to build polyubiquitin chains on substrates by sequential transfers of single ubiquitins. Measurements with millisecond time resolution directly demonstrate that substrate polyubiquitylation proceeds sequentially. Our results present an unprecedented glimpse into the mechanism of RING ubiquitin ligases and illuminate the quantitative parameters that underlie the rate and pattern of ubiquitin chain assembly

Political power, technology, and total war: Two French views

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68009/2/10.1177_002200275800200404.pd

Analysis of some compliance calibration data for chevron-notch bar and rod specimens

A set of equations describing certain fracture mechanics parameters for chevron-notch bar and rod specimens are presented. They are developed by fitting earlier compliance calibration data. The difficulty in determining the minimum stress intensity coefficient and the critical crack length is discussed

Seepage investigation of Blackfoot River, Idaho

Thesis (CE)--University of Illinois, 1915Primarily typescript; portions of text are ms and blueprint copies of m

Lepto-axiogenesis with light right-handed neutrinos

We study lepto-axiogenesis in theories where the right-handed neutrino is light enough that its dynamics affect the determination of the baryon asymmetry. When compared with theories of high-scale lepto-axiogenesis where the Majorana neutrino mass may be treated as an effective dimension-five operator, we find that the predicted saxion mass is lower. Two distinct scenarios emerge. In the first, processes that generate the baryon asymmetry are in equilibrium down to the mass of the right-handed neutrino. In the second, the relevant processes never reach equilibrium; the baryon number freezes in. We comment on implications for supersymmetric spectra and discuss constraints on late decays of supersymmetric relics and from dark radiation. In contrast to high-scale lepto-axiogenesis, which predicts superpartners with masses of 10-100 TeV or more, we find this scenario is consistent with a wider range of superpartner masses, all the way down to current direct search bounds.Comment: 59 pages, 6 figure

The Future of Drug Development for Neglected Tropical Diseases: How the European Commission Can Continue to Make a Difference

In this article, the four coordinators of neglected tropical disease (NTD) drug development projects funded under the European Commission (EC) Framework Programme 7 argue that the EC should reassess their funding strategy to cover the steps necessary to translate a lead compound into a drug candidate for testing in clinical trials, and suggest ways in which this might be achieved

Discovery potential for split supersymmetry with thermal dark matter

Supersymmetric extensions of the Standard Model with scalar superpartners above 10 TeV are well motivated since the Higgs boson mass can be explained by quantum corrections while maintaining gauge coupling unification. If supersymmetry breaking is transmitted to gauginos via anomaly mediation, the gaugino masses are loop suppressed compared to scalar masses, and the lightest supersymmetric particle is the Higgsino or wino, which can be the dark matter. In this setup, we identify the regions of parameter space that reproduce the observed Higgs boson mass and the thermal abundance of dark matter. We analyze the effects of complex phases in the gaugino mass parameters on the electron electric dipole moment (EDM) and the dark matter scattering cross section. We find that, for scalar masses up to 10 PeV and any size of the complex phases, the model with Higgsino dark matter is within reach of planned experiments -- Advanced ACME via electron EDM and LUX-ZEPLIN via dark matter direct detection -- with complementary discovery potentials, and the model with wino dark matter is within reach of future electron EDM experiments.Comment: 9 pages, 6 figure