PRESCRIPTION OF OPIOIDS TO YOUTH 2005-2016: AN EXAMINATION OF TRENDS, PATIENT CHARACTERISTICS, AND OUTCOMES THROUGH 12 MONTHS

Data on all outpatient opioid prescriptions (N=71,647) to youth below age 21 (N=42,020) from 2005-2016 were extracted from electronic medical records within a university hospital system, including demographic characteristics, markers of morbidity, and mortality. Relative risk was calculated for markers of morbidity and mortality based on sociodemographic characteristics. The sample was primarily male (55.0%), Hispanic/Latino (50.1%), English-speaking (88.9%), and publicly insured(50.1%). Mean age was 13.54 (sd = 6.50). From 2005-2016, overall frequency of opioid prescriptions increased by 86.6% (from 2470 to 4610) with the largest increase (206.2%) observed from 2005-2008 (2470 to 7562). Patients who were older, White, and Non-Hispanic were more likely to receive multiple opioid prescriptions. Large increases in opioid-related morbidity and mortality were documented, although base-rates remained low. Significantly increased risk of adverse outcomes was observed in patients receiving multiple opioid prescriptions, and in patients who were older, of minority race, and publicly insured or uninsured

GrassPlot v. 2.00 : first update on the database of multi-scale plant diversity in Palaearctic grasslands

GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). Following a previous Long Database Report (Dengler et al. 2018, Phyto-coenologia 48, 331–347), we provide here the first update on content and functionality of GrassPlot. The current version (GrassPlot v. 2.00) contains a total of 190,673 plots of different grain sizes across 28,171 independent plots, with 4,654 nested-plot series including at least four grain sizes. The database has improved its content as well as its functionality, including addition and harmonization of header data (land use, information on nestedness, structure and ecology) and preparation of species composition data. Currently, GrassPlot data are intensively used for broad-scale analyses of different aspects of alpha and beta diversity in grassland ecosystems

The status and role of genetic diversity of trees for the conservation and management of riparian ecosystems: a European experts’ perspective

1. Riparian vegetation supports high biodiversity providing many services and is, therefore, an important landscape element. Riparian ecosystems are subject to numerous pressures leading to population decline and genetic erosion of riparian plants. This may have cascading effects at various ecosystem levels, including decreasing ecosystem services, so identifying the current status of genetic diversity of riparian tree species is vital to improve the effectiveness of restoration efforts. 2. We aimed to elicit expert views on the status and importance of genetic diversity of tree species, and conservation needs across European riparian ecosystems. Sharing of such information among researchers, managers and policymakers has the potential to enhance ecological restoration and management of riparian ecosystems. 3. We identified experts in riparian genetic resources conservation and management across Europe. These included stakeholders with different perspectives, ranging from researchers to practitioners. We designed a set of questionnaires where our identified experts were asked to answer questions related to the status and conservation of genetic diversity of riparian tree species in their respective countries. Specifically, we asked about societal awareness, legislative tools, good practices and conservation or restoration projects accounting for intraspecific genetic diversity and differentiation of tree species in riparian ecosystems. Questionnaire responses were analyzed and discussed in light of the scientific literature to define needs and priorities related to the management and conservation of genetic diversity of riparian tree species. 4. The experts recognized that a combination of in situ and ex situ measures and/or integrative conservation of riparian ecosystems is the most appropriate option for conserving the genetic diversity of riparian tree species. Simultaneous application of conservation measures at the level of priority species, identified by experts, and protection of riparian areas are required. 5. Synthesis and applications. This study revealed the importance of recognizing the ecological processes that shape the genetic diversity of riparian tree species in hydrographic networks (dendritic spatial configuration, specific patterns of gene flow among riparian populations, fragmentation of river by dams) but also the need to overcome socio-economic barriers, such as lack of policy priority, deficiency in funding and weak legislation framework.Publishe

Changes in the Chemical Composition of Plum Distillate During Maturation with Oak Chips under Different Conditions

U radu je ispitan utjecaj dozrijevanja u kontaktu s hrastovim trijeskama na sastav i koncentraciju destilata šljive. Destilatu šljive su tijekom starenja dodane lagano pržene trijeske francuskog hrasta (Quercus sessiflora i Quercus robur) ili trijeske dobivene od starih bačava u kojima je odležao konjak. Ispitan je utjecaj količine dodanih trijeski, temperature, načina dozrijevanja (statičnog ili uz cirkulaciju) te primjene ultrazvuka. Dozrijevanjem destilata šljive u prisutnosti hrastovih trijeski povećala se količina ekstraktibilnih organskih spojeva (uključujući tanine) i promijenila boja destilata, u ovisnosti o vrsti i količini dodanih trijeski te uvjetima dozrijevanja. Koncentracija se šećera, kao što su glukoza, ksiloza i arabinoza, povećala ovisno o uvjetima dozrijevanja i vrsti trijeski. Razgradnjom lignina oslobođene su određene količine sinapaldehida, siringaldehida, coniferaldehida i vanilina, u ovisnosti o uvjetima pokusa. Od hlapljivih spojeva, koncentracija se viših alkohola i alifatskih (acikiličkih) aldehida u većem broju varijanti pokusa smanjila, dok se koncentracija furanskih aldehida, ovisno o vrsti i količini trijeski te uvjetima dozrijevanja, povećala. Koncentracija se estera, poput etilacetata u većem broju varijanti pokusa smanjila, a etil-kaproata, etil-kaprilata i etil- -kaprata postupno povećala. Neki su fenoli i laktoni pronađeni u uzorcima destilata nakon dozrijevanja, a najmanje su koncentracije tih spojeva pronađene u uzorcima destilata dozrelog u kontaktu s hrastovim trijeskama dobivenim od bačava u kojima je odležao konjak.This study investigates the effect of ageing on the qualitative and quantitative composition of plum distillate in contact with oak wood chips. Maturation was performed with lightly toasted French oak (Quercus sessiflora and Quercus robur) chips or oak chips made from fragments of empty barrels that had been used for ageing cognac. The effects of oak chip dose, process temperature, ageing system (static or circulatory) and ultrasound treatment were assessed. Maturation of plum distillate samples with oak chips resulted in higher levels of extractable organics (including tannins) and colour changes, which were correlated with the type and dose of oak chips, and the conditions of maturation. The content of sugars such as glucose, xylose and arabinose also increased, depending on the conditions and type of oak chips. Degradation of lignin resulted in liberation of sinapaldehyde, syringaldehyde, coniferaldehyde and vanillin, with intensities depending on the applied parameters. In terms of volatiles, decreases in the concentration of higher alcohols and aliphatic aldehydes were observed in the majority of maturation experiments, while concentrations of furanic aldehydes increased depending on the type and dose of oak chips, as well as on the conditions of maturation. The quantities of esters such as ethyl acetate decreased in the majority of experimental variants, whereas concentrations of ethyl caproate, ethyl caprylate and ethyl caprate increased gradually. Some phenols and lactones were detected in all matured samples, with the lowest levels found in the samples aged with oak chips made from cognac barrels

GrassPlot v. 2.00 – first update on the database of multi-scale plant diversity in Palaearctic grasslands

Abstract: GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). Following a previous Long Database Report (Dengler et al. 2018, Phyto- coenologia 48, 331–347), we provide here the first update on content and functionality of GrassPlot. The current version (GrassPlot v. 2.00) contains a total of 190,673 plots of different grain sizes across 28,171 independent plots, with 4,654 nested-plot series including at least four grain sizes. The database has improved its content as well as its functionality, including addition and harmonization of header data (land use, information on nestedness, structure and ecology) and preparation of species composition data. Currently, GrassPlot data are intensively used for broad-scale analyses of different aspects of alpha and beta diversity in grassland ecosystems

Phylogenetic structure of European forest vegetation

[Aims] (a) To determine the contribution of current macro-environmental factors in explaining the phylogenetic structure of European forest vegetation, (b) to map and describe spatial patterns in their phylogenetic structure and (c) to examine which lineages are the most important contributors to phylogenetic clustering and whether their contribution varies across forest types and regions. [Location] Europe. [Taxon] Angiosperms. [Methods] We analysed the phylogenetic structure of 61,816 georeferenced forest vegetation plots across Europe considering alternative metrics either sensitive to basal (ancient evolutionary dynamics) or terminal (recent dynamics) branching in the phylogeny. We used boosted regression trees to model metrics of the phylogenetic structure as a function of current macro-environmental factors. We also identified clades encompassing significantly more taxa than under random expectation in phylogenetically clustered plots. [Results] Phylogenetic clustering was driven by climatic stress and instability and was strong in the areas glaciated during the Pleistocene, likely reflecting limited postglacial migration, and to a lower extent in areas of northern-central Europe and in summer-dry Mediterranean regions. Phylogenetic overdispersion was frequent in the hemiboreal zone in Russia, in some areas around the Mediterranean Basin, and along the Atlantic seaboard of the Iberian Peninsula. The families Ericaceae, Poaceae and Fagaceae were overrepresented in clustered plots in different regions of Europe. [Main conclusions] We provide the first maps and analyses on the phylogenetic structure of European forest vegetation at the plot level. Our results highlight the role of environmental filtering, postglacial dispersal limitation and spatial transitions between major biomes in determining the distribution of plant lineages in Europe.The study was supported by the Czech Science Foundation (19-28491X). IB and JAC were funded by the Basque Government (IT936-16). JCS considers this work a contribution to his VILLUM Investigator project “Biodiversity Dynamics in a Changing World” funded by VILLUM FONDEN (grant 16549)

Reuse of oak chips for modification of the volatile fraction of alcoholic beverages

New or used barrels can be applied in ageing of alcoholic beverages. Compounds adsorbed in wood migrate between beverages along with wood extractives. As barrel ageing is costly and time-consuming, processes using wood fragments have been gaining interest. These generate wood residues for which the reuse is still not well established. This work aims at the reuse of oak fragments for the additive ageing of alcoholic beverages. Oak chips, previously immersed in fortified wine, were applied to beer, wine and grape marc spirit. Wood compounds and adsorbed wine volatiles were extracted, with more impact and satisfactory yields on beer composition. Also, wood adsorbed beverages compounds in a subtractive ageing phenomena. Beer formulations using different binomial wood concentration/temperature combinations were generated and presented to trained tasters. Higher temperatures and wood concentrations led to prominence of wood descriptors and lower perception of fruity and floral aromas, reflecting the changes in chemical composition.Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 – Programa Operacional Regional do Norte. Fermentum – Engenharia das Fermentações Lda. also participated in co-funding and provided beer samples used in this work, which authors would like to acknowledge. Lastly, authors would like to thank Mr. Benoît Verdier and Seguin Moreau for supplying the woods and Mr. Paulo Coutinho and Quinta do Portal for supplying the fortified wineinfo:eu-repo/semantics/publishedVersio