Measurements of hyperfine structure in Ta II

We report the first extensive measurements of hyperfine structure in Ta II. Spectra of Ta II were recorded by high-resolution Fourier transform spectrometry in the region 10 000-53 000 cm-1(1886-10 000 Å) and the majority of observed lines show significant hyperfine structure. Computer fits to several hundred of these line profiles have yielded values of the magnetic dipole hyperfine interaction constant A for 88 energy levels with an uncertainty of between 0.5 and 10 per cent for the majority of A factors. The A factors range from −0.078 to +0.065 cm−1 for the even levels and from −0.064 to +0.083 cm−1 for the odd levels. For the majority of these A factors no previous measurements are known. Approximate values of the electric quadrupole hyperfine interaction constant B were found for 73 levels. These measurements of A and B factors allow, for the first time, the effects of hyperfine structure in Ta II lines to be correctly accounted for both in abundance analysis and in the resolution of blended lines in astrophysical spectr

Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration:A whole cell recording study in situ

Sympathetic preganglionic neurones (SPNs) convey sympathetic activity flowing from the CNS to the periphery to reach the target organs. Although previous in vivo and in vitro cell recording studies have explored their electrophysiological characteristics, it has not been possible to relate these characteristics to their roles in cardiorespiratory reflex integration. We used the working heart–brainstem preparation to make whole cell patch clamp recordings from T3–4 SPNs (n = 98). These SPNs were classified by their distinct responses to activation of the peripheral chemoreflex, diving response and arterial baroreflex, allowing the discrimination of muscle vasoconstrictor-like (MVC(like), 39%) from cutaneous vasoconstrictor-like (CVC(like), 28%) SPNs. The MVC(like) SPNs have higher baseline firing frequencies (2.52 ± 0.33 Hz vs. CVC(like) 1.34 ± 0.17 Hz, P = 0.007). The CVC(like) have longer after-hyperpolarisations (314 ± 36 ms vs. MVC(like) 191 ± 13 ms, P < 0.001) and lower input resistance (346 ± 49  MΩ vs. MVC(like) 496 ± 41 MΩ, P < 0.05). MVC(like) firing was respiratory-modulated with peak discharge in the late inspiratory/early expiratory phase and this activity was generated by both a tonic and respiratory-modulated barrage of synaptic events that were blocked by intrathecal kynurenate. In contrast, the activity of CVC(like) SPNs was underpinned by rhythmical membrane potential oscillations suggestive of gap junctional coupling. Thus, we have related the intrinsic electrophysiological properties of two classes of SPNs in situ to their roles in cardiorespiratory reflex integration and have shown that they deploy different cellular mechanisms that are likely to influence how they integrate and shape the distinctive sympathetic outputs

Is there a significant change in the price transmission between producer and retail prices within the British Pork industry?

The purpose of this study is to examine price transmission between the producer and retail in the UK pork industry. It aims to find the direction of causality in the long and short-run, and whether there is a long-run relationship between producer and retail prices. This study used monthly time series data for producer and retail prices ranging from 1988-2016. Econometric tests were used such as the Augmented Dickey-Fuller (1979) and Phillips-Perron (1988) Unit Root tests; Bai-Perron (1998) Unit Root test allowing for multiple structural breaks; Johansen (1991) and Engle-Granger (1987) Co-integration tests; Granger (1988) Causality, and the Error Correction Model showing the speed of recovery in the long-run relationship after a shock. The results of the Unit Root tests found both producer and retail prices to be integrated of order one I(1). Three structural breaks were found occurring in the years of 1996, 2002 and 2012. The Co-integration tests found that there is one long-run relationship between producer and retail prices. The Error Correction Model showed the return to a new equilibrium after a shock was 9% per month totalling over 11 months for a full recovery from a shock. The Granger (1988) Causality test indicated that producer prices do Granger cause retail prices in the short-run. In this study the latest econometric techniques were used including structural breaks which some previous studies overlooked. This study into the producer and retail prices in the UK pork industry is the latest study of this kind since the Brexit decision

Measurement of nuclear effects in neutrino interactions with minimal dependence on neutrino energy

We present a phenomenological study of nuclear effects in neutrino charged-current interactions, using transverse kinematic imbalances in exclusive measurements. Novel observables with minimal dependence on neutrino energy are proposed to study quasielastic scattering, and especially resonance production. They should be able to provide direct constraints on nuclear effects in neutrino- and antineutrino-nucleus interactions.Comment: 7 pages, 9 figures, accepted version by PR

Forage Preferences of the European Beaver Castor fiber

By the beginning of the twentieth century, hunting and land use change had reduced the European beaver Castor fiber to a relict population of no more than 1200 individuals. In some European states, re introduction has successfully established viable populations, whilst other schemes have failed. Environmental, social and economic issues associated with beaver reintroduction have given rise to a range of information needs in relation to the species«SQ» ecology. In 2005, six European beavers were translocated from Bavaria to a reintroduction site in southern England. The following year, a 6 month study was undertaken to investigate which tree species and size classes were most frequently utilised by the beavers, and to determine if the utilised species and size classes reflected resource availability within the home range. These questions were answered by comparing the use and the availability of foraged tree species in two ways: (1) using a survey of tree stumps; and (2) as a food choice experiment. The results showed that the reintroduced beavers were highly selective in relation to both the species and the size of the trees they used i.e. the reintroduced beavers selected species in significantly different proportions to their availability. However, they selected similar size classes between the preferred tree species, and did not utilise human timber. The relevance of the study is discussed with respect to information needs associated with the reintroduction of a keystone species, overcoming negative perceptions, population viability, welfare and soft release strategies

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo.

In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD). MDD patients received sertraline or placebo in a double-blind 4-week trial; baseline, 1 week, and 4 weeks serum samples were profiled using a gas chromatography time of flight mass spectrometry metabolomics platform. Intermediates of TCA and urea cycles, fatty acids and intermediates of lipid biosynthesis, amino acids, sugars and gut-derived metabolites were changed after 1 and 4 weeks of treatment. Some of the changes were common to the sertraline- and placebo-treated groups. Changes after 4 weeks of treatment in both groups were more extensive. Pathway analysis in the sertraline group suggested an effect of drug on ABC and solute transporters, fatty acid receptors and transporters, G signaling molecules and regulation of lipid metabolism. Correlation between biochemical changes and treatment outcomes in the sertraline group suggested a strong association with changes in levels of branched chain amino acids (BCAAs), lower BCAAs levels correlated with better treatment outcomes; pathway analysis in this group revealed that methionine and tyrosine correlated with BCAAs. Lower levels of lactic acid, higher levels of TCA/urea cycle intermediates, and 3-hydroxybutanoic acid correlated with better treatment outcomes in placebo group. Results of this study indicate that biochemical changes induced by drug continue to evolve over 4 weeks of treatment and that might explain partially delayed response. Response to drug and response to placebo share common pathways but some pathways are more affected by drug treatment. BCAAs seem to be implicated in mechanisms of recovery from a depressed state following sertraline treatment

Th Ages for Metal-Poor Stars

With a sample of 22 metal-poor stars, we demonstrate that the heavy element abundance pattern (Z > 55) is the same as the r-process contributions to the solar nebula. This bolsters the results of previous studies that there is a universal r-process production pattern. We use the abundance of thorium in five metal-poor stars, along with an estimate of the initial Th abundance based on the abundances of stable r-process elements, to measure their ages. We have four field red giants with errors of 4.2 Gyr in their ages and one M92 giant with an error of 5.6 Gyr, based on considering the sources of observational error only. We obtain an average age of 11.4 Gyr, which depends critically on the assumption of an initial production ratio of Th/Eu of 0.496. If the Universe is 15 Gyr old, then the initial Th/Eu value should be 0.590, in agreement with some theoretical models of the r-process.Comment: 26 pages, to be published in Ap

The FERRUM project: Transition probabilities for forbidden lines in [FeII] and experimental metastable lifetimes

Accurate transition probabilities for forbidden lines are important diagnostic parameters for low-density astrophysical plasmas. In this paper we present experimental atomic data for forbidden [FeII] transitions that are observed as strong features in astrophysical spectra. Aims: To measure lifetimes for the 3d^6(^3G)4s a ^4G_{11/2} and 3d^6(^3D)4s b ^4D_{1/2} metastable levels in FeII and experimental transition probabilities for the forbidden transitions 3d^7 a ^4F_{7/2,9/2}- 3d^6(^3G)4s a ^4G_{11/2}. Methods: The lifetimes were measured at the ion storage ring facility CRYRING using a laser probing technique. Astrophysical branching fractions were obtained from spectra of Eta Carinae, obtained with the Space Telescope Imaging Spectrograph onboard the Hubble Space Telescope. The lifetimes and branching fractions were combined to yield absolute transition probabilities. Results: The lifetimes of the a ^4G_{11/2} and the b ^4D_{1/2} levels have been measured and have the following values, 0.75(10) s and 0.54(3) s respectively. Furthermore, we have determined the transition probabilities for two forbidden transitions of a ^4F_{7/2,9/2}- a ^4G_{11/2} at 4243.97 and 4346.85 A. Both the lifetimes and the transition probabilities are compared to calculated values in the literature.Comment: 5 pages, accepted for publication in A&

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins generated by repeat-associated, non-ATG translation. To address this question we developed in vitro and in vivo models to dissect repeat RNA and dipeptide repeat protein toxicity. Expression of pure repeats in Drosophila caused adult-onset neurodegeneration attributable to poly-(glycine-arginine) proteins. Thus, expanded repeats promoted neurodegeneration through neurotoxic proteins. Expression of individual dipeptide repeat proteins with a non-GGGGCC RNA sequence showed both poly-(glycine-arginine) and poly-(proline-arginine) proteins caused neurodegeneration. These findings are consistent with a dual toxicity mechanism, whereby both arginine-rich proteins and repeat RNA contribute to C9orf72-mediated neurodegeneration