Observation of a nanophase segregation in LiCl aqueous solutions from Transient Grating Experiments

Transient Grating experiments performed on supercooled LiCl, RH2O solutions with R>6 reveal the existence of a strong, short time, extra signal which superposes to the normal signal observed for the R=6 solution and other glass forming systems. This extra signal shows up below 190 K, its shape and the associated timescale depend only on temperature, while its intensity increases with R. We show that the origin of this signal is a phase separation between clusters with a low solute concentration and the remaining, more concentrated, solution. Our analysis demonstrates that these clusters have a nanometer size and a composition which are rather temperature independent, while increasing R simply increases the number of these clusters.Comment: 19 pages+ 8 figures+ 2 table

Charge centers in CaF2_2: Ab initio calculation of elementary physical properties

Charge centers in ionic crystals provide a channel for elementary interaction between electromagnetic radiation and the lattice. We calculate the electronic ground state energies which are needed to create a charge center -- namely a $F$- and a $H$-center. In well agreement with common understanding the $F$-center results in being accompanied by a small lattice distortion whereas the $H$-center is accompanied by a very large lattice deformation. Opposite to the common understanding the additional positive charge in the charge center results rather to be localized on a F$_4^{3-}$ complex than on a F$_2^-$-complex. From the ground states of the charge centers we derive binding energies, diffusion barriers and agglomeration energies for $M$-center formation. These microscopic quantities are of fundamental interest to understand the dynamic processes which are initiated if the crystals interact with extreme intense deep ultra violet radiation. We further derive the equilibrium concentrations of charge centers in grown crystals.Comment: to appear in Phys. Rev. B in Aug. 2006, 11 Fig

Normal tau polarisation as a sensitive probe of CP violation in chargino decay

CP violation in the spin-spin correlations in chargino production and subsequent two-body decay into a tau and a tau-sneutrino is studied at the ILC. From the normal polarisation of the tau, an asymmetry is defined to test the CP-violating phase of the higgsino mass parameter \mu. Asymmetries of more than \pm70% are obtained, also in scenarios with heavy first and second generation sfermions. Bounds on the statistical significances of the CP asymmetries are estimated. As a result, the normal tau polarisation in the chargino decay is one of the most sensitive probes to constrain or measure the phase \phi_\mu at the ILC, motivating further detailed experimental studies.Comment: 20 pages, 10 figures, gzipped tar fil

Proteasome Lid Bridges Mitochondrial Stress with Cdc53/Cullin1 NEDDylation Status

Cycles of Cdc53/Cullin1 rubylation (a.k.a NEDDylation) protect ubiquitin-E3 SCF (Skp1-Cullin1-F-box protein) complexes from self-destruction and play an important role in mediating the ubiquitination of key protein substrates involved in cell cycle progression, development, and survival. Cul1 rubylation is balanced by the COP9 signalosome (CSN), a multi-subunit derubylase that shows 1:1 paralogy to the 26 S proteasome lid. The turnover of SCF substrates and their relevance to various diseases is well studied, yet, the extent by which environmental perturbations influence Cul1 rubylation/derubylation cycles per se is still unclear. In this study, we show that the level of cellular oxidation serves as a molecular switch, determining Cullin1 rubylation/derubylation ratio. We describe a mutant of the proteasome lid subunit, Rpn11 that exhibits accumulated levels of Cullin1-Rub1 conjugates, a characteristic phenotype of csn mutants. By dissecting between distinct phenotypes of rpn11 mutants, proteasome and mitochondria dysfunction, we were able to recognize the high reactive oxygen species (ROS) production during the transition of cells into mitochondrial respiration, as a checkpoint of Cullin1 rubylation in a reversible manner. Thus, the study adds the rubylation cascade to the list of cellular pathways regulated by redox homeostasis

Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review

Symptomatic and functional recovery are important patient-reported outcome measures (PROMs) in community-acquired pneumonia (CAP) that are increasingly used as trial endpoints. This systematic review summarises the literature on PROMs in CAP.Comprehensive searches in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement were conducted to March 2017. Eligible studies included adults discharged from hospital following confirmed CAP and reporting PROMs.Fifteen studies (n=5644 patients) were included; most of moderate quality. Studies used a wide range of PROMs and assessment tools. At 4-6 weeks’ post-discharge, the commonest symptom reported was fatigue (45% to 72.6% of patients, 3 studies), followed by cough (35.3% to 69.7%) and dyspnoea (34.2% to 67.1%), corresponding values from studies restricted by ag

Model-independent constraints on spin observables

We discuss model-independent constraints on spin observables in exclusive and inclusive reactions, with special attention to the case of photoproduction.Comment: 6 pages, 5 figures, Talk by J.-M. Richard at NSTAR 2009, IHEP, Beijing (China), April 19-22, 2009, Proc. to appear in "Chinese Physics C

Physics Opportunities at mu+mu- Higgs Factories

We update theoretical studies of the physics opportunities presented by mu+mu- Higgs factories. Interesting measurements of the Standard Model Higgs decays into {\bar b}b, tau+tau- and WW* may be possible if the Higgs mass is less than about 160 GeV, as preferred by the precision electroweak data, the mass range being extended by varying appropriately the beam energy resolution. A suitable value of the beam energy resolution would also enable the uncertainty in the b-quark mass to be minimized, facilitating measurements of parameters in the MSSM at such a first mu+mu- Higgs factory. These measurements would be sensitive to radiative corrections to the Higgs-fermion-antifermion decay vertices, which may violate CP. Radiative corrections in the MSSM may also induce CP violation in Higgs-mass mixing, which can be probed via various asymmetries measurable using polarized mu+mu- beams. In addition, Higgs-chargino couplings may be probed at a second mu+mu- Higgs factory.Comment: Report of the Higgs factory working group of the ECFA-CERN study on Neutrino Factory & Muon Storage Rings at CERN. 28 p

Interference Effects, Time Reversal Violation and Search for New Physics in Hadronic Weak Decays

We propose some methods for studying hadronic sequential two-body decays involving more spinning particles. It relies on the analysis of T-odd and T-even asymmetries, which are related to interference terms. The latter asymmetries turn out to be as useful as the former ones in inferring time reversal violating observables; these in turn may be sensitive, under some particular conditions, to possible contributions beyond the standard model. Our main result is that one can extract such observables even after integrating the differential decay width over almost all of the available angles. Moreover we find that the correlations based exclusively on momenta are quite general, since they provide as much information as those involving one or more spins. We generalize some methods already proposed in the literature for particular decay channels, but we also pick out a new kind of time reversal violating observables. Our analysis could be applied, for example, to data of LHCb experiment.Comment: 35 page

Ice: a strongly correlated proton system

We discuss the problem of proton motion in Hydrogen bond materials with special focus on ice. We show that phenomenological models proposed in the past for the study of ice can be recast in terms of microscopic models in close relationship to the ones used to study the physics of Mott-Hubbard insulators. We discuss the physics of the paramagnetic phase of ice at 1/4 filling (neutral ice) and its mapping to a transverse field Ising model and also to a gauge theory in two and three dimensions. We show that H3O+ and HO- ions can be either in a confined or deconfined phase. We obtain the phase diagram of the problem as a function of temperature T and proton hopping energy t and find that there are two phases: an ordered insulating phase which results from an order-by-disorder mechanism induced by quantum fluctuations, and a disordered incoherent metallic phase (or plasma). We also discuss the problem of decoherence in the proton motion introduced by the lattice vibrations (phonons) and its effect on the phase diagram. Finally, we suggest that the transition from ice-Ih to ice-XI observed experimentally in doped ice is the confining-deconfining transition of our phase diagram.Comment: 12 pages, 9 figure

`In pursuit of the Nazi mind?' the deployment of psychoanalysis in the allied struggle against Germany

This paper discusses how psychoanalytic ideas were brought to bear in the Allied struggle against the Third Reich and explores some of the claims that were made about this endeavour. It shows how a variety of studies of Fascist psychopathology, centred on the concept of superego, were mobilized in military intelligence, post-war planning and policy recommendations for ‘denazification’. Freud's ideas were sometimes championed by particular army doctors and government planners; at other times they were combined with, or displaced by, competing, psychiatric and psychological forms of treatment and diverse studies of the Fascist ‘personality’. This is illustrated through a discussion of the treatment and interpretation of the deputy leader of the Nazi Party, Rudolf Hess, after his arrival in Britain in 1941