Driving Co-Created Value Through Local Tourism Srvice Systems (LTSS) in Tourism Sector

Purpose – Our purpose is to qualify Local Tourism Area (LTA) as Local Tourism Service System (LTSS), glocal network for value co-creation and equifinality for stakeholders. We identify the conditions and the critical aspects useful for the start-up and the development of a network characterized by a strong international competitiveness. Methodology/approach – Our methodology integrates Service Science Management and Engineering and Viable Systems Approach. SSME is useful for qualifying a Service System; VSA is helpful to interpret tourism territories as Systems. SSME&VSA highlights Structural Variety and Systems Relationship that qualify a LTSS as a long lasting network. Findings – This work provides a general cognitive scheme useful for interpreting LTA as LTSS. So, we can consider a new managing perspective and new ways for developing local service systems according to a governance process based on information sharing, consonance of interpretative patterns and resonance of value categories. Practical implications – Our perspective induces new way of thinking about local systems: territory is not a simply “product” - as static views suggest - but a “service” according to a dynamic view. So, we can see how government guides the development of LTS ensuring distinctive brand destination and place reputation in tourism market. Originality/value – Our paper offers a schema for directing decision makers according to LTA as a LTSS. In the next future, the qualification of the LTSS could be useful to generate a method for measuring the drivers of our model, according to the harmonization among the different governance and the improving reputation of entire servic

A VSA Communication Model for Service Systems Governance.

This paper proposes a conceptual framework for governance and management of the decision making process for corporate communication. The aim is to address a gap in the literature in that to date, by adopting some basic assumptions from Viable Systems Approach, integrated with Service Science perspective, in order to identify communication resources, the nature (static and dynamic) of the corporate communication activities, and “engineering” communication process. Parsons’ sociological approach, with reference to the classification of organisational decisions (policy, allocation and coordination) results fundamental to contextualise this approach to the decision-making within corporate communication function/departmen

Improvements of Decision Support Systems for Public Administrations via a Mechanism of Co-creation of Value

This paper focuses on a possible improvement of knowledge-based decision support systems for human resource management within Public Administrations, using a co-creation of value's mechanism, according to the Service-Dominant Logic (SDL) paradigm. In particular, it applies ontology-driven data entry procedures to trigger the cooperation between the Public Administration itself and its employees. Advantages in such sense are evident: constraining the data entry process by means of the term definition ontology improves the quality of gathered data, thus reducing potential mismatching problems and allowing a suitable skill gap analysis among real and ideal workers competence profiles. The procedure foresees the following steps: analyzing organograms and job descriptions; modelling Knowledge, Skills and Attitudes (KSA) for job descriptions; transforming KSAs of job descriptions into a standard-based model with integrations of other characteristics; extracting information from Curricula Vitae according to the selected model; comparing profiles and roles played by the employees. The 'a priori' ontology-driven approach adequately supports the operations that involve both the Public Administration and employees, as for the data storage of job descriptions and curricula vitae. The comparison step is useful to understand if employees perform roles that are coherent with their own professional profiles. The proposed approach has been experimented on a small test case and the results show that its objective evaluation represents an improvement for a decision support system for the re-organization of Italian Public Administrations where, unfortunately often, people are engaged in activities that are not so close to their competences

Outcome of relapsed/refractory acute promyelocytic leukaemia in children, adolescents and young adult patients — a 25‐year Italian experience

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Dasatinib-Blinatumomab for Ph-Positive Acute Lymphoblastic Leukemia in Adults

BACKGROUND: Outcomes in patients with Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) have improved with the use of tyrosine kinase inhibitors. Molecular remission is a primary goal of treatment.METHODS: We conducted a phase 2 single-group trial of first-line therapy in adults with newly diagnosed Ph-positive ALL (with no upper age limit). Dasatinib plus glucocorticoids were administered, followed by two cycles of blinatumomab. The primary end point was a sustained molecular response in the bone marrow after this treatment.RESULTS: Of the 63 patients (median age, 54 years; range, 24 to 82) who were enrolled, a complete remission was observed in 98%. At the end of dasatinib induction therapy (day 85), 29% of the patients had a molecular response, and this percentage increased to 60% after two cycles of blinatumomab; the percentage of patients with a molecular response increased further after additional blinatumomab cycles. At a median follow-up of 18 months, overall survival was 95% and disease-free survival was 88%; disease-free survival was lower among patients who had an IKZF1 deletion plus additional genetic aberrations (CDKN2A or CDKN2B, PAX5, or both [i.e., IKZF1 plus]). ABL1 mutations were detected in 6 patients who had increased minimal residual disease during induction therapy, and all these mutations were cleared by blinatumomab. Six relapses occurred. Overall, 21 adverse events of grade 3 or higher were recorded. A total of 24 patients received a stem-cell allograft, and 1 death was related to transplantation (4%).CONCLUSIONS: A chemotherapy-free induction and consolidation first-line treatment with dasatinib and blinatumomab that was based on a targeted and immunotherapeutic strategy was associated with high incidences of molecular response and survival and few toxic effects of grade 3 or higher in adults with Ph-positive ALL. (Funded by Associazione Italiana per la Ricerca sul Cancro and others; GIMEMA LAL2116 D-ALBA EudraCT number, 2016-001083-11; ClinicalTrials.gov number, NCT02744768.)