Analyse des critères d'évaluation de systèmes multi-agents adaptatifs

http://www.emse.fr/~picard/publications/kaddoum09jfsma.pdfInternational audienceLa complexité croissante des applications actuelles favorise le développement de systèmes multi-agents auto-organisateurs possédant des propriétés self-? . Ces systèmes autonomes présentent des capacités intéressantes permettant la gestion de la dynamique endogène et exogène des applications étudiées. De nouveaux critères doivent être étudiés afin de caractériser et évaluer l'apport de ces propriétés self-? et leur influence sur les performances du système. Dans cet article, différentes catégories regroupant les principaux critères d'évaluation sont décrites afin de guider l'évaluation de ce type de systèmes depuis les phases de conception jusqu'aux phases d'exécution : évaluation du système en cours de fonctionnement, caractéristiques intrinsèques et méthodologie de conception

Specific fibre composition and metabolism of the rectus abdominis muscle of bovine Charolais cattle

Background: An important variability of contractile and metabolic properties between muscles has been highlighted. In the literature, the majority of studies on beef sensorial quality concerns M. longissimus thoracis. M. rectus abdominis (RA) is easy to sample without huge carcass depreciation and may appear as an alternative to M. longissimus thoracis for fast and routine physicochemical analysis. It was considered interesting to assess the muscle fibres of M. rectus abdominis in comparison with M. longissimus thoracis (LT) and M. triceps brachii (TB) on the basis of metabolic and contractile properties, area and myosin heavy chain isoforms (MyHC) proportions. Immunohistochemical, histochemical, histological and enzymological techniques were used. This research concerned two populations of Charolais cattle: RA was compared to TB in a population of 19 steers while RA was compared to LT in a population of 153 heifers. Results: RA muscle had higher mean fibre areas (3350 μm2 vs 2142 to 2639 μm2) than the two other muscles. In RA muscle, the slow-oxidative fibres were the largest (3957 μm2) and the fast-glycolytic the smallest (2868 μm2). The reverse was observed in TB muscle (1725 and 2436 μm2 respectively). In RA muscle, the distinction between fast-oxidative-glycolytic and fast-glycolytic fibres appeared difficult or impossible to establish, unlike in the other muscles. Consequently the classification based on ATPase and SDH activities seemed inappropriate, since the FOG fibres presented rather low SDH activity in this muscle in comparison to the other muscles of the carcass. RA muscle had a higher proportion of I fibres than TB and LT muscles, balanced by a lower proportion either of IIX fibres (in comparison to TB muscle) or of IIA fibres (in comparison to LT muscle). However, both oxidative and glycolytic enzyme activities were lower in RA than in TB muscle, although the LDH/ICDH ratio was higher in RA muscle (522 vs 340). Oxidative enzyme activities were higher in RA than in LT muscle, whereas glycolytic enzyme activity was lower. In RA muscle, contractile and metabolic properties appeared to be less well-correlated than in the two other muscles. Conclusions: RA muscle has some particularities in comparison to the LT and TB muscles, especially concerning the unusual large cross-section surface of SO fibres and the very low oxidative activity of intermediate IIA fibres

The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences

The role of the cerebellum in schizophrenia has been highlighted by Andreasen's hypothesis of “cognitive dysmetria,” which suggests a general dyscoordination of sensorimotor and mental processes. Studies in schizophrenic patients have brought observations supporting a cerebellar impairment: high prevalence of neurological soft signs, dyscoordination, abnormal posture and propioception, impaired eyeblink conditioning, impaired adaptation of the vestibular-ocular reflex or procedural learning tests, and lastly functional neuroimaging studies correlating poor cognitive performances with abnormal cerebellar activations. Despite those compelling evidences, there has been, to our knowledge, no recent review on the clinical, cognitive, and functional literature supporting the role of the cerebellum in schizophrenia. We conducted a Medline research focusing on cerebellar dysfunctions in schizophrenia. Emphasis was given to recent literature (after 1998). The picture arising from this review is heterogeneous. While in some domains, the role of the cerebellum seems clearly defined (ie, neurological soft signs, posture, or equilibrium), in other domains, the cerebellar contribution to schizophrenia seems limited or indirect (ie, cognition) if present at all (ie, affectivity). Functional models of the cerebellum are proposed as a background for interpreting these results

Overexpressed or intraperitoneally injected human transferrin prevents photoreceptor degeneration in rd10 mice

PURPOSE: Retinal degeneration has been associated with iron accumulation in age-related macular degeneration (AMD), and in several rodent models that had one or several iron regulating protein impairments. We investigated the iron concentration and the protective role of human transferrin (hTf) in rd10 mice, a model of retinal degeneration. METHODS: The proton-induced X-ray emission (PIXE) method was used to quantify iron in rd10 mice 2, 3, and 4 weeks after birth. We generated mice with the β-phosphodiesterase mutation and hTf expression by crossbreeding rd10 mice with TghTf mice (rd10/hTf mice). The photoreceptor loss and apoptosis were evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling in 3-week-old rd10/hTf mice and compared with 3-week-old rd10 mice. The neuroprotective effect of hTf was analyzed in 5-day-old rd10 mice treated by intraperitoneal administration with hTf for up to 25 days. The retinal hTf concentrations and the thickness of the outer nuclear layer were quantified in all treated mice at 25 days postnatally. RESULTS: PIXE analysis demonstrated an age-dependent iron accumulation in the photoreceptors of rd10 mice. The rd10/hTf mice had the rd10 mutation, expressed high levels of hTf, and showed a significant decrease in photoreceptor death. In addition, rd10 mice intraperitoneally treated with hTf resulted in the retinal presence of hTf and a dose-dependent reduction in photoreceptor degeneration. CONCLUSIONS: Our results suggest that iron accumulation in the retinas of rd10 mutant mice is associated with photoreceptor degeneration. For the first time, the enhanced survival of cones and rods in the retina of this model has been demonstrated through overexpression or systemic administration of hTf. This study highlights the therapeutic potential of Tf to inhibit iron-induced photoreceptor cell death observed in degenerative diseases such as retinitis pigmentosa and age-related macular degeneration

Henri Seyrig (1895-1973)Introduction

Né dans un milieu aisé en 1895, Henri Seyrig est étudiant à Oxford, en 1914, lorsqu’éclate la guerre. Mobilisé en 1916, il s’illustre à Verdun puis rejoint l’armée d’Orient en Macédoine en 1917. Ce passage par les Balkans marque un tournant dans sa vie. Il en revient avec une passion pour la Grèce qui le conduit à passer l’agrégation de grammaire et à entrer à l’École d’Athènes dès 1922. En plus des activités archéologiques habituelles aux membres de l’École, il effectue trois voyages en Syri..

Snow accumulation and ablation measurements in a midlatitude mountain coniferous forest (Col de Porte, France, 1325 m altitude): the Snow Under Forest (SnoUF) field campaign data set

Forests strongly modify the accumulation, metamorphism and melting of snow in midlatitude and high-latitude regions. Recently, snow routines in hydrological and land surface models were improved to incorporate more accurate representations of forest snow processes, but model intercomparison projects have identified deficiencies, partly due to incomplete knowledge of the processes controlling snow cover in forests. The Snow Under Forest (SnoUF) project was initiated to enhance knowledge of the complex interactions between snow and vegetation. Two field campaigns, during the winters 2016–2017 and 2017–2018, were conducted in a coniferous forest bordering the snow study at Col de Porte (1325 m a.s.l., French Alps) to document the snow accumulation and ablation processes. This paper presents the field site, the instrumentation and the collection and postprocessing methods. The observations include distributed forest characteristics (tree inventory, lidar measurements of forest structure, subcanopy hemispherical photographs), meteorology (automatic weather station and an array of radiometers), snow cover and depth (snow pole transect and laser scan) and snow interception by the canopy during precipitation events. The weather station installed under dense canopy during the first campaign has been maintained since then and has provided continuous measurements throughout the year since 2018. Data are publicly available from the repository of the Observatoire des Sciences de l'Univers de Grenoble (OSUG) data center at https://doi.org/10.17178/SNOUF.2022 (Sicart et al., 2022).</p

Rabies Postexposure Prophylaxis, Marseille, France, 1994–2005

The administration of human rabies postexposure prophylaxis near Marseille (southern France) has changed since the eradication of terrestrial mammal rabies in 2001. Most injuries were associated with indigenous dogs; rabies vaccine was overprescribed. We suggest that the World Health Organization guidelines be adapted for countries free of terrestrial mammal rabies

The ImageCLEF 2011 plant images classification task

International audienceImageCLEFs plant identification task provides a testbed for the system-oriented evaluation of tree species identification based on leaf images. The aim is to investigate image retrieval approaches in the con- text of crowdsourced images of leaves collected in a collaborative manner. This paper presents an overview of the resources and assessments of the plant identification task at ImageCLEF 2011, summarizes the retrieval approaches employed by the participating groups, and provides an anal- ysis of the main evaluation results

Invest Ophthalmol Vis Sci

PURPOSE. Albinism is a group of genetic disorders that includes several conditions related to a defect in melanin production. There is a broad phenotypic and genotypic variability between the different forms. The aim of this study was to assess the ophthalmologic characteristics according to patients' genotypes in a cohort followed in the Reference Center for oculocutaneous albinism (OCA) of Bordeaux University Hospital, France.METHODS. A retrospective observational study was conducted in a cohort of patients with OCA seen in consultation in the ophthalmology department between 2017 and 2021 in whom a genetic analysis was performed.RESULTS. In total, 127 patients with OCA were included in this study and matched with the results of the genetic analysis. In the population aged over 6 years, there was no statistical difference in binocular visual acuity between the OCA1, OCA2, and OCA4 forms (P = 0.27). There was difference in ametropia between the three forms (P = 0.003). A twoby-two comparison using the Bonferroni correction showed a significant difference in ametropia between the OCA2 and OCA4 forms (P = 0.007) and between the OCA1 and OCA2 forms (P = 0.0075). Regardless of the form, most patients (75.4%) had grade 4 foveal hypoplasia. There was no association between the grade of foveal hypoplasia and the gene involved (P = 0.87).CONCLUSIONS. We described a genotype-phenotype correlation for the three most represented forms of albinism in our cohort. This study allowed assessing the degree of visual deficiency in young children with OCA