Retrospective analysis of the diagnostic effectiveness of the sentinel lymph node biopsy (SLNB) in vulvar cancer

Objectives: Inguinal lymphadenectomy used in the treatment of vulvar cancer often results in complications, such aslymphoedema or abnormal wound healing. Aim of this study was assessment of the diagnostic effectiveness of the sentinellymph node biopsy (SLNB) procedure in patients treated due to vulvar cancer.Material and methods: Eighty-four patients diagnosed with squamous cell vulvar carcinoma (FIGO I-IV) underwentpreoperative lymphoscintigraphy with technetium 99 to map sentinel lymph node. During surgery sentinel lymph nodeswere identified and resected, followed by complete bilateral groin lymphadenectomy.Results: Sentinel lymph nodes were mapped with lymphoscintigraphy and biopsied in 84.3% and 90.1% of patients, respectively.False negative predictive value (FNPV) was 9.1% and false negative rate (FNR) was recorded in 16.7% of cases. Patientsin advanced stages (FIGO III and IV) had significantly lower rate of lymphatic mapping compared to those in stage I and II(OR = 0.148, p = 0.022). Detection of sentinel lymph node in lymphoscintigraphy for tumor grade 2 and 3 was nearly eighttimes lower than for grade 1 cancers, however without statistical significance (OR = 0.126, p = 0.058).Conclusions: The use of SLNB should be limited to vulvar cancer patients in early clinical stages

Energy and thermal models for simulation of workload and resource management in computing systems

In the recent years, we have faced the evolution of high-performance computing (HPC) systems towards higher scale, density and heterogeneity. In particular, hardware vendors along with software providers, HPC centers, and scientists are struggling with the exascale computing challenge. As the density of both computing power and heat is growing, proper energy and thermal management becomes crucial in terms of overall system efficiency. Moreover, an accurate and relatively fast method to evaluate such large scale computing systems is needed. In this paper we present a way to model energy and thermal behavior of computing system. The proposed model can be used to effectively estimate system performance, energy consumption, and energy-efficiency metrics. We evaluate their accuracy by comparing the values calculated based on these models against the measurements obtained on real hardware. Finally, we show how the proposed models can be applied to workload scheduling and resource management in large scale computing systems by integrating them in the DCworms simulation framework

Modeling Data Center Building Blocks for Energy-efficiency and Thermal Simulations

International audienceIn this paper we present a concept and specification of Data Center Efficiency Building Blocks (DEBBs), which represent hardware components of a data center complemented by descriptions of their energy efficiency. Proposed building blocks contain hardware and thermodynamic models that can be applied to simulate a data center and to evaluate its energy efficiency. DEBBs are available in an open repository being built by the CoolEmAll project. In the paper we illustrate the concept by an example of DEBB defined for the RECS multi-server system including models of its power usage and thermodynamic properties. We also show how these models are affected by specific architecture of modeled hardware and differences between various classes of applications. Proposed models are verified by a comparison to measurements on a real infrastructure. Finally, we demonstrate how DEBBs are used in data center simulations

Reliability-oriented resource management for High-Performance Computing

Reliability is an increasingly pressing issue for High-Performance Computing systems, as failures are a threat to large-scale applications, for which an even single run may incur significant energy and billing costs. Currently, application developers need to address reliability explicitly, by integrating application-specific checkpoint/restore mechanisms. However, the application alone cannot exploit system knowledge, which is not the case for system-wide resource management systems. In this paper, we propose a reliability-oriented policy that can increase significantly component reliability by combining checkpoint/restore mechanisms exploitation and proactive resource management policies

Predictive Reliability and Fault Management in Exascale Systems: State of the Art and Perspectives

© ACM, 2020. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version was published in ACM Computing Surveys, Vol. 53, No. 5, Article 95. Publication date: September 2020. https://doi.org/10.1145/3403956[EN] Performance and power constraints come together with Complementary Metal Oxide Semiconductor technology scaling in future Exascale systems. Technology scaling makes each individual transistor more prone to faults and, due to the exponential increase in the number of devices per chip, to higher system fault rates. Consequently, High-performance Computing (HPC) systems need to integrate prediction, detection, and recovery mechanisms to cope with faults efficiently. This article reviews fault detection, fault prediction, and recovery techniques in HPC systems, from electronics to system level. We analyze their strengths and limitations. Finally, we identify the promising paths to meet the reliability levels of Exascale systems.This work has received funding from the European Union's Horizon 2020 (H2020) research and innovation program under the FET-HPC Grant Agreement No. 801137 (RECIPE). Jaume Abella was also partially supported by the Ministry of Economy and Competitiveness of Spain under Contract No. TIN2015-65316-P and under Ramon y Cajal Postdoctoral Fellowship No. RYC-2013-14717, as well as by the HiPEAC Network of Excellence. Ramon Canal is partially supported by the Generalitat de Catalunya under Contract No. 2017SGR0962.Canal, R.; Hernández Luz, C.; Tornero-Gavilá, R.; Cilardo, A.; Massari, G.; Reghenzani, F.; Fornaciari, W.... (2020). Predictive Reliability and Fault Management in Exascale Systems: State of the Art and Perspectives. ACM Computing Surveys. 53(5):1-32. https://doi.org/10.1145/3403956S132535Abella, J., Hernandez, C., Quinones, E., Cazorla, F. J., Conmy, P. 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IEEE Internet Com

Minimization of Costs and Energy Consumption in a Data Center by a Workload-Based Capacity Management

International audienceIn this paper we present an approach to improve power and cooling capacity management in a data center by taking into account knowledge about applications and workloads. We apply power capping techniques and proper cooling infrastructure configuration to achieve savings in energy and costs. To estimate values of a total energy consumption and costs we simulate both IT software/hardware and cooling infrastructure at once using the CoolEmAll SVD Toolkit. We also investigated the use of power capping to adjust data center operation to variable power supply and pricing. By better adjusting cooling infrastructure to specific types of workloads, we were able to find a configuration which resulted in energy, OPEX and CAPEX savings in the range of 4–25 %

Reuse of Data Center Waste Heat in Nearby Neighborhoods: A Neural Networks-Based Prediction Model

This paper addresses the problem of data centers’ cost efficiency considering the potential of reusing the generated heat in district heating networks. We started by analyzing the requirements and heat reuse potential of a high performance computing data center and then we had defined a heat reuse model which simulates the thermodynamic processes from the server room. This allows estimating by means of Computational Fluid Dynamics simulations the temperature of the hot air recovered by the heat pumps from the server room allowing them to operate more efficiently. To address the time and space complexity at run-time we have defined a Multi-Layer Perceptron neural network infrastructure to predict the hot air temperature distribution in the server room from the training data generated by means of simulations. For testing purposes, we have modeled a virtual server room having a volume of 48 m3 and two typical 42U racks. The results show that using our model the heat distribution in the server room can be predicted with an error less than 1 °C allowing data centers to accurately estimate in advance the amount of waste heat to be reused and the efficiency of heat pump operation

CoolEmAll D2.4 First release of the simulation and visualisation toolkit

This deliverable describes the realisation of the first prototype of the simulation, visualisation and decision support toolkit and the interaction of its components. It further describes the usage and the tests of the components of the 1st Prototype of the SVD toolkit. Another focus of this deliverable is describing the heterogeneous deployment architecture of the SVD toolkit and the invoking of the different components for performing an automatic simulation.This deliverable is split into four major parts. Each part describes the different properties of the individual components. Special focus is put on the distributed deployment architecture, realization, usage and tests of this 1st prototype