Nucleoside diphosphate kinase A (NM23-H1) as a potential biomarker candidate for colorectal cancer

Comunicaciones a congreso

Ab initio study of the influence of nanoscale doping inhomogeneities in the phase separated state of La1−x_{1-x}Cax_{x}MnO3_3

The chemical influence in the phase separation phenomenon that occurs in perovskite manganites is discussed by means of ab initio calculations. Supercells have been used to simulate a phase separated state, that occurs at Ca concentrations close to the localized to itinerant crossover. We have first considered a model with two types of magnetic ordering coexisting within the same compound. This is not stable. However, a non-isotropic distribution of chemical dopants is found to be the ground state. This leads to regions in the system with different effective concentrations, that would always accompany the magnetic phase separation at the same nanometric scale, with hole-rich regions being more ferromagnetic in character and hole-poor regions being in the antiferromagnetic region of the phase diagram, as long as the system is close to a phase crossover.Comment: 8 pages, 7 figures, 1 tabl

In the search of early stages biomarkers for non small cell lung cancer

Comunicaciones a congreso

Natalizumab y Leucoencefalopatía Multifocal Progresiva: adecuación a las recomendaciones del Ministerio de Sanidad de España

Introducción y Objetivo: Valorar el seguimiento de las recomendaciones emitidas por el ministerio de sanidad dirigidas a minimizarel riesgo de aparación de Leucoencefalopatía Multifocal Progresiva (LMP) asociada al tratamiento con natalizumab por parte de losprofesionales sanitarios de nuestro centro. Material y método: Revisión del 100% de pacientes diagnosticados de Esclerosis Múltiple a tratamiento con natalizumab (septiembre2008-junio 2013). Resultados: 34 pacientes. La duración de tratamiento fue inferior a 1 año en 10 pacientes, entre 1 y 2 años para 11 pacientes ysuperior a 2 años en 13 pacientes. Se encuentran 24 resultados de serología VJC: positiva 14 y negativa10. Ningún paciente habíarecibido inmunosupresores y en el 100% de ellos se realizaron resonancias. Fueron informados acerca del riesgo de desarrollar LMP18 pacientes, 10 con serología VJC positiva llevando 7 de ellos más de dos años a tratamiento con natalizumab. Discusión: Los facultativos se ajustan a las recomendaciones en la gran mayoría de los pacientes sin embargo, la información previaal inicio de tratamiento y una vez alcanzados los 2 años no se realiza de manera extendida.Sería adecuado realizar una estratificación de riesgo en función de presencia o ausencia de determinados factores que permitiríauna selección segura y eficaz de la terapia para EM más adecuada para cada paciente

Natalizumab y Leucoencefalopatía Multifocal Progresiva: adecuación a las recomendaciones del Ministerio de Sanidad de España

Introducción y Objetivo: Valorar el seguimiento de las recomendaciones emitidas por el ministerio de sanidad dirigidas a minimizarel riesgo de aparación de Leucoencefalopatía Multifocal Progresiva (LMP) asociada al tratamiento con natalizumab por parte de losprofesionales sanitarios de nuestro centro. Material y método: Revisión del 100% de pacientes diagnosticados de Esclerosis Múltiple a tratamiento con natalizumab (septiembre2008-junio 2013). Resultados: 34 pacientes. La duración de tratamiento fue inferior a 1 año en 10 pacientes, entre 1 y 2 años para 11 pacientes ysuperior a 2 años en 13 pacientes. Se encuentran 24 resultados de serología VJC: positiva 14 y negativa10. Ningún paciente habíarecibido inmunosupresores y en el 100% de ellos se realizaron resonancias. Fueron informados acerca del riesgo de desarrollar LMP18 pacientes, 10 con serología VJC positiva llevando 7 de ellos más de dos años a tratamiento con natalizumab. Discusión: Los facultativos se ajustan a las recomendaciones en la gran mayoría de los pacientes sin embargo, la información previaal inicio de tratamiento y una vez alcanzados los 2 años no se realiza de manera extendida.Sería adecuado realizar una estratificación de riesgo en función de presencia o ausencia de determinados factores que permitiríauna selección segura y eficaz de la terapia para EM más adecuada para cada paciente

Occurrence of organotin compounds in waters of the spanish coast under the European Water Framework Directive

Organotin compounds (OTCs), such as tributyltin (TBT), are persistent organic pollutants that are present in water samples (surface water, river water, sea water, waste water, etc.) because of anthropogenic activities (antifouling agents in ship paints, biocides in polymers, etc.). The toxicity and endocrine disruption potential of these chemicals have been demonstrated even at very low levels (<1 ng L−1) (Devos et al. 2012). Due to the extensive presence of OTCs in all environmental media as well as their adverse effects on human health and biota, quantitative and qualitative determination of those com-pounds in complex environmental matrices has become a matter of great concern, mainly butyl and phenyl-substituted. Also, these compounds are included in the list of priority substances according to the EU Directive 2013/39/EU amending Directives 2000/60/EC and 2008/105/EC as regards priority substances in the field of water policy. This directive specifies annual average environmental quality standard (AA-EQS) of 0.2 ng L−1 TBT and a maximum allowable environmental quality standard (MAC-EQS) of 1.5 ng L−1 TBT for all surface waters. Samples were collected in two semiconfined coastal areas, one of them an area with high industrial and port activities (Ría de Vigo) and the other one with high touristic and agricultural activity (Mar Menor).The sampling campaigns were performed in spring and autumn of 2015. The levels of MBT, DBT, TBT, MPhT, DPhT and TPhT in the seawater samples were analyzed by HS-SPME-GC–QqQMS/ MS method (Moscoso-Pérez et al. 2015). MPhT, DPhT and TPhT were not detected in any sample at levels higher than LOQ. For butylated compounds, MBT, DBT and TBT were detected in 100% of the analyzed samples in the Mar Menor. In the Vigo estuary, MBT has been detected in 83.3% of the samples, the DBT in 75% and the TBT in 88%. The TBT is present in 92% of the total of 39 analyzed samples, being detected in 100% of the samples of the Mar Menor and in 88% of the samples of the Ría de Vigo. These levels are similar than those detected in other locations, and lower than the detected in ports near the coast of Gijón characterized by a great maritime traffic (Centineo et al. 2004).Program of Consolidation and Structuring of Units of Competitive Investigation of the University System of Galicia (Xunta de Galicia) potentially cofinanced by ERDF in the frame of the operative Program of Galicia 2007-2013 (reference: GRC2013-047) and by the Ministry of Economy and Competitiveness (IMPACTA, project reference: CTM2013-48194-C3-2-R, and ARPA-ACUA, project reference: CTM2016-77945-C3-3-R)

Hyaluronic acid hydrogels reinforced with laser spun bioactive glass micro- and nanofibres doped with lithium

The repair of articular cartilage lesions in weight-bearing joints remains as a significant challenge due to the low regenerative capacity of this tissue. Hydrogels are candidates to repair lesions as they have similar properties to cartilage extracellular matrix but they are unable to meet the mechanical and biological requirements for a successful outcome. Here, we reinforce hyaluronic acid (HA) hydrogels with 13-93-lithium bioactive glass micro- and nanofibres produced by laser spinning. The glass fibres are a reinforcement filler and a platform for the delivery of therapeutic lithium-ions. The elastic modulus of the composites is more than three times higher than in HA hydrogels. Modelling of the reinforcement corroborates the experimental results. ATDC5 chondrogenic cells seeded on the composites are viable and more proliferation occurs on the hydrogels containing fibres than in HA hydrogels alone. Furthermore, the chondrogenic behavior on HA constructs with fibres containing lithium is more marked than in hydrogels with no-lithium fibres.Xunta de Galicia | Ref. ED431B 2016/042Xunta de Galicia | Ref. POS-A/2013/161Xunta de Galicia | Ref. ED481D 2017/010Xunta de Galicia | Ref. ED481B 2016/047-

TEMPORAL AND SPATIAL VARIABILITY OF ATMOSPHERIC PARTICLE NUMBER SIZE DISTRIBUTIONS ACROSS SPAIN

This study synthesizes for the first time results from simultaneous aerosol measurements performed at seven diverse locations distributed all over the Spanish geography. The observations were carried out during two field campaigns in 2012–2013, one-month each and during different seasons. These field campaigns were performed in the framework of the Spanish Network of DMAs (REDMAAS) activities. Measurement sites were grouped as polluted sites (urban background) and clean sites (rural background and high-altitude sites). Seasonal differences were more important at polluted sites, mainly related to meteorology and aerosol sources. Higher total particle concentrations were found during the cold period, driven mainly by Aitken-mode particles (traffic-related aerosol particles).This work has been financed by the Ministry of Science and Innovation (CGL2011-15008-E, CGL2010-1777, CGL2011-27020, CGL2014-52877-R, CGL2010-11095-E, CGL2012-39623-C02-01, CGL2014-55230-R & PI15/0051

Tidal and wind influences on circulation in the southern mouth of the Ría de Vigo (NW Iberian Peninsula)

Tidal and wind influences on the velocity field in the Ría de Vigo were assessed using atmospheric data from two meteorological stations located at Bouzas port and on an oceanic buoy off Silleiro Cape along with oceanic data from an ADCP moored in the Ría for a 72-day period. A two-layer circulation pattern was observed. Near-surface and near-bottom currents are primarily influenced by wind (especially remote winds), separated by an intermediate layer dominated by tidal variability. At subtidal frequencies, residual currents are well correlated with wind variability. Remote wind forcing exhibited a markedly high correlation with surface layer currents, indicating the major role played by wind in the long-term upwelling-modulated circulation of the Ría