The Family History of Reed W. Phillips

This is five generations of the family of Reed W. Phillips of Missouri. Family names include Phillips, Bybee, Johnson, Schmidt, Jeffries, Ross, Foster, and Hergemueller. It includes personal stories and genealogical data

On unbounded p-summable Fredholm modules

We prove that odd unbounded p-summable Fredholm modules are also bounded p-summable Fredholm modules (this is the odd counterpart of a result of A. Connes for the case of even Fredholm modules)

An Early Look at a Scoping Review of Systematic Review Methodologies in Engineering

This research work-in-progress paper is a scoping review of published systematic literature reviews (SLRs) in engineering. SLRs are considered one of the highest levels of proof for evidence based decision making, but they are only as good as the methods used, starting with the search strategy. With studies described as “systematic literature reviews” proliferating through engineering disciplines, including engineering education, it is necessary to examine how well these studies reflect a methodologically sound understanding of established SLR processes. The initial search returned 4,992 results, after removing duplicates. After completing the abstract review, we included 2,674 results for full text review. A preliminary analysis of the citations included for full text shows that SLRs have increased dramatically over the past decade in engineering education and approximately 14.1\% of included results for full text analysis contain an education related term in the title, abstract, or publication title. This trend implies that more education on the SLR research method may be needed in engineering education graduate programs and through professional development opportunities

Connectivity Conservation and Endangered Species Recovery: A Study in the Challenges of Defining Conservation-Reliant Species

Many species listed under the US Endangered Species Act (ESA) face continuing threats and will require intervention to address those threats for decades. These species, which have been termed conservation-reliant, pose a challenge to the ESA\u27s mandate for recovery of self-sustaining populations. Most references to conservation-reliant species by federal agencies involve the restoration of population connectivity. However, the diverse threats to connectivity faced by different species have contrasting implications in the context of the ESA\u27s mandate. For species facing long-term threats from invasive species or climate change, restoration of natural dispersal may not be technically feasible in the foreseeable future. For other species, restoration of natural dispersal is feasible, but carries economic and political cost. Federal agencies have used a broad definition of conservation reliance to justify delisting of species in the latter group even if they remain dependent on artificial translocation. Distinguishing the two groups better informs policy by distinguishing the technical challenges posed by novel ecological stressors from normative questions such as the price society is willing to pay to protect biodiversity, and the degree to which we should grow accustomed to direct human intervention in species\u27 life cycles as a component of conservation in the Anthropocene Epoch

Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors

Sensitivity to rewarding and reinforcing drug effects has a critical role in initial use, but the role of initial aversive drug effects has received less attention. Methamphetamine effects on dopamine re-uptake and efflux are associated with its addiction potential. However, methamphetamine also serves as a substrate for the trace amine-associated receptor 1 (TAAR1). Growing evidence in animal models indicates that increasing TAAR1 function reduces drug self-administration and intake. We previously determined that a non-synonymous single nucleotide polymorphism (SNP) i

Effects of Monovalent and Divalent Cations on Ca2+ Fluxes Across Chromaffin Secretory Membrane Vesicles

Abstract: Bovine chromaffin secretory vesicle ghosts loaded with Na+ were found to take up Ca2+ when incubated in K+ media or in sucrose media containing micromolar concentrations of free Ca2+. Li+- or choline+loaded ghosts did not take up Ca2+. The Ca2+ accumulated by Na+-loaded ghosts could be released by the Ca2+ ionophore A23187, but not by EGTA. Ca2+ uptake was inhibited by external Sr2+, Na +, Li +, or choline +. All the 45Ca2+ accumulated by Na+-dependent Ca2+ uptake could be released by external Na +, indicating that both Ca2+ influx and efflux occur in a Na+-dependent manner. Na + -dependent Ca2+ uptake and release were only slightly inhibited by Mg2+. In the presence of the Na+ ionophore Monensin the Ca2+ uptake by Na +-loaded ghosts was reduced. Ca2+ sequestered by the Na+-dependent mechanism could also be released by external Ca2+ or Sr2+ but not by Mg2+, indicating the presence of a Ca2+/Ca2+ exchange activity in secretory membrane vesicles. This Ca2+/Ca2+ exchange system is inhibited by Mg2+, but not by Sr2+. The Na + -dependent Ca2+ uptake system in the presence of Mg2+ is a saturable process with an apparent Km of 0.28 μM and a Vmax= 14.5 nmol min−1 mg protein−1. Ruthenium red inhibited neither the Na+/Ca2+ nor the Ca2+/Ca2+ exchange, even at high concentrations

Expansion parallax of the planetary nebula IC 418

In this paper, we present radio continuum observations of the planetary nebula IC 418 obtained at two epochs separated by more than 20 years. These data allow us to show that the angular expansion rate of the ionization front in IC 418 is 5.8 $\pm$ 1.5 mas yr$^{-1}$. If the expansion velocity of the ionization front is equal to the expansion velocity of the gas along the line of sight as measured by optical spectroscopy, then the distance to IC 418 must be 1.1 $\pm$ 0.3 kpc. Recent theoretical predictions appropriate for the case of IC 418, however, suggest that the ionization front may be expanding about 20% faster than the material. Under this assumption, the distance to IC 418 would increase to 1.3 $\pm$ 0.4 kpc.Comment: Accepted in the Astronomical Journa