Chondrodystrophia foetalis in the foetus and the infant

1. Two definite varieties of chondrodystrophia foetalis can be recognised clinically as well as microscopically. 2. It is a general disease, affecting many tissues but mainly those parts of the skeleton developed in cartilage. 3. A definite diagnosis can always.be made with the aid of X-rays. 4. The disease is present before ossification commences in any given bone and results in defective preparation for ossification in cartilage, causing a deficient attraction of true bone-forming cells. 5. It is highly probable that softness i of the skeleton due to disease affecting the cartilage, enables mechanical influences, most likely pressure of the amnion, to cause the deformities of achondroplasia. 6. The knowledge we possess of the metabolic influence of the pituitary and sexual glands points to an abnormal function of either or both of these structures as the most likely agent to cause the disturbance in the cartilage and elsewhere

Priority setting for research in health care: An application of value of information analysis to glycoprotein IIb/IIIa antagonists in non-ST elevation acute coronary syndrome

The purpose of this study is to explain the rationale for the value of information approach to priority setting for research and to describe the methods intuitively for those familiar with basic decision analytical modeling. A policy-relevant case study is used to show the feasibility of the method and to illustrate the type of output that is generated and how these might be used to frame research recommendations. The case study relates to the use of glycoprotein IIb/IIIa antagonists for the treatment of patients with non-ST elevation acute coronary syndrome. This is an area that recently has been appraised by the National Institute for Health and Clinical Excellence

Economic evidence for the prevention and treatment of atopic eczema: a protocol for a systematic review

Background: Eczema, synonymous with atopic eczema or atopic dermatitis, is a chronic skin disease that has a similar impact on health-related quality of life as other chronic diseases. The proposed research aims to provide a comprehensive systematic assessment of the economic evidence base available to inform economic modelling and decision making on interventions to prevent and treat eczema at any stage of the life course. Whilst the Global Resource of Eczema Trials (GREAT) database collects together the effectiveness evidence for eczema there is currently no such systematic resource on the economics of eczema. It is important to gain an overview of the current state of the art of economic methods in the field of eczema in order to strengthen the economic evidence base further. Methods/design: The proposed study is a systematic review of the economic evidence surrounding interventions for the prevention and treatment of eczema. Relevant search terms will be used to search MEDLINE, EMBASE, Database of Abstracts of Reviews of Effects, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, NHS Economic Evaluation Database, Health Technology Assessment, Cumulative Index to Nursing and Allied Health Literature, Econ Lit, Scopus, Cost-Effectiveness Analysis Registry and Web of Science in order to identify relevant evidence. To be eligible for inclusion studies will be primary empirical studies evaluating the cost, utility or full economic evaluation of interventions for preventing or treating eczema. Two reviewers will independently assess studies for eligibility and perform data abstraction. Evidence tables will be produced presenting details of study characteristics, costing methods, outcome methods and quality assessment. The methodological quality of studies will be assessed using accepted checklists. Discussion: The systematic review is being undertaken to identify the type of economic evidence available, summarise the results of the available economic evidence and critically appraise the quality of economic evidence currently available to inform future economic modelling and resource allocation decisions about interventions to prevent or treat eczema. We aim to use the review to offer guidance about how to gather economic evidence in studies of eczema and/or what further research is necessary in order to inform this

A passage from India - Anglo Indians in Victoria : a community gallery exhibition

Drawing on cultural artefacts, images and interactive audio-visual material, this exhibition depicts a vivid portrait of the Anglo-Indian community in Australia.</div

A multi-layer `gas of circles' Markov random field model for the extraction of overlapping near-circular objects

We propose a multi-layer binary Markov random field (MRF) model that assigns high probability to object configurations in the image domain consisting of an unknown number of possibly touching or overlapping near-circular objects of approximately a given size. Each layer has an associated binary field that specifies a region corresponding to objects. Overlapping objects are represented by regions in different layers. Within each layer, long-range interactions favor connected components of approximately circular shape, while regions in different layers that overlap are penalized. Used as a prior coupled with a suitable data likelihood, the model can be used for object extraction from images, e.g. cells in biological images or densely-packed tree crowns in remote sensing images. We present a theoretical and experimental analysis of the model, and demonstrate its performance on various synthetic and biomedical images

Attitudes of students from south-east and east Asian countries to slaughter and transport of livestock

Attitudes to animals have been extensively studied for people in developed countries, but not for those in developing countries. The attitudes of prospective stakeholders in the livestock sectors in south-east and east Asia toward transport and slaughter were examined by surveying university students studying veterinary medicine and animal science in Malaysia, Thailand, China and Vietnam, with a total of 739 students taking part. Students had greater acceptability of transport than slaughter issues for livestock, and female students found most transport and slaughter issues of greater concern than male students. Veterinary students were more accepting of several issues than animal science students, in particular killing animals that were injured or ill. Religion had a major effect on attitudes. Muslim students found using animals that died naturally for products least acceptable. Compared to them, Hindu students were less accepting of killing injured or ill animals and Buddhist students less accepting of euthanasing healthy pets. Students with more experience of pets were less accepting of both transport and slaughter issues. It is concluded that concern was exhibited by future stakeholders in the SE and E Asian livestock industries for slaughter and, to a lesser extent, transport issues, although attitudes were influenced by their religion, gender and experience of pet-keeping

How accelerating the electrification of the van sector in Great Britain can deliver faster CO₂ and NOₓ reductions

As a major emission contributor with significant growth potential, the light goods vehicles (vans) play an important part in achieving net-zero. In 2020 the UK government committed to phasing out sales of new internal combustion engine (ICE) vans by 2030, but the impact of the policy and how far are we to decarbonize the entire van fleet by 2050 is unclear. This paper investigates the CO2 and NOx emission trends in the van sector in Great Britain under the 2030 ICE phase-out. ECCo model1 is used to forecast the future van population by powertrain. The annual van mileage is estimated based on the van activity survey2. The instantaneous emission model PHEM, NAEI emissions inventory and remote sensing measurements are used to parameterize real-world driving emission factors of CO2 and NOx. Scenarios have been set out to assess the impact of enablers and barriers affecting the pace of emission reductions. Results suggest vans are on track to reach the tailpipe net-zero target by 2050 under all scenarios, and the speed of NOx reduction is even faster. A rapid transition to battery electric vans in the early to mid-2020s will significantly lower CO2, with associated estimated monetary benefits of £1.3 billion

Pharmaceutical care for elderly patients shared between community pharmacists and general practitioners: A randomised evaluation. RESPECT (Randomised Evaluation of Shared Prescribing for Elderly people in the Community over Time) [ISRCTN16932128]

Background: This trial aims to investigate the effectiveness and cost implications of 'pharmaceutical care' provided by community pharmacists to elderly patients in the community. As the UK government has proposed that by 2004 pharmaceutical care services should extend nationwide, this provides an opportunity to evaluate the effect of pharmaceutical care for the elderly. Design: The trial design is a randomised multiple interrupted time series. We aim to recruit 700 patients from about 20 general practices, each associated with about three community pharmacies, from each of the five Primary Care Trusts in North and East Yorkshire. We shall randomise the five resulting groups of practices, pharmacies and patients to begin pharmaceutical care in five successive phases. All five will act as controls until they receive the intervention in a random sequence. Until they receive training community pharmacists will provide their usual dispensing services and so act as controls. The community pharmacists and general practitioners will receive training in pharmaceutical care for the elderly. Once trained, community pharmacists will meet recruited patients, either in their pharmacies (in a consultation room or dispensary to preserve confidentiality) or at home. They will identify drug-related issues/problems, and design a pharmaceutical care plan in conjunction with both the GP and the patient. They will implement, monitor, and update this plan monthly. The primary outcome measure is the 'Medication Appropriateness Index'. Secondary measures include adverse events, quality of life, and patient knowledge and compliance. We shall also investigate the cost of pharmaceutical care to the NHS, to patients and to society as a whole.published_or_final_versio

Phylogenetic lineages in the Botryosphaeriaceae

Botryosphaeria is a species-rich genus with a cosmopolitan distribution, commonly associated with dieback and cankers of woody plants. As many as 18 anamorph genera have been associated with Botryosphaeria, most of which have been reduced to synonymy under Diplodia (conidia mostly ovoid, pigmented, thick-walled), or Fusicoccum (conidia mostly fusoid, hyaline, thin-walled). However, there are numerous conidial anamorphs having morphological characteristics intermediate between Diplodia and Fusicoccum, and there are several records of species outside the Botryosphaeriaceae that have anamorphs apparently typical of Botryosphaeria s.str. Recent studies have also linked Botryosphaeria to species with pigmented, septate ascospores, and Dothiorella anamorphs, or Fusicoccum anamorphs with Dichomera synanamorphs. The aim of this study was to employ DNA sequence data of the 28S rDNA to resolve apparent lineages within the Botryosphaeriaceae. From these data, 12 clades are recognised. Two of these lineages clustered outside the Botryosphaeriaceae, namely Diplodia-like anamorphs occurring on maize, which are best accommodated in Stenocarpella (Diaporthales), as well as an unresolved clade including species of Camarosporium/Microdiplodia. We recognise 10 lineages within the Botryosphaeriaceae, including an unresolved clade (Diplodia/Lasiodiplodia/Tiarosporella), Botryosphaeria s.str. (Fusicoccum anamorphs), Macrophomina, Neoscytalidium gen. nov., Dothidotthia (Dothiorella anamorphs), Neofusicoccum gen. nov. (Botryosphaeria-like teleomorphs, Dichomera-like synanamorphs), Pseudofusicoccum gen. nov., Saccharata (Fusicoccum- and Diplodia-like synanamorphs), “Botryosphaeria” quercuum (Diplodia-like anamorph), and Guignardia (Phyllosticta anamorphs). Separate teleomorph and anamorph names are not provided for newly introduced genera, even where both morphs are known. The taxonomy of some clades and isolates (e.g. B. mamane) remains unresolved due to the absence of ex-type cultures

Quantum catastrophe of slow light

Catastrophes are at the heart of many fascinating optical phenomena. The rainbow, for example, is a ray catastrophe where light rays become infinitely intense. The wave nature of light resolves the infinities of ray catastrophes while drawing delicate interference patterns such as the supernumerary arcs of the rainbow. Black holes cause wave singularities. Waves oscillate with infinitely small wave lengths at the event horizon where time stands still. The quantum nature of light avoids this higher level of catastrophic behaviour while producing a quantum phenomenon known as Hawking radiation. As this letter describes, light brought to a standstill in laboratory experiments can suffer a similar wave singularity caused by a parabolic profile of the group velocity. In turn, the quantum vacuum is forced to create photon pairs with a characteristic spectrum. The idea may initiate a theory of quantum catastrophes, in addition to classical catastrophe theory, and the proposed experiment may lead to the first direct observation of a phenomenon related to Hawking radiation.Comment: Published as "A laboratory analogue of the event horizon using slow light in an atomic medium