39 research outputs found
Tongan speech levels: practice and talk about practice in the cultural construction of social hierarchy
The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review
Background: The presence of circulating cell-free DNA from tumours in blood (ctDNA) is of major importance to those interested in early cancer detection, as well as to those wishing to monitor tumour progression or diagnose the presence of activating mutations to guide treatment. In 2014, the UK Early Cancer Detection Consortium undertook a systematic mapping review of the literature to identify blood-based biomarkers with potential for the development of a non-invasive blood test for cancer screening, and which identified this as a major area of interest. This review builds on the mapping review to expand the ctDNA dataset to examine the best options for the detection of multiple cancer types. Methods: The original mapping review was based on comprehensive searches of the electronic databases Medline, Embase, CINAHL, the Cochrane library, and Biosis to obtain relevant literature on blood-based biomarkers for cancer detection in humans (PROSPERO no. CRD42014010827). The abstracts for each paper were reviewed to determine whether validation data were reported, and then examined in full. Publications concentrating on monitoring of disease burden or mutations were excluded. Results: The search identified 94 ctDNA studies meeting the criteria for review. All but 5 studies examined one cancer type, with breast, colorectal and lung cancers representing 60% of studies. The size and design of the studies varied widely. Controls were included in 77% of publications. The largest study included 640 patients, but the median study size was 65 cases and 35 controls, and the bulk of studies (71%) included less than 100 patients. Studies either estimated cfDNA levels non-specifically or tested for cancer-specific mutations or methylation changes (the majority using PCR-based methods). Conclusion: We have systematically reviewed ctDNA blood biomarkers for the early detection of cancer. Pre-analytical, analytical, and post-analytical considerations were identified which need to be addressed before such biomarkers enter clinical practice. The value of small studies with no comparison between methods, or even the inclusion of controls is highly questionable, and larger validation studies will be required before such methods can be considered for early cancer detection
The PREDICTS database: a global database of how local terrestrial biodiversity responds to human impacts
Biodiversity continues to decline in the face of increasing anthropogenic pressures
such as habitat destruction, exploitation, pollution and introduction of
alien species. Existing global databases of species’ threat status or population
time series are dominated by charismatic species. The collation of datasets with
broad taxonomic and biogeographic extents, and that support computation of
a range of biodiversity indicators, is necessary to enable better understanding of
historical declines and to project – and avert – future declines. We describe and
assess a new database of more than 1.6 million samples from 78 countries representing
over 28,000 species, collated from existing spatial comparisons of
local-scale biodiversity exposed to different intensities and types of anthropogenic
pressures, from terrestrial sites around the world. The database contains
measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35)
biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains
more than 1% of the total number of all species described, and more than
1% of the described species within many taxonomic groups – including flowering
plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans
and hymenopterans. The dataset, which is still being added to, is
therefore already considerably larger and more representative than those used
by previous quantitative models of biodiversity trends and responses. The database
is being assembled as part of the PREDICTS project (Projecting Responses
of Ecological Diversity In Changing Terrestrial Systems – www.predicts.org.uk).
We make site-level summary data available alongside this article. The full database
will be publicly available in 2015
Justin B. Richland, Arguing with tradition: The language of law in Hopi Tribal Court. Chicago: University of Chicago Press, 2008. Pp. xii. 187. Pb $16.00.
W. Lance Bennett and Martha S. Feldman, Reconstructing reality in the coutroom. London: Tavistock, 1981. Pp. x + 203.
Donal Carbaugh, Situating selves: The communication of social identities in American scenes. (Human communication Processes.) Albany: State University of New York Press, 1996. Pp. xv, 238. Pb $19.95.
Tongan Chiefly Language: The Formation Of An Honorific Speech Register
In this paper we examine the formation over time of a lexical honorific speech register, Tongan lea faka\u27eiki, or \u27chiefly language\u27. Use of the comparative historical method enables us to consider honorific register formation within a framework of greater temporal and spatial scope that has been typical for studies of register formation, and to identify some properties of such formation that have not been documented before. Our evidence shows that the higher and lower levels of honorification in this speech register have been formed at different times and through predominantly different etymological processes, even as they draw on the same broader set of word formation processes. In recorded speech, the differences between the sources of the two sub-registers are even more pronounced, preserving and reproducing the historical differences in their formation.