Combination of gemcitabine and cetuximab in patients with advanced cholangiocarcinoma: a phase II study

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Acupuncture as a Complementary Therapy for Cancer Care: Acceptability and Preferences of Patients and Informal Caregivers

Background: Acupuncture can effectively manage cancer-related side effects, for both patients undergoing treatment and for cancer survivors. It may also be effective in managing physiological and psychological symptoms common among informal caregivers of cancer patients. Objectives: The aim of this survey was to explore the acceptability and preferences of cancer patients, cancer survivors, and their informal caregivers in relation to acupuncture. Methods: The survey was conducted from 20th November to 27th November 2018. The questionnaire was developed to explore acceptability and preferences, including motivation, symptoms to be addressed, and practical issues (location, cost, etc.), in relation to acupuncture. Results: The survey response rate was 94.5% in cancer patients and cancer survivors and 100% in caregivers. Acceptability of acupuncture was 34.5% (n = 40/116) and 48.0% (n = 26/54) in cancer patients and caregivers, respectively. About 52.5% (n = 21/40) of patients preferred to undergo acupuncture at the day center clinic, whereas caregivers had no specific preference. Patients and cancer survivors would use acupuncture for symptoms of fatigue (60%), listlessness (57.5%), and pain (47.5%). Informal caregivers expressed an interest in using acupuncture for their pain, stress, and sleeping difficulties 48.0% (n = 26/54). Conclusion: Cancer patients, cancer survivors, and informal caregivers would accept acupuncture as a complementary therapy. This openness and preference to acupuncture provide the foundations for this complementary therapy to be incorporated into holistic and supportive cancer care, both for patients and those supporting them

Combination of gemcitabine and cetuximab in patients with advanced cholangiocarcinoma: a phase II study of the Belgian Group of Digestive Oncology

Background: Cholangiocarcinomas are uncommon tumours with a poor prognosis, that frequently present epidermal growth factor receptor overexpression. Methods: In a multi-centre phase II trial, patients with unresectable cholangiocarcinoma, naïve to chemotherapy, received Cetuximab (400 mg/m2 at week 1, then 250 mg/m2/week) and Gemcitabine (1 g/m2 on day 1, 8 and 15 every 4 weeks). Primary end point was progression-free survival (PFS) rate at 6 months, using a Simon 2-stage design. Moreover, we assessed the impact of KRAS status and skin toxic effect on efficacy. Results: Forty-four patients (41% locally advanced/59% metastatic) were enrolled. Median age was 61.5 years; ECOG PS was 0 (68%) or 1. Six months PFS reached 47%. Median OS was 13.5 months [95% confidence interval (CI) 9.8-31.8 months]. Nine patients (20.4%) had PR and disease-control rate was 79.5%. Grade 3/4-related toxic effects were haematological (52.2%), skin rash (13.6%) and fatigue (11.4%). KRAS mutations were found in 7 of 27 patients and had no influence on PFS. Skin toxic effect =grade 2 was associated with increased PFS (P = 0.05).Conclusion(s): Our study met its primary end point, suggesting that Gemcitabine-Cetuximab has activity in cholangiocarcinoma. KRAS status was not associated with PFS, unlike skin toxic effect, which could be used as a surrogate marker for efficacy

Is the Other-Race Effect in Working Memory Due to Attentional Refreshing?

The other-race effect is the observation that faces from another ethnicity induce worst recall performance than faces from one’s own ethnicity. This effect has been defined as a type of familiarity effect, with more familiar faces better recalled than less familiar faces. In this study, we tested the hypothesis that a working memory maintenance mechanism called attentional refreshing mediates the other-race effect and that faces from one’s own ethnicity are refreshed more efficiently than faces from other ethnicities. In two experiments, face ethnicity was orthogonally manipulated with cognitive load of a concurrent processing task in a complex-span paradigm (Exp. 1) and with the memory load in a Brown-Peterson paradigm (Exp. 2). Both cognitive and memory load effects are indices of the functioning of attentional refreshing. Testing Caucasian young adults, Caucasian and East-Asian faces were contrasted. Results from both experiments were congruent and against our initial hypothesis. The other-race effect in working memory does not appear to be supported by attentional refreshing. Furthermore, the results are congruent with the idea that faces as a whole are not maintained in working memory via attentional refreshing

Familiarity Effect on Attentional Maintenance in Visuospatial Working Memory

This repository contains the raw data and the stimuli used in the following article: Schneider, P., Vergauwe, E. & Camos, V. The visual familiarity effect on attentional working memory maintenance. Memory and Cognition (2024). https://doi.org/10.3758/s13421-024-01548-1 All images have been uploaded with the permission of the original creator Anja Soldan. source: Soldan, A., Zarahn, E., Hilton, H. J. & Stern, Y. (2008). Global familiarity of visual stimuli affects repetition-related neural. Neuroimage, 39(1), 515–526

Does long-term memory affect refreshing in verbal working memory?

Attentional refreshing allows the maintenance of information in working memory and has received growing interest in recent years. However, it is still ill-defined and several proposals have been put forward to account for its functioning. Among them, some proposals suggest that refreshing relies on the retrieval of knowledge from semantic long-term memory. To examine such a proposal, the present study examined the impact on refreshing of two effects known to affect the retrieval from semantic long-term memory: word frequency and lexicality. In working memory span tasks, participants had to maintain memoranda varying in either frequency, or lexicality while performing concurrent tasks. By examining recall performance in complex span tasks and response times for the concurrent task in Brown-Peterson tasks, the present study provided evidence that long-term memory effects (a) affected recall without interacting with manipulation of refreshing and (b) did not affect refreshing speed. These findings challenge the idea that refreshing acts through the retrieval of knowledge from semantic long-term memory. Different WM models are discussed to account for these findings

Deferoxamine does not increase the risk for bacteremia in hemodialysis patients

SCOPUS: ar.jinfo:eu-repo/semantics/publishe