Psychological impacts of the 2019 Quebec floods: findings from a large population-based study

Background During Spring 2019, many regions in Quebec (Canada) experienced severe floods. As much as 5,245 households were flooded and 7,452 persons were evacuated, causing extensive material and human damages. A large population-based study was therefore conducted to examine medium-term effects of this natural disaster on health and well-being. Methods Six to eight months post-floods, households located in the flooded zones (in one of the 6 Quebec regions the most severely affected) were randomly invited to participate to a telephone or a web-based survey (response rate=15.3%). Several psychological health outcomes were examined, including psychological distress (based on the 6-item Kessler Scale, score 0-24) and post-traumatic stress (based on the 15-item Impact of Event Scale, score 0-75). These outcomes were compared among 3 levels of exposure using Chi-square test: flooded (floodwater in ≥ 1 liveable room), disrupted (floodwater in non-liveable areas, loss of utilities, loss of access to services, or evacuation), and unaffected. Results Of the 3,437 participating households, 349 (10.2%) were flooded and 1230 (35.8%) were disrupted (but not flooded) during the 2019 floods. A steep gradient was observed for moderate/severe symptoms of post-traumatic stress (score ≥ 26) according to the level of exposure to flooding (unaffected: 3.0%; disrupted: 14.6%; flooded: 44.1%; p < 0.0005). For psychological distress (score ≥ 7), the baseline level (i.e. unaffected group) was 7.3% while it reached 15.0% and 38.4% in the disrupted and the flooded groups, respectively (p < 0.0005). Conclusions This study is among the largest to examine the psychological impacts of flooding. The magnitude of effects observed in flooded households is consistent with the literature and calls for stronger social and economic measures to support flood victims. Such support should help coping with initial stress, but also alleviating secondary stressors classically observed in post-flood settings

Guide to identifying alert thresholds for heat waves in Canada based on evidence

Among natural-disaster risks, heat waves are responsible for a large number of deaths, diseases and economic losses around the world. As they will increase in severity, duration and frequency over the decades to come within the context of climate change, these extreme events constitute a genuine danger to human health, and heat-warning systems are strongly recommended by public health authorities to reduce this risk of diseases and of excessive mortality and morbidity. Thus, evidence-based public alerting criteria are needed to reduce impacts on human health before and during persistent hot weather conditions.\ud The goal of this guide is to identify alert thresholds for heat waves in Canada based on evidence, and to propose an approach for better defining heat waves in the Canadian context in order to reduce the risks to human health and contribute to the well-being of Canadians. This guide is the result of the collaboration among various research and public institutions working on: 1) meteorological and climate aspects, i.e. the Meteorological Service of Canada (MSC, Environment and Climate Change Canada), and the ESCER centre at the Université du Québec à Montréal, and 2) public health, i.e. Health Canada and the Institut National de Santé Publique du Québec

Climate change alone cannot explain boreal caribou range recession in Quebec since 1850

The contraction of species range is one of the most significant symptoms of biodiversity loss worldwide. While anthropogenic activities and habitat alteration are major threats for several species, climate change should also be considered. For species at risk, differentiating the effects of human disturbances and climate change on past and current range transformations is an important step towards improved conservation strategies. We paired historical range maps with global atmospheric reanalyses from different sources to assess the potential effects of recent climate change on the observed northward contraction of the range of boreal populations of woodland caribou (Rangifer tarandus caribou) in Quebec (Canada) since 1850. We quantified these effects by highlighting the discrepancies between different southern limits of the caribou's range (used as references) observed in the past and reconstitutions obtained through the hindcasting of the climate conditions within which caribou are currently found. Hindcasted southern limits moved ~105 km north over time under all reanalysis datasets, a trend drastically different from the ~620 km reported for observed southern limits since 1850. The differences in latitudinal shift through time between the observed and hindcasted southern limits of distribution suggest that caribou range recession should have been only 17% of what has been observed since 1850 if recent climate change had been the only disturbance driver. This relatively limited impact of climate reinforces the scientific consensus stating that caribou range recession in Quebec is mainly caused by anthropogenic drivers (i.e. logging, development of the road network, agriculture, urbanization) that have modified the structure and composition of the forest over the past 160 years, paving the way for habitat-mediated apparent competition and overharvesting. Our results also call for a reconsideration of past ranges in models aiming at projecting future distributions, especially for endangered species. -- Keywords : anthropogenic disturbances ; climate niche ; eastern Canada ; modelling ; Rangifer tarandus caribou ; species distribution model

Faire-face aux changements ensemble (FACE) : mieux s’adapter aux changements climatiques au Canada et en Afrique de l’Ouest dans le domaine des ressources en eau - rapport final

Vu la fin prématurée du projet initial, un court nouveau projet intitulé « Les leishmanioses canines: réévaluation des transmissions, prophylaxie et indicateur épidémiologique en sante publique », sous la direction du professeur Abdelkbir Rhalem, Laboratoire de Parasitologie et des zoonoses parasitaires de l’Institut Agronomique et Vétérinaire Hassan II au Maroc, en collaboration avec le ministère de la santé (Dr Abderrahmane Laamrani El Idrissi, Chef de Service des Maladies parasitaires) a été amorcé en janvier 2015. Ce projet vise (1) à évaluer le rôle réservoir du chien pour des parasites du genre Leishmania sp. responsables chez l’homme de la forme viscérale (L.infantum) et les formes cutanées (L.infantum Mon- 24 et L. tropica) et (2) à utiliser le modèle chien comme indicateur de santé publique pour déterminer les conditions de transmission de la maladie et son évolution (prévalence et incidence). La première phase s’est terminée avec succès et la deuxième phase est amorcée (rapport prévu fin 2016)

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-κB by Human T-Lymphotropic Virus Type 1 Tax Protein

Nuclear factor (NF)-κB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-κB occurs predominantly in the cytoplasm, where Tax1 binds NF-κB Essential Modulator (NEMO/IKKγ) and triggers the activation of IκB kinases. Several independent studies have shown that Tax1-mediated NF-κB activation is dependent on Tax1 ubiquitination. Here, we identify by co-immunoprecipitation assays NEMO-Related Protein (NRP/Optineurin) as a binding partner for Tax1 in HTLV-1 infected and Tax1/NRP co-expressing cells. Immunofluorescence studies reveal that Tax1, NRP and NEMO colocalize in Golgi-associated structures. The interaction between Tax1 and NRP requires the ubiquitin-binding activity of NRP and the ubiquitination sites of Tax1. In addition, we observe that NRP increases the ubiquitination of Tax1 along with Tax1-dependent NF-κB signaling. Surprisingly, we find that in addition to Tax1, NRP interacts cooperatively with the Tax1 binding protein TAX1BP1, and that NRP and TAX1BP1 cooperate to modulate Tax1 ubiquitination and NF-κB activation. Our data strongly suggest for the first time that NRP is a critical adaptor that regulates the assembly of TAX1BP1 and post-translationally modified forms of Tax1, leading to sustained NF-κB activation

La modélisation du climat - où en sommes nous ?

Parmi les changements majeurs dans les facteurs internes qui peuvent influencer l’état actuel et futur du système climatique, l’augmentation récente de la concentration des gaz à effet de serre (CO2, CH4, et autres) dans l’atmosphère, de 280 à 360 ppmv (partie par million en volume) environ pour le CO2 de 1750 à 1995 (Figs 1a et b), représente l’un des plus rapides et des plus importants changements intervenus dans la composition de l’atmosphère voire dans l’histoire du climat. La concentrati..