ERP in the MIS Curriculum: A Tri-Perspective

Business students need curricula that stress the whole enterprise rather than the individual functions and components. To become effective leaders, business students need to understand how organizations formulate plans and manager their operations using ERP systems. To enhance our undergraduate and graduate programs in Information Systems, an increasing number of universities have entered or are contemplating entering into alliances with leading vendors of ERP software and are planning to redesign their curricula to help students understand the requirements and the design of enterprise- wide systems solutions through use of ERP

DSS Access on the World Wide Web: An Empirical Test of an Open DSS Protocol

The World Wide Web (WWW) was designed to be a pool of human knowledge, which would allow collaborators to share their ideas and all aspects of a common project [1]. This goal for the WWW makes it an ideal distribution system for the Decision Support Systems (DSSs) of the future. The purpose of this research study is to validate a protocol that was designed to allow DSS information to be found and transmitted via the WWW. This paper describes an empirical study designed to determine if users can utilize an Open DSS protocol to create specifications which fully describe specific DSS applications. The results of this study will be presented at the conferenc

A map of human genome variation from population-scale sequencing

The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype. Here we present results of the pilot phase of the project, designed to develop and compare different strategies for genome-wide sequencing with high-throughput platforms. We undertook three projects: low-coverage whole-genome sequencing of 179 individuals from four populations; high-coverage sequencing of two mother-father-child trios; and exon-targeted sequencing of 697 individuals from seven populations. We describe the location, allele frequency and local haplotype structure of approximately 15 million single nucleotide polymorphisms, 1 million short insertions and deletions, and 20,000 structural variants, most of which were previously undescribed. We show that, because we have catalogued the vast majority of common variation, over 95% of the currently accessible variants found in any individual are present in this data set. On average, each person is found to carry approximately 250 to 300 loss-of-function variants in annotated genes and 50 to 100 variants previously implicated in inherited disorders. We demonstrate how these results can be used to inform association and functional studies. From the two trios, we directly estimate the rate of de novo germline base substitution mutations to be approximately 10−8 per base pair per generation. We explore the data with regard to signatures of natural selection, and identify a marked reduction of genetic variation in the neighbourhood of genes, due to selection at linked sites. These methods and public data will support the next phase of human genetic researc