Observation of Motion Dependent Nonlinear Dispersion with Narrow Linewidth Atoms in an Optical Cavity

As an alternative to state-of-the-art laser frequency stabilisation using ultra-stable cavities, it has been proposed to exploit the non-linear effects from coupling of atoms with a narrow transition to an optical cavity. Here we have constructed such a system and observed non-linear phase shifts of a narrow optical line by strong coupling of a sample of strontium-88 atoms to an optical cavity. The sample temperature of a few mK provides a domain where the Doppler energy scale is several orders of magnitude larger than the narrow linewidth of the optical transition. This makes the system sensitive to velocity dependent multi-photon scattering events (Dopplerons) that affect the cavity field transmission and phase. By varying the number of atoms and the intra-cavity power we systematically study this non-linear phase signature which displays roughly the same features as for much lower temperature samples. This demonstration in a relatively simple system opens new possibilities for alternative routes to laser stabilization at the sub 100 mHz level and superradiant laser sources involving narrow line atoms. The understanding of relevant motional effects obtained here has direct implications for other atomic clocks when used in relation with ultranarrow clock transitions.Comment: 9 pages (including 4 pages of Supplemental Information), 6 figures. Updated to correspond to the published versio

Experiments in Interrupted Growth Molecular Beam Epitaxy Technology

From a device structure standpoint it would be advantageous to sandwich laterally defined features between layers of epitaxially grown material. In silicon this is commonly dope by growing the bottom layer, patterning the desired feature, and growing a second layer. Unfortunately, this process has not been practical in GaAs for the same reason that there is no true MOS technology in GaAs: The. GaAs surface is irreparably damaged when it is exposed to the atmosphere leading to the formation of undesirable interface states. Heterojunction FET\u27s are feasible only because high quality epilayers are grown during a single run in an ultrahigh vacuum environment. Standard growth methods allow for variation of doping and material content only in one direction, normal to the wafer surface. Varying the material in more than one dimension without the use of prohibitively exotic equipment requires removal of the wafer from the growth apparatus for lateral processing between material growths. Thus the problem that this thesis attempts to address: How to protect a GaAs surface during a lateral processing step and initiate regrowth leaving behind an electrically invisible restart interface. The potential applications of the development of a successful interrupted growth scheme for GaAs are numerous and far reaching. Specifically it would allow the fabrication of advantageous device geometries that are not possible under single material growth runs. Although this thesis deals exclusively with ion implanted interrupted growth by Molecular Beam Epitaxy, some of the concepts arid theories can be extended to other growth methods. It is both a review of previous work and a report of our attempts at Purdue to fabricate the first interrupted growth HIGFET\u27s and MISFET\u27s. Mechanisms behind the success and failure of GaAs interrupted growth are discussed and several experiments involving passivation materials and new interrupted growth schemes are propose

Pharmacological interventions for painful sickle cell vaso-occlusive crises in adults.

BACKGROUND: Sickle cell disease (SCD) is a group of inherited disorders of haemoglobin (Hb) structure in a person who has inherited two mutant globin genes (one from each parent), at least one of which is always the sickle mutation. It is estimated that between 5% and 7% of the world\u27s population are carriers of the mutant Hb gene, and SCD is the most commonly inherited blood disorder. SCD is characterized by distorted sickle-shaped red blood cells. Manifestations of the disease are attributed to either haemolysis (premature red cell destruction) or vaso-occlusion (obstruction of blood flow, the most common manifestation). Shortened lifespans are attributable to serious comorbidities associated with the disease, including renal failure, acute cholecystitis, pulmonary hypertension, aplastic crisis, pulmonary embolus, stroke, acute chest syndrome, and sepsis. Vaso-occlusion can lead to an acute, painful crisis (sickle cell crisis, vaso-occlusive crisis (VOC) or vaso-occlusive episode). Pain is most often reported in the joints, extremities, back or chest, but it can occur anywhere and can last for several days or weeks. The bone and muscle pain experienced during a sickle cell crisis is both acute and recurrent. Key pharmacological treatments for VOC include opioid analgesics, non-opioid analgesics, and combinations of drugs. Non-pharmacological approaches, such as relaxation, hypnosis, heat, ice and acupuncture, have been used in conjunction to rehydrating the patient and reduce the sickling process. OBJECTIVES: To assess the analgesic efficacy and adverse events of pharmacological interventions to treat acute painful sickle cell vaso-occlusive crises in adults, in any setting. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) via the Cochrane Register of Studies Online, MEDLINE via Ovid, Embase via Ovid and LILACS, from inception to September 2019. We also searched the reference lists of retrieved studies and reviews, and searched online clinical trial registries. SELECTION CRITERIA: Randomized, controlled, double-blind trials of pharmacological interventions, of any dose and by any route, compared to placebo or any active comparator, for the treatment (not prevention) of painful sickle cell VOC in adults. DATA COLLECTION AND ANALYSIS: Three review authors independently assessed studies for eligibility. We planned to use dichotomous data to calculate risk ratio (RR) and number needed to treat for one additional event, using standard methods. Our primary outcomes were participant-reported pain relief of 50%, or 30%, or greater; Patient Global Impression of Change (PGIC) very much improved, or much or very much improved. Our secondary outcomes included adverse events, serious adverse events, and withdrawals due to adverse events. We assessed GRADE and created three \u27Summary of findings\u27 tables. MAIN RESULTS: We included nine studies with data for 638 VOC events and 594 participants aged 17 to 42 years with SCD presenting to a hospital emergency department in a painful VOC. Three studies investigated a non-steroidal anti-inflammatory drug (NSAID) compared to placebo. One study compared an opioid with a placebo, two studies compared an opioid with an active comparator, two studies compared an anticoagulant with a placebo, and one study compared a combination of three drugs with a combination of four drugs. Risk of bias across the nine studies varied. Studies were primarily at an unclear risk of selection, performance, and detection bias. Studies were primarily at a high risk of bias for size with fewer than 50 participants per treatment arm; two studies had 50 to 199 participants per treatment arm (unclear risk). Non-steroidal anti-inflammatory drugs (NSAID) compared with placebo No data were reported regarding participant-reported pain relief of 50% or 30% or greater. The efficacy was uncertain regarding PGIC very much improved, and PGIC much or very much improved (no difference; 1 study, 21 participants; very low-quality evidence). Very low-quality, uncertain results suggested similar rates of adverse events across both the NSAIDs group (16/45 adverse events, 1/56 serious adverse events, and 1/56 withdrawal due to adverse events) and the placebo group (19/45 adverse events, 2/56 serious adverse events, and 1/56 withdrawal due to adverse events). Opioids compared with placebo No data were reported regarding participant-reported pain relief of 50% or 30%, PGIC, or adverse events (any adverse event, serious adverse events, and withdrawals due to adverse events). Opioids compared with active comparator No data were reported regarding participant-reported pain relief of 50% or 30% or greater. The results were uncertain regarding PGIC very much improved (33% of the opioids group versus 19% of the placebo group). No data were reported regarding PGIC much or very much improved. Very low-quality, uncertain results suggested similar rates of adverse events across both the opioids group (9/66 adverse events, and 0/66 serious adverse events) and the placebo group (7/64 adverse events, 0/66 serious adverse events). No data were reported regarding withdrawal due to adverse events. Quality of the evidence We downgraded the quality of the evidence by three levels to very low-quality because there are too few data to have confidence in results (e.g. too few participants per treatment arm). Where no data were reported for an outcome, we had no evidence to support or refute (quality of the evidence is unknown). AUTHORS\u27 CONCLUSIONS: This review identified only nine studies, with insufficient data for all pharmacological interventions for analysis. The available evidence is very uncertain regarding the efficacy or harm from pharmacological interventions used to treat pain related to sickle cell VOC in adults. This area could benefit most from more high quality, certain evidence, as well as the establishment of suitable registries which record interventions and outcomes for this group of people

A Predicted Correlation Between Age Gradient and Star Formation History in FIRE Dwarf Galaxies

We explore the radial variation of star formation histories in dwarf galaxies simulated with Feedback In Realistic Environments (FIRE) physics. The sample contains 9 low-mass field dwarfs with M_ star = 10^5 - 10^7 M_sun from previous FIRE results, and a new suite of 17 higher mass field dwarfs with M_star = 10^7 - 10^9 M_sun introduced here. We find that age gradients are common in our dwarfs, with older stars dominant at large radii. The strength of the gradient correlates with overall galaxy age such that earlier star formation produces a more pronounced gradient. The relation between formation time and strength of the gradient is driven by both mergers and star-formation feedback. Mergers can both steepen and flatten the age gradient depending on the timing of the merger and star formation history of the merging galaxy. In galaxies without significant mergers, early feedback pushes stars to the outskirts at early times. Interestingly, among galaxies without mergers, those with large dark matter cores have flatter age gradients because these galaxies have more late-time feedback. If real galaxies have age gradients as we predict, stellar population studies that rely on sampling a limited fraction of a galaxy can give a biased view of its global star formation history. We show that central fields can be biased young by a few Gyrs while outer fields are biased old. Fields positioned near the 2D half-light radius will provide the least biased measure of a dwarf galaxy's global star formation history.Comment: 13 pages, 8 figures. Submitted to MNRAS, comments welcom

The influence of current and future climate-induced risk on the agricultural sector in East and Central Africa: Sensitizing the ASARECA strategic plan to climate change

Rainfed agriculture is and will remain the dominant source of staple food production for the majority of the rural poor in Eastern and Central Africa (ECA). It is clear that larger investments in agriculture by a broad range of stakeholders will be required if this sector is to meet the food security requirements of tomorrow’s Africa. Many factors contribute to the current low levels of investment, but production uncertainty associated with between- and within-season rainfall variability remains a fundamental constraint to many investors who often overestimate the impact of climate induced uncertainty. The climate of Africa is warmer than it was 100 years ago. Model-based predictions of future greenhouse gas-induced climate change for the continent clearly suggest that this warming will continue and, in most scenarios, accelerate. The projections for rainfall are less uniform; large regional differences exist in rainfall variability. However, there is likely to be an increase in annual mean precipitation in East Africa

Risk Factors for Soil-Transmitted Helminth Infections during the First 3 Years of Life in the Tropics; Findings from a Birth Cohort.

Background: Soil-transmitted helminths (STH) infect more than 2 billion humans worldwide, causing significant morbidity in children. There are few data on the epidemiology and risk factors for infection in pre-school children. To investigate risk factors for infection in early childhood, we analysed data prospectively collected in the ECUAVIDA birth cohort in Ecuador. Methods and Findings: Children were recruited at birth and followed up to 3 years of age with periodic collection of stool samples that were examined microscopically for STH parasites. Data on social, demographic, and environmental risk factors were collected from the mother at time of enrolment. Associations between exposures and detection of STH infections were analysed by multivariable logistic regression. Data were analysed from 1,697 children for whom a stool sample was obtained at 3 years. 42.3% had at least one STH infection in the first 3 years of life and the most common infections were caused by A. lumbricoides (33.2% of children) and T. trichiura (21.2%). Hookworm infection was detected in 0.9% of children. Risk of STH infection was associated with factors indicative of poverty in our study population such as Afro-Ecuadorian ethnicity and low maternal educational level. Maternal STH infections during pregnancy were strong risk factors for any childhood STH infection, infections with either A. lumbricoides or T. trichiura, and early age of first STH infection. Children of mothers with moderate to high infections intensities with A. lumbricoides were most at risk. Conclusions: Our data show high rates of infection with STH parasites during the first 3 years of life in an Ecuadorian birth cohort, an observation that was strongly associated with maternal STH infections during pregnancy. The targeted treatment of women of childbearing age, in particular before pregnancy, with anthelmintic drugs could offer a novel approach to the prevention of STH infections in pre-school children

The excitation spectrum for weakly interacting bosons in a trap

We investigate the low-energy excitation spectrum of a Bose gas confined in a trap, with weak long-range repulsive interactions. In particular, we prove that the spectrum can be described in terms of the eigenvalues of an effective one-particle operator, as predicted by the Bogoliubov approximation.Comment: LaTeX, 32 page