Spatial cross-correlation of Antarctic Sea ice and seabed topography

A time series of derived sea ice concentrations as observed about Antarctica by the Nimbus-7 Scanning Multichannel Microwave Radiometer (SMMR) satellite in 1983 is considered. The degree of spatial cross correlation between these data and seabed topography is quantified. The approach is to implement a statistical image processing filter designed to extract local patterns of spatial cross correlation over the entire sea ice field as it undergoes daily changes. Throughout the sea ice, it was found that large scale variations in sea ice concentration correlate systematically with variations in the topography of the seabed. Generally speaking, high concentrations of sea ice occur over deep ocean, whereas areas of encavement, early dissipation and polynya formation develop over topographic features of high elevation. The latter was studied in detail with respect to the features Maud Rise, Astrid Ridge and the continental shelf in the Cosmonaut and Ross Seas. In each case, it is shown that an encavement in sea ice, a polynya, or both develops in the vicinity of the feature in question. As these results are quantified in terms of spatial cross correlation, a potential role is inferred for seabed topography in such fluctuations in the sea ice about Antarctica

Critical role of canonical transient receptor potential channel 7 in initiation of seizures

Status epilepticus (SE) is a life-threatening disease that has been recognized since antiquity but still causes over 50,000 deaths annually in the United States. The prevailing view on the pathophysiology of SE is that it is sustained by a loss of normal inhibitory mechanisms of neuronal activity. However, the early process leading to the initiation of SE is not well understood. Here, we show that, as seen in electroencephalograms, SE induced by the muscarinic agonist pilocarpine in mice is preceded by a specific increase in the gamma wave, and genetic ablation of canonical transient receptor potential channel (TRPC) 7 significantly reduces this pilocarpine-induced increase of gamma wave activity, preventing the occurrence of SE. At the cellular level, TRPC7 plays a critical role in the generation of spontaneous epileptiform burst firing in cornu ammonis (CA) 3 pyramidal neurons in brain slices. At the synaptic level, TRPC7 plays a significant role in the long-term potentiation at the CA3 recurrent collateral synapses and Schaffer collateral-CA1 synapses, but not at the mossy fiber-CA3 synapses. Taken together, our data suggest that epileptiform burst firing generated in the CA3 region by activity-dependent enhancement of recurrent collateral synapses may be an early event in the initiation process of SE and that TRPC7 plays a critical role in this cellular event. Our findings reveal that TRPC7 is intimately involved in the initiation of seizures both in vitro and in vivo. To our knowledge, this contribution to initiation of seizures is the first identified functional role for the TRPC7 ion channel.Fil: Phelan, K. D.. University of Arkansas for Medical Sciences; Estados UnidosFil: Shwe, U. T.. University of Arkansas for Medical Sciences; Estados UnidosFil: Abramowitz, J.. National Institute of Environmental Health Sciences; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences; Estados UnidosFil: Zheng, F.. University of Arkansas for Medical Sciences; Estados Unido

Quantum oscillations and a non-trivial Berry phase in the noncentrosymmetric superconductor BiPd

We report the measurements of de Haas-van Alphen (dHvA) oscillations in the noncentrosymmetric superconductor BiPd. Several pieces of a complex multi-sheet Fermi surface are identified, including a small pocket (frequency 40 T) which is three dimensional and anisotropic. From the temperature dependence of the amplitude of the oscillations, the cyclotron effective mass is ($0.18$ $\pm$ 0.1) $m_e$. Further analysis showed a non-trivial $\pi$-Berry phase is associated with the 40 T pocket, which strongly supports the presence of topological states in bulk BiPd and may result in topological superconductivity due to the proximity coupling to other bands.Comment: 5 pages, 3 figure

“Being in a group with others who have mental illness makes all the difference”: The views and experiences of parents who attended a mental health parenting program

© 2017 Background The relationship between parental mental illness and poor outcomes in children is well established. While parents with mental illness could benefit from accessing parenting programs, this population tends to be reluctant to do so. To address this need, we developed an adaptation of the Triple P program specific to people with mental illness, and this paper presents the views and experiences of parents who attended this program. The program is a ten week intervention consisting of a six week group parenting program, followed by four weekly home visits. Methodology This client satisfaction evaluation consists of 18 telephone interviews with program participants as well as feedback from the Triple P Client Satisfaction Questionnaire (CSQ) (N = 116). While this evaluation sought to gain participant feedback on the entire program, the focus was on gaining insight into the usefulness of a modified program specifically for this population, and how the unique components of this modified Triple P program are perceived by the participants. Results Both the qualitative and quantitative findings indicate high satisfaction with the program, and highlight the value of a parenting program designed specifically for parents with mental illness. In particular, participants stressed that the design of the program was essential to their satisfaction and engagement with the program. Analysis of the interview data identified a number of reasons why participants engaged with this particular parenting program and found it very useful, in particular: being in a group with others with mental illness; focus on child development and parenting with a mental illness; and the home visits. Conclusion This study adds to the limited evidence base specific to parent programs for parents who experience mental illness, and highlights the importance participants attach to sharing the group experience with other parents who also experience mental illness, and the significance of this in facilitating engagement in parenting programs

Virus Sharing, Genetic Sequencing, and Global Health Security

The WHO’s Pandemic Influenza Preparedness (PIP) Framework was a milestone global agreement designed to promote the international sharing of biological samples to develop vaccines, while that ensuring poorer countries would have access to those vaccines. Since the PIP Framework was negotiated, scientists have developed the capacity to use genetic sequencing data (GSD) to develop synthetic viruses rapidly for product development of life-saving technologies in a time-sensitive global emergency—threatening to unravel the Framework. Access to GSD may also have major implications for biosecurity, biosafety, and intellectual property (IP). By rendering the physical transfer of viruses antiquated, GSD may also undermine the effectiveness of the PIP Framework itself, with disproportionate impacts on poorer countries. We examine the changes that need to be made to the PIP Framework to address the growing likelihood that GSD might be shared instead of physical virus samples. We also propose that the international community harness this opportunity to expand the scope of the PIP Framework beyond only influenza viruses with pandemic potential. In light of non-influenza pandemic threats such as the Middle East Respiratory Syndrome (MERS) and Ebola, we call for an international agreement on the sharing of the benefits of research – such as vaccines and treatments – for other infectious diseases to ensure not only a more secure and healthy world, but also a more just world, for humanity

Nano-magnetic droplets and implications to orbital ordering in La1-xSrxCoO3

Inelastic cold neutron scattering on LaCoO3 provided evidence for a distinct low energy excitation at 0.6 meV coincident with the thermally induced magnetic transition. Coexisting strong ferromagnetic (FM) and weaker antiferromagnetic (AFM) correlations that are dynamic follow the activation to the excited state, identified as the intermediate S=1 spin triplet. This is indicative of dynamical orbital ordering favoring the observed magnetic interactions. With hole doping as in La1-xSrxCoO3, the FM correlations between Co spins become static and isotropically distributed due to the formation of FM droplets. The correlation length and condensation temperature of these droplets increase rapidly with metallicity due to the double exchange mechanism.Comment: To appear in Phys. Rev. Let