Discovery of Radio Emission from the Tight M8 Binary: LP 349-25

We present radio observations of 8 ultracool dwarfs with a narrow spectral type range (M8-M9.5) using the Very Large Array at 8.5 GHz. Only the tight M8 binary LP 349-25 was detected. LP 349-25 is the tenth ultracool dwarf system detected in radio and its trigonometric parallax pi = 67.6 mas, recently measured by Gatewood et al., makes it the furthest ultracool system detected by the Very Large Array to date, and the most radio-luminous outside of obvious flaring activity or variability. With a separation of only 1.8 AU, masses of the components of LP 349-25 can be measured precisely without any theoretical assumptions (Forveille et al.), allowing us to clarify their fully-convective status and hence the kind of magnetic dynamo in these components which may play an important role to explain our detection of radio emission from these objects. This also makes LP 349-25 an excellent target for further studies with better constraints on the correlations between X-ray, radio emission and stellar parameters such as mass, age, temperature, and luminosity in ultracool dwarfs.Comment: accepted by ApJ, referee's comments included, typo in equation 1 correcte

SMA observations of the proto brown dwarf candidate SSTB213 J041757

Context. The previously identified source SSTB213 J041757 is a proto brown dwarf candidate in Taurus, which has two possible components A and B. It was found that component B is probably a class 0/I proto brown dwarf associated with an extended envelope. Aims. Studying molecular outflows from young brown dwarfs provides important insight into brown dwarf formation mechanisms, particularly brown dwarfs at the earliest stages such as class 0, I. We therefore conducted a search for molecular outflows from SSTB213 J041757. Methods. We observed SSTB213 J041757 with the Submillimeter Array to search for CO molecular outflow emission from the source. Results. Our CO maps do not show any outflow emission from the proto brown dwarf candidate. Conclusions. The non-detection implies that the molecular outflows from the source are weak; deeper observations are therefore needed to probe the outflows from the source.Comment: 7 pages, 4 figures, accepted for publication in A&

A Cultural Study on Linguistic Metaphors of Love in Poetry

Language is one of the cultural factors. Love, an abstract concept is mainly interpreted by metaphors which are considered as part of culture. It is consequently inevitable that the linguistic metaphors of love are under the influence of culture. In this research, we centre on investigating cultural factors in linguistic metaphors of romantic love in Vietnamese modern poetry, and then compare them to those in English. It is shown in our findings that linguistic metaphors of romantic love are considerably influenced by lifestyles, habits and customs and geographical conditions. Therefore, there are many variations in the ways of expressing romantic love between Vietnamese and English although the conceptualization is chiefly similar

Temperature Controlled Packaging Container for Biologics and Pharmaceuticals

Clinical Supplies Management, Inc. (CSM) provides clinical trial services to biotechnology and pharmaceutical companies by shipping pharmaceuticals to clinics and other patients. In winter 2014, CSM presented a temperature control packaging project to the Cal Poly Senior Project class. As a result, three Cal Poly Mechanical Engineering Students were tasked to design, manufacture, and qualify a shipping container that would maintain ten 10 mL vials between 2-8°C for 96 hours. The final product would have to cost less to ship than the Credo Cube, CSM’s current temperature control packaging product. After considerable research and analysis on possible temperature control technologies, it was determined that the most reliable and economical solution was similar technology to the Credo Cube. The main features of the product are as follows: Vacuum Insulated Paneling (VIP) is used as a thermal resistor to reduce the heat transfer from the surroundings to the payload Phase change material (PCM) maintains the desired payload temperature An optimization for the specified payload was performed by creating designs to reduce the tare weight, and dimensional weight using the above technologies. During the manufacturing phase, the selected vendor for phase change material was unwilling to accommodate a lead time within the senior project’s scope. This was believed to be partially due to the low volume and direct competition of the potential product. CSM was in contact with the vendor, and it was decided that the legal steps needed to move forward with the selected PCM would be too far outside of the project’s scope. Consequently, it was decided between the project team and CSM that using water as a prototype PCM was acceptable. Instead of a final product, a proof of concept prototype and a calculator that would help CSM redesign the product if other VIP or PCM were to be pursued in the future acted as the final deliverables. Although the prototype was not able to maintain temperature within range for 96 hours, the design can easily be scaled to do so with further testing and the use of the provided calculator. The following report details the design, manufacture, and qualification of the shipping container prototype

Discovery of the Youngest Molecular Outflow associated with an Intermediate-mass protostellar Core, MMS-6/OMC-3

We present sub-arcsecond resolution HCN (4-3) and CO (3-2) observations made with the Submillimeter Array (SMA), toward an extremely young intermediate-mass protostellar core, MMS 6-main, located in the Orion Molecular Cloud 3 region (OMC-3). We have successfully imaged a compact molecular outflow lobe (~1500 AU) associated with MMS6-main, which is also the smallest molecular outflow ever found in the intermediate-mass protostellar cores. The dynamical time scale of this outflow is estimated to be <100 yr. The line width dramatically increases downstream at the end of the molecular outflow ({\Delta}v~25 km s^{-1}), and clearly shows the bow-shock type velocity structure. The estimated outflow mass (~10^{-4} M_{sun}) and outflow size are approximately 2-4 orders and 1-3 orders of magnitude smaller, while the outflow force (~10^{-4} M_{sun} km s^{-1} yr^{-1}) is similar, as compared to the other molecular outflows studied in OMC-2/3. These results show that MMS 6-main is a protostellar core at the earliest evolutionary stage, most likely shortly after the 2nd core formation.Comment: Accepted to ApJ

HPLC and CMS Analysis of Clomipramine Metabolism: A Multi-Drug Study

Daily use of multiple medications is commonplace for many Americans. While pharmacists monitor prescriptions for drug interactions, consumers rarely check the possible side effects when using an over-the-counter product. In this fictional case study, Sam is prescribed clomipramine and ciprofloxacin, while also taking Tylenol PM. All three medications are orally administered, and drug metabolism is catalyzed in the liver by cytochrome P450 enzymes (CYP450). CYP isoenzymes CYP1A2, CYP3A4 and CYP2C19 are responsible for clomipramine metabolism and formation of major bioactive metabolite desmethylclomipramine, while CYP2D6 hydroxylates clomipramine and metabolite into hydroxyclomipramine and hydroxydesmethylclomipramine, respectively. Multi-drug use can inhibit or induce metabolic activity. The extent to which activity is affected is determined by dose and ligand-enzyme binding strength. Ciprofloxacin is a known CYP1A2 inhibitor, while diphenhydramine inhibits CYP2D6. Quantification and visualization of metabolites formed from clomipramine, ciprofloxacin, and diphenhydramine in rat liver microsomes was performed using compact mass spectrometry and high-performance liquid chromatography. Chromatograms were analyzed for molecular weights of parent clomipramine and metabolized products. Data indicated a reduction ranging from 21.1% to 30.1% inhibition of clomipramine metabolism into desmethylclomipramine. It was concluded that CYP isoenzymes CYP1A2, CYP3A4, and CYP2C19 played a role in diminishing clomipramine metabolite formation. These results illustrate the need for research and education when administering multiple drug

Phoebe Framework and Experimental Results for Estimating Fetal Age and Weight

Fetal age and weight estimation plays an important role in pregnant treatments. There are many estimation formulas created by the combination of statistics and obstetrics. However, such formulas give optimal estimation if and only if they are applied into specified community. This research proposes a so-called Phoebe framework that supports physicians and scientists to find out most accurate formulas with regard to the community where scientists do their research. The built-in algorithm of Phoebe framework uses statistical regression technique for fetal age and weight estimation based on fetal ultrasound measures such as bi-parietal diameter, head circumference, abdominal circumference, fetal length, arm volume, and thigh volume. This algorithm is based on heuristic assumptions, which aim to produce good estimation formulas as fast as possible. From experimental results, the framework produces optimal formulas with high adequacy and accuracy. Moreover, the framework gives facilities to physicians and scientists for exploiting useful statistical information under pregnant data. Phoebe framework is a computer software available at http://phoebe.locnguyen.net

Detection of lithium in nearby young late-M dwarfs

Late M-type dwarfs in the solar neighborhood include a mixture of very low-mass stars and brown dwarfs which is difficult to disentangle due to the lack of constraints on their age such as trigonometric parallax, lithium detection and space velocity. We search for young brown dwarf candidates among a sample of 28 nearby late-M dwarfs with spectral types between M5.0 and M9.0, and we also search for debris disks around three of them. Based on theoretical models, we used the color $I-J$, the $J$-band absolute magnitude and the detection of the Li I 6708 $\AA$ doublet line as a strong constraint to estimate masses and ages of our targets. For the search of debris disks, we observed three targets at submillimeter wavelength of 850 $\mu$m. We report here the first clear detections of lithium absorption in four targets and a marginal detection in one target. Our mass estimates indicate that two of them are young brown dwarfs, two are young brown dwarf candidates and one is a young very low-mass star. The closest young field brown dwarf in our sample at only $\sim$15 pc is an excellent benchmark for further studying physical properties of brown dwarfs in the range 100$-$150 Myr. We did not detect any debris disks around three late-M dwarfs, and we estimated upper limits to the dust mass of debris disks around them.Comment: 10 pages, 5 figures, accepted for publication in Astronomy and Astrophysic