36 research outputs found

    Liver Involvement Associated with Dengue Infection in Adults in Vietnam

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    Globally, the number of adults hospitalized with dengue has increased markedly in recent years. It has been suggested that hepatic dysfunction is more significant in this group than among children. We describe the spectrum and evolution of disease manifestations among 644 adults with dengue who were prospectively recruited on admission to a major infectious disease hospital in southern Vietnam and compare them with a group of patients with similar illnesses not caused by dengue. Transaminase levels increased in virtually all dengue patients and correlated with other markers of disease severity. However, peak enzyme values usually occurred later than other complications. Clinically severe liver involvement was infrequent and idiosyncratic, but usually resulted in severe bleeding. Chronic co-infection with hepatitis B was associated with modestly but significantly increased levels of alanine aminotransferase, but did not otherwise impact the clinical picture

    Pro-poor intervention strategies in irrigated agriculture in Asia: poverty in irrigated agriculture: issues and options: Vietnam

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    Irrigated farming / Poverty / Farm income / Irrigation management / Institutions / Legal aspects / Water rates / User charges / Participatory management / Privatization / Participatory rural appraisal / Performance indexes / Irrigation programs / Irrigation systems / Pumping / Irrigation canals / Social aspects / Economic aspects / Rivers / Hydrology / Dams / Households / Income / Regression analysis / Drainage / Cooperatives / Water delivery / Water distribution / Rice / Financing / Drought / Vietnam / Red River Delta / Nam Duong Irrigation System / Nam Thach Han Irrigation System / Han River

    Synthesis of new simplified hemiasterlin derivatives with α,β-unsaturated carbonyl moiety.

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    International audienceIn this Letter, we report a convenient and efficient method for the synthesis of new simplified derivatives of hemiasterlin in which the α,α-dimethylbenzylic moiety A is replaced by α,β-unsaturated aryl groups as Michael acceptor. Most of these derivatives have a strong cytotoxic activity on three human tumor cell lines (KB, Hep-G2 and MCF7). Analogs 17b and 17f showed a high cytotoxicity against KB and Hep-G2 cancer cell lines comparable to paclitaxel and ellipticine

    Synthesis of new bioisosteric hemiasterlin analogues with extremely high cytotoxicity

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    International audienceIn this article, we report a convenient and efficient method for the synthesis of new simplified derivativesof hemiasterlin in which the α,α-dimethylbenzylic moiety A is replaced by α,β-unsaturated aryl groupsas Michael acceptor. Most of these derivatives have a strong cytotoxic activity on three human tumorcell lines (KB, Hep-G2 and MCF7). Analogs 17b and 17f showed a high cytotoxicity against KB andHep-G2 cancer cell lines comparable to paclitaxel and ellipticine

    Unexpected cases in field diagnosis of African swine fever virus in Vietnam: The needs consideration when performing molecular diagnostic tests

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    Background: The first confirmed case of African swine fever (ASF) in Vietnam was reported officially in February 2019. To date, ASF virus (ASFV) have been detected in 63/63 provinces in Vietnam. Currently, real-time polymerase chain reaction (PCR) is considered to be a powerful tool for viral detection in field samples, including ASFV. However, some recent reports have suggested that mismatches in primer and probe binding regions may directly affect real-time PCR qualification, leading a false-negative result.Aim: This study aims to further examine a conflicting result obtained from two OIE recommended methods, conventional PCR and real-time PCR, for ASFV detection.Methods: Two ASF suspected pigs from different provinces in the north of Vietnam were selected for this study based on clinical signs and postmortem lesions. The different results obtained by OIE-recommended conventional PCR and real-time PCR were further analyzed by the Sanger sequencing method and virus isolation in combination with hemadsorption (HAD) test using porcine alveolar macrophages cells.Results: The results showed that when the primer sequence matched perfectly with the sequences of field isolates, a mutation in probe binding region was found, indicating that a single mismatch in the probe binding site may cause a false-negative result by real-time PCR in detecting ASFV in clinical samples in Vietnam. An agreement between conventional PCR, using PPA1/PPA2 primers and two golden standard methods, virus isolation in combination with HAD assay, and sequencing method was observed in this study.Conclusion: A single mismatch in the probe binding site caused a failse-negative result by realtime PCR method in field diagnosis of ASFV. The needs consideration when selecting the appropriate molecular diagnostic methods is based on the current databases of ASFV sequences,  particularly for epidemiological surveillance of ASF. Keywords: African swine fever, PCR, Pigs, Real-time PCR, Vietna

    CSA: Thực hành nông nghiệp thông minh với khí hậu ở Việt Nam

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    During the last five years, Vietnam has been one of the countries most affected by climate change. Severe typhoons, flooding, cold spells, salinity intrusion, and drought have affected agriculture production across the country, from upland to lowland regions. Fortunately for Vietnam, continuous work in developing climate-smart agriculture has been occurring in research organizations and among innovative farmers and entrepreneurs. Application of various CSA practices and technologies to adapt to the impact of climate change in agriculture production have been expanding. However, there is a need to accelerate the scaling process of these practices and technologies in order to ensure growth of agriculture production and food security, increase income of farmers, make farming climate resilient, and contribute to global climate change mitigation. This book aims to provide basic information to researchers, managers, and technicians and extentionists at different levels on what CSA practices and technologies can be up scaled in different locations in Vietnam

    Impact of trade liberalization on industrial pollution : empirical evidence from Vietnam

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    This study assesses the impact of trade liberalization on the environment in Vietnam. In particular it looks at the link between the amount of pollution produced by the country’s manufacturing industries and the degree to which this is affected by trade liberalization policies. The study was carried out by Pham Thai Hung, Bui Anh Tuan and Nguyen The Chinh, from Vietnam’s National Economics University. It finds that trade liberalization in the country exacerbates industrial pollution at both the firm and industry level. This trade-off is worrying as Vietnam has recently become a WTO member and further trade liberalization commitments are now in the pipeline. In light of their findings, the researchers recommend that the environmental impact of any future trade reforms should be carefully considered and that steps should be taken to mitigate any potential negative effects such reforms might have. They suggest that polluting industries should be given priority in any clean-up programme. They highlight key steps which can be taken to help reduce pollution, including the strict enforcement of environmental regulations support to promoting information technology application and technology advancement in the manufacturing sector

    Spatial distribution of elemental concentrations in street dust of Hanoi, Vietnam

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    Street dust samples were collected at 163 locations across four different zones of Hanoi, Vietnam, covering different traffic and population densities. Samples were sieved into three fractions of different particle sizes and analyzed for elemental concentrations (K, Ca, Mn, Fe, Zn, Pb) using an X-ray fluorescence (XRF) instrument. The metal concentrations in street dust were compared among different sampling zones and with samples from background to evaluate the degree of pollution. The smallest size particle fraction (diameter 180 μm). While concentrations of metals like Ca and Fe are spatially similar, concentrations of Pb and Zn in street dust varied between different zones, with the highest concentrations observed in dust from the downtown area, and lowest levels in the new suburb areas. Overall, compared to studies from cities in other countries, the mean concentration of Pb in street dust in Hanoi was relatively low, suggesting a lower risk to human health due to inhalation or ingestion of Pb-containing dust particles than in cities where Pb concentrations were several times higher
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