7 research outputs found
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
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- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
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- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
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- Ammar Ahmed Siddique
- Amro Dana
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- Yaghmour Jamal
- Yahya Bilal Shuaibu
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- Yazgan Yasemin
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- Yeung Kar Long
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- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
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- Young Stevie
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- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials
- Author
- Acerboni-Flores Francesc
- Achor Timothy S.
- Adams John D.
- Al-Asiri Jamal
- Alavedra-Massana Anna
- Altman Kyle M.
- Anglada-Torres Neus
- Apostle Kelly L.
- Baele Joseph R.
- Bailey Daniel
- Bartel Claire
- Beckish Michael L.
- Bedard Julia C.
- Belaye Tigist
- Berenguer Alexandre
- Berhaneselase Eleni
- Bhandari Mohit
- Bhandari Mohit
- Blasman Jenna
- Bosse Michael
- Boulton Christina
- Boulton Christina
- Boyce Robert
- Boyer Dory S.
- Bray Christopher C.
- Breslin Mary A.
- Brown Timothy R.
- Brownrigg Maggie
- Bueno-Ruiz Mercedes
- Burnikel Alex
- Camara Megan
- Caparros-García Ariadna
- Carballo Alejandro
- Carlisle Robert M.
- Choo Andrew M.
- Churchill Christine
- Clark Linda
- Cole Austin A.
- Colello Michael
- Cross Andrew W.
- Cruz Alejandro
- Culbert Hunter
- Cámara-Cabrera Jaume
- Davies Jonah
- Degani Yasmin
- Dehghan Niloofar
- Del Fabbro Gina
- Della Rocca Gregory J.
- Demyanovich Haley
- Demyanovich Haley K.
- Denkers Matthew
- Devereaux P. J.
- Dew Timothy
- Ding Anthony
- Dodds Shannon
- Dodds Shannon
- Domènech Mònica Salomó
- Donohue Erin
- Dykes Tayler
- D’Alleyrand Jean-Claude
- Eglseder Andrew
- Fan Chen “Brenda”
- Faucher Gregory K.
- Fillat-Gomà Ferran
- Fowler Justin
- Fraifogl Joanne
- Friedrich Jeff
- Fuentes-López Ruben
- Gajari Vamshi
- Gallant Jodi
- Garcia-Rodriguez Ramona
- García Yaiza
- Gardner Michael J.
- Garg Kartik
- Garibaldi Alisha
- Garitty Michael J.
- Gary Joshua L.
- Gaski Greg
- Gaski Greg E.
- George Annie
- Gimeno-Calavia Nuria
- Girardi Cara
- Gitajn I. Leah
- Gjorgjievski Marko
- Graells-Alonso Guillem
- Grissom Frances
- Guerra-Farfán Ernesto
- Guerra-Farfán Ernesto
- Gurich Richard W.
- Guyatt Gordon H.
- Hagen Jennifer E.
- Hale Diamond
- Halliday Paul G.
- Harris Anthony D.
- Harris Anthony D.
- Hebden Joan
- Hebden Joan
- Heels-Ansdell Diane
- Hill Lauren C.
- Hofer Erin Adams
- Holzman Michael A.
- Horne Brandon
- Howe Andrea
- Hsu Joseph
- Hudgins Andrea
- Huggins Brandon S.
- Hunter Michael D.
- Hurkett Colin
- Hymes Robert A.
- Jahangir Amir Alex
- Jeray Kyle J.
- Jerele Jennifer
- Johal Herman
- Johnson Aaron
- Jones Clifford B.
- Jornet-Gibert Montsant
- Joseph Katherine
- Joshi Manjari G.
- Kandemir Utku
- Karim Ammar
- Karunakar Madhav
- Kempton Laurence
- Kettering Eric
- Kimmel Joseph
- Knapp Thomas
- Koenig Chris
- Krupko Thomas
- Langhammer Christopher
- Lazarus David E.
- Lebrun Christopher
- Lemke H. Michael
- Leonard Jordan
- Li Silvia
- Liang Stephen
- Little Kelly
- Loeffler Markus F.
- Lowe Jason
- Lowney Maya
- Malekzadeh A. Stephen
- Maltz Ethan J.
- Manson Theodore
- Marcano-Fernández Francesc
- Marcano-Fernández Francesc
- Marcano-Fernández Francesc A.
- Marchand Lucas
- Marmor Meir
- Marshall William A.
- Martin Abigail
- Martinez Eric
- Martí-Garín David
- Martínez-Carreres Laia
- Martínez-Grau Patricia
- Martínez-Álvarez Marta
- Marvel Debra
- Matityahu Amir
- Mayberry Robert Miles
- Mayfield Ada
- McClellan R. Trigg
- McKay Paula
- McKay Paula
- McKee Michael
- McKinley Todd O.
- Medeiros Michelle
- Mehta Samir
- Meinberg Eric
- Miclau Theodore
- Miller Adam
- Millon S. John
- Mitchell Phillip
- Moody M. Christian
- Moola Farhad O.
- Morshed Saam
- Mossuto Franca
- Mullins C. Daniel
- Mullins Daniel C.
- Mullis Brian H.
- Munz John W.
- Nascone Jason
- Natoli Roman M.
- Nguyen Uyen
- Obremskey William T.
- on behalf of the PREP-IT Investigators
- Osborn Patrick
- O’Hara Lyndsay M.
- O’Hara Lyndsay M.
- O’Hara Nathan N.
- O’Toole Robert V.
- Palmer Jana
- Palmer M. Jason
- Parker Wesley
- Paryavi Ebrahim
- Patrick Matthew
- Paul Alexandra
- Payne Kyrsten
- Pechero Guillermo
- Pelfort Xavier
- Pellejero-García Raúl
- Pensy Raymond
- Perey Bertrand H.
- Persico Federico
- Petrisor Brad A.
- Petrisor Bradley A.
- Peñalver Juan Manuel
- Pham Kayla H.
- Phelps Kevin
- Pichiotino Erin R.
- Pierrie Sarah
- Pogorzelski David
- Pogorzelski David
- Pollak Andrew
- Poole Andrew S.
- Porter Scott E.
- Prayson Michael
- Pritchett Charles
- Rajaratnam Krishan
- Ramsey Lolita
- Ramsey T. Bennett
- Rao Mayank
- Ray Shea Bielby
- Ristevski Bill
- Rivera Jessica
- Robertson Emily
- Rodriguez Andres
- Rodriguez Elsa
- Rojas Alejandra
- Romeo Nicholas M.
- Routt Milton L. “ Chip”
- Rudisill L. Edwin
- Rudnicki Joshua
- Ruth John T.
- Ràfols-Perramon Ona
- Sadasivan Kalia
- Saeed Sabina
- Sanders John L.
- Sanz-Molero Matsuyama
- Schaller Thomas M.
- Schulman Jeff E.
- Schwartz Justin
- Schwartzbach Cary C.
- Sciadini Marcus
- Scott Taryn
- Scott Taryn
- Seach Andrea
- Serrano-Sanz Jorge
- Sethi Manish
- Seymour Rachel
- Shearer David
- Sietsema Debra L.
- Sims Michael L.
- Sims Stephen
- Slobogean Gerard P.
- Slobogean Gerard P.
- Smith Cory D.
- Snider Rebecca G.
- Soler-Cano Albert
- Sorkin Anthony T.
- Spicer Ella
- Sprague Sheila
- Sprague Sheila
- Sridhar Michael S.
- Stewart Russell
- Stinner Daniel J.
- Stone Trevor B.
- Szasz Olivia Paige
- Szatkowski Jan P.
- Sánchez-Fernández Joel
- Sánchez-Palomino Estrella
- Talbot Max
- Talerico Michael
- Taljaard Monica
- Tanner Stephanie L.
- Taylor Michel
- Thabane Lehana
- Thabane Lehana
- Toogood Paul
- Townsend Christine E.
- Trochez Karen
- Vallier Heather A.
- Van Chi
- Velasco-Barrera Aldo
- Venkatarayappa Indresh
- Virkus Walter W.
- Viskontas Darius G.
- Vlasak Richard
- Wadenpfuhl Leanne K.
- Walker Clark M.
- Warner Stephen J.
- Watson J. Tracy
- Wells Jeffrey
- Wentworth Daniel
- Wild Jason
- Williams Alyse
- Williams Dale
- Wilson Eleanor S.
- Wise Jeremy
- Wood Amber
- Wood Amber
- Yela-Verdú Christian
- Zomar Mauri
- Zura Robert
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 30/09/2020
- Field of study
An amendment to this paper has been published and can be accessed via the original article
Patient and stakeholder engagement learnings: PREP-IT as a case study
- Author
- Acerboni-Flores Francesc
- Achor Timothy
- Adams John D.
- Ahn Jaimo
- Ahn James S.
- Alavedra-Massana Anna
- Allen Elizabeth M.
- Altman Kyle M.
- Anglada-Torres Neus
- Apostle Kelly L.
- Babcock Sharon
- Baele Joseph R.
- Bailey Daniel
- Bansal Mira
- Bartel Claire
- Beckish Michael
- Bedard Julia C.
- Beer Robert
- Belaye Tigist
- Berenguer Alexandre
- Bergin Patrick F.
- Berhaneselase Eleni
- Bhanat Eldrin L.
- Bhandari Mohit
- Blasman Jenna
- Bosse Michael
- Boulton Christina
- Boyce Robert
- Boyer Dory S.
- Bray Christopher
- Breslin Mary A.
- Brown Timothy R.
- Brownrigg Maggie
- Bueno-Ruiz Mercedes
- Bullard Debra
- Burnikel Alex
- Camara Megan
- Caparros-García Ariadna
- Carballo Alejandro
- Carlisle II Robert M.
- Carroll Eben A.
- Champion Heather K.
- Choo Andrew M.
- Churchill Christine
- Clark Linda
- Coe Marcus
- Cole Austin A.
- Colello Michael
- Cross Andrew W.
- Crus Alejandro
- Cuff Jaslynn A.N.
- Culbert Hunter
- Cámara-Cabrera Jaume
- D'alleyrand Jean-Claude
- Das Sharmistha
- Davies Jonah
- Degani Yasmin
- Dehghan Niloofar
- Del Fabbro Gina
- Della Rocca Gregory J.
- Demyanovich Haley
- DePalo Peter
- Devereaux Pj
- Dew Timothy
- Ding Anthony
- Dodds Shannon
- Donegan Derek
- Donohue Erin
- Dooley Mary
- Dwyer Kevin
- Dykes Tayler
- Eglseder Andrew
- English Antoinisha D.
- Esposito John
- Fan Chen "Brenda"
- Faucher Gregory
- Fillat-Gomà Ferran
- Fowler Justin
- Fowler Justin
- Fraifogl Joanne
- Friedrich Jeff
- Fuentes-López Ruben
- Gage Mark J.
- Gajari Vamshi
- Garcia-Rodriguez Ramona
- García Yaiza
- Gardner Michael J.
- Garg Kartik
- Garibaldi Alisha
- Garitty Michael J.
- Gary Joshua L.
- Gaski Greg E.
- Gimeno-Clavia Nuria
- Girardi Cara
- Gitajn Leah
- Goodman J. Brett
- Graells-Alonso Guillem
- Graves Matthew L.
- Grissom Frances
- Guerra-Farfán Ernesto
- Gurich Jr Richard W.
- Guyatt Gordon H.
- Haaser Sharon M.
- Hagen Jennifer E.
- Hale Diamond
- Hall Amy E.
- Haller Justin M.
- Halliday Paul G.
- Halvorson Jason J.
- Harris Anthony
- Harris Mitchel B.
- Hebden Joan
- Heels-Ansdell Dianne
- Heng Marilyn
- Higgins Thomas F.
- Hill Lauren C.
- Hofer Erin Adams
- Holden Martha B.
- Hollinsworth Troy
- Holzman Michael A.
- Horan Annamarie
- Horne Brandon
- Howe Andrea
- Hsu Joseph
- Hudgins Andrea
- Huggins Brandon S.
- Hunter Michael D.
- Hurkett Colin
- Hymes Robert A.
- Iwu Ashley
- Jaeblon Todd
- Jahangir Amir Alex
- Jeray Kyle J.
- Jerele Jennifer
- Johnson Aaron
- Johnson Leslie N.
- Jones Clifford B.
- Jornet-Gibert Montsant
- Joseph Katherine
- Joshi Manjari G.
- Kandemir Utku
- Karim Ammar
- Karunakar Madhav
- Kempton Laurence
- Kettering Eric
- Kimmel Joseph
- Knapp Thomas
- Koenig Chris
- Krupko Thomas
- Kuczinski Ashley
- Langhammer Christopher
- Lazarus David E.
- Lebrun Christopher
- Lemke H. Michael
- Lhowe David W.
- Li Silvia
- Liang Stephen
- Little Kelly
- Loeffler Markus F.
- Love T Rosie
- Lowe Jason
- Lowney Maya
- Mahal Nirmen
- Malekzadeh A. Stephen
- Maltz Ethan J.
- Manson Theodore
- Marcano-Fernández Francesc
- Marchand Lucas
- Marmor Meir
- Marshall William A.
- Martin Abigail
- Martinez Eric
- Martí-Garín David
- Martínez-Carreres Laia
- Martínez-Grau Patricia
- Martínez-álvarez Marta
- Marvel Debra
- Matityahu Amir
- Mayberry Robert Miles
- Mayfield Ada
- McClellan R. Trigg
- McGee Skeketha L.
- McKay Paula
- McKee Michael
- McKinley Todd O.
- McTague Michael F.
- Medeiros Michelle
- Medeiros Michellic
- Mehta Samir
- Meinberg Eric
- Miclau Theodore
- Miller Adam
- Millon S. John
- Mitchell Phillip
- Moody M. Christian
- Moola Farhad O.
- Morellato John
- Morshed Saam
- Mossuto Franca
- Mullin Devin S.
- Mullins C. Daniel
- Mullins Daniel C.
- Mullis Brian H.
- Munz John W.
- Nascone Jason
- Natoli Roman M.
- Neese Ashley
- Nguyen Uyen
- O'Hara Lyndsay M.
- O'Hara Nathan
- O'Hara Nathan N.
- O'Toole Robert
- Obremskey William T.
- Osborn Patrick
- Palmer Jana
- Palmer M. Jason
- Paniagua Ariana
- Panjshiri Farhanaz
- Parker Wesley
- Paryavi Ebrahim
- Patrick Matthew
- Paul Alexandra
- Payne Kyrsten
- Pechero Guillermo
- Pelfort Xavier
- Pellejero-García Raúl
- Pensy Raymond
- Perey Bertrand H.
- Perfetto Eleanor M.
- Petrisor Bradley A.
- Peñalver Juan Manuel
- Pfaff Branden
- Pham Kayla H.
- Phelps Kevin
- Pichiotino Erin R.
- Pierrie Sarah
- Pilson Holly
- Pogorzelski David
- Polk Genevieve
- Pollack Andrew
- Poole Andrew S.
- Porter Scott E.
- Potter David
- Prayson Michael
- Pritchett Chris
- Ramsey Lolita
- Ramsey T. Bennett
- Rao Mayank
- Ray Shea Bielby
- Reilly Rachel M.
- Reily Clifford A
- Rivera Jessica
- Robertson Emily
- Rodriguez Andres
- Rodriguez Elsa
- Rojas Alejandra
- Romeo Nicholas M.
- Rothberg David L.
- Routt Milton L. "Chip"
- Rudisill Jr L. Edwin
- Rudnicki Joshua
- Russell George V.
- Russell Mark
- Ruth John T.
- Ràfols-Perramon Ona
- Sadasivan Kalia
- Saeed Sabina
- Salomò Domènech Mònica
- Sanders John L.
- Sanz-Molero Matsuyama
- Schaller Thomas M.
- Schulman Jeff E.
- Schwartz Justin
- Schwartzbach Cary C.
- Sciadini Marcus
- Scott Taryn
- Seach Andrea
- Serrano-Sanz Jorge
- Sethi Manish
- Seymour Rachel
- Shearer David
- Sietsema Debra L.
- Sims Michael L.
- Sims Stephen
- Slobogean Gerard P.
- Slobogean Gerard P.
- Smith Cory D.
- Smith R. Malcolm
- Snider Rebecca G.
- Soler-Cano Albert
- Sorkin Anthony T.
- Sparrow Cindy
- Spicer Ella
- Sprague Sheila
- Sprague Sheila
- Sridhar Michael S.
- Stewart Russell
- Stinner Daniel J.
- Stone Trevor B.
- Szasz Olivia Page
- Szatkowski Jan P.
- Sánchez-Fernández Joel
- Sánchez-Palomino Estrella
- Talbot Max
- Talerico Michael
- Taljaard Monica
- Tanner Stephanie L.
- Taylor Michel
- Thabane Lehana
- Toogood Paul
- Townsend Christine E.
- Trochez Karen
- Vallier Heather A.
- Van Chi
- VanDemark II Robert
- Velasco-Barrera Aldo
- Venkatarayappa Indresh
- Virkus Walter W.
- Viskontas Darius G.
- Vlasak Richard
- von Keudel Arvind G.
- Wadenpfuhl Leanne K
- Walker Clark M.
- Warner Stephen J.
- Watson J. Tracy
- Weaver Michael J.
- Wells Jeffrey
- Wentworth Daniel
- Wild Jason
- William Alyse
- Williams Wendy
- Wilson Eleanor S.
- Wise Jeremy
- Wood Amber
- Yela-Verdú Christian
- Zomar Mauri
- Zura Robert
- Publication venue
- 'Future Medicine Ltd'
- Publication date
- 01/04/2021
- Field of study
Assessing unfiltered beer-based marinades effects on ether and ester linked phosphatidylcholines and phosphatidylethanolamines in grilled beef and moose meat
- Author
- Assmann
- Biffin
- Blank
- Boselli
- Callemien
- Charles F. Manful
- Chrysochou
- Dvořáková
- Eroğlu
- Evan Wheeler
- Fogerty
- Fogerty
- Folch
- Gao
- Gundermann
- Ham
- Jeong
- Kayla J.T. Warren
- Keller
- Keller
- Kuda
- Law
- Manful
- Miller
- Muhammad Nadeem
- Natalia P. Vidal
- Neuman
- Papaioannou
- Pham
- Raymond H. Thomas
- Scott
- Shahidi
- Stadelmann-Ingrand
- Sun
- Tanamati
- Thu H. Pham
- Toldrá
- Valencak
- van der Veen
- Vidal
- Vidal
- Viegas
- Viegas
- Wang
- Xie
- Xiong
- Yalagala
- Yanishlieva
- Yashin
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials
- Author
- A. Stephen Malekzadeh
- Aaron Johnson
- Abigail Martin
- Ada Mayfield
- Adam Miller
- Albert Soler-Cano
- Aldo Velasco-Barrera
- Alejandra Rojas
- Alejandro Carballo
- Alejandro Cruz
- Alex Burnikel
- Alexandra Paul
- Alexandre Berenguer
- Alisha Garibaldi
- Alyse Williams
- Amber Wood
- Amir Alex Jahangir
- Amir Matityahu
- Ammar Karim
- Amy E. Hall
- Andrea Howe
- Andrea Howe
- Andrea Howe
- Andrea Hudgins
- Andrea Seach
- Andres Rodriguez
- Andrew Eglseder
- Andrew M. Choo
- Andrew Pollak
- Andrew S. Poole
- Andrew W. Cross
- Anna Alavedra-Massana
- Annamarie Horan
- Annie George
- Anthony D. Harris
- Anthony D. Harris
- Anthony D. Harris
- Anthony Ding
- Anthony T. Sorkin
- Antoinisha D. English
- Ariadna Caparros-García
- Arvind G. von Keudell
- Ashley Iwu
- Ashley Kuczinski
- Ashley Neese
- Austin A. Cole
- Bertrand H. Perey
- Bill Ristevski
- Brad A. Petrisor
- Bradley A. Petrisor
- Branden Pfaff
- Branden Pfaff
- Brandon Horne
- Brandon S. Huggins
- Brian H. Mullis
- C. Daniel Mullins
- Cara Girardi
- Cary C. Schwartzbach
- Charles Pritchett
- Chen “Brenda” Fan
- Chi Van
- Chris Koenig
- Christian Yela-Verdú
- Christina Boulton
- Christine Churchill
- Christine E. Townsend
- Christopher C. Bray
- Christopher Langhammer
- Christopher Lebrun
- Cindy Sparrow
- Claire Bartel
- Clark M. Walker
- Clifford A. Reilly
- Clifford B. Jones
- Colin Hurkett
- Cory D. Smith
- Dale Williams
- Daniel Bailey
- Daniel C. Mullins
- Daniel C. Mullins
- Daniel J. Stinner
- Daniel Wentworth
- Darius G. Viskontas
- David E. Lazarus
- David L. Rothberg
- David Martí-Garín
- David Pogorzelski
- David Pogorzelski
- David Potter
- David Shearer
- David W. Lhowe
- Debra Bullard
- Debra L. Sietsema
- Debra L. Sietsema
- Debra Marvel
- Derek Donegan
- Devin S. Mullin
- Diamond Hale
- Diane Heels-Ansdell
- Diane Heels-Ansdell
- Dory S. Boyer
- Eben A. Carroll
- Ebrahim Paryavi
- Eladia Tauste-Rubio
- Eldrin L. Bhanat
- Eleanor S. Wilson
- Eleni Berhaneselase
- Elizabeth M. Allen
- Ella Spicer
- Ella Spicer
- Elsa Rodriguez
- Emily Robertson
- Eric Kettering
- Eric Martinez
- Eric Meinberg
- Erin Adams Hofer
- Erin Donohoe
- Erin R. Pichiotino
- Ernesto Guerra-Farfan
- Estrella Sánchez-Palomino
- Ethan J. Maltz
- Farhad O. Moola
- Farhanaz Panjshiri
- Federico Persico
- Ferran Fillat-Gomà
- Franca Mossuto
- Francesc A. Marcano-Fernández
- Francesc Acerboni-Flores
- Francesc Marcano-Fernández
- George V. Russell
- Gerard P. Slobogean
- Gerard P. Slobogean
- Gerard P. Slobogean
- Gerard P. Slobogean
- Gerard P. Slobogean
- Gina Del Fabbro
- Gordon H. Guyatt
- Greg E. Gaski
- Gregory J. Della Rocca
- Gregory J. Della Rocca
- Gregory K. Faucher
- Guillem Graells-Alonso
- Guillermo Pechero
- Guillermo Pechero Jr., MD
- H. Michael Lemke
- Haley Demyanovich
- Haley K. Demyanovich
- Haley K. Demyanovich
- Haley K. Demyanovich
- Heather A. Vallier
- Heather K. Champion
- Herman Johal
- Holly Pilson
- Hunter Culbert
- I. Leah Gitajn
- I. Leah Gitajn
- Indresh Venkatarayappa
- J. Brett Goodman
- J. Tracy Watson
- Jaimo Ahn
- Jamal Al-Asiri
- James S. Ahn
- Jan P. Szatkowski
- Jana Palmer
- Jaslynn A.N. Cuff
- Jason J. Halvorson
- Jason Lowe
- Jason Nascone
- Jason Wild
- Jaume Cámara-Cabrera
- Jean-Claude D'Alleyrand
- Jean-Claude D'Alleyrand
- Jean-Claude D'Alleyrand
- Jeff E. Schulman
- Jeff Friedrich
- Jeff Wells
- Jeffrey Wells
- Jeffrey Wells
- Jeffrey Wells
- Jenna Blasman
- Jennifer E. Hagen
- Jennifer Jerele
- Jeremy Wise
- Jessica Rivera
- Joan Hebden
- Joan Minguell-Monyart
- Joanne Fraifogl
- Jodi Gallant
- Joel Sánchez-Fernández
- John D. Adams
- John G. Esposito
- John L. Sanders
- John Morellato
- John T. Ruth
- John W. Munz
- Jonah Davies
- Jordan Leonard
- Jordi Selga-Marsa
- Jordi Teixidor-Serra
- Jordi Tomas-Hernandez
- Jorge Nuñez-Camarena
- Jorge Serrano-Sanz
- Jose Vicente Andres-Peiro
- Joseph Hsu
- Joseph Kimmel
- Joseph R. Baele
- Joshua L. Gary
- Joshua Rudnicki
- Joshua Rudnicki
- Joshua Rudnicki
- Jothi Murali
- Juan Antonio Porcel-Vasquez
- Juan Manuel Peñalver
- Julia C. Bedard
- Justin Fowler
- Justin Fowler
- Justin M. Haller
- Justin Schwartz
- Kalia Sadasivan
- Karen Trochez
- Kartik Garg
- Katherine Joseph
- Kayla H. Pham
- Kelly L. Apostle
- Kelly Little
- Kevin Dwyer
- Kevin Phelps
- Krishan Rajaratnam
- Kyle J. Jeray
- Kyle J. Jeray
- Kyle J. Jeray
- Kyle M. Altman
- Kyrsten Payne
- L. Edwin Rudisill Jr.
- Laia Martínez-Carreres
- Lauren C. Hill
- Laurence Kempton
- Leanne K. Wadenpfuhl
- Lehana Thabane
- Lehana Thabane
- Leslie N. Johnson
- Linda Clark
- Lolita Ramsey
- Lolita Ramsey
- Lucas Marchand
- Lucas S. Marchand
- Lyndsay M. O'Hara
- M. Christian Moody
- M. Jason Palmer
- Madhav Karunakar
- Maggie Brownrigg
- Manish Sethi
- Manjari G. Joshi
- Marcus Coe
- Marcus Sciadini
- Marilyn Heng
- Mark J. Gage
- Mark Russell
- Marko Gjorgjievski
- Markus F. Loeffler
- Marta Gonzalez-Amigo
- Marta Martínez-Álvarez
- Martha B. Holden
- Martha Holden
- Mary A. Breslin
- Mary Dooley
- Matsuyama Sanz-Molero
- Matthew Denkers
- Matthew L. Graves
- Matthew Patrick
- Mauri Zomar
- Max Talbot
- Maya Lowney
- Mayank Rao
- Mayank Rao
- Megan Camara
- Megan Camara
- Meir Marmor
- Mercedes Bueno-Ruiz
- Michael A. Holzman
- Michael Bosse
- Michael Colello
- Michael D. Hunter
- Michael F. McTague
- Michael F. McTague
- Michael J. Gardner
- Michael J. Garitty
- Michael J. Weaver
- Michael L. Beckish
- Michael L. Sims
- Michael McKee
- Michael Prayson
- Michael S. Sridhar
- Michael Talerico
- Michel Taylor
- Michelle Medeiros
- Michelle Medeiros
- Milton L. “Chip” Routt
- Mira Bansal
- Mitchel B. Harris
- Mohit Bhandari
- Mohit Bhandari
- Mohit Bhandari
- Monica Taljaard
- Montsant Jornet-Gibert
- Ms Frances Grissom
- Mònica Salomó Domènech
- Nathan N. O'Hara
- Nathan N. O'Hara
- Nathan N. O'Hara
- Neus Anglada-Torres
- Nicholas M. Romeo
- Niloofar Dehghan
- Nuria Gimeno-Calavia
- Olivia Paige Szasz
- Ona Ràfols-Perramon
- P.J. Devereaux
- Patricia Martínez-Grau
- Patrick F. Bergin
- Patrick Osborn
- Paul G. Halliday
- Paul Toogood
- Paula McKay
- Paula McKay
- Peter DePalo
- Phillip Mitchell
- R. Malcolm Smith
- R. Trigg McClellan
- Rachel M. Reilly
- Rachel Seymour
- Ramona Garcia-Rodriguez
- Raymond Pensy
- Raúl Pellejero-García
- Rebecca G. Snider
- Richard Vlasak
- Richard W. Gurich Jr.
- Robert A. Hymes
- Robert Beer
- Robert Boyce
- Robert M. Carlisle II
- Robert Miles Mayberry
- Robert V. O'Toole
- Robert V. O'Toole
- Robert VanDemark III
- Robert Zura
- Roman M. Natoli
- Ruben Fuentes-López
- Russell Stewart
- S. John Millon
- Saam Morshed
- Saam Morshed
- Sabina Saeed
- Samir Mehta
- Sarah Pierrie
- Scott E. Porter
- Shannon Dodds
- Sharmistha Das
- Sharon Babcock
- Sharon M. Haaser
- Shea Bielby Ray
- Sheila Sprague
- Sheila Sprague
- Sheila Sprague
- Sheila Sprague
- Sheketha L. McGee
- Silvia Li
- Stephanie L. Tanner
- Stephen J. Warner
- Stephen Liang
- Stephen Sims
- T. Bennett Ramsey
- Taryn Scott
- Tayler Dykes
- Theodore Manson
- Theodore Miclau
- Thomas F. Higgins
- Thomas Knapp
- Thomas Krupko
- Thomas M. Schaller
- Tigist Belaye
- Timothy Dew
- Timothy R. Brown
- Timothy S. Achor
- Todd Jaeblon
- Todd O. McKinley
- Trevor B. Stone
- Troy Hollinsworth
- Utku Kandemir
- Uyen Nguyen
- Vamshi Gajari
- Vicente Molero-Garcia
- Walter W. Virkus
- Wendy Williams
- Wesley Parker
- William A. Marshall
- William T. Obremskey
- Xavier Pelfort
- Yaiza Garcia-Sanchez
- Yasmin Degani
- Zachary M. Olsen
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2021
- Field of study
Introduction: Cluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional model of obtaining informed consent from participant's before initiating any trial related activities may not be suitable. We describe our experience of engaging patient advisors to identify an optimal model of consent for the PREP-IT trials. This paper also examines surrogate measures of success for the selected model of consent. Methods: The PREP-IT program consists of two multi-center cluster randomized crossover trials that engaged patient advisors to determine an optimal model of consent. Patient advisors and stakeholders met regularly and reached consensus on decisions related to the trial design including the model for consent. Patient advisors provided valuable insight on how key decisions on trial design and conduct would be received by participants and the impact these decisions will have. Results: Patient advisors, together with stakeholders, reviewed the pros and cons and the requirements for the traditional model of consent, deferred consent, and waiver of consent. Collectively, they agreed upon a deferred consent model, in which patients may be approached for consent after their fracture surgery and prior to data collection. The consent rate in PREP-IT is 80.7%, and 0.67% of participants have withdrawn consent for participation. Discussion: Involvement of patient advisors in the development of an optimal model of consent has been successful. Engagement of patient advisors is recommended for other large trials where the traditional model of consent may not be optimal
Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies
- Author
- Aaron James Holland
- Abdullah Jumana T.
- Abrams Jonathan M.
- Abrashoff Riley
- Acevedo Andres B.
- Acha Iker
- Acosta Daniela M. Meza
- Adam Megan M.
- Adams Dante Q.
- Adams Elena R
- Adams Kalvyn N
- Akbar Zainab A.
- Akruwala Ushmi H.
- Al-Ghazwi Adel
- AlAbbas Batool H.
- Alahmed Mohammed S.
- AlAwadhi Areej A.
- Albakr Mohammed A.
- Albalushi Yusef J.
- Albaum Jonathan
- Aldhamen Ahmed
- Ales Nolan
- Alesmail Mohammad
- Alhabeeb Abdulelah
- Alhamli Dania
- AlHarbi Yazeed A.
- Alhuseini Isehaq
- Alkaabi Suhail
- Alkhezzi Tameem
- Alkubaisi Mohamed
- Allanqawi Nasser
- Allsbrook Martin
- Almohsen Yousef A.
- Almquist Justin Thomas
- Alnaji Teeb
- Alnasrallah Yousef A
- Alonzi Nicholas
- Alosaimi Meshal
- Alqabani Emeen
- Alrubaie Mohammad
- Alsinan Reema A.
- Altenbern Ava L.
- Altokhais Abdullah
- Alyami Saleh A.
- Ameijenda Federico
- Amer Hamzi
- Amos Meggan
- Anderson Hunter J.
- Andrew Carter
- Andringa Jesse C
- Angwin Abigail
- Aradhya Arvind J.
- Aramians Andrew
- Arango Camila Villamil
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- Wallace Steven P.
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- Wang Hongda
- Wang Jiawei
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- Weigand Anthony A
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- Wickenden Evan
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- Zenner Thomas
- Zhang Jiaqi
- zhang Jinhua
- Zhao Noah Y.
- Zhao Tiannie
- Zhao Tianwei
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- Ziebold Josh J
- Ziegler Lucas J.
- Zimmermann Ingrid H
- Zygmunt James C.
- Publication venue
- 'American Astronomical Society'
- Publication date
- 09/05/2023
- Field of study
Flare frequency distributions represent a key approach to addressing one of
the largest problems in solar and stellar physics: determining the mechanism
that counter-intuitively heats coronae to temperatures that are orders of
magnitude hotter than the corresponding photospheres. It is widely accepted
that the magnetic field is responsible for the heating, but there are two
competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To
date, neither can be directly observed. Nanoflares are, by definition,
extremely small, but their aggregate energy release could represent a
substantial heating mechanism, presuming they are sufficiently abundant. One
way to test this presumption is via the flare frequency distribution, which
describes how often flares of various energies occur. If the slope of the power
law fitting the flare frequency distribution is above a critical threshold,
α=2 as established in prior literature, then there should be a
sufficient abundance of nanoflares to explain coronal heating. We performed
>600 case studies of solar flares, made possible by an unprecedented number
of data analysts via three semesters of an undergraduate physics laboratory
course. This allowed us to include two crucial, but nontrivial, analysis
methods: pre-flare baseline subtraction and computation of the flare energy,
which requires determining flare start and stop times. We aggregated the
results of these analyses into a statistical study to determine that α=1.63±0.03. This is below the critical threshold, suggesting that Alfv\'en
waves are an important driver of coronal heating.Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The
Astrophysical Journal on 2023-05-09, volume 948, page 7
\u3ci\u3eDrosophila\u3c/i\u3e Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution
- Author
- Abdelnabi Mai
- Abrams Marita K
- Abusheikh Tariq
- Ackerman Cheri M
- Adams Andrew
- Adams Stephanie J
- Agarwalla Anant
- Agbley Kwabea
- Aldrup Megan E
- Alldredge Justin
- Allen Alicia B
- Alvarez Consuelo J
- Alvendia Erica L
- Ament Caitlin
- Anderson John E
- Archambault Alexi
- Armistead Isaac O
- Armstrong Andrew R
- Armstrong William
- Aronhalt Todd
- Ashrawi Yara
- Asinof Sam
- Aso Soham
- Augustine LaJerald
- Baatenberg Lara
- Bahr Thomas J
- Bailey Robert J
- Baker Atlee
- Baker Morgan
- Baldassari Shane M
- Banker Roxanne
- Barberi Chelsea R
- Barnett Jason M
- Bartling Justina R
- Baumgardner Jordan S
- Beck Christopher
- Beck Lauren R
- Beckett Alissa
- Bedard James E J
- Bednarski April E
- Beken Levent H
- Belella Carissa
- Bellush James M
- Benitez Pedro
- Benson Jonathon M
- Bertolet Anne
- Bhalla Satish C
- Bhatiya Chinmoy I
- Blaker Amanda L
- Blunden Christopher E
- Bodenberg Jessica M
- Boham Sampson K
- Bor Matthew J
- Botsford Bobbi
- Boudoures Anna L
- Boudreaux Lauren R
- Bourland Megan
- Brand Jordan P
- Braverman John M
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- Brock Ethan J
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- Burg Martin G
- Burke Christa
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- Bushhouse Kelsey T
- Butzler Sarah C
- Caesar Nicole M
- Campana Christopher
- Carney Jordan E
- Caronna Jason
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- Dawson Seth G
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- Diekema Emily J
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- Fefelova Nadezhda
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- Fese Jessica
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- Flohr Sarah
- Flores Amanda H
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- Foret Don
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- Fosselman Daniel S
- Foust Jonathan D
- Franchi Spencer L
- Freda Philip J
- Freeburg Trip
- French Kristin M
- Friedman Harrison
- Friedrichs Chelsey
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- Garrett Amanda D
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- Geary James F
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- Harris Cameron B
- Hatfield Kristen R
- Hauke Jeanette
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- Havill Jessen T
- Heckman Jonathan M
- Hedeen Heather
- Helmreich Eric
- Hendricksma Jesse
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- Howell Emily J
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- Ighile Osagie
- Intriago Stephanie
- Jacobs Dontae A
- Janssen Bridget M
- Jarrell Jenifer N
- Jelgerhuis Sarah A
- Jelsema Timothy R
- Jewell Elizabeth S
- Jimenez Luis A
- Jipp Jacob
- Johnson Ashlee G
- Johnson Benjamin K
- Johnson Cristen
- Johnson Diana E
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- Johnson Lauriaun
- Johnson Todd D
- Jones Christopher J
- Jones Jennifer K
- Jones Kelly K
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- Kabaso Rita
- Kaehler Marian M
- Kaisler Maria
- Kammrath Anna
- Kandahari Adrese
- Kappes Michelle L
- Karaska Elizabeth A
- Katz Brandon M
- Kaur Sukhjit
- Kehoe James L
- Kelley Colleen V
- Kelly Elisabeth A
- Kennedy Andre
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- Keny Lauren J
- Kerber John M
- Keysock Nicholas
- Khan Ambreen
- Khayrullina Guzal
- Khoshabian Colin
- Khoury Christopher B
- Kiernan Elizabeth
- Kiley John
- Kim Andrew J
- Kim Anna
- Kim Van
- King Jessica E
- Klett Bethany M
- Knepper John Mark
- Knob Christopher R
- Knouse Kristin A
- Knudsen Nelson H
- Koaches Hannah C
- Koehler Jessica
- Koenig Dana
- Kokan Nighat P
- Kolibas Kimberly S
- Kooienga Ross D
- Koplinsky Chad A
- Kraftmann Karen J
- Kubricky Cassandra
- Kufel Christina N
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- Kuleck Gary A
- Kulich Danielle
- Kung Faith
- Kus Jordan E
- Kuschner Cyrus E
- Kusner Matt
- Kwan Wa Shum Yuki
- Ladzekpo Danielle
- LaForge Kristin M
- Lamb Travis
- Lambright Anthony K
- Lammers Jennifer A
- Lane Curtiss E
- Langner Christine
- Lau Dawn
- Lea Charlotte
- Leads Rachel R
- Leatherman Emily C
- LeBlanc Mark T
- Lee Cassidy T
- Lee Paul
- Lemmon Eric
- Leung Wilson
- Lewis Benjamin M
- Li Linghui
- Light Morgan R
- Limle Austin B
- Lin Devry
- Lindbeck Peter
- Lippert Rachel N
- Lopez Lenin
- Lopilato Jane E
- Louie Christopher A
- Lowell Shannon M
- Lu Alvin
- Lucas Gabi
- Luippold Erin K
- Lupey Lena N
- Lydon Anniken M
- Macchi Christopher R
- Machone Joshua F
- Macias Elizabeth
- Macias Jason S
- Maffa Amanda
- Mageeney Catherine M
- Malkowitz Lorraine
- Mammo Danny
- Maniaci Brian J
- Marra Jonathan
- Martinez Megan
- Martiniuc Daniela
- Martinov Tijana
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- May Francis J
- Mayorga Lissett
- Mazur Tammy
- Mazzeo Cheryl
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- McCartha Shannon R
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- McFarland Darryl
- McLaughlin Christopher
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- Monsma Nicholaus
- Moran Joseph V
- Morgan Abbie
- Morlock Elaine V
- Morris William M
- Morrow Adam T
- Mudumbi Krishna
- Mullen Gregory J
- Muller Sarah E
- Musick Adam E
- Musokotwane Sepo
- Myirski Kevin
- Naik Monal
- Naik Priyanka
- Neufeld Lacey
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- O\u27Rouke Allison
- Obiorah Ifeanyi
- Ochoa Andrea
- Odisho George
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- Osterloh Jeanette M
- Overvoorde Paul J
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- Pamnani Brad
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- Primus Shekerah
- Puetz William J
- Quach Michael
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- Raimey England
- Ramic Alen
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- Ramsey Kimberley
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- Shoemaker Emma
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- Silva Valeria
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- Soliterman Eugenia A
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- Spaeder Lindsay A
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- Sparks Jeri
- Spencer Eric
- Spencer Sarah
- Sreenivasan Aparna
- Stagaard Erica
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- Starkey Kristin M
- Statton Geeta
- Sterling Allison M
- Svoronos Petros
- Swanson Bryant R
- Sweeney Edward P
- Tache Melissa A
- Tare Archana
- Tenney Jenna C
- Tewilliager Ashley A
- Thistle Katrina
- Thomas Jessica G
- Thompson Jeffrey S
- Thomsen Kristen M
- Tilot Amanda K
- Timko Ashley S
- Tirasawasdichai Tiara
- Tomkins Trisha
- Torchon Karvyn
- Townsend Ashley
- Tran Danny L
- Trieu Melissa
- Tuberty Sarah
- Tucci Jessica M
- Tumminello Richard A
- Turner Bryce A
- Tynon Marykathryn
- Uitvlugt Chris
- Undem Blair
- Unruh Anna K
- Unzicker Matthew R
- Urick Damian
- Valdez Isabel
- VanderVennen Marielle
- VanDyken Rachel E
- VanEck Eve
- Velasquez Vicente
- Verbofsky Evan M
- Vernon William B
- Vetor Ashley
- Villerot Matthew M
- Vondy Kayla
- Vrable Abby
- Vue Samantha
- Vuong Tam
- Vylonis Megan B
- Waggoner Andrew W
- Walji Tezin A
- Walker Chelsea A
- Wan Tiffany
- Wande Lucia
- Ward Alyssa
- Waters Mary
- Watson David T
- Wawersik Matthew
- Weaver Jennifer A
- Welker Anne A
- Wellinghoff Jules
- Wendland Pete
- Westphal Kyle
- White Jackie X
- Williams Charlotte
- Winkler Stacey
- Winn Wesley W
- Winters Jenifer
- Woehlke Sarah
- Wolski Matthew W
- Wolyniak Michael J
- Wong Jeanette
- Wong Jeremy N
- Woyski Dustin S
- Wurzler Juliana A
- Wylie Anna
- Wysocki Lauren M
- Xiong David
- Xu Amy
- Xu Thomas Q
- Yalamanchili Monica
- Yang Bib
- Yarrington Bryan
- Yemelyanova Anastasia K
- Youngblom Jim
- Yu Nicole S
- Yuan Han
- Zaborowicz Matthew A
- Zarrasola Stephanie
- Zhang Yi
- Zhu Xiao
- Zidan Ameer
- Zumkehr Joannee
- Publication venue
- ScholarWorks@GVSU
- Publication date
- 01/05/2015
- Field of study
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu