Reconstructing medieval April-July mean temperatures in East Anglia, 1256-1431

This paper presents the first annually resolved temperature reconstruction for England in the Middle Ages. To effect this reconstruction the starting date of the grain harvest in Norfolk has been employed as a temperature proxy. Using c. 1,000 manorial accounts from Norfolk, 616 dates indicating the onset of the grain harvest were extracted for the period 1256 to 1431 and a composite Norfolk series was constructed. These data were then converted into a temperature series by calibrating a newly constructed comparison series of grain harvest dates in Norfolk from 1768 to 1816 with the Central England Temperature series. These results were verified over the period 1818-1867. For the British Isles no other annually resolved proxy data are available and the onset of the grain harvest remains the only proxy for assessing April-July mean temperatures. In addition, this is the first time-series regarding the onset of grain harvests in medieval Europe known so far. The long-term trend in the reconstructed medieval temperature series suggests that there was a cooling in the mean April-July temperatures over the period 1256 to 1431. Average temperatures dropped from 13°C to 12.4°C, which possibly indicates the onset of the Little Ice Age. The decline in values was not steady, however, and the reconstruction period contains decades of warmer spring-early summer temperatures (for example the 1320s to the early 1330s and the 1360s) as well as colder conditions (for example the late 1330s, 1340s and the 1380s). The decline in grain-growing-season average temperatures would not have been a major problem for medieval agriculture, rather the phases of very high interannual variability partly found in the medieval time-series, such as 1315-1335 and 1360-1375, would have proved disruptiv

Stratégies intégrées d’insertion en emploi de personnes vivant en logement social : Analyse d’expériences nord-américaines et françaises – Rapport synthèse

Ce rapport est issu d'une recherche intitulée Stratégies intégrées d'insertion résidentielle et professionnelle: analyse d'expériences nord-américaines et européennes, menée à la demande et avec la collaboration de Nicole Forget-Bashonga de la Cuisine collective d'Hochelaga-Maisonneuve et du Conseil pour le développement local et communautaire d'Hochelaga-Maisonneuve, de Jean-François Gilker du GRT Bâtir son quartier, de Jean- Pierre Racette de la Société d'habitation populaire de l'Est de Montréal (SHAPEM) et de Céline Vézina de la Corporation de développement de l'Est (CDEST). À l'occasion, se sont aussi joints aux discussions, Patrice Rodriguez, consultant en économie sociale, Adrien Sansregret de l'Office municipal d'habitation de Montréal (OMHM) et Vincent van Schendel de l'ARUC-Économie sociale. Ce projet de recherche a également été accrédité par le CAP-Logement communautaire de l'Alliance de Recherche Universités-Communautés (ARUC) - Économie sociale. Nous tenons enfin à souligner l’aimable collaboration de Madame Barbara Maass, bibliothécaire à la Société d’habitation du Québec, à Montréal, ainsi que des personnes que nous avons rencontrées à titre d’informateurs-clés et dont les noms sont mentionnés à la section 1 du présent rapport.Le projet de recherche a obtenu, à l'origine, l'appui technique de Vincent van Schendel, alors aux Services aux collectivités de l'UQAM, et une recommandation favorable du Comité des services aux collectivités (CSAC) auprès du Comité d'aide financière aux chercheures-chercheurs (CAFACC) de l’UQAM. Ce dernier a jugé favorablement le projet et lui a octroyé une subvention dans le cadre du Programme d'aide financière à la recherche à la création (PAFARC) de l'UQAM - Volet 2: Recherche dans le cadre des services aux collectivités

Significant enhancements of nitrogen oxides, black carbon, and ozone in the North Atlantic lower free troposphere resulting from North American boreal wildfires

Copyright © 2006 American Geophysical Union. All Rights Reserved.Extensive wildfires burned in northern North America during summer 2004, releasing large amounts of trace gases and aerosols into the atmosphere. Emissions from these wildfires frequently impacted the PICO-NARE station, a mountaintop site situated 6–15 days downwind from the fires in the Azores Islands. To assess the impacts of the boreal wildfire emissions on the levels of aerosol black carbon (BC), nitrogen oxides and O3 downwind from North America, we analyzed measurements of CO, BC, total reactive nitrogen oxides (NO y ), NO x (NO + NO2) and O3 made from June to September 2004 in combination with MOZART chemical transport model simulations. Long-range transport of boreal wildfire emissions resulted in large enhancements of CO, BC, NO y and NO x , with levels up to 250 ppbv, 665 ng mˉ³, 1100 pptv and 135 pptv, respectively. Enhancement ratios relative to CO were variable in the plumes sampled, most likely because of variations in wildfire emissions and removal processes during transport. Analyses of ΔBC/ΔCO, ΔNO y /ΔCO and ΔNO x /ΔCO ratios indicate that NO y and BC were on average efficiently exported in these plumes and suggest that decomposition of PAN to NO x was a significant source of NO x . High levels of NO x suggest continuing formation of O3 in these well-aged plumes. O3 levels were also significantly enhanced in the plumes, reaching up to 75 ppbv. Analysis of ΔO3/ΔCO ratios showed distinct behaviors of O3 in the plumes, which varied from significant to lower O3 production. We identify several potential reasons for the complex effects of boreal wildfire emissions on O3 and conclude that this behavior needs to be explored further in the future. These observations demonstrate that boreal wildfire emissions significantly contributed to the NO x and O3 budgets in the central North Atlantic lower free troposphere during summer 2004 and imply large-scale impacts on direct radiative forcing of the atmosphere and on tropospheric NO x and O3

North American Boreal Wildfire and Anthropogenic Emissin Impacts in the Lower Free Troposphere over the North Atlantic Region: observations at the PICO-NARE station

AGU Fall Meeting. San Francisco, California, 11-15 December 2006.We present analyses of CO, O3, nitrogen oxides (NOx and NOy) and aerosol black carbon (BC) measurements made in the lower free troposphere (FT) over the North Atlantic region during summers 2004 (ICARTT period) and 2005

Design and fabrication of materials with desired deformation behavior

Figure 1: Two examples of real and replicated objects. Thanks to our data-driven process, we are able to measure, simulate, and obtain material combinations of non-linear base materials that match a desired deformation behavior. We can then print those objects with multi-material 3D printers using two materials (blue and black) with varying internal microstructure. This paper introduces a data-driven process for designing and fab-ricating materials with desired deformation behavior. Our process starts with measuring deformation properties of base materials. For each base material we acquire a set of example deformations, and we represent the material as a non-linear stress-strain relationship in a finite-element model. We have validated our material measure-ment process by comparing simulations of arbitrary stacks of base materials with measured deformations of fabricated material stacks. After material measurement, our process continues with designing stacked layers of base materials. We introduce an optimization pro-cess that finds the best combination of stacked layers that meets a user’s criteria specified by example deformations. Our algorithm employs a number of strategies to prune poor solutions from the combinatorial search space. We demonstrate the complete process by designing and fabricating objects with complex heterogeneous materials using modern multi-material 3D printers

Hesperomyces virescens (Fungi, Ascomycota, Laboulbeniales) attacking Harmonia axyridis (Coleoptera, Coccinellidae) in its native range

This study intended to find data on obligate ectoparasitic Laboulbeniales (Fungi, Ascomycota) on Chinese Harmonia axyridis (Coleoptera, Coccinellidae). After having screened over four thousand dried specimens of H. axyridis and close relatives, we present the first (historical) record of Chinese H. axyridis infected with Hesperomyces virescens. We suggest that H. virescens is a historically globally distributed species and hypothesize that (native) infection was lost when H. axyridis was introduced in North America.Organismic and Evolutionary Biolog

Planning, implementation and scientific goals of the Studies of Emissions and Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys (SEAC4RS) field mission

The Studies of Emissions and Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys (SEAC4RS) field mission based at Ellington Field, Texas, during August and September 2013 employed the most comprehensive airborne payload to date to investigate atmospheric composition over North America. The NASA ER-2, DC-8, and SPEC Inc. Learjet flew 57 science flights from the surface to 20 km. The ER-2 employed seven remote sensing instruments as a satellite surrogate and eight in situ instruments. The DC-8 employed 23 in situ and five remote sensing instruments for radiation, chemistry, and microphysics. The Learjet used 11 instruments to explore cloud microphysics. SEAC4RS launched numerous balloons, augmented AErosol RObotic NETwork, and collaborated with many existing ground measurement sites. Flights investigating convection included close coordination of all three aircraft. Coordinated DC-8 and ER-2 flights investigated the optical properties of aerosols, the influence of aerosols on clouds, and the performance of new instruments for satellite measurements of clouds and aerosols. ER-2 sorties sampled stratospheric injections of water vapor and other chemicals by local and distant convection. DC-8 flights studied seasonally evolving chemistry in the Southeastern U.S., atmospheric chemistry with lower emissions of NOx and SO2 than in previous decades, isoprene chemistry under high and low NOx conditions at different locations, organic aerosols, air pollution near Houston and in petroleum fields, smoke from wildfires in western forests and from agricultural fires in the Mississippi Valley, and the ways in which the chemistry in the boundary layer and the upper troposphere were influenced by vertical transport in convective clouds

Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization

AbstractIn migrating adherent cells such as fibroblasts and endothelial cells, the microtubule-organizing center (MTOC) reorients toward the leading edge [1–3]. MTOC reorientation repositions the Golgi toward the front of the cell [1] and contributes to directional migration [4]. The mechanism of MTOC reorientation and its relation to the formation of stabilized microtubules (MTs) in the leading edge, which occurs concomitantly with MTOC reorientation [3], is unknown. We show that serum and the serum lipid, lysophosphatidic acid (LPA), increased Cdc42 GTP levels and triggered MTOC reorientation in serum-starved wounded monolayers of 3T3 fibroblasts. Cdc42, but not Rho or Rac, was both sufficient and necessary for LPA-stimulated MTOC reorientation. MTOC reorientation was independent of Cdc42-induced changes in actin and was not blocked by cytochalasin D. Inhibition of dynein or dynactin blocked LPA- and Cdc42-stimulated MTOC reorientation. LPA also stimulates a Rho/mDia pathway that selectively stabilizes MTs in the leading edge [5, 6]; however, activators and inhibitors of MTOC reorientation and MT stabilization showed that each response was regulated independently. These results establish an LPA/Cdc42 signaling pathway that regulates MTOC reorientation in a dynein-dependent manner. MTOC reorientation and MT stabilization both act to polarize the MT array in migrating cells, yet these processes act independently and are regulated by separate Rho family GTPase-signaling pathways

Cytoplasmic dynein nomenclature

A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature. This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded by multiple genes. We propose names for the mammalian cytoplasmic dynein subunit genes and proteins that reflect the phylogenetic relationships of the genes and the published studies clarifying the functions of the polypeptides. This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms

Overcoming multiple drug resistance mechanisms in medulloblastoma

Introduction: Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients. We analysed whether circumvention of chemoresistance pathways (drug export, DNA repair and apoptotic inhibition) can restore chemotherapeutic efficacy in a panel of MB cell lines. Results: We demonstrate, by immunohistochemistry in patient tissue microarrays, that ABCB1 is expressed in 43% of tumours and is significantly associated with high-risk. We show that ABCB1, O6-methylguanine-DNA-methyltransferase (MGMT) and BCL2 family members are differentially expressed (by quantitative reverse transcription polymerase chain reaction, Western blotting and flow cytometry) in MB cell lines. Based on these findings, each pathway was then inhibited or circumvented and cell survival assessed using clonogenic assays. Inhibition of ABCB1 using vardenafil or verapamil resulted in a significant increase in sensitivity to etoposide in ABCB1-expressing MB cell lines. Sensitivity to temozolomide (TMZ) was MGMT-dependent, but two novel imidazotetrazine derivatives (N-3 sulfoxide and N-3 propargyl TMZ analogues) demonstrated ≥7 fold and ≥3 fold more potent cytotoxicity respectively compared to TMZ in MGMT-expressing MB cell lines. Activity of the BAD mimetic ABT-737 was BCL2A1 and ABCB1 dependent, whereas the pan-BCL2 inhibitor obatoclax was effective as a single cytotoxic agent irrespective of MCL1, BCL2, BCL2A1, or ABCB1 expression. Conclusions: ABCB1 is associated with high-risk MB; hence, inhibition of ABCB1 by vardenafil may represent a valid approach in these patients. Imidazotetrazine analogues of TMZ and the BH3 mimetic obatoclax are promising clinical candidates in drug resistant MB tumours expressing MGMT and BCL2 anti-apoptotic members respectively