Naming the Stones: A Moment in Civil War History Witnessed by a New England Boy

From whaling ships to war ships A child\u27s perspective of this warfare transformation Clara Stites\u27 earlier books for young readers are set in the California of the 1800s. With this novel, she shifts her setting to New Bedford, MA during the early months of the Civil War. Namin...

Night Journey to Vicksburg

Coming of age Becoming a man in the midst of slavery Night Journey to Vicksburg is Susan Rowan Masters\u27 fourth novel for young readers and the first that draws on historical resources. Set in the spring of 1863, just before the Battle of Vicksburg, this book illuminates hi...

Knee Biomechanics of Older Adults During Common Recreational and Daily Activities

Among older adults, socialization is a key motivating factor for participation in physical activity. In order to develop evidence-based physical activity recommendations for older adults with knee pathologies a better understanding of knee biomechanics during social recreational activities is needed. The purpose of this study was to determine knee joint kinematics and kinetics in healthy older adults during golf and bowling. Knee biomechanics during these recreational activities were also compared to those experienced during activities of daily living. Motion analysis data were collected as subjects performed walking, stair ascent, stair descent, and either golf or bowling. Knee angles, peak knee moments, and peak ground reaction force were recorded. Comparisons were made between the recreational activity and activities of daily living. Knee flexion angle at peak knee extensor moment during bowling was as high as during stair descent. Peak knee extensor moment was as high during bowling as during stair ascent. For the golf lead knee, knee flexion angle at peak knee extensor moment and peak knee extensor moment were as high as during stair ascent. Peak knee abduction moment, peak knee internal rotation angle, and peak knee external rotation angle for the golf lead knee were larger than all activities of daily living. For the golf trail knee, peak knee external rotation angle was larger than all activities of daily living. These results suggest that the greatest challenge for the knee of healthy older males during bowling is in the sagittal plane. Additionally, these results indicate that golf poses challenges in all three planes for the lead knee and in the transverse plane for the trail knee

Viral Infection Brings Mitochondrial Traffic to a Standstill

Mitochondria are dynamic organelles with many functions. In this issue of Cell Host & Microbe, Kramer and Enquist (2012) show that mitochondrial motility and morphology are disrupted during alphaherpesvirus infection, which aids viral replication and transport in neurons

The Intestinal Microbiota and Viral Susceptibility

Many infections start with microbial invasion of mucosal surfaces, which are typically colonized by a community of resident microbes. A growing body of literature demonstrates that the resident microbiota plays a significant role in host susceptibility to pathogens. Recent work has largely focused on the considerable effect that the intestinal microbiota can have upon bacterial pathogenesis. These studies reveal many significant gaps in our knowledge about the mechanisms by which the resident community impacts pathogen invasion and the nature of the ensuing host immune response. It is likely that as viral pathogens become the focus of studies that examine microbiota–host interaction, substantial effects of resident communities exerted via diverse mechanisms will be elucidated. Here we provide a perspective of the exciting emerging field that examines how the intestinal microbiota influences host susceptibility to viruses

Distributional Effects of the High School Degree in Germany

This paper investigates the impact of a high school degree on the wage distribution in the period from 1984 to 2004 in Germany. In that period the share of male workers with a high school degree increased from 16 to 25 percent. An econometric evaluation estimator is used to analyze quantile treatment effects for the whole population of male workers and for the subpopulation of workers with a high school degree. It turns out that the impact of a high school degree on the wage distribution for all workers is positive, whereas its impact on the wage distribution of the workers with a high school degree does statistically not differ from zero. This suggests that the selection of students into grammer schools might have been too restrictive. For more workers higher education would have raised their productivity and wages

Learning to THINK...Thinking to LEARN

How do you create a systemic school culture of THINKING? In this interactive presentation learn how 3 Miami-Dade schools are using a set of consistent visual tools to teach critical, creative THINKING and communication to all learners. This session will capitalize on connecting the visuals to the latest brain research and its implications on the developmental needs of PreK-Adult learners. Examples of practice will be highlighted by these schools

Related Enteric Viruses Have Different Requirements for Host Microbiota in Mice

Accumulating evidence suggests that intestinal bacteria promote enteric virus infection in mice. For example, previous work demonstrated that antibiotic treatment of mice prior to oral infection with poliovirus reduced viral replication and pathogenesis. Here, we examined the effect of antibiotic treatment on infection with coxsackievirus B3 (CVB3), a picornavirus closely related to poliovirus. We treated mice with a mixture of five antibiotics to deplete host microbiota and examined CVB3 replication and pathogenesis following oral inoculation. We found that, as seen with poliovirus, CVB3 shedding and pathogenesis were reduced in antibiotic-treated mice. While treatment with just two antibiotics, vancomycin and ampicillin, was sufficient to reduce CVB3 replication and pathogenesis, this treatment had no effect on poliovirus. The quantity and composition of bacterial communities were altered by treatment with the five-antibiotic cocktail and by treatment with vancomycin and ampicillin. To determine whether more-subtle changes in bacterial populations impact viral replication, we examined viral infection in mice treated with milder antibiotic regimens. Mice treated with one-tenth the standard concentration of the normal antibiotic cocktail supported replication of poliovirus but not CVB3. Importantly, a single dose of one antibiotic, streptomycin, was sufficient to reduce CVB3 shedding and pathogenesis while having no effect on poliovirus shedding and pathogenesis. Overall, replication and pathogenesis of CVB3 are more sensitive to antibiotic treatment than poliovirus, indicating that closely related viruses may differ with respect to their reliance on microbiota. IMPORTANCE Recent data indicate that intestinal bacteria promote intestinal infection of several enteric viruses. Here, we show that coxsackievirus, an enteric virus in the picornavirus family, also relies on microbiota for intestinal replication and pathogenesis. Relatively minor depletion of the microbiota was sufficient to decrease coxsackievirus infection, while poliovirus infection was unaffected. Surprisingly, a single dose of one antibiotic was sufficient to reduce coxsackievirus infection. Therefore, these data indicate that closely related viruses may differ with respect to their reliance on microbiota

Changes in fluxes of heat, H2O, and CO2 caused by a large wind farm

The Crop Wind-Energy Experiment (CWEX) provides a platform to investigate the effect of wind turbines and large wind farms on surface fluxes of momentum, heat, moisture, and carbon dioxide (CO2). In 2010 and 2011, eddy covariance flux stations were installed between two lines of turbines at the southwest edge of a large Iowa wind farm from late June to early September. We report changes in fluxes of momentum, sensible heat, latent heat, and CO2 above a corn canopy after surface air had passed through a single line of turbines. In 2010, our flux stations were placed within a field with homogeneous land management practices (same tillage, cultivar, chemical treatments). We stratify the data according to wind direction, diurnal condition, and turbine operational status. Within these categories, the downwind–upwind flux differences quantify turbine influences at the crop surface. Flux differences were negligible in both westerly wind conditions and when the turbines were non operational. When the flow is perpendicular (southerly) or slightly oblique (southwesterly) to the row of turbines during the day, fluxes of CO2 and water (H2O) are enhanced by a factor of five in the lee of the turbines (from three to five turbine diameter distances downwind from the tower) as compared to a west wind. However, we observe a smaller CO2 flux increase of 30–40% for these same wind directions when the turbines are off. In the nighttime, there is strong statistical significance that turbine wakes enhance upward CO2 fluxes and entrain sensible heat toward the crop. The direction of the scalar flux perturbation seems closely associated to the differences in canopy friction velocity. Spectra and co-spectra of momentum components and co-spectra of heat also demonstrate nighttime influence of the wind turbine turbulence at the downwind station

Prediction of pregnancy state from milk mid-infrared (MIR) spectroscopy in dairy cows

Submitted 2020-07-14 | Accepted 2020-08-18 | Available 2020-12-01https://doi.org/10.15414/afz.2020.23.mi-fpap.224-232Pregnancy assessment is a very important tool for the reproductive management in efficient and profitable dairy farms. Nowadays, mid-infrared (MIR) spectroscopy is the method of choice in the routine milk recording system for quality control and to determine standard milk components. Since it is well known that there are changes in milk yield and composition during pregnancy, the aim of this study was to develop a discriminant model to predict the pregnancy state from routinely recorded MIR spectral data. The data for this study was from the Austrian milk recording system. Test day records of Fleckvieh, Brown Swiss and Holstein Friesian cows between 3 and 305 days of lactation were included in the study. As predictor variables, the first derivative of 212 selected MIR spectral wavenumbers were used. The data set contained roughly 400,000 records from around 40,000 cows and was randomly split into calibration and validation set by farm. Prediction was done with Partial Least Square Discriminant Analysis. Indicators of model fit were sensitivity, specificity, balanced accuracy and Area Under Receiver Operating Characteristic Curve (AUC). In a first approach, one discriminant model for all cows across the whole lactation and gestation lengths was applied. The sensitivity and specificity of this model in validation were 0.856 and 0.836, respectively. Splitting up the results for different lactation stages showed that the model was not able to predict pregnant cases before the third month of lactation and vice versa not able to predict non-pregnancy after the third month of lactation. Consequently, in the second approach a prediction model for each different (expected) pregnancy stage and lactation stage was developed. Balanced accuracies ranged from 0.523 to 0.918. 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Mid-infrared prediction of bovine milk fatty acids across multiple breeds, production systems, and countries. Journal of Dairy Science, 94(4), 1657–1667. https://doi.org/10.3168/jds.2010-3408Soyeurt, H., Bastin, C., Colinet, F. G., Arnould, V. M.-R., Berry, D. P., Wall, E., Dehareng, F., Nguyen, H. N., Pardenne, P., Schefers, J., Vandenplas, J., Weigel, K., Coffey, M., Théron, L., Detilleux, J., Reding, E., Gengler, N. & McParland, S. (2012). Mid-infrared prediction of lactoferrin content in bovine milk: potential indicator of mastitis. Animal, 6(11), 1830–1838. https://doi.org/10.1017/s1751731112000791Toffanin, V., De Marchi, M., Lopez-Villalobos, N., & Cassandro, M. (2015). Effectiveness of mid-infrared spectroscopy for prediction of the contents of calcium and phosphorus, and titratable acidity of milk and their relationship with milk quality and coagulation properties. International Dairy Journal, 41, 68–73. https://doi.org/10.1016/j.idairyj.2014.10.002Vanlierde, A., Vanrobays, M.-L., Dehareng, F., Froidmont, E., Soyeurt, H., McParland, S., S., Lewis, E., Deighton, M. H., Grandl, F., Kreuzer, M., Gredler, B., Dardenne, P. & Gengler, N. (2015). Hot topic: Innovative lactation-stage-dependent prediction of methane emissions from milk mid-infrared spectra. Journal of Dairy Science, 98(8), 5740–5747. https://doi.org/10.3168/jds.2014-8436Vanlierde, A., Soyeurt, H., Gengler, N., Colinet, F. G., Froidmont, E., Kreuzer, M., Grandl, F., Bell, M., Lund, P., Olijhoek, D. W., Eugéne M., Martin, C., Kuhla, B. & Dehareng, F. (2018). Short communication: Development of an equation for estimating methane emissions of dairy cows from milk Fourier transform mid-infrared spectra by using reference data obtained exclusively from respiration chambers. Journal of Dairy Science, 101(8). https://doi.org/10.3168/jds.2018-14472