Ideal Bose gas in fractal dimensions and superfluid 4^4He in porous media

Physical properties of ideal Bose gas with the fractal dimensionality between D=2 and D=3 are theoretically investigated. Calculation shows that the characteristic features of the specific heat and the superfluid density of ideal Bose gas in fractal dimensions are strikingly similar to those of superfluid Helium-4 in porous media. This result indicates that the geometrical factor is dominant over mutual interactions in determining physical properties of Helium-4 in porous media.Comment: 13 pages, 6 figure

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia

Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase (TK) contributes to the pathogenesis and development of resistance to ABL-TK inhibitors (TKI). The PI3K pathway thus is an attractive therapeutic target in BCR-ABL positive leukemias, but its role in BCR-ABL negative ALL is conjectural. Moreover, the functional contribution of individual components of the PI3K pathway in ALL has not been established. Experimental design: We compared the activity of the ATP-competitive pan-PI3K inhibitor NVP-BKM120, the allosteric mTORC1 inhibitor RAD001, the ATP-competitive dual PI3K/mTORC1/C2 inhibitors NVP-BEZ235 and NVP-BGT226 and the combined mTORC1 and mTORC2 inhibitors Torin 1, PP242 and KU-0063794 using long-term cultures of ALL cells (ALL-LTC) from patients with B-precursor ALL that expressed the BCR-ABL or TEL-ABL oncoproteins or were BCR-ABL negative. Results: Dual PI3K/mTOR inhibitors profoundly inhibited growth and survival of ALL cells irrespective of their genetic subtype and their responsiveness to ABL-TKI. Combined suppression of PI3K, mTORC1 and mTORC2 displayed greater antileukemic activity than selective inhibitors of PI3K, mTORC1 or mTORC1 and mTORC2. Conclusions: Inhibition of the PI3K/mTOR pathway is a promising therapeutic approach in patients with ALL. Greater antileukemic activity of dual PI3K/mTORC1/C2 inhibitors appears to be due to the redundant function of PI3K and mTOR. Clinical trials examining dual PI3K/mTORC1/C2 inhibitors in patients with B-precursor ALL are warranted, and should not be restricted to particular genetic subtypes

Limitations on the superposition principle: superselection rules in non-relativistic quantum mechanics

The superposition principle is a very basic ingredient of quantum theory. What may come as a surprise to many students, and even to many practitioners of the quantum craft, is tha superposition has limitations imposed by certain requirements of the theory. The discussion of such limitations arising from the so-called superselection rules is the main purpose of this paper. Some of their principal consequences are also discussed. The univalence, mass and particle number superselection rules of non-relativistic quantum mechanics are also derived using rather simple methods.Comment: 22 pages, no figure

Numerical study of multilayer adsorption on fractal surfaces

We report a numerical study of van der Waals adsoprtion and capillary condensation effects on self-similar fractal surfaces. An assembly of uncoupled spherical pores with a power-law distributin of radii is used to model fractal surfaces with adjustable dimensions. We find that the commonly used fractal Frankel-Halsey-Hill equation systematically fails to give the correct dimension due to crossover effects, consistent with the findings of recent experiments. The effects of pore coupling and curvature dependent surface tension were also studied.Comment: 11 pages, 3 figure

Tectonics of the Lepontine Alps: ductile thrusting and folding in the deepest tectonic levels of the Central Alps

The Lepontine dome represents a unique region in the arc of the Central and Western Alps, where complex fold structures of upper amphibolite facies grade of the deepest stage of the orogenic belt are exposed in a tectonic half-window. The NW-verging Mont Blanc, Aar und Gotthard basement folds and the Lower Penninic gneiss nappes of the Central Alps were formed by ductile detachment of the upper European crust during its Late Eocene–Early Oligocene SE-directed underthrust below the upper Penninic and Austroalpine thrusts and the Adriatic plate. Four underthrust zones are distinguished in the NW-verging stack of Alpine fold nappes and thrusts: the Canavese, Piemont, Valais and Adula zones. Up to three schistosities S1–S3, folds F1–F3 and a stretching lineation XI with top-to-NW shear indicators were developed in the F1–F3 fold nappes. Spectacular F4 transverse folds, the SW-verging Verzasca, Maggia, Ziccher, Alpe Bosa and Wandfluhhorn anticlines and synclines overprint the Alpine nappe stack. Their formation under amphibolite facies grade was related to late ductile folding of the southern nappe roots during dextral displacement of the Adriatic indenter. The transverse folding F4 was followed since 30 Ma by the pull-apart exhumation and erosion of the Lepontine dome. This occurred coevally with the formation of the dextral ductile Simplon shear zone, the S-verging backfolding F5 and the formation of the southern steep belt. Exhumation continued after 18 Ma with movement on the brittle Rhone-Simplon detachment, accompanied by the N-, NW- and W-directed Helvetic and Dauphiné thrusts. The dextral shear is dated by the 29–25 Ma crustal-derived aplite and pegmatite intrusions in the southern steep belt. The cooling by uplift and erosion of the Tertiary migmatites of the Bellinzona region occurred between 22 and 18 Ma followed by the exhumation of the Toce dome on the brittle Rhone–Simplon fault since 18 Ma

Development of a chromium-thoria alloy

Low temperature ductility and high temperature strength of pure chromium and chromium-thoria alloy prepared from vapor deposited powder