Shock-Wave Experiment with the Chelyabinsk LL5 Meteorite : Experimental Parameters and the Texture of the Shock-Affected Material

A spherical geometry shock experiment with the light-colored lithology material of the Chelyabinsk LL5 ordinary chondrite was carried out. The material was affected by shock and thermal metamorphism whose grade ranged from initial stage S3-4 to complete melting. The temperature and pressure were estimated at >2000 degrees C and >90 GPa. The textural shock effects were studied by optical and electron microscopy. A single experimental impact has produced the whole the range of shock pressures and temperatures and, correspondingly, four zones identified by petrographic analysis: (1) a melt zone, (2) a zone of melting silicates, (3) a black ring zone, and (4) a zone of weakly shocked initial material. The following textural features of the material were identified: displacement of the metal and troilite phases from the central melt zone; the development of a zone of mixed lithology (light-colored fragments in silicate melt); the origin of a dark-colored lithology ring; and the generation of radiating shock veinlets. The experimental sample shows four textural zones that correspond to the different lithology types of the Chelyabinsk LL5 meteorite found in fragments of the meteoritic shower in the collection at the Ural Federal University. Our results prove that shock wave loading experiment can be successfully applied in modeling of space shocks and can be used to experimentally model processes at the small bodies of the solar system.Peer reviewe

Formation and development of the processing industry in the AIC of the region

The theoretical grounding of the management system of animal feedingstuff milling of the region was performed. The facilities of animal feedingstuff milling are divided according to the degree of independence of business conducting and directions of sales of the products manufactured. The factors of the internal and external environment of the animal feedingstuff milling of the region were considered. The analysis was performed and the tendencies in the development of animal feedingstuff milling of the region and the system of its management were revealed; the directions of the development of animal feedingstuff milling of the agrarian region were grounded. The potential capacity of the regional market of animal feedingstuff for livestock breeding of the region was calculated. It was offered to form the body of economic management in the form of an independent legal entity bearing the responsibility for execution of the functions imposed on it to develop and implement the plan of development of animal feedingstuff milling – JSC Animal Feedingstuff Cluster of the Altai Territory.peer-reviewe

A Cross-Sectional Survey on Medication Management Practices for Noncommunicable Diseases in Europe During the Second Wave of the COVID-19 Pandemic

Maintaining healthcare for noncommunicable diseases (NCDs) is particularly important during the COVID-19 pandemic; however, diversion of resources to acute care, and physical distancing restrictions markedly affected management of NCDs. We aimed to assess the medication management practices in place for NCDs during the second wave of the COVID-19 pandemic across European countries. In December 2020, the European Network to Advance Best practices & technoLogy on medication adherencE (ENABLE) conducted a cross-sectional, web-based survey in 38 European and one non-European countries. Besides descriptive statistics of responses, nonparametric tests and generalized linear models were used to evaluate the impact on available NCD services of the number of COVID-19 cases and deaths per 100,000 inhabitants, and gross domestic product (GDP) per capita. Fifty-three collaborators from 39 countries completed the survey. In 35 (90%) countries face-to-face primary-care, and out-patient consultations were reduced during the COVID-19 pandemic. The mean ± SD number of available forms of teleconsultation services in the public healthcare system was 3 ± 1.3. Electronic prescriptions were available in 36 (92%) countries. Online ordering and home delivery of prescription medication (avoiding pharmacy visits) were available in 18 (46%) and 26 (67%) countries, respectively. In 20 (51%) countries our respondents were unaware of any national guidelines regarding maintaining medication availability for NCDs, nor advice for patients on how to ensure access to medication and adherence during the pandemic. Our results point to an urgent need for a paradigm shift in NCD-related healthcare services to assure the maintenance of chronic pharmacological treatments during COVID-19 outbreaks, as well as possible future disasters

Magnetic resonance imaging correlates of neuro-axonal pathology in the MS spinal cord.

In people with multiple sclerosis (MS), the spinal cord is the structure most commonly affected by clinically detectable pathology at presentation, and a key part of the central nervous system involved in chronic disease deterioration. Indices, such as the spinal cord cross-sectional area at the level C2 have been developed as tools to predict future disability, and-by inference-axonal loss. However, this and other histo-pathological correlates of spinal cord magnetic resonance imaging (MRI) changes in MS remain incompletely understood. In recent years, there has been a surge of interest in developing quantitative MRI tools to measure specific tissue features, including axonal density, myelin content, neurite density, and orientation, among others, with an emphasis on the spinal cord. Quantitative MRI techniques including T1 and T2 , magnetization transfer and a number of diffusion-derived indices have all been applied to MS spinal cord. Particularly diffusion-based MRI techniques combined with microscopic resolution achievable using high magnetic field scanners enable a new level of anatomical detail and quantification of indices that are clinically meaningful.Barts Charity (grants # 468/1506 & G‐001109

Experimental constraints on the ordinary chondrite shock darkening caused by asteroid collisions

Context. Shock-induced changes in ordinary chondrite meteorites related to impacts or planetary collisions are known to be capable of altering their optical properties. Thus, one can hypothesize that a significant portion of the ordinary chondrite material may be hidden within the observed dark C/X asteroid population. Aims. The exact pressure-temperature conditions of the shock-induced darkening are not well constrained. Thus, we experimentally investigate the gradual changes in the chondrite material optical properties as a function of the shock pressure. Methods. A spherical shock experiment with Chelyabinsk LL5 was performed in order to study the changes in its optical properties. The spherical shock experiment geometry allows for a gradual increase of shock pressure from similar to 15 GPa at a rim toward hundreds of gigapascals in the center. Results. Four distinct zones were observed with an increasing shock load. The optical changes are minimal up to similar to 50 GPa. In the region of similar to 50-60 GPa, shock darkening occurs due to the troilite melt infusion into silicates. This process abruptly ceases at pressures of similar to 60 GPa due to an onset of silicate melting. At pressures higher than similar to 150 GPa, recrystallization occurs and is associated with a second-stage shock darkening due to fine troilite-metal eutectic grains. The shock darkening affects the ultraviolet, visible, and near-infrared region while changes to the MIR spectrum are minimal. Conclusions. Shock darkening is caused by two distinct mechanisms with characteristic pressure regions, which are separated by an interval where the darkening ceases. This implies a reduced amount of shock-darkened material produced during the asteroid collisions.Peer reviewe

Clinical aspects of hypoglycemia syndrome in newborn children

The aim of the study – identification of the causes and clinical features of hypoglycemic syndrome in hospitalized newborns.Цель исследования -выявить причины и клинические особенности гипогликемического синдрома у госпитализированных новорожденных детей

Reversals of radio emission direction in PSR B1822-09

The pulse profile of pulsar B1822-09 exhibits a very peculiar kind of mode changing: a "precursor" appearing just in front of the Main-Pulse (MP) exhibits periods of nulling, during which an interpulse (IP) becomes detectable at rotation phase separated by roughly 180 deg from the precursor. We propose that this bizarre phenomenon, which requires an information transfer between the two components, occurs by means of reversal of a direction of coherent radio emission generated in the same emission region. This interpretation naturally explains the lack of weak radio emission in the off-pulse regions, as well as the problem of information transfer between emission regions associated with the MP precursor and the IP. The reversals also imply nulling. The model has profound physical implications: (i) the mechanism of coherent radio emission must allow radiation into two, opposite, intermittently changing directions; (ii) the radio waves must be able to propagate through inner regions of the neutron star magnetosphere with strong magnetic field. Most importantly, the model implies inward radio emission in pulsar magnetosphere.Comment: 9 pages, 2 figures, submitted to ApJ Letter

Alterations to nuclear architecture and genome behavior in senescent cells.

The organization of the genome within interphase nuclei, and how it interacts with nuclear structures is important for the regulation of nuclear functions. Many of the studies researching the importance of genome organization and nuclear structure are performed in young, proliferating, and often transformed cells. These studies do not reveal anything about the nucleus or genome in nonproliferating cells, which may be relevant for the regulation of both proliferation and replicative senescence. Here, we provide an overview of what is known about the genome and nuclear structure in senescent cells. We review the evidence that nuclear structures, such as the nuclear lamina, nucleoli, the nuclear matrix, nuclear bodies (such as promyelocytic leukemia bodies), and nuclear morphology all become altered within growth-arrested or senescent cells. Specific alterations to the genome in senescent cells, as compared to young proliferating cells, are described, including aneuploidy, chromatin modifications, chromosome positioning, relocation of heterochromatin, and changes to telomeres