How Young Adults Make Meaning of Their Family Intergenerational Solidarity Through the Use of Music

This qualitative research project explores how young adults make meaning of their family intergenerational solidarity through the use of music. The project employed a type of Interpretative Phenomenological Analysis (IPA) to unlock meaning-making themes among young adults. Data collection consisted of interviewing ten young adults whose family had unintentionally or intentionally used music to increase their family intergenerational solidarity. The interviews were semi-structured. This study attempted to capture the depth of each young adult’s meaning-making. Seven general themes emerged: (a) I have experienced bonding with my family members through the use of music; (b) I have experienced emotional and/or psychological change through the use of music; (c) I have experienced the transmission (up, down, or laterally) of musical preference and/or talent among family members, (d) I have had a strong emotional experience with music (SEM) in the presence of my family; (e) I have experienced the bonding of my family members over a musical performance and/or with the use of a musical instrument; (f) I have experienced music triggering the recollection of family memories; and (g) I found music to be meaningful during a holiday(s), tradition(s), or religious or cultural experience(s). The first theme, I have experienced bonding with my family members through the use of music, sets the scene for those which follow. The six following themes represent six ways in which the young adults obtained the first theme: greater cohesion with family members of different generations through the use of music. All ten of the young adults experienced the strengthening of their family intergenerational solidarity through the use of music

Impact of Covid - 19 Pandemic on Orthopaedics at Northwell Health, New York.

The Novel Coronavirus (COVID-19) pandemicplaced an immense strain on healthcare systems and orthopedic surgeons across the world. To limit the spread, federal and state governments mandated the cancellation of all non-urgent surgical cases to address surging hospital admissions and manage workforce and resource reallocation. During the pandemic surge, thousands of surgical cancellations have been required. We outline our experience through the onset and advance of the surge, detail our incident response, and discuss the transition toward recovery

Predicting Elective Orthopaedic Sports Medicine Surgical Cancellations Based on Patient Demographics.

Purpose:To evaluate whether patient demographics are associated with cancellation of elective orthopaedic sports medicine surgical procedures. Methods:We retrospectively reviewed the electronic medical records of 761 patients who were scheduled to undergo an elective sports medicine orthopaedic operation from January 1, 2015, to December 31, 2017. The patients were divided into 2 groups: those who underwent the scheduled procedure (group A) and those in whom the operation was canceled for any reason prior to the surgical date and not rescheduled (group B). Univariate analysis assessed patient factors consisting of age, sex, race, language, marital status, occupation status, type of insurance (Medicaid or Medicare vs private), smoking history, employment status, and history of surgery to determine which demographic factors led to an increased risk of elective case cancellation. Results:Patients who canceled were significantly older (46.5 years vs 41.5 years, t = 2.432, P = .015) than those who do not. In addition, current smokers (22.5% vs 10.9%, χ2 = 10.85, P = .001), patients with Medicare or Medicaid versus private insurance (16.7% vs 10.0%, χ2 = 5.35, P = .021), non-English-speaking patients (29.5% vs 11.6%, χ2 = 11.43, P = .001), and patients without a history of surgery requiring anesthesia (18.8% vs 9.6%, χ2 = 9.96, P = .002) were all more likely to cancel. When all studied variables were examined in a logistic regression analysis, of the above demographic variables, only insurance status was no longer significant, given its correlation with age and language. Conclusions:Increased age (≥46.5 years), non-English speaking, smoking, lack of a history of surgery requiring anesthesia, and Medicaid or Medicare insurance were found to contribute to an increased risk of elective orthopaedic surgery cancellation. Level of Evidence:Level III, case-control study

The Segmented Aperture Interferometric Nulling Testbed (SAINT) III: Control Systems Analysis and Preliminary Results

This work presents a detailed current performance analysis for the telescope, pointing, and coronagraph com- ponent subsystems of the Segmented Aperture Interferometric Nulling Testbed (SAINT). The project pairs an active segmented mirror with the Visible Nulling Coronagraph (VNC) towards demonstrating capabilities for the future space observatories needed to directly detect and characterize Earth-sized worlds around nearby stars. We describe approaches to optimize subsystem wavefront sensing and control parameters, summarizing relevant scal- ing relations between these parameters, residual errors, and observed contrast measurements. Preliminary results from diagnostic testing under various control states are presented along with intermediate contrast measurements towards demonstrating the full system

"Like a virgin": Absence of rheumatoid arthritis and treponematosis, good sanitation and only rare gout in Italy prior to the 15th century.

Origin of disease has special interest for rheumatologists, for whom absence of etiologic information generally mandates empirical approaches. Hypotheses have been offered that rheumatoid arthritis and syphilis were New World diseases, only transmitted to the Old World subsequent to the passages of Christopher Columbus (1-7). The pertinent search is for polyarticular erosive disease, sparing axial joints (8-10) and for oligostotic or polyostotic periosteal reaction (3, 4). The phenomenon of interest is not the focal periosteal reaction that occurs secondary to trauma (9, 10), but rather the more diffuse reaction indicative of pres- "Like a virgin": Absence of rheumatoid arthritis and treponematosis, good sanitation and only rare gout in Italy prior to the 15th century "Come una vergine": in Italia, niente artrite reumatoide o sifilide, solo poca gotta, e buona sanita prima del XV secolo BM. Rothschild1, A. Coppa2, PP. Petrone3 1Arthritis Center of Northeast Ohio, Youngstown, OH; Department of Internal Medicine, Northeast Ohio Universities College of Medicine, Rootstown, OH; Department of Biomedical Engineering, University of Akron, Akron, OH; Department of Earth Sciences, Carnegie Museum of Natural History, Pittsburgh, PA; 2Dipartimento di Biologia Animale e dell'Uomo, Sede di Antropologia, Universita di Roma "La Sapienza", Roma; 3Museo di Antropologia, Centro Musei di Scienze Naturali, Universita di Napoli "Federico II", Napoli RUBRICA LA REUMATOLOGIA NELLA LETTERATURA… Reumatismo, 2004; 56(1):61-66 Reumatismo, 2004; 56(1):61-66 RIASSUNTO Obiettivi: Lo studio e stato condotto con lo scopo di compiere alcune valutazioni e di verificare, anche indirettamente, una serie di ipotesi: 1. che l'artrite reumatoide e la sifilide siano malattie originate nelle Americhe e che siano state trasmesse nel Vecchio Continente successivamente ai viaggi di Cristoforo Colombo; 2. che l'intossicazione da piombo, causa di iperuricemia e quindi di gotta, fosse frequente ai tempi dell'antica Roma; 3. valutare lo stato di salute pubblica in Italia prima del XV secolo, attraverso la stima della prevalenza delle spondiloartriti; 4. valutare la frequenza dei traumi ossei nell'Italia antica, grazie all'analisi dei fenomeni di reazione periosteale focale. Metodi: Gli scheletri provenienti da diversi siti archeologici di epoca diversa (eta del bronzo/peste del 1485-86) sono stati esaminati macroscopicamente per documentare segni di reazione periosteale focale e caratteristiche peculiari di artrite reumatoide, gotta, spondiloartriti e treponematosi ossea. Risultati: L'esame di 688 campioni ha rivelato una bassa frequenza di reazione periosteale con distribuzione focale (perlomeno nel periodo compreso fra 3400-700 anni fa), con una brusca impennata nel XV secolo. Una reazione periosteale di tipo diffuso e stata messa in evidenza solo in singoli soggetti con un quadro isolato di osteoartropatia ipertrofica. Le erosioni ossee sono risultate poco frequenti e sempre con distribuzione oligo-articolare. Non si sono osservate erosioni marginali, a parte un unico caso, a livello metatarsale, con le caratteristiche tipiche della gotta. Erosioni subcondrali, fusione di articolazioni periferiche e coinvolgimento dello scheletro assiale suggestive di spondiloartrite sono state rilevate nell'1-3% dei campioni esaminati, indipendemente dalla datazione del sito archeologico. Conclusioni: L'Italia, prima di Cristoforo Colombo, si presentava "come una vergine". Malattie come artrite reumatoide ed infezioni da treponema (in particolare sifilide) non sarebbero state presenti, fornendo cosi un'ulteriore prova che si tratta di forme morbose originarie delle Americhe. Segni di reazione periosteale dovuta a traumi minori erano rare prima del XV secolo, ovvero ai tempi dell'epidemia di peste del 1485-86. Cio suggerisce il ruolo potenziale di attivita domestiche, piuttosto che di quelle esterne, nello sviluppo di questo particolare tipo di lesione. L'ipotesi di un ruolo dell'intossicazione da piombo come cofattore causale nel declino dell'impero romano appare poco probabile, data la rarita dei casi di gotta osservati. La frequenza di spondiloartriti e risultata ridotta rispetto a quella che si osserva su popolazioni in precarie condizioni igienico-sanitarie, lasciandoci cosi intuire buoni standard di salute pubblica nell'Italia di quei tempi. Indirizzo per la corrispondenza: Prof. Dr. Bruce M. Rothschild The Arthritis Center of Northeast Ohio, 5500 Market Street, Youngstown, OH 44512 e-mail: [email protected] ence of a systemic disease (e.g., treponemal or hypertrophic osteoarthropathy) (9-11). Four thousand years of Italian cemeteries provide fertile ground to assess those hypotheses

Machine-Learning Approach Identifies a Pattern of Gene Expression in Peripheral Blood that can Accurately Detect Ischaemic Stroke

Early and accurate diagnosis of stroke improves the probability of positive outcome. The objective of this study was to identify a pattern of gene expression in peripheral blood that could potentially be optimised to expedite the diagnosis of acute ischaemic stroke (AIS). A discovery cohort was recruited consisting of 39 AIS patients and 24 neurologically asymptomatic controls. Peripheral blood was sampled at emergency department admission, and genome-wide expression profiling was performed via microarray. A machine-learning technique known as genetic algorithm k-nearest neighbours (GA/kNN) was then used to identify a pattern of gene expression that could optimally discriminate between groups. This pattern of expression was then assessed via qRT-PCR in an independent validation cohort, where it was evaluated for its ability to discriminate between an additional 39 AIS patients and 30 neurologically asymptomatic controls, as well as 20 acute stroke mimics. GA/kNN identified 10 genes (ANTXR2, STK3, PDK4, CD163, MAL, GRAP, ID3, CTSZ, KIF1B and PLXDC2) whose coordinate pattern of expression was able to identify 98.4% of discovery cohort subjects correctly (97.4% sensitive, 100% specific). In the validation cohort, the expression levels of the same 10 genes were able to identify 95.6% of subjects correctly when comparing AIS patients to asymptomatic controls (92.3% sensitive, 100% specific), and 94.9% of subjects correctly when comparing AIS patients with stroke mimics (97.4% sensitive, 90.0% specific). The transcriptional pattern identified in this study shows strong diagnostic potential, and warrants further evaluation to determine its true clinical efficacy

Improving Prediction from Dirichlet Process Mixtures via Enrichment

Flexible covariate-dependent density estimation can be achieved by modelling the joint density of the response and covariates as a Dirichlet process mixture. An appealing aspect of this approach is that computations are relatively easy. In this paper, we examine the predictive performance of these models with an increasing number of covariates. Even for a moderate number of covariates, we find that the likelihood for x tends to dominate the posterior of the latent random partition, degrading the predictive performance of the model. To overcome this, we suggest using a different nonparametric prior, namely an enriched Dirichlet process. Our proposal maintains a simple allocation rule, so that computations remain relatively simple. Advantages are shown through both predictive equations and examples, including an application to diagnosis Alzheimer's disease

Micro-CT investigation of garnet-spinel clusters in mantle peridotite xenoliths

We have investigated the origin of garnet in garnet-spinel peridotite mantle xenoliths from two well known localities, Pali-Aike (Patagonia) and Vitim (Siberia). We used micro-CT scanning to examine the textures of garnet-spinel clusters and the relationship between garnet and spinel. CT scanning yields different mineral modes in terms of spinel and garnet than observed in thin-section, because distribution of these phases is inhomogeneous, and a larger volume is visible in a CT scan than in a thin section. We conclude that garnet formed after spinel in both localities, but the xenoliths record a complex tectonic history, in which the original garnets in garnet peridotites were transformed to spinel pyroxene clusters in spinel peridotites, via lithospheric thinning. This stage was followed by deformation of the spinel peridotites, producing a lineation. A final stage of isobaric cooling caused garnet to re-grow around the spinel clusters. Aspect ratios of garnets differ from those of garnet-spinel clusters; the latter are more similar to those of spinel pyroxene clusters. Kelyphite is a secondary feature resulting from heating and rapid decompression during entrainment in the host alkali basaltic lavas and has no relationship with the formation of the garnet-spinel clusters