15 research outputs found

    An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma

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    Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare. We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology. A painless, erythematous skin nodule of about 7 mm diameter was removed from the scalp and diagnosed as a metastasis from thyroid cancer. After total thyroidectomy, a histological diagnosis of follicular thyroid cancer was made. Two cycles of radioactive iodine were performed. Both the follicular thyroid carcinoma and the metastasis were investigated for the presence of BRAF/RAS and TERT promoter mutations. The results showed that the cutaneous metastasis was BRAF wild-type and TERT promoter-mutated (position g.1,295,228 C>T); in contrast, the primary thyroid lesion was negative for both molecular markers

    Artefatti e beni culturali dotati di senso: il condominio solidale di Villapizzone.

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    Case study per la valorizzazione dei beni culturali prodotto su C

    Evaluation of wear in rolling contact tests by means of 2D image analysis

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    Twin-disk tests are an effective method to characterize the material response to rolling sliding contact, to reproduce the damage phenomena of real components at a laboratory scale in controlled working conditions. Usually the monitoring is performed by means of “gross” parameters, such as weight loss, coefficient of friction and Barkhausen noise, and micrographs of the sample sections, at the end of the test. Visual inspection of the sample contact surface at the macro-scale yields further information about the process under analysis. In twin-disk tests, the samples are visually inspected at predetermined steps, typically by acquiring the image of their surface when the samples are stationary. The availability of a system able to capture the images of the samples while they roll during the tests is of interest to better monitor the damage evolution. In this paper, we present the results of the experiments carried out to extract quantitative information from the images captured on railway wheel samples during rolling contact tests: suitable image processing has been designed with the objective of finding meaningful, synthetic indices for the monitoring and the interpretation of the wear process, also in relation to prior knowledge about the process. The experimental work was focused on the definition of the indices, on the analysis of their behavior on different steels, and on their usefulness to predict uneven wear during the tests on the test bench
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