641 research outputs found
Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma
Burkitt lymphoma (BL) is a very aggressive subtype of non-Hodgkin's lymphoma that occurs with higher frequency in patients with HIV/AIDS. Patients with HIV-related BL (HIV-BL) are usually treated with high-intensity, multi-agent chemotherapy regimens. The addition of the monoclonal antibody Rituximab to chemotherapy has also been studied in this setting. The potential risks and benefits of commonly used regimens are reviewed herein, along with a discussion of controversial issues in the practical management of HIV-BL, including concurrent anti-retroviral therapy, treatment of relapsed and/or refractory disease, and the role of stem cell transplantation
Equilibrium solutions of the shallow water equations
A statistical method for calculating equilibrium solutions of the shallow
water equations, a model of essentially 2-d fluid flow with a free surface, is
described. The model contains a competing acoustic turbulent {\it direct}
energy cascade, and a 2-d turbulent {\it inverse} energy cascade. It is shown,
nonetheless that, just as in the corresponding theory of the inviscid Euler
equation, the infinite number of conserved quantities constrain the flow
sufficiently to produce nontrivial large-scale vortex structures which are
solutions to a set of explicitly derived coupled nonlinear partial differential
equations.Comment: 4 pages, no figures. Submitted to Physical Review Letter
Complex Patterns in Reaction-Diffusion Systems: A Tale of Two Front Instabilities
Two front instabilities in a reaction-diffusion system are shown to lead to
the formation of complex patterns. The first is an instability to transverse
modulations that drives the formation of labyrinthine patterns. The second is a
Nonequilibrium Ising-Bloch (NIB) bifurcation that renders a stationary planar
front unstable and gives rise to a pair of counterpropagating fronts. Near the
NIB bifurcation the relation of the front velocity to curvature is highly
nonlinear and transitions between counterpropagating fronts become feasible.
Nonuniformly curved fronts may undergo local front transitions that nucleate
spiral-vortex pairs. These nucleation events provide the ingredient needed to
initiate spot splitting and spiral turbulence. Similar spatio-temporal
processes have been observed recently in the ferrocyanide-iodate-sulfite
reaction.Comment: Text: 14 pages compressed Postscript (90kb) Figures: 9 pages
compressed Postscript (368kb
Inverse monoids and immersions of 2-complexes
It is well known that under mild conditions on a connected topological space
, connected covers of may be classified via conjugacy
classes of subgroups of the fundamental group of . In this paper,
we extend these results to the study of immersions into 2-dimensional
CW-complexes. An immersion between
CW-complexes is a cellular map such that each point has a
neighborhood that is mapped homeomorphically onto by . In order
to classify immersions into a 2-dimensional CW-complex , we need to
replace the fundamental group of by an appropriate inverse monoid.
We show how conjugacy classes of the closed inverse submonoids of this inverse
monoid may be used to classify connected immersions into the complex
Local Spin-Gauge Symmetry of the Bose-Einstein Condensates in Atomic Gases
The Bose-Einstein condensates of alkali atomic gases are spinor fields with
local ``spin-gauge" symmetry. This symmetry is manifested by a superfluid
velocity (or gauge field) generated by the Berry phase of the
spin field. In ``static" traps, splits the degeneracy of the
harmonic energy levels, breaks the inversion symmetry of the vortex nucleation
frequency , and can lead to {\em vortex ground states}. The
inversion symmetry of , however, is not broken in ``dynamic"
traps. Rotations of the atom cloud can be generated by adiabatic effects
without physically rotating the entire trap.Comment: Typos in the previous version corrected, thanks to the careful
reading of Daniel L. Cox. 13 pages + 2 Figures in uuencode + gzip for
Effect of daptomycin and vancomycin on Staphylococcus epidermidis biofilms: An in vitro assessment using fluorescence in situ hybridization
Colonization of in-dwelling catheters by microbial biofilms is a major concern in patient health eventually leading to catheter-related blood stream infections. Biofilms are less susceptible to standard antibiotic therapies that are effective against planktonic bacteria. Standard procedure for the detection of microorganisms on the catheter tip is culture. However, viable but non-culturable cells (VBNCs) may be missed. The aim of this study was to evaluate the use of fluorescence in situ hybridization (FISH) as an indicator to visualize and quantify the effect of the antibiotics daptomycin and vancomycin on biofilms in situ. We established an in vitro catheter biofilm model of Staphylococcus epidermidis biofilms on polyurethane catheters. Biofilm activity was measured by FISH and correlated to colony forming units (CFU) data. Digital image analysis was used for quantification of total biofilm mass and the area of the FISH positive biofilm cells. FISH showed a pronounced effect of both antibiotics on the biofilms, with daptomycin having a significantly stronger effect in terms of both reduction of biofilm mass and number of FISH-positive cells. This supports the anti-biofilm capacity of daptomycin. Interestingly, neither antibiotic was able to eradicate all of the FISH-positive cells. In summary, FISH succeeded in visualization, quantification, and localization of antibiotic activity on biofilms. This technique adds a new tool to the arsenal of test systems for anti-biofilm compounds. FISH is a valuable complementary technique to CFU since it can be highly standardized and provides information on biofilm architecture and quantity and localization of survivor cells
Critical collapse of collisionless matter - a numerical investigation
In recent years the threshold of black hole formation in spherically
symmetric gravitational collapse has been studied for a variety of matter
models. In this paper the corresponding issue is investigated for a matter
model significantly different from those considered so far in this context. We
study the transition from dispersion to black hole formation in the collapse of
collisionless matter when the initial data is scaled. This is done by means of
a numerical code similar to those commonly used in plasma physics. The result
is that for the initial data for which the solutions were computed, most of the
matter falls into the black hole whenever a black hole is formed. This results
in a discontinuity in the mass of the black hole at the onset of black hole
formation.Comment: 22 pages, LaTeX, 7 figures (ps-files, automatically included using
psfig
Observation of critical phenomena and self-similarity in the gravitational collapse of radiation fluid
We observe critical phenomena in spherical collapse of radiation fluid. A
sequence of spacetimes is numerically computed, containing
models () that adiabatically disperse and models () that
form a black hole. Near the critical point (), evolutions develop a
self-similar region within which collapse is balanced by a strong,
inward-moving rarefaction wave that holds constant as a function of a
self-similar coordinate . The self-similar solution is known and we show
near-critical evolutions asymptotically approaching it. A critical exponent
is found for supercritical () models.Comment: 10 pages (LaTeX) (to appear in Phys. Rev. Lett.), TAR-039-UN
Applying black hole perturbation theory to numerically generated spacetimes
Nonspherical perturbation theory has been necessary to understand the meaning
of radiation in spacetimes generated through fully nonlinear numerical
relativity. Recently, perturbation techniques have been found to be successful
for the time evolution of initial data found by nonlinear methods. Anticipating
that such an approach will prove useful in a variety of problems, we give here
both the practical steps, and a discussion of the underlying theory, for taking
numerically generated data on an initial hypersurface as initial value data and
extracting data that can be considered to be nonspherical perturbations.Comment: 14 pages, revtex3.0, 5 figure
From Labyrinthine Patterns to Spiral Turbulence
A new mechanism for spiral vortex nucleation in nongradient reaction
diffusion systems is proposed. It involves two key ingredients: An Ising-Bloch
type front bifurcation and an instability of a planar front to transverse
perturbations. Vortex nucleation by this mechanism plays an important role in
inducing a transition from labyrinthine patterns to spiral turbulence. PACS
numbers: 05.45.+b, 82.20.MjComment: 4 pages uuencoded compressed postscrip
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