Electrohydrodynamic behavior in twisted-wedge nematic structures

A new type of domain for nematic liquid crystals with a twisted-wedge structure is presented. This new type of domain appears from the low frequency range to 10 kHz. This behavior was observed for square and pulsed excitations. The liquid crystal was N-(p-methoxybenzylidene)-p'-butylaniline) (MBBA) used at room temperature. These domains offer a higher degree of complexity than conventional Williams domains. The corresponding stability chart is presented

The seasonal cycle of the greenhouse gas balance of a continental tundra site in the Indigirka lowlands, NE Siberia

International audienceCarbon dioxide and methane fluxes were measured at a tundra site near Chokurdakh, in the lowlands of the Indigirka river in north-east Siberia. This site is one of the few stations on Russian tundra and it is different from most other tundra flux stations in its continentality. A suite of methods was applied to determine the fluxes of NEE, GPP, Reco and methane, including eddy covariance, chambers and leaf cuvettes. Net carbon dioxide fluxes were unusually high, compared with other tundra sites, with NEE=?92 g C m?2 yr?1, which is composed of an Reco=+141 g C m?2 yr?1 and GPP=?232 g C m?2 yr?1. This large carbon dioxide sink may be explained by the continental climate, that is reflected in low winter soil temperatures (?14°C), reducing the respiration rates, and short, relatively warm summers, stimulating high photosynthesis rates. Interannual variability in GPP was dominated by the frequency of light limitation (Rg ?2), whereas Reco depends most directly on soil temperature and time in the growing season, which serves as a proxy of the combined effects of active layer depth, leaf area index, soil moisture and substrate availability. The methane flux, in units of global warming potential, was +28 g C-CO2e m?2 yr?1, so that the greenhouse gas balance was ?64 g C-CO2e m?2 yr?1. Methane fluxes depended only slightly on soil temperature and were highly sensitive to hydrological conditions and vegetation composition

Multipartite Entanglement in Rabi Driven Superconducting Qubits

Exploring highly connected networks of qubits is invaluable for implementing various quantum algorithms and simulations as it allows for entangling qubits with reduced circuit depth. Here, we demonstrate a multi-qubit STAR (Sideband Tone Assisted Rabi driven) gate. Our scheme is inspired by the ion qubit M{\o}lmer-S{\o}rensen gate and is mediated by a shared photonic mode and Rabi-driven superconducting qubits, which relaxes restrictions on qubit frequencies during fabrication and supports scalability. We achieve a two-qubit gate with maximum state fidelity of 0.95 in 310 ns, a three-qubit gate with state fidelity 0.905 in 217 ns, and a four-qubit gate with state fidelity 0.66 in 200 ns. Furthermore, we develop a model of the gate that show the four-qubit gate is limited by shared resonator losses and the spread of qubit-resonator couplings, which must be addressed to reach high-fidelity operations.Comment: 16 pages, 14 figure

A Case-base Approach to Workforces’ Satisfaction Assessment

It is well known that human resources play a valuable role in a sustainable organizational development. Indeed, this work will focus on the development of a decision support system to assess workers’ satisfaction based on factors related to human resources management practices. The framework is built on top of a Logic Programming approach to Knowledge Representation and Reasoning, complemented with a Case Based approach to computing. The proposed solution is unique in itself, once it caters for the explicit treatment of incomplete, unknown, or even self-contradictory information, either in terms of a qualitative or quantitative setting. Furthermore, clustering methods based on similarity analysis among cases were used to distinguish and aggregate collections of historical data or knowledge in order to reduce the search space, therefore enhancing the cases retrieval and the overall computational process

C-Terminus Glycans with Critical Functional Role in the Maturation of Secretory Glycoproteins

The N-glycans of membrane glycoproteins are mainly exposed to the extracellular space. Human tyrosinase is a transmembrane glycoprotein with six or seven bulky N-glycans exposed towards the lumen of subcellular organelles. The central active site region of human tyrosinase is modeled here within less than 2.5 Å accuracy starting from Streptomyces castaneoglobisporus tyrosinase. The model accounts for the last five C-terminus glycosylation sites of which four are occupied and indicates that these cluster in two pairs - one in close vicinity to the active site and the other on the opposite side. We have analyzed and compared the roles of all tyrosinase N-glycans during tyrosinase processing with a special focus on the proximal to the active site N-glycans, s6:N337 and s7:N371, versus s3:N161 and s4:N230 which decorate the opposite side of the domain. To this end, we have constructed mutants of human tyrosinase in which its seven N-glycosylation sites were deleted. Ablation of the s6:N337 and s7:N371 sites arrests the post-translational productive folding process resulting in terminally misfolded mutants subjected to degradation through the mannosidase driven ERAD pathway. In contrast, single mutants of the other five N-glycans located either opposite to the active site or into the N-terminus Cys1 extension of tyrosinase are temperature-sensitive mutants and recover enzymatic activity at the permissive temperature of 31°C. Sites s3 and s4 display selective calreticulin binding properties. The C-terminus sites s7 and s6 are critical for the endoplasmic reticulum retention and intracellular disposal. Results herein suggest that individual N-glycan location is critical for the stability, regional folding control and secretion of human tyrosinase and explains some tyrosinase gene missense mutations associated with oculocutaneous albinism type I

Composition and distribution of the peracarid crustacean fauna along a latitudinal transect off Victoria Land (Ross Sea, Antarctica) with special emphasis on the Cumacea

The following study was the first to describe composition and structure of the peracarid fauna systematically along a latitudinal transect off Victoria Land (Ross Sea, Antarctica). During the 19th Antarctic expedition of the Italian research vessel “Italica” in February 2004, macrobenthic samples were collected by means of a Rauschert dredge with a mesh size of 500 m at depths between 85 and 515 m. The composition of peracarid crustaceans, especially Cumacea was investigated. Peracarida contributed 63% to the total abundance of the fauna. The peracarid samples were dominated by amphipods (66%), whereas cumaceans were represented with 7%. Previously, only 13 cumacean species were known, now the number of species recorded from the Ross Sea increased to 34. Thus, the cumacean fauna of the Ross Sea, which was regarded as the poorest in terms of species richness, has to be considered as equivalent to that of other high Antarctic areas. Most important cumacean families concerning abundance and species richness were Leuconidae, Nannastacidae, and Diastylidae. Cumacean diversity was lowest at the northernmost area (Cape Adare). At the area off Coulman Island, which is characterized by muddy sediment, diversity was highest. Diversity and species number were higher at the deeper stations and abundance increased with latitude. A review of the bathymetric distribution of the Cumacea from the Ross Sea reveals that most species distribute across the Antarctic continental shelf and slope. So far, only few deep-sea records justify the assumption of a shallow-water–deep-sea relationship in some species of Ross Sea Cumacea, which is discussed from an evolutionary point of view

Creativity, play and transgression: children transforming spatial design

Spatial designers, who engage children in their design process, most often frame children in this context as experts in their own lives. Findings from a study based at the University of Sheffield, point to new understandings of this participatory role, in which children move towards the role of designer. Drawing on interviews including visual methods with 16 spatial designers and guided by phenemonography, the paper seeks to represent the designers’ perspectives on the under-explored area of child–designer interactions. Findings suggest that the designers understand these interactions to comprise a reciprocal and co-created space – a sphere of behaviours, actions and ways of being which together becomes an enabler of change. It is proposed that what Bhabha (The Location of Culture, 1994) refers to as a ‘Third Space’ in which the ‘dominant culture might be temporarily subverted and its structural systems of power and control renegotiated’ can be re-imagined in this co-design context. The paper weaves together theoretical discourse and empirical illustrations of perceived creativity, play and transgression, which – at their intersection – support a potential transformation of understandings of children as co-designers and of the design process itself

Prototyping open digital tools for urban commoning

The paper will discuss an experimental co-design approach to the development of a digital toolkit prototype and a resulting set of co-design principles, which are put forward as a way of infrastructuring future design of digital tools for urban commoning. Focus is placed on the case study of a commoning hub in a Parisian suburb where the toolkit was co-designed through a series of prototyping workshops, carried out with hub users and addressing key hub needs. The prototyping process explored possibilities for re-appropriating and re-framing existing digital technologies as open toolkits, which can be further re-purposed by users, here and beyond, after the design of an initial toolkit prototype