Epidemiology

Epidemiology 2nd edition is a methodological and practical guide to conducting evidence-based quantitative research in all health sciences. With a multidisciplinary focus, it integrates a wealth of case studies and examples to demonstrate the application of theory to real-life research and draws from a broad spectrum of health disciplines. The book follows a two level 'methods based' approach which clearly differentiates between introductory knowledge that all students of epidemiology should be familiar with and 'beyond the basics' information for the interested or more advanced reader. Each chapter includes tips, key definitions and critical thinking exercises to help readers engage with key concepts and extend their knowledge of epidemiological methodologies

Epidemiology

Epidemiology is a methodological, well grounded and versatile tool-kit to conduct evidence-based quantitative research in all health sciences. It integrates a wide spectrum of case studies and examples from the different disciplines thereby fostering the multi-disciplinary approach in the health sciences. It follows a two level 'methods based' approach differentiating between "basic" knowledge that all students of epidemiology should be familiar with and "beyond the basics" information for the interested or more advanced reader

Brennglas Corona

BRENNGLAS CORONA Brennglas Corona / Reinhold, Sonja (Rights reserved) ( -

Electronic nose responses and acute phase proteins correlate in blood using a bovine respiratory infection

This study aimed (i) to assess the ability of electronic nose (e-nose) technology to differentiate between blood samples of experimentally infected and non-infected subjects, and (ii) to evaluate e-nose responses given by volatile organic compounds in relation to the acute phase reaction generated in the host. In an animal model of gram-negative bacterial infection (20 calves; intratracheal inoculation of Mannheimia haemolytica A1), the concentrations of the acute phase proteins (APPs; i.e. lipopolysaccharide binding protein and haptoglobin) were measured in serum samples before and after challenge, and headspaces of pre- and post-inoculation serum samples were analysed using a conducting polymer based e-nose. Significant changes of certain e-nose sensor responses allowed discrimination between samples before and after challenge. The maximal changes in responses of sensitive e-nose sensors corresponded to the peak of clinical signs. Significant correlations linked decreasing responses of multiple e-nose sensors to increasing concentrations of APPs in the peripheral blood

Investigating Speaker Embedding Disentanglement on Natural Read Speech

Disentanglement is the task of learning representations that identify and separate factors that explain the variation observed in data. Disentangled representations are useful to increase the generalizability, explainability, and fairness of data-driven models. Only little is known about how well such disentanglement works for speech representations. A major challenge when tackling disentanglement for speech representations are the unknown generative factors underlying the speech signal. In this work, we investigate to what degree speech representations encoding speaker identity can be disentangled. To quantify disentanglement, we identify acoustic features that are highly speaker-variant and can serve as proxies for the factors of variation underlying speech. We find that disentanglement of the speaker embedding is limited when trained with standard objectives promoting disentanglement but can be improved over vanilla representation learning to some extent.Comment: To be published at 15th ITG conference on speech communicatio

Regeneration of Pulmonary Tissue in a Calf Model of Fibrinonecrotic Bronchopneumonia Induced by Experimental Infection with Chlamydia psittaci

Pneumonia is a cause of high morbidity and mortality in humans. Animal models are indispensable to investigate the complex cellular interactions during lung injury and repair in vivo. The time sequence of lesion development and regeneration is described after endobronchial inoculation of calves with Chlamydia psittaci. Calves were necropsied 2–37 days after inoculation (dpi). Lesions and presence of Chlamydia psittaci were investigated using histology and immunohistochemistry. Calves developed bronchopneumonia at the sites of inoculation. Initially, Chlamydia psittaci replicated in type 1 alveolar epithelial cells followed by an influx of neutrophils, vascular leakage, fibrinous exudation, thrombosis and lobular pulmonary necrosis. Lesions were most extensive at 4 dpi. Beginning at 7 dpi, the number of chlamydial inclusions declined and proliferation of cuboidal alveolar epithelial cells and sprouting of capillaries were seen at the periphery of necrotic tissue. At 14 dpi, most of the necrosis had been replaced with alveoli lined with cuboidal epithelial cells resembling type 2 alveolar epithelial cells and mild fibrosis, and hyperplasia of organized lymphoid tissue were observed. At 37 dpi, regeneration of pulmonary tissue was nearly complete and only small foci of remodeling remained. The well-defined time course of development and regeneration of necrotizing pneumonia allows correlation of morphological findings with clinical data or treatment regimen

On Feature Importance and Interpretability of Speaker Representations

Unsupervised speech disentanglement aims at separating fast varying from slowly varying components of a speech signal. In this contribution, we take a closer look at the embedding vector representing the slowly varying signal components, commonly named the speaker embedding vector. We ask, which properties of a speaker's voice are captured and investigate to which extent do individual embedding vector components sign responsible for them, using the concept of Shapley values. Our findings show that certain speaker-specific acoustic-phonetic properties can be fairly well predicted from the speaker embedding, while the investigated more abstract voice quality features cannot.Comment: Presented at the ITG conference on Speech Communication 202

Evaluation of a Respiration Rate Sensor for Recording Tidal Volume in Calves under Field Conditions

In the assessment of pulmonary function in health and disease, both respiration rate (RR) and tidal volume (Vt) are fundamental parameters of spontaneous breathing. The aim of this study was to evaluate whether an RR sensor, which was previously developed for cattle, is suitable for additional measurements of Vt in calves. This new method would offer the opportunity to measure Vt continuously in freely moving animals. To measure Vt noninvasively, the application of a Lilly-type pneumotachograph implanted in the impulse oscillometry system (IOS) was used as the gold standard method. For this purpose, we applied both measuring devices in different orders successively, for 2 days on 10 healthy calves. However, the Vt equivalent (RR sensor) could not be converted into a true volume in mL or L. For a reliable recording of the Vt equivalent, a technical revision of the RR sensor excluding artifacts is required. In conclusion, converting the pressure signal of the RR sensor into a flow equivalent, and subsequently into a volume equivalent, by a comprehensive analysis, provides the basis for further improvement of the measuring system