Machinery used for drop forging

Bakalářská práce obsahuje rozdělení a přehled strojů používaných v procesu zápustkového kování a jejich moderních inovací. U jednotlivých mechanismů je popsán princip, konstrukční uspořádání a jeho výhody nebo nevýhody, popřípadě i příklad používaného stroje, u kterého je popsána jeho charakteristika, základní parametry a možnosti výroby s příkladem zhotovených výkovků.The bachelor thesis contains distribution and overview of the machines used in the proces of die forging and their modern innovation. For individual mechanism is described principle, structural arrangements and advantages or disadvantages, or the example of used machine for which is described his charaterisctic, basic parameters and productions possibilities with example of made forged.

Proposal of tool for the tines manufacturing

Abstrakt podléhá utajení.Abstract is secret.

Tepelný tok plazmatu na pevné struktury v tokamacích

Tepelný tok plazmatu na pevné struktury v tokamacích Petr Vondráček Odvod energie a částic z plazmatu je klíčovým tématem pro budoucí fúzní reaktory založené na principu magnetického udržení plazmatu, jmenovitě pro tokamaky. Zásadní oblastí pro fúzní výzkum je dobré porozumění procesům řídícím tepelné toky plazmatu dopadající na první stěnu tokamaků. Tato doktorská práce se zaměřuje na experimentální studium tepelných toků plazmatu v různých oblastech tokamaku COMPASS. Pro tyto účely byl v rámci doktorské práce vybudován nový infračervený termografický systém. Pomocí systému jsou studována čtyři hlavní témata. Za prvé je zkoumána úzká okrajová vrstva plazmatu s velice strmým profilem tepelného toku v plazmatických výbojích limitovaných na vnitřním sloupku tokamaku. Je ukázáno, že radiální tloušťka této vrstvy je konzistentní s modelem založeným na transportu částic plazmatu dominovaném drifty. Za druhé je podrobně studováno tepelné namáhání náběžných hran spár v limiterových deskách. Je domonstrováno, že rozložení tepelného toku okolo poloidálních hran je dobře popsáno pomocí optické aproximace. Též je poprvé experimentálně pozorováno tepelné namáhání magneticky stíněných stran toroidálních limiterových spár v souladu s výsledky particle-in-cell simulací. Za třetí jsou zkoumány lokalizované tepelné otisky...Plasma Heat Flux to Solid Structures in Tokamaks Petr Vondráček Energy and particle exhaust is the key issue for future fusion reactors based on magnetic plasma confinement, namely for tokamaks. Good understanding of processes controlling plasma heat fluxes impinging the first wall of tokamaks is of a main concern for fusion research. This doctoral thesis is focused on experimental investigation of plasma heat fluxes in different locations of the COMPASS tokamak. A new infrared thermography system was built for this purpose as a part of this PhD research. There are four main topics studied using the system. First of all, a narrow near-SOL heat flux channel with a very steep radial profile is characterised in HFS limited discharges. It is shown that the near-SOL heat flux decay length is consistent with the drift-based model of the SOL heat transport. Secondly, heat loading of leading edges of misaligned limiters is broadly studied. The optical approximation of the heat flux distribution around a poloidal leading edge is confirmed as a valid approach. Heat loading of a magnetically shadowed side of a toroidal limiter gap is observed experimentally for the first time confirming predictions of particle-in-cell code simulations. Thirdly, localised hot-spots caused by the impact of runaway electrons as well as...Katedra fyziky povrchů a plazmatuDepartment of Surface and Plasma ScienceMatematicko-fyzikální fakultaFaculty of Mathematics and Physic

Multifunctional House Brno - Holásky

Tato diplomová práce se zabývá návrhem novostavby polyfunkčního domu na jihovýchodním okraji Brna v městské čtvrti Holásky. Třípodlažní stavba kombinuje svojí funkcí účely bydlení, stomatologického centra a lékárny. Provozovny a prostory zázemí budovy jsou umístěny v přízemí. Celkem dvanáct bytových jednotek se nachází v nadzemních podlažích a jsou dispozičně koncipovány jako 2+kk a 3+kk. Navržený dům se dá geometricky definovat jako pravoúhlý lichoběžník a svým tvarem kopíruje trojúhelníkový tvar rovinaté stavební parcely. Parkování je řešeno kolmým stáním podél přilehlé komunikace. Obvodové stěny všech podlaží jsou z cihelných tvárnic Porotherm v tloušťce 500 mm s vloženou minerální izolací. Stropní konstrukce je řešena jako železobetonová deska, která je rozdělena do souboru menších křížem vyztužených desek. Objekt je zastřešen plochou střechou, na které jsou umístěny solární panely sloužící pro ohřev vody a snižující provozní náklady budovy. Snížení vlivu objektu na životní prostředí přispívá efektivní zacházení s dešťovou vodou, která je shromažďována a zpětně využívána. Architektonicky objekt působí kompaktně a tím redukuje celkovou energetickou náročnost. Práce obsahuje projektovou dokumentaci pro provádění stavby.This diploma thesis deals with design of new building multifunctional house in southeastern outskirts of Brno in urban district Holásky. The three-storey building combines purpose of permanent housing, stomatology center and pharmacy. Business premises and technical facilities are located on the ground floor. Overall twelve dwelling units with layout design as one-bedroom flat and two-bedroom flat are placed on above-ground floors. Designed building has rectangular trapezoid shape and copies triangle shape of flat building plot. Parking spaces are perpendicular to adjacent access road. External walls are made of 500 mm thick Porotherm hollow clay blocks with inserted mineral insulation. Ceiling structure is designed as reinforced concrete slab, which is divided into set of smaller two way slabs. Building is roofed with flat roof, on it are placed solar collectors used for water heating and reducing operating costs. Effective management of rainwater which is collected and reused helps decrease environmental impact of building. Total energy consumption of the building is reduced by building compactness. Thesis contains project documentation for the construction.

Family house in Čechočovice

Tato bakalářská práce řeší návrh rodinného domu v Čechočovicích v okrese Třebíč. Rodinný dům je navržen jako dvoupodlažní, částečně podsklepený objekt, zastřešen dvěmi pultovými střechami. Projekt vznikl za účelem návrhu trvalého bydlení pro 5člennou rodinu s možností dvou garážových stání. Obvodové stěny v suterénu jsou z keramických tvárnic systému Porotherm a zateplené extrudovaným polystyrenem. Obvodové stěny nadzemních podlaží jsou z cihelných tvárnic Porotherm s vloženou minerální izolací. Stropní konstrukce je řešena ze systému Porotherm. Parcela je v mírném sklonu. Součástí návrhu je tepelně technické posouzení, požárně bezpečnostní řešení a posouzení z hlediska akustiky a denního osvětlení. Práce obsahuje výkresovou a dokumentační část a je zpracována ve formě prováděcího projektu.This bachelor thesis deals with the design of a family house in Čechočovice in the district of Třebíč. The family house is designed as a two-storey, partially basement building, roofed by two ramps. The project was created for the purpose of designing a permanent home for a 5-member family with the possibility of two garage parking spaces. The perimeter walls in the basement are made of ceramic blocks of the Porotherm system and insulated with extruded polystyrene. The perimeter walls of the above floors are made of Porotherm brick blocks with embedded mineral insulation. The ceiling structure is designed from the Porotherm system. The plot is slightly inclined. Part of the proposal is thermal engineering assessment, fire safety solutions and assessment in terms of acoustics and daylight. The thesis contains a drawings and technical documentation and it is composed as an implementation project.

Generation of two Duchenne muscular dystrophy patient-specific induced pluripotent stem cell lines DMD02 and DMD03 (MUNIi001-A and MUNIi003-A)

Duchenne muscular dystrophy (DMD) affects 1:3500–5000 newborn boys and manifests with progressive skeletal muscle wasting, respiratory failure and eventual heart failure. Symptoms show different onset from patients' childhood to the second decade of age. We reprogrammed fibroblasts from two independent DMD patients with a complete loss of dystrophin expression, carrying deletions of exons 45–50 and 48–50. The resulting hiPSCs show expression of pluripotency markers (NANOG, OCT4, SSEA4), differentiation capacity into all three germ layers, normal karyotype, genetic identity to the originating parental fibroblasts and the patient-specific dystrophin mutation

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety ‘Mode of Action’ framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/ mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety ‘Mode of Action’ framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology

Plasma Heat Flux to Solid Structures in Tokamaks

Plasma Heat Flux to Solid Structures in Tokamaks Petr Vondráček Energy and particle exhaust is the key issue for future fusion reactors based on magnetic plasma confinement, namely for tokamaks. Good understanding of processes controlling plasma heat fluxes impinging the first wall of tokamaks is of a main concern for fusion research. This doctoral thesis is focused on experimental investigation of plasma heat fluxes in different locations of the COMPASS tokamak. A new infrared thermography system was built for this purpose as a part of this PhD research. There are four main topics studied using the system. First of all, a narrow near-SOL heat flux channel with a very steep radial profile is characterised in HFS limited discharges. It is shown that the near-SOL heat flux decay length is consistent with the drift-based model of the SOL heat transport. Secondly, heat loading of leading edges of misaligned limiters is broadly studied. The optical approximation of the heat flux distribution around a poloidal leading edge is confirmed as a valid approach. Heat loading of a magnetically shadowed side of a toroidal limiter gap is observed experimentally for the first time confirming predictions of particle-in-cell code simulations. Thirdly, localised hot-spots caused by the impact of runaway electrons as well as..

Parallel Heat Flux Decay Length Study in the COMPASS Tokamak Using MWIR and LWIR Cameras

A comprehensive study of a parallel heat flux in a tokamak scrape-off layer (SOL) has been performed in the COMPASS tokamak recently. Specially shaped high field side (HFS) limiter was used to estimate a heat flux radial decay length for small limiter radial misalignment. Long wavelength IR microbolometer and medium wavelength IR InSb camera were used for this purpose. This paper compares results obtained by the means of both cameras and demonstrates observation of very narrow heat flux decay length close to the last closed flux surface (LCFS) independantly on used camera