958 research outputs found

    Der unzuverlässige Narrator. Figuren-Erzählen in Thomas Manns Roman Doktor Faustus

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    Die Abhandlung zeigt an der neben der Ich-, der Du- und der Er-Form bisher noch unbeachtet gebliebenen vierten Erzählform, dem Figuren-Erzählen, dass der Narrator inkompetent, unzuverlässig, ja irreführend berichten kann und es dem Leser überlässt, über den Sinn seiner Erzählung zu entscheiden. Das gravierendste Beispiel für dieses Verfahren in der deutschen Literatur bildet Thomas Manns später Roman Doktor Faustus.The text offers the narration in the First, Second and Third person singular another yet undiscovered form: the character narration which leaves the narrator to report in incompetent, unreliable, even misleading ways and thus leaves it to the reader to decide on the meaning of his narrative. The most serious example for this procedure in German literature is Thomas Mann's late novel Doktor Faustus.El texto aporta otra forma narrativa aún no descubierta además de la primera, la segunda y la tercera persona del singular: la narración personal, que permite al narrador relatar de forma incompetente, poco fiable e incluso confusa, y que permite al lector decidir el significado de lo narrado. El mejor ejemplo de este procedimiento en el marco de la literatura alemana es la novela de Thomas Mann: Doktor Faustus.Die Abhandlung zeigt an der neben der Ich-, der Du- und der Er-Form bisher noch unbeachtet gebliebenen vierten Erzählform, dem Figuren-Erzählen, dass der Narrator inkompetent, unzuverlässig, ja irreführend berichten kann und es dem Leser überlässt, über den Sinn seiner Erzählung zu entscheiden. Das gravierendste Beispiel für dieses Verfahren in der deutschen Literatur bildet Thomas Manns später Roman Doktor Faustus

    Nova Geminorum 1912 and the Origin of the Idea of Gravitational Lensing

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    Einstein's early calculations of gravitational lensing, contained in a scratch notebook and dated to the spring of 1912, are reexamined. A hitherto unknown letter by Einstein suggests that he entertained the idea of explaining the phenomenon of new stars by gravitational lensing in the fall of 1915 much more seriously than was previously assumed. A reexamination of the relevant calculations by Einstein shows that, indeed, at least some of them most likely date from early October 1915. But in support of earlier historical interpretation of Einstein's notes, it is argued that the appearance of Nova Geminorum 1912 (DN Gem) in March 1912 may, in fact, provide a relevant context and motivation for Einstein's lensing calculations on the occasion of his first meeting with Erwin Freundlich during a visit in Berlin in April 1912. We also comment on the significance of Einstein's consideration of gravitational lensing in the fall of 1915 for the reconstruction of Einstein's final steps in his path towards general relativity.Comment: 31 p

    World Ocean Review 2015 : living with the oceans 3. Marine resources - opportunities and risks

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    The third issue of the World Ocean Review, WOR 3, is devoted to marine resources – metals and energy – and their utilization. It gives the facts about the extraction of known oil and gas deposits below the ocean floor and examines the impacts upon flora and fauna. It explains how gas hydrates form on continental shelves and what potential they hold. The review further explores in detail the opportunities and risks presented and posed by extracting mineral resources from the seabed: manganese nodules, cobalt crusts and massive sulphides

    World Ocean Review 2015 : Mit den Meeren leben 3. Rohstoffe aus dem Meer - Chancen und Risiken

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    Die dritte Ausgabe des „World Ocean Review“ widmet sich den metallischen und energetischen Ressourcen des Meeres und ihrer Nutzung. Er liefert Fakten über den Abbau der bekannten Öl- und Gasvorkommen unterhalb des Meeresbodens und beleuchtet die Auswirkungen auf Flora und Fauna. Er erklärt die Entstehung und Potenziale der Gashydratvorkommen an den Kontinentalrändern und liefert detaillierte Informationen über Chancen und Risiken der Nutzung mineralischer Rohstoffe: Manganknollen, Kobaltkrusten und Massivsulfide

    Deep-learning-based synthesis of post-contrast T1-weighted MRI for tumour response assessment in neuro-oncology:a multicentre, retrospective cohort study

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    International audienceBackground Gadolinium-based contrast agents (GBCAs) are widely used to enhance tissue contrast during MRI scans and play a crucial role in the management of patients with cancer. However, studies have shown gadolinium deposition in the brain after repeated GBCA administration with yet unknown clinical significance. We aimed to assess the feasibility and diagnostic value of synthetic post-contrast T1-weighted MRI generated from pre-contrast MRI sequences through deep convolutional neural networks (dCNN) for tumour response assessment in neuro-oncology. Methods In this multicentre, retrospective cohort study, we used MRI examinations to train and validate a dCNN for synthesising post-contrast T1-weighted sequences from pre-contrast T1-weighted, T2-weighted, and fluid-attenuated inversion recovery sequences. We used MRI scans with availability of these sequences from 775 patients with glioblastoma treated at Heidelberg University Hospital, Heidelberg, Germany (775 MRI examinations); 260 patients who participated in the phase 2 CORE trial (1083 MRI examinations, 59 institutions); and 505 patients who participated in the phase 3 CENTRIC trial (3147 MRI examinations, 149 institutions). Separate training runs to rank the importance of individual sequences and (for a subset) diffusion-weighted imaging were conducted. Independent testing was performed on MRI data from the phase 2 and phase 3 EORTC-26101 trial (521 patients, 1924 MRI examinations, 32 institutions). The similarity between synthetic and true contrast enhancement on post-contrast T1-weighted MRI was quantified using the structural similarity index measure (SSIM). Automated tumour segmentation and volumetric tumour response assessment based on synthetic versus true post-contrast T1-weighted sequences was performed in the EORTC-26101 trial and agreement was assessed with Kaplan-Meier plots. Interpretation Generating synthetic post-contrast T1-weighted MRI from pre-contrast MRI using dCNN is feasible and quantification of the contrast-enhancing tumour burden from synthetic post-contrast T1-weighted MRI allows assessment of the patient's response to treatment with no significant difference by comparison with true post-contrast T1-weighted sequences with administration of GBCAs. This finding could guide the application of dCNN in radiology to potentially reduce the necessity of GBCA administration
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