38 research outputs found
Missing killer immunoglobulin-like receptor (KIR) ligand confers protection from relapse in recipients of unrelated hematopoietic cell transplantation (HCT) for AML
Universal Role for HLA-C and KIR2Dl Ligand Mismatch in Severe Acute Graft-Versus-Host Disease After Unrelated Donor Hematopoietic Stem Cell Transplantation (U-HSCT) in Japanese and Caucasian Transplant Recipients: An Analysis on Behalf of International Histocompatibility Working Group in Hematopoietic Cell Transplantation
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Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation
Comparison of statistics in association tests of genetic markers for survival outcomes
Computationally efficient statistical tests are needed in association testing of large scale genetic markers for
survival outcomes. In this study, we explore several test statistics based on the Cox proportional hazards model
for survival data. First, we consider the classical partial likelihood-based Wald and score tests. A revised way to
compute the score statistics is explored to improve the computational efficiency. Next, we propose a Cox–Snell
residual-based score test, which allows us to handle the controlling variables more conveniently. We also
illustrated the incorporation of these three tests into a permutation procedure to adjust for the multiple testing.
In addition, we examine a simulation-based approach proposed by Lin (2005) to adjust for multiple testing.
We presented the comparison of these four statistics in terms of type I error, power, family-wise error rate,
and computational efficiency under various scenarios via extensive simulation
HLAs and risk of acute graft-vs.-host disease after marrow transplantation from an HLA-identical sibling
Missing killer immunoglobulin-like receptor (KIR) ligand confers protection from relapse in recipients of unrelated hematopoietic cell transplantation (HCT) for AML
ASSOCIATION BETWEEN CTL PRECURSOR FREQUENCY TO HLA-C MISMATCHES AND HLA-C ANTIGEN CELL SURFACE EXPRESSION
Transplantation and autoimmunit