Properties of Carbon-Oxygen White Dwarfs From Monte Carlo Stellar Models

We investigate properties of carbon-oxygen white dwarfs with respect to the composite uncertainties in the reaction rates using the stellar evolution toolkit, Modules for Experiments in Stellar Astrophysics (MESA) and the probability density functions in the reaction rate library STARLIB. These are the first Monte Carlo stellar evolution studies that use complete stellar models. Focusing on 3 M$_{\odot}$ models evolved from the pre main-sequence to the first thermal pulse, we survey the remnant core mass, composition, and structure properties as a function of 26 STARLIB reaction rates covering hydrogen and helium burning using a Principal Component Analysis and Spearman Rank-Order Correlation. Relative to the arithmetic mean value, we find the width of the 95\% confidence interval to be $\Delta M_{{\rm 1TP}}$ $\approx$ 0.019 M$_{\odot}$ for the core mass at the first thermal pulse, $\Delta$$t_{\rm{1TP}}$ $\approx$ 12.50 Myr for the age, $\Delta \log(T_{{\rm c}}/{\rm K}) \approx$ 0.013 for the central temperature, $\Delta \log(\rho_{{\rm c}}/{\rm g \ cm}^{-3}) \approx$ 0.060 for the central density, $\Delta Y_{\rm{e,c}} \approx$ 2.6$\times$10$^{-5}$ for the central electron fraction, $\Delta X_{\rm c}(^{22}\rm{Ne}) \approx$ 5.8$\times$10$^{-4}$, $\Delta X_{\rm c}(^{12}\rm{C}) \approx$ 0.392, and $\Delta X_{\rm c}(^{16}\rm{O}) \approx$ 0.392. Uncertainties in the experimental $^{12}$C($\alpha,\gamma)^{16}\rm{O}$, triple-$\alpha$, and $^{14}$N($p,\gamma)^{15}\rm{O}$ reaction rates dominate these variations. We also consider a grid of 1 to 6 M$_{\odot}$ models evolved from the pre main-sequence to the final white dwarf to probe the sensitivity of the initial-final mass relation to experimental uncertainties in the hydrogen and helium reaction rates.Comment: Accepted for publication in The Astrophysical Journal; 19 Pages, 23 Figures, 5 Table

Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent

Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s). Most studies into virus entry have used cultured fibroblasts but since keratinocytes represent the primary entry site for HSV-1 infection in its human host, we initiated studies to characterize the entry pathway of HSV-1 into human keratinocytes. Electron microscopy studies visualized free capsids in the cytoplasm and enveloped virus particles in vesicles suggesting viral uptake both by direct fusion at the plasma membrane and by endocytic vesicles. The ratio of the two entry modes differed in primary human keratinocytes and in the keratinocyte cell line HaCaT. Inhibitor studies further support a role for endocytosis during HSV-1 entry. Infection was inhibited by the cholesterol-sequestering drug methyl-beta-cyclodextrin, which demonstrates the requirement for host cholesterol during virus entry. Since the dynamin-specific inhibitor dynasore and overexpression of a dominant-negative dynamin mutant blocked infection, we conclude that the entry pathways into keratinocytes are dynamin-mediated. Electron microscopy studies confirmed that virus uptake is completely blocked when the GTPase activity of dynamin is inhibited. Ex vivo infection of murine epidermis that was treated with dynasore further supports the essential role of dynamin during entry into the epithelium. Thus, we conclude that HSV-1 can enter human keratinocytes by alternative entry pathways that require dynamin and host cholesterol

Energy estimation of cosmic rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30–80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy—corrected for geometrical effects—is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal

Energy estimation of cosmic rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30–80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy—corrected for geometrical effects—is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal

Sum Rules for Magnetic Moments and Polarizabilities in QED and Chiral Effective-Field Theory

We elaborate on a recently proposed extension of the Gerasimov-Drell-Hearn (GDH) sum rule which is achieved by taking derivatives with respect to the anomalous magnetic moment. The new sum rule features a {\it linear} relation between the anomalous magnetic moment and the dispersion integral over a cross-section quantity. We find some analogy of the linearized form of the GDH sum rule with the `sideways dispersion relations'. As an example, we apply the linear sum rule to reproduce the famous Schwinger's correction to the magnetic moment in QED from a tree-level cross-section calculation and outline the procedure for computing the two-loop correction from a one-loop cross-section calculation. The polarizabilities of the electron in QED are considered as well by using the other forward-Compton-scattering sum rules. We also employ the sum rules to study the magnetic moment and polarizabilities of the nucleon in a relativistic chiral EFT framework. In particular we investigate the chiral extrapolation of these quantities.Comment: 24 pages, 7 figures; several additions, published versio

DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy

Abstract DNA lesions resulting from impaired progression of replication forks are implicated in genetic instability and tumorigenesis. Because the cellular response to these lesions poses an important tumorigenesis barrier, the responsible signalling and repair pathways are often mutated or inactive in tumours. Here, we discuss how such deficiencies can in turn be exploited for cancer therapy. Replication-associated lesions During every round of DNA replication, moving replication forks encounter countless obstacles and lesions on the DNA template, such as DNA-bound proteins, difficult to replicate secondary structures or unrepaired DNA damage Replication-associated lesions in early tumorigenesis Recent studies suggest the existence of tumorigenesis barriers that slow or inhibit the progression of pre-neoplastic lesions to neoplasia (tumours). One such barrier involves oncogene-induced DNA replication stress. This replication stress leads to activation of DNA damage response pathways involving the ATM (ataxia telangiectasia mutated)-Chk2 (checkpoint kinase 2) and the ATR (ataxia telangiectasia mutated-and Rad3-related)-Chk1 signalling cascades, arrest in S-and G 2 -phases of the cell cycle and apoptosis. The activation of the DNA damage response precedes genomic instability in tumour developmen

Making or breaking climate targets: The AMPERE study on staged accession scenarios for climate policy

This study explores a situation of staged accession to a global climate policy regime from the current situation of regionally fragmented and moderate climate action. The analysis is based on scenarios in which a front runner coalition -- the EU or the EU and China -- embarks on immediate ambitious climate action while the rest of the world makes a transition to a global climate regime between 2030 and 2050. We assume that the ensuing regime involves strong mitigation efforts but does not require late joiners to compensate for their initially higher emissions. Thus, climate targets are relaxed, and although staged accession can achieve significant reductions of global warming, the resulting climate outcome is unlikely to be consistent with the goal of limiting global warming to 2 degrees. The addition of China to the front runner coalition can reduce pre-2050 excess emissions by 20.30%, increasing the likelihood of staying below 2 degrees. Not accounting for potential co-benefits, the cost of front runner action is found to be lower for the EU than for China. Regions that delay their accession to the climate regime face a trade-off between reduced short term costs and higher transitional requirements due to larger carbon lock-ins and more rapidly increasing carbon prices during the accession period

Homoleptic complexes of a porphyrinatozinc(II)-2,2’:6’,2’’-terpyridine ligand

Three homoleptic complexes containing the metalloligand 7-(4-([2,2′:6′,2′′-terpyridin]-4′-yl)phenyl)-5,10,15,20-tetraphenylporphyrinatozinc(II), 1, have been prepared. [Zn(1)2][PF6]2, [Fe(1)2][PF6]2 and [Ru(1)2][PF6]2 were characterized by 1H and 13C NMR spectroscopy and mass spectrometry, and the electrochemical and photophysical properties of the complexes have been investigated. In solution, each complex undergoes two reversible porphyrin-centred oxidation processes, with an additional reversible metal-centred oxidation for [Fe(1)2][PF6]2 and [Ru(1)2][PF6]2. Solution absorption spectra are dominated by the Soret and Q bands of the metalloligand 1. Spectroelectrochemical data for the complexes are presented. The results of a nanosecond transient absorption spectroscopic investigation of [Zn(1)2][PF6]2, [Fe(1)2][PF6]2 and [Ru(1)2][PF6]2 are presented. For [Zn(1)2][PF6]2, S1 excitation leads to an efficient intersystem-crossing to the T1 state, whilst for [Fe(1)2][PF6]2, excitation of the 1MLCT transition is followed by fast deactivation to the 3MC state followed by thermal decay to the ground state. Excitation of the 1MLCT transition of [Ru(1)2][PF6]2 results in an intersystem crossing to 3MLCT; triplet-to-triplet energy transfer occurs giving the [Zn(TPP)] T1 state which regenerates the ground state of the complex

Non-Linear I-V Characteristics of Double Schottky Barriers and Polycrystalline Semiconductors

An attempt to determine theoretically the highly non-linear current-voltage (I-V) characteristics of polycrystalline semiconductors, such as ZnO-based varistors, is made from the electrical properties of individual grain boundaries under dc bias. The role played by the fluctuations of double Schottky barrier heights at grain interfaces on driving electrical breakdown phenomena of macroscopic samples is pointed out in terms of a binary mixture model. An alternative trial form for the double Schottky barrier height is introduced to reproduce the breakdown voltage as well as the high non-linear coefficient alpha, where I propto V^{alpha}. ------------- Copies upon request to: [email protected]: CM-ICTP/92/1