Equality of P-partition generating functions

To every labeled poset (P,\omega), one can associate a quasisymmetric generating function for its (P,\omega)-partitions. We ask: when do two labeled posets have the same generating function? Since the special case corresponding to skew Schur function equality is still open, a complete classification of equality among (P,\omega) generating functions is likely too much to expect. Instead, we determine necessary conditions and separate sufficient conditions for two labeled posets to have equal generating functions. We conclude with a classification of all equalities for labeled posets with small numbers of linear extensions.Comment: 24 pages, 19 figures. Incorporates minor changes suggested by the referees. To appear in Annals of Combinatoric

Electron Transfer-oxy Radical Mechanism for Anti-cancer Agents: 9-anilinoacridines

A possible mode of action involving electron transfer is advanced for the 9- anilinoacridines. The mechanism entails formation of toxic oxy radicals which destroy the neoplasm. Cyclic voltammetry was performed on iminium type ions derived by protonation of the acridines. Reductions were generally reversible with potentials of about - 0.60 V. Involvement of quinoidal metabolites is also a possibility. The relationship of electrochemical behavior to structure and physiological activity is addressed

The Consequences of Polyandry for Sibship Structures, Distributions of Relationships and Relatedness, and Potential for Inbreeding in a Wild Population

We thank the Tsawout and Tseycum First Nations for access to Mandarte Island, Pirmin Nietlisbach, Lukas Keller, Greta Bocedi, Brad Duthie, and Matthew Wolak for helpful discussions, and the European Research Council, National Sciences and Engineering Research Council of Canada, and Swiss National Science Foundation for funding. Field data collected following UBC Animal Care Committee (A07-0309) and Environment Canada (Master banding permit 10596) guidelines.Peer reviewedPublisher PD

Anti-cancer Action of Metal Complexes: Electron Transfer and Oxidative Stress?

Evidence is presented in support of an electron transfer mechanism for various metal complexes possessing anti-neoplastic properties. Cyclic voltammetry was performed on several metallocenes, bis(acetato)bis(imidazole)Cu(II), and coordination compounds (Cu or Fe) of the anti-tumor agents, bipyridine, phenanthroline, hydroxyurea, diethyldithiocarbamate, and α, α1-bis(8-hydroxyquinolin-7-yl)-4-methoxytoluene. The favorable reduction potentials ranged from +0.5 to -0.5 V. Electrochemical behavior is correlated in some cases with structure and physiological activity. Relevant literature data are discussed

Using LaX scintillator in a new low-background Compton telescope

The ability of Compton telescopes to perform imaging and spectroscopy in space depends directly on the speed and energy resolution of the calorimeter detectors in the telescope. The calorimeter detectors flown on space-borne or balloon-borne Compton telescopes have included NaI(Tl), CsI(Na), HPGe and liquid organic scintillator. By employing LaX scintillators for the calorimeter, one can take advantage of the unique speed and resolving power of the material to improve the instrument sensitivity and simultaneously enhance its spectroscopic performance and thus its imaging performance. We present a concept for a space-borne Compton telescope that employs LaX as a calorimeter and estimate the improvement in sensitivity over past realizations of Compton telescopes. With some preliminary laboratory measurements, we estimate that in key energy bands, typically corrupted with neutron-induced internal nuclear emissions, this design enjoys a twenty-fold improvement in background rejection

Gas micro-well track imaging detectors for gamma-ray astronomy

We describe our program to develop gas micro-well detectors (MWDs) as three-dimensional charged particle trackers for use in advanced gamma-ray telescope concepts. A micro-well detector consists of an array of individual micro-patterned gas proportional counters opposite a planar drift electrode. The well anodes and cathodes may be connected in X and Y strips, respectively, to provide two-dimensional imaging. When combined with transient digitizer electronics, which record the time signature of the charge collected in the wells of each strip, full three-dimensional reconstruction of charged-particle tracks in large gas volumes is possible. Such detectors hold great promise for advanced Compton telescope (ACT) and advanced pair telescope (APT) concepts due to the very precise measurement of charged particle momenta that is possible (Compton recoil electrons and electron-positron pairs, respectively). We present preliminary lab results, including detector fabrication, prototype electronics, and initial detector testing. We also discuss applications to the ACT and APT mission concepts, based on GEANT3 and GEANT4 simulations

Position Resolution in LaBr3 and LaCl3 Scintillators Using Position-Sensitive Photomultiplier Tubes

Advanced scintillator materials such as LaBr3:Ce and LaCl3:Ce hold great promise for future hard X-ray and gamma-ray astrophysics missions due to their high density, high light output, good linearity, and fast decay times. Of particular importance for future space-based imaging instruments, such as coded-aperture telescopes, is the precise spatial location of individual gamma-ray interactions. We have investigated the position and energy resolution achievable within monolithic (5 cm × 5 cm × 1 cm) LaBr3:Ce and LaCl3:Ce crystals using position-sensitive light readout devices, including a position-sensitive photomultiplier tube and a multi-anode photomultiplier tube. We present the results of these tests and discuss the applicability of such advanced scintillators to future high-energy imaging astrophysics missions

Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents

The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm. Electrochemical studies were performed with some of the main types of agents: iminium ions (adenine iminium from alkylating species, iminium metabolite of 6-mercaptopurine, nitidine, other polynuclear iminiums) and metal complexes (Pt(II)diaquodiammine-guanosine, copper salicylaldoximes). Reduction potentials ranged from -0.4 to -1.2 V. Literature data for quinones are presented and radiation is discussed. Based on the theoretical framework, a rationale is offered for the carcinogen-anti-cancer paradox and the role of antioxidants