206 research outputs found

    ‘Has anyone here seen Amos?’ – re-establishing ‘prophetic imagination’ at the centre of religious education and formation

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    In 1989 Australian author and illustrator Bob Graham published a children’s book entitled Has anyone here seen William? This article seeks to construct a parallel narrative in relation to the category of the prophet, with a particular focus on the need to engage in prophetic imagination within the twin contexts of religious education (hereafter R.E.) and formation. In doing so it also makes reference to one of the archetypical biblical prophets - Amos. The article’s primary interlocutor is scripture scholar Walter Brueggemann (1982, 2002a, 2002b) who has written on topics as diverse as scripture exegesis and the theology of pain and homecoming. He has also written prominently on prophetic imagination, understood as the capacity to stand outside the dominant discourse or power structure of one’s day and critique it. As we will demonstrate throughout the article, Brueggemann’s scholarship in this area is complemented and refined through contact with the African-American philosopher Cornel West’s (1999) approach to prophetic critique, along with other commentators. Held together, both thinkers impel us to consider why teaching ‘about prophets’ needs to be complemented by an explicit cultivation of prophetic imagination, and how this might be seeded in crucial contexts such as religious education and formation. Following a brief introduction (part one) the second part explores the nature of the prophetic challenge. Part three focuses on recovery of the prophetic imagination, while part four examines ways to cultivate the prophetic imagination today. The final section considers conclusions and future directions in relation to topics raised throughout the paper

    Perioperative hazards in myotonic dystrophy

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    A 32-year-old man with myotonic dystrophy underwent a thoracotomy for removal of a mediastinal thymoma. Pre-operative examination revealed features of myotonic dystrophy, the only other abnormality was mild restrictive pulmonary disease. Anaesthesia was induced with thiopentone and maintained with enflurane, nitrous oxide, oxygen and curare. Following surgery, the patient was mechanically ventilated for several hours and remained intubated for 9 hours. The anaesthesia and surgery were tolerated well; however, postoperative complications included refractory dysrhythmias, hypoxia, pneumoccocal pneumonia and pulmonary emboli. More intensive preoperative pulmonary evaluation and physiotherapy coupled with more aggressive postoperative pulmonary care might have resulted in a smoother recovery phase.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75595/1/j.1365-2044.1980.tb03827.x.pd

    936-86 Plasma Fibrinogen Level Predicts Severity of Intimal Thickening After Cardiac Transplantation

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    Diffuse atherosclerosis is the primary reason for late graft failure after cardiac transplantation. Because there is increasing evidence that imbalances in the hemostatic and fibrinolytic pathways are associated with allogeneic rejection, we hypothesized that atherothrombotic risk factors may contribute to accelerated atherosclerosis. We therefore prospectively evaluated the burden of coronary atherosclerosis by intravascular ultrasound (IVUS) in 20 patients and measured plasma fibrinogen (FGN). lipoprotein (a) (Lp(a)) and net fibrinolytic activity of plasma using a standard fibrin plate assay. Intimal thickening was quantified using IVUS by measuring the intimal index (li=intimal area/[intimal area+luminal area]) in 2–5 segments of the LAD using planimetry. The maximal Ii per patient was calculated and indexed to the time post-transplant (Mxli/Yr). FGN predicted severity of Mxli/Yr (r2=0.41, p=0.008). In patients with decreased plasma fibrinolytic activity (lytic zone <100 mm2). Mxli/Yr was increased ten-fold (0.21±0.17 vs. 0.02±0.02, p=0.002). Because Lp(a) colocalizes with fibrinogen in the vessel wall and inhibits fibrinolysis, we correlated plasma Lp(a) levels with the degree of intimal thickening. Lp(a) did not predict Mxli/Yr (p=NS). In conclusion, these data suggest that plasma FGN and net fibrinolytic activity predict the degree of intimal thickening and that fibrin deposition may play an integral role in diffuse coronary atherosclerosis after cardiac transplantation

    On the scattering of longitudinal elastic waves from axisymmetric defects in coated pipes

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    This is the post-print version of the final paper published in Journal of Sound and Vibration. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2013 Elsevier B.V.Viscoelastic coatings are widely used to protect pipelines from their surrounding environment. These coatings are known to attenuate ultrasonic waves guided along the pipe walls, which may limit the range of a pulse/echo based inspection technique that seeks to detect defects in a pipeline. This article aims to investigate the attenuation of longitudinal modes in a coated pipe by comparing predicted and measured values for the reflection coefficient of an axisymmetric defect in a pipe coated with bitumen. This extends recent work undertaken by the authors for torsional modes, and also provides an independent investigation into the validity of those values proposed by the authors for the shear properties of bitumen, based on a comparison between prediction and experiment for torsional modes. Predictions are generated using a numerical mode matching approach for axially uniform defects, and a hybrid finite element based method for non-uniform defects. Values for the shear and longitudinal properties of bitumen are investigated and it is shown that the shear properties of the viscoelastic material play a dominant role in the propagation of longitudinal modes in a coated pipeline. Moreover, by using the shear values obtained from experiments on torsional modes, it is shown that good agreement between prediction and measurement for uniform and non-uniform defects may also be obtained for the longitudinal L(0,2) mode. This provides further validation for the shear bulk acoustic properties proposed for bitumen in the low ultrasonic frequency range, although in order to apply this methodology in general it is demonstrated that one must measure independently the reflection coefficient of both the torsional T(0,1) and the longitudinal L(0,2) mode before arriving at values for the shear properties of a viscoelastic material

    Highly syntenic regions in the genomes of soybean, Medicago truncatula, and Arabidopsis thaliana

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    BACKGROUND: Recent genome sequencing enables mega-base scale comparisons between related genomes. Comparisons between animals, plants, fungi, and bacteria demonstrate extensive synteny tempered by rearrangements. Within the legume plant family, glimpses of synteny have also been observed. Characterizing syntenic relationships in legumes is important in transferring knowledge from model legumes to crops that are important sources of protein, fixed nitrogen, and health-promoting compounds. RESULTS: We have uncovered two large soybean regions exhibiting synteny with M. truncatula and with a network of segmentally duplicated regions in Arabidopsis. In all, syntenic regions comprise over 500 predicted genes spanning 3 Mb. Up to 75% of soybean genes are colinear with M. truncatula, including one region in which 33 of 35 soybean predicted genes with database support are colinear to M. truncatula. In some regions, 60% of soybean genes share colinearity with a network of A. thaliana duplications. One region is especially interesting because this 500 kbp segment of soybean is syntenic to two paralogous regions in M. truncatula on different chromosomes. Phylogenetic analysis of individual genes within these regions demonstrates that one is orthologous to the soybean region, with which it also shows substantially denser synteny and significantly lower levels of synonymous nucleotide substitutions. The other M. truncatula region is inferred to be paralogous, presumably resulting from a duplication event preceding speciation. CONCLUSION: The presence of well-defined M. truncatula segments showing orthologous and paralogous relationships with soybean allows us to explore the evolution of contiguous genomic regions in the context of ancient genome duplication and speciation events

    Pneumocephalus after posterior fossa exploration in the sitting position

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    Entrainment of air following exploration of posterior cranial fossa in the sitting position was studied in five patients. Intracranial pressure was monitored through a ventriculostomy catheter after closure of the dura. In three patients nitrous oxide was added to the breathing mixture only after the baseline intracranial pressure had stabilised following closure of the dura. A marked rise in intracranial pressure was observed immediately. A rapid decrease in intracranial pressure occurred when nitrous oxide administration was stopped. Two patients were given nitrous oxide from the beginning. No change in intracranial pressure was noted. Computerised tomogram on the first postoperative day revealed a significant amount of air in eight cases.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72920/1/j.1365-2044.1982.tb01711.x.pd

    Attenuation of coronary vascular resistance by selective alpha1,-adrenergic blockade in patients with coronary artery disease

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    Alpha-adrenergic-mediated coronary vasoconstriction during stress such as cold pressor testing may contribute to myocardial ischemia by increasing coronary vascular resistance in patients with severe coronary artery disease. Nonselective alpha-receptor blockade with phen-tolamine abolishes both the peripheral and coronary vasoconstriction during cold pressor testing, but causes reflex tachycardia and increased inotropy. To determine the role of selective alpha1-receptor blockade, the changes in coronary vascular resistance during cold pressor testing were measured in 18 patients with coronary artery disease before and after intravenous administration of 100 mg of trimazosin. Cold pressor testing was performed at a constant paced subanginal heart rate of 95 ± 5 beats/min (± 1SD). Before trimazosin, cold pressor testing increased mean arterial pressure by 9 ± 4% (102 ± 14 to 111 ± 14 mm Hg, p < 0.001) with no change in coronary sinus blood flow, but significantly increased coronary vascular resistance by 15 ± 19% (1.02 ± 0.46 to 1.15 ± 0.57 units, p < 0.05). Five minutes after trimazosin, cold pressor testing increased mean arterial pressure by 6 ± 5% (p < 0.001) with a marked attenuation of the increase in coronary vascular resistance (6 ± 11%, p = NS), which was significantly less than before trimazosin (p < 0.02). Trimazosin did not increase plasma norepinephrine concentration at rest, suggesting that in the dosage used trimazosin caused selective alpha1-receptor blockade.These data suggest that although the hypertensive response to cold pressor testing is somewhat blunted by selective alpha1,-adrenoceptor blockade, the reflex coronary vasoconstriction during adrenergic stimulation in some patients with coronary artery disease can be significantly attenuated. Use of agents that block alpha2-adrenoceptors has been clinically unsatisfactory because of the adverse myocardial effects of increased norepinephrine release. Selective alpha1-receptor blockade may have an additional advantage over nonselective alpha-adrenergic blockade in that the release of norepinephrine is also attenuated, thus potentially producing less augmentation of heart rate and myocardial oxygen demand

    One-dimensional fluids with second nearest-neighbor interactions

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    As is well known, one-dimensional systems with interactions restricted to first nearest neighbors admit a full analytically exact statistical-mechanical solution. This is essentially due to the fact that the knowledge of the first nearest-neighbor probability distribution function, p1(r)p_1(r), is enough to determine the structural and thermodynamic properties of the system. On the other hand, if the interaction between second nearest-neighbor particles is turned on, the analytically exact solution is lost. Not only the knowledge of p1(r)p_1(r) is not sufficient anymore, but even its determination becomes a complex many-body problem. In this work we systematically explore different approximate solutions for one-dimensional second nearest-neighbor fluid models. We apply those approximations to the square-well and the attractive two-step pair potentials and compare them with Monte Carlo simulations, finding an excellent agreement.Comment: 26 pages, 12 figures; v2: more references adde

    Mixing across the Arctic Ocean : microstructure observations during the Beringia 2005 Expedition

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    Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 35 (2008): L08606, doi:10.1029/2008GL033532.Turbulent-scale temperature and conductivity were measured during the pan-arctic Beringia 2005 Expedition. The rates of dissipation of thermal variance and diapycnal diffusivities are calculated along a section from Alaska to the North Pole, across deep flat basins (Canada and Makarov Basins) and steep ridges (Alpha-Mendeleev and Lomonosov Ridges). The mixing rates are observed to be small relative to lower latitudes but also remarkably non-uniform. Relatively elevated turbulence is found over deep topography, confirming the dominant role of bottom-generated internal waves. Measured patterns of mixing in the Arctic are also associated with other mechanisms, such as double-diffusive structures and deep overflows. A better knowledge of the distribution of mixing is essential to understand the dynamics of the changing Arctic environment.This work was funded by the National Science Foundation through a Small Grant for Exploratory Research (ARC-0527874) and grant ARC-0612342 with additional support from the Doherty Foundation and internal WHOI Funds
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