Weekly variability of hydrography and transport of northwestern inflows into the northern North Sea

Quantifying the variability of North Sea inflows and understanding the temporal variability of their physical properties are essential for understanding, modelling and managing the ecosystems of the North Sea. The Joint North Sea Information System (JONSIS) line hydrographic section crosses the path of the main inflows of Atlantic water into the northwestern North Sea. We use observations from an autonomous underwater glider to observe the inflows at high spatial and temporal resolutions. The glider completed 10 partial sections of the JONSIS line in October and November of 2013. Key water masses of the inflow are identified; their spatial distribution varies greatly from section to section. This is not apparent from long-running ship surveys of the JONSIS line, which are generally several months apart. In particular, the distribution of water of most recent Atlantic origin varies as summer stratification decays throughout autumn: at the start of the deployment it is present as a thin layer beneath the thermocline; at the end of the deployment, it occupies the full depth of the water column. Thermohaline flow, i.e. that which is driven by horizontal density gradients, is focused into three or four jets (approximately 10 km wide). Jets as narrow as these have not previously been observed in the region. We also observe baroclinic eddies. The thermohaline transport of the inflows is compared with the absolute transport that is derived by referencing geostrophic shear to the glider's dive-average current. Thermohaline transport (approximately 0.2 Sv) is consistently smaller than absolute transport (approximately 0.5 Sv). The week-to-week variability in hydrography and flow structure identified in this study is relevant to on-going efforts to define a background state against which the nature of anthropogenic changes can be assessed, and future modelling efforts should represent the spatial and temporal variability that we have identified

Turbulent kinetic energy dissipation rate and associated fluxes in the western tropical Atlantic estimated from ocean glider observations

Ocean gliders enable us to collect the high-resolution microstructure observations necessary to calculate the dissipation rate of turbulent kinetic energy, ε, on timescales of weeks to months: far longer than is normally possible using traditional ship-based platforms. Slocum gliders have previously been used to this end; here, we report the first detailed estimates of ε calculated using the Batchelor spectrum method on observations collected by a FP07 fast thermistor mounted on a Seaglider. We use these same fast thermistor observations to calculate ε following the Thorpe scale method and find very good agreement between the two methods. The Thorpe scale method yields larger values of ε, but the average difference, which is less than an order of magnitude, is smaller than reported elsewhere. The spatio-temporal distribution of ε is comparable for both methods. Maximum values of ε (10−7 W kg−1) are observed in the surface mixed layer; values of approximately 10−9 W kg−1 are observed between approximately 200 and 500 m depth. These two layers are separated by a 100 m thick layer of low ε (10−10 W kg−1), which is co-located with a high-salinity layer of Subtropical Underwater and a peak in the strength of stratification. We calculate the turbulent heat and salt fluxes associated with the observed turbulence. Between 200 and 500 m, ε induces downward fluxes of both properties that, if typical of the annual average, would have a very small influence on the heat and salt content of the overlying salinity-maximum layer. We compare these turbulent fluxes with two estimates of double-diffusive fluxes that occur in regions susceptible to salt fingers, such as the western tropical Atlantic. We find that the double-diffusive fluxes of both heat and salt are larger than the corresponding turbulent fluxes

Ventilation of the Arabian Sea Oxygen Minimum Zone by Persian Gulf Water

Dense overflows from marginal seas are critical pathways of oxygen supply to the Arabian Sea oxygen minimum zone (OMZ), yet these remain inadequately understood. Climate models struggle to accurately reproduce the observed extent and intensity of the Arabian Sea OMZ due to their limited ability to capture processes smaller than their grid scale, such as dense overflows. Multi-month repeated sections by underwater gliders off the coast of Oman resolve the contribution of dense Persian Gulf Water (PGW) outflow to oxygen supply within the Arabian Sea OMZ. We characterize PGW properties, seasonality, transport and mixing mechanisms to explain local processes influencing water mass transformation and oxygen fluxes into the OMZ. Atmospheric forcing at the source region and eddy mesoscale activity in the Gulf of Oman control spatiotemporal variability of PGW as it flows along-shelf off the northern Omani coast. Subseasonally, it is modulated by stirring and shear-driven mixing driven by eddy-topography interactions. The oxygen transport from PGW to the OMZ is estimated to be 1.3 Tmol yr−1 over the observational period, with dramatic inter- and intra-annual variability (±1.6 Tmol yr−1). We show that this oxygen is supplied to the interior of the OMZ through the combined action of double-diffusive and shear-driven mixing. Intermittent shear-driven mixing enhances double-diffusive processes, with mechanical shear conditions (Ri < 0.25) prevailing 14% of the time at the oxycline. These findings enhance our understanding of fine-scale processes influencing oxygen dynamics within the OMZ that can provide insights for improved modeling and prediction efforts

Injection of oxygenated Persian Gulf Water into the southern Bay of Bengal

Persian Gulf Water (PGW) is an oxygenated, high-salinity water mass that has recently been detected in the Bay of Bengal (BoB). However, little is known about the transport pathways of PGW into the BoB. Ocean glider observations presented here demonstrate the presence of PGW in the southwestern BoB. Output from an ocean reanalysis product shows that this PGW signal is associated with a northward-flowing filament of high-salinity water. Particle tracking experiments reveal two pathways: one in the eastern Arabian Sea that takes a minimum of 2 years and another in the western Arabian Sea that takes a minimum of 3 years. The western pathway connects to the BoB via equatorial currents. The greatest influx of PGW occurs between 82° and 87°E during the southwest monsoon. We propose that injection of PGW to the BoB oxygen minimum zone (OMZ) contributes to keeping oxygen concentrations in the BoB above the level at which denitrification occurs

Muc5b Is the Major Polymeric Mucin in Mucus from Thoroughbred Horses With and Without Airway Mucus Accumulation

Mucus accumulation is a feature of inflammatory airway disease in the horse and has been associated with reduced performance in racehorses. In this study, we have analysed the two major airways gel-forming mucins Muc5b and Muc5ac in respect of their site of synthesis, their biochemical properties, and their amounts in mucus from healthy horses and from horses with signs of airway mucus accumulation. Polyclonal antisera directed against equine Muc5b and Muc5ac were raised and characterised. Immunohistochemical staining of normal equine trachea showed that Muc5ac and Muc5b are produced by cells in the submucosal glands, as well as surface epithelial goblet cells. Western blotting after agarose gel electrophoresis of airway mucus from healthy horses, and horses with mucus accumulation, was used to determine the amounts of these two mucins in tracheal wash samples. The results showed that in healthy horses Muc5b was the predominant mucin with small amounts of Muc5ac. The amounts of Muc5b and Muc5ac were both dramatically increased in samples collected from horses with high mucus scores as determined visually at the time of endoscopy and that this increase also correlated with increase number of bacteria present in the sample. The change in amount of Muc5b and Muc5ac indicates that Muc5b remains the most abundant mucin in mucus. In summary, we have developed mucin specific polyclonal antibodies, which have allowed us to show that there is a significant increase in Muc5b and Muc5ac in mucus accumulated in equine airways and these increases correlated with the numbers of bacteria

Individuals with Fear of Blushing Explicitly and Automatically Associate Blushing with Social Costs

To explain fear of blushing, it has been proposed that individuals with fear of blushing overestimate the social costs of their blushing. Current information-processing models emphasize the relevance of differentiating between more automatic and more explicit cognitions, as both types of cognitions may independently influence behavior. The present study tested whether individuals with fear of blushing expect blushing to have more negative social consequences than controls, both on an explicit level and on a more automatic level. Automatic associations between blushing and social costs were assessed in a treatment-seeking sample of individuals with fear of blushing who met DSM-IV criteria for social anxiety disorder (n = 49) and a non-anxious control group (n = 27) using a single-target Implicit Association Test (stIAT). In addition, participants’ explicit expectations about the social costs of their blushing were assessed. Individuals with fear of blushing showed stronger associations between blushing and negative outcomes, as indicated by both stIAT and self-report. The findings support the view that automatic and explicit associations between blushing and social costs may both help to enhance our understanding of the cognitive processes that underlie fear of blushing

Longitudinal peak strain detects a smaller risk area than visual assessment of wall motion in acute myocardial infarction

<p>Abstract</p> <p>Background</p> <p>Opening of an occluded infarct related artery reduces infarct size and improves survival in acute ST-elevation myocardial infarction (STEMI). In this study we performed tissue Doppler analysis (peak strain, displacement, mitral annular movement (MAM)) and compared with visual assessment for the study of the correlation of measurements of global, regional and segmental function with final infarct size and transmurality. In addition, myocardial risk area was determined and a prediction sought for the development of infarct transmurality ≥50%.</p> <p>Methods</p> <p>Twenty six patients with STEMI submitted for primary percutaneous coronary intervention (PCI) were examined with echocardiography on the catheterization table. Four to eight weeks later repeat echocardiography was performed for reassessment of function and magnetic resonance imaging for the determination of final infarct size and transmurality.</p> <p>Results</p> <p>On a global level, wall motion score index (WMSI), ejection fraction (EF), strain, and displacement all showed significant differences (p ≤ 0.001, p ≤ 0.001, p ≤ 0.001 and p = 0.03) between the two study visits, but MAM did not (p = 0.17). On all levels (global, regional and segmental) and both pre- and post PCI, WMSI showed a higher correlation with scar transmurality compared to strain. We found that both strain and WMSI predicted the development of scar transmurality ≥50%, but strain added no significant information to that obtained with WMSI in a logistic regression analysis.</p> <p>Conclusions</p> <p>In patients with acute STEMI, WMSI, EF, strain, and displacement showed significant changes between the pre- and post PCI exam. In a ROC-analysis, strain had 64% sensitivity at 80% specificity and WMSI around 90% sensitivity at 80% specificity for the detection of scar with transmurality ≥50% at follow-up.</p

Serum Uric Acid and Adiposity: Deciphering Causality Using a Bidirectional Mendelian Randomization Approach

Background: Although the relationship between serum uric acid (SUA) and adiposity is well established, the direction of the causality is still unclear in the presence of conflicting evidences. We used a bidirectional Mendelian randomization approach to explore the nature and direction of causality between SUA and adiposity in a population-based study of Caucasians aged 35 to 75 years. Methods and Findings: We used, as instrumental variables, rs6855911 within the SUA gene SLC2A9 in one direction, and combinations of SNPs within the adiposity genes FTO, MC4R and TMEM18 in the other direction. Adiposity markers included weight, body mass index, waist circumference and fat mass. We applied a two-stage least squares regression: a regression of SUA/adiposity markers on our instruments in the first stage and a regression of the response of interest on the fitted values from the first stage regression in the second stage. SUA explained by the SLC2A9 instrument was not associated to fat mass (regression coefficient [95 % confidence interval]: 0.05 [20.10, 0.19] for fat mass) contrasting with the ordinary least square estimate (0.37 [0.34, 0.40]). By contrast, fat mass explained by genetic variants of the FTO, MC4R and TMEM18 genes was positively and significantly associated to SUA (0.31 [0.01, 0.62]), similar to the ordinary least square estimate (0.27 [0.25, 0.29]). Results were similar for the other adiposity markers. Conclusions: Using a bidirectional Mendelian randomization approach in adult Caucasians, our findings suggest tha

Automatic and Deliberate Affective Associations with Sexual Stimuli in Women with Superficial Dyspareunia

Current views suggest that in women with superficial dyspareunia the prospect of penile–vaginal intercourse automatically activates fear-related associations. The automatic activation of negative associations is assumed to interfere with the development of sexual arousal. In turn, this may further aggravate the dyspareunia-related complaints. To assess whether automatic negative associations are involved in this sexual pain disorder, women with superficial dyspareunia (n = 35) and a control group (n = 35) completed a modified pictorial Affective Simon Task (AST). Questioning the role of dysfunctional automatic associations in superficial dyspareunia, the AST indicated that symptomatic women displayed relatively positive rather than negative automatic associations with sexual stimuli. At the self-report level, however, affective associations with sex cues were significantly more negative for women with dyspareunia than for controls. This discrepancy between “reflective” and “reflexive” affective associations with sexual stimuli in women with dyspareunia points to the relevance of conscious appraisal and deliberate rather than automatic processes in the onset and maintenance of dyspareunia