Smaller, Closer, Dirtier: Diesel Backup Generators in California

Quantifies the threat to air quality and human health by backup generators, and examines air quality in Los Angeles, San Diego, Sacramento, and Fresno, with some analysis of San Francisco as well

Qualitative Factors as Determinants of Continued Success:An Examination of eBusiness Entrepreneurial Firms Using the NewVenture Template

In this study, we analyze eBusiness entrepreneurs nominated by the Ernst & Young Entrepreneur of the Year Award program to ascertain whether qualitative factors are correlated with success. We find qualitative factors are incrementally informative above and beyond the information provided by quantitative factors. More specifically, firms that are able to maintain their innovative strategies by improving upon the product (or service) they offer and are able to meet the long-term needs of the customer are more likely to experience increased sales growth and have greater access to capital which results in a successful harvest strategy

Black Holes and Causal Structure in Anti-de Sitter Isometric Spacetimes

The observation that the 2+1 dimensional BTZ black hole can be obtained as a quotient space of anti-de Sitter space leads one to ask what causal behaviour other such quotient spaces can display. In this paper we answer this question in 2+1 and 3+1 dimensions when the identification group has one generator. Among other things we find that there does not exist any 3+1 generalization of the rotating BTZ hole. However, the non-rotating generalization exists and exhibits some unexpected properties. For example, it turns out to be non-static and to possess a non-trivial apparent horizon.Comment: LaTeX, 22 pages, 10 postscript figures, uses epsf.te

High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors

The non-essential amino acid neurotransmitter glycine (Gly) may serve as a biomarker for brain tumors. Using 36 biopsies from patients with brain tumors [12 glioblastoma multiforme (GBM); 10 low-grade (LG), including 7 schwannoma and 3 pylocytic astrocytoma; 7 meningioma (MN); 7 brain metastases (MT), including 3 adenocarcinoma and 4 breast cancer] and 9 control biopsies from patients undergoing surgery for epilepsy, we tested the hypothesis that the presence of glycine may distinguish among these brain tumor types. Using high-resolution magic angle spinning (HRMAS) 1H magnetic resonance spectroscopy (MRS), we determined a theoretically optimum echo time (TE) of 50 ms for distinguishing Gly signals from overlapping myo-inositol (Myo) signals and tested our methodology in phantom and biopsy specimens. Quantitative analysis revealed higher levels of Gly in tumor biopsies (all combined) relative to controls; Gly levels were significantly elevated in LG, MT and GBM biopsies (P≤0.05). Residual Myo levels were elevated in LG and MT and reduced in MN and GBM (P<0.05 vs. control levels). We observed higher levels of Gly in GBM as compared to LG tumors (P=0.05). Meanwhile, although Gly levels in GBM and MT did not differ significantly from each other, the Gly:Myo ratio did distinguish GBM from MT (P<0.003) and from all other groups, a distinction that has not been adequately made previously. We conclude from these findings that Gly can serve as a biomarker for brain tumors and that the Gly:Myo ratio may be a useful index for brain tumor classification

Quasi-variational coupled-cluster theory: Performance of perturbative treatments of connected triple excitations

Quasi-variational coupled-cluster methods are applied to a selection of diatomic molecules. The potential energy curves, spectroscopic constants, and size consistency errors are calculated and compared to those obtained from both single- and multi-reference methods. The effects of connected triple excitations are introduced with either the standard perturbative (T) formulation, or in the renormalised form, and its symmetrised approximation. It is found that the renormalised ansatz is significantly superior to the standard formulation when describing bond breaking and that in most circumstances, the computationally simpler symmetrisation gives nearly identical results

Identifying biological pathways that underlie primordial short stature using network analysis

Mutations in CUL7, OBSL1 and CCDC8, leading to disordered ubiquitination, cause one of the commonest primordial growth disorders, 3-M syndrome. This condition is associated with i) abnormal p53 function, ii) GH and/or IGF1 resistance, which may relate to failure to recycle signalling molecules, and iii) cellular IGF2 deficiency. However the exact molecular mechanisms that may link these abnormalities generating growth restriction remain undefined. In this study, we have used immunoprecipitation/mass spectrometry and transcriptomic studies to generate a 3-M ‘interactome’, to define key cellular pathways and biological functions associated with growth failure seen in 3-M. We identified 189 proteins which interacted with CUL7, OBSL1 and CCDC8, from which a network including 176 of these proteins was generated. To strengthen the association to 3-M syndrome, these proteins were compared with an inferred network generated from the genes that were differentially expressed in 3-M fibroblasts compared with controls. This resulted in a final 3-M network of 131 proteins, with the most significant biological pathway within the network being mRNA splicing/processing. We have shown using an exogenous insulin receptor (INSR) minigene system that alternative splicing of exon 11 is significantly changed in HEK293 cells with altered expression of CUL7, OBSL1 and CCDC8 and in 3-M fibroblasts. The net result is a reduction in the expression of the mitogenic INSR isoform in 3-M syndrome. From these preliminary data, we hypothesise that disordered ubiquitination could result in aberrant mRNA splicing in 3-M; however, further investigation is required to determine whether this contributes to growth failure

Sport, physical activity and the establishment of Health and Wellbeing Boards in Nottingham and Nottinghamshire

This paper will examine the emergence of Health and Wellbeing Boards in Nottinghamshire and the City of Nottingham and explore the implications for sport and physical activity. At the time of writing the transfer of responsibilities for Public Health and the establishment of Health and Wellbeing Boards in both the City of Nottingham and within Nottinghamshire County Council are considered to be relatively advanced by the Strategic Health Authorities, the respective local authorities and by the boards of the two Primary Care Trusts. "Shadow"� Health and Well being Board have been established in both authorities and they have been meeting regularly for s everal months. Public health and commissioning staff have also been successfully relocated and new strategies and priorities are starting to emerge. Nottingham and Nottinghamshire have traditionally acknowledged the role of sport and physical activity to the wider determinants of public health and given a relatively high priority to the contribution that sport and physical activity can make to the ir preventative health and early intervention agendas. This paper will look at the transition to Health and Wellbeing boards to assess how the role of sport and physical activity may be changing and to identify opportunities for its contribution to policy and practise in the future. It will examine both the theory and practise behind the emerging governance arr angements, the strategic objectives and priorities, and the developing evidential base for future policy and delivery within the two areas

Neutrophil Leukocyte Migration in Psoriasis Vulgaris

Neutrophil migration in patients with psoriasis vulgaris was assessed using both in vitro and in vivo techniques. In vitro chemotaxis towards endotoxin-activated serum and casein was found to be normal; however, random filter migration was increased in patients with extensive lesions. No significant difference was observed between the effects of psoriatic and normal serum on control leukocyte in vitro migration. In vitro skin window chamber random migration and chemotaxis toward 50% autologous serum were also found to be normal in univolved skin, regardless of disease severity.We have not been able to confirm previous reports of abnormal leukocyte chemotaxis in psoriasis and submit that neutrophil migration into psoriatic plaques in vivo is the result of a local accumulation of chemotactic factors rather than of enhanced leukocyte chemotactic activity

Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments

Recent studies have shown that the transport of microtubules (MTs) and neurofilaments (NFs) within the axon is rapid, infrequent, asynchronous, and bidirectional. Here, we used RNA interference to investigate the role of cytoplasmic dynein in powering these transport events. To reveal transport of MTs and NFs, we expressed EGFP-tagged tubulin or NF proteins in cultured rat sympathetic neurons and performed live-cell imaging of the fluorescent cytoskeletal elements in photobleached regions of the axon. The occurrence of anterograde MT and retrograde NF movements was significantly diminished in neurons that had been depleted of dynein heavy chain, whereas the occurrence of retrograde MT and anterograde NF movements was unaffected. These results support a cargo model for NF transport and a sliding filament model for MT transport

Liquids on Topologically Nanopatterned Surfaces

We report here surface x-ray scattering studies of the adsorption of simple hydrocarbon liquid films on nanostructured surfaces—silicon patterned by an array of nanocavities. Two different regimes, filling and growing, are observed for the wetting film evolution as a function of the chemical potential offset $\Delta \mu$ from the bulk liquid-vapor coexistence. The strong influence of geometrical effects is manifested by a $\Delta \mu$ dependence of liquid adsorption $\Gamma$ in the nanocavities that is stronger than the van der Waals behavior $\Gamma ~\Delta \mu -1/3$ for flat surfaces. The observed $\Delta \mu$ dependence is, however, much weaker than predicted for the infinitely deep parabolic cavities, suggesting that the finite-size effects contribute significantly to the observed adsorption behavior.Engineering and Applied Science