Multi-objective Optimization of Hard Milling Using Taguchi Based Grey Relational Analysis

The influence of hard coatings and machining parameters, in particular cutting speed, feed per tooth and depth of cut on specific cutting energy, productivity and surface quality in milling of hardened cold work tool steel, were investigated in this paper. Taguchi\u27s design of experiments was employed for planning of experiments using L27 orthogonal array. Optimal setting of machining parameters for multi-objective characteristics was determined using grey relational analysis. The principal component analysis was used to define the corresponding weight factors of each quality characteristics under optimization. Analysis of variance was conducted and it was revealed that feed per tooth is the most significant parameter affecting quality characteristics. Finally, results of confirmation test with the optimal machining parameters settings have shown that the proposed model improves overall performance of hard milling process

Topological data analysis of contagion maps for examining spreading processes on networks

Social and biological contagions are influenced by the spatial embeddedness of networks. Historically, many epidemics spread as a wave across part of the Earth's surface; however, in modern contagions long-range edges -- for example, due to airline transportation or communication media -- allow clusters of a contagion to appear in distant locations. Here we study the spread of contagions on networks through a methodology grounded in topological data analysis and nonlinear dimension reduction. We construct "contagion maps" that use multiple contagions on a network to map the nodes as a point cloud. By analyzing the topology, geometry, and dimensionality of manifold structure in such point clouds, we reveal insights to aid in the modeling, forecast, and control of spreading processes. Our approach highlights contagion maps also as a viable tool for inferring low-dimensional structure in networks.Comment: Main Text and Supplementary Informatio

Optimization of high-precision cylinder manufacturing

Rad se bavi optimizacijom postupka razvrtanja provrta tako da se kontroliranim postupkom mogu postići odgovarajuće geometrijske specifikacije bez završnog honanja. U svrhu sistematskog poboljšanja proizvodne tehnologije, izabran je transparentni postupak uz primjenu kvalitetnih alata. SKP cilindričnosti provrta i hrapavosti površine (Ra) originalnog postupka razvrtanja pokazuje slabu mogućnost obrade i ukazuje na nedostatke uređaja za stezanje. Brzina posmaka i brzina vretena prepoznati su kao ključni čimbenici u postizanju odgovarajućih tolerancija provrta. Plan eksperimenata i modeliranje postupka određeni su DOE metodologijom. Regresijskom analizom dobiveni su modeli za oba tražena odgovora (cilindričnost provrta i hrapavost površine) sa 73 % i 96 % pouzdanosti. Model optimizacije primijenjen je u stvarnoj proizvodnji.This paper deals with the reaming process optimization. The aim of optimization is that with controlled process suitable geometrical specifications could be achieved without final honing. To attain systematic improvements in manufacturing technology, transparent approach with the use of quality tools has been selected. SPC of bore cylindricity and surface roughness (Ra) of the original reaming process shows poor process capability and demonstrates shortcomings of the clamping device. Feed rate and spindle speed were identified as key factors in achieving required bore tolerances. Plan of experiments and process modelling was performed by DOE methodology. Regression analysis gives models for both responses, and they are adequate at 73 % and 96 % confidence level respectively. Optimization model was implemented in real production

Epidemiology of Uromodulin-Associated Kidney Disease – Results from a Nation-Wide Survey

BACKGROUND/AIMS: Uromodulin-associated kidney disease (UAKD) is caused by uromodulin mutations and leads to end-stage renal disease. Our objective was to examine the epidemiology of UAKD. METHODS: Data from all UAKD families in Austria were collected. Patients included in the Austrian Dialysis and Transplantation Registry (OEDTR) with unclear diagnoses or genetic diseases were asked whether they had (1) a family history of kidney disease or (2) had suffered from gout. Patients with gout and autosomal dominant renal disease underwent mutational analysis. Kaplan-Meier and Cox analysis was employed to estimate time to renal failure. RESULTS: Of the 6,210 patients in the OEDTR, 541 were approached with a questionnaire; 353 patients answered the questionnaire. Nineteen of them gave two affirmative answers. In 7 patients, an autosomal dominant renal disease was found; in 1 patient a UMOD mutation was identified. One family was diagnosed through increased awareness as a consequence of the study. At present, 14 UAKD patients from 5 families are living in Austria (1.67 cases per million), and 6 of them require renal replacement therapy (0.73 per 1,000 patients). Progression to renal failure was significantly associated with UMOD genotype. CONCLUSION: UAKD patients can be identified by a simple questionnaire. UMOD genotype may affect disease progression

The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power

We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 nm for inorganic species and under 2 μm for biomolecules) with the high mass-resolving power of an Orbitrap (>240,000 at m/z 200). This allows exogenous and endogenous metabolites to be visualized in 3D with subcellular resolution. We imaged the distribution of neurotransmitters—gamma-aminobutyric acid, dopamine and serotonin—with high spectroscopic confidence in the mouse hippocampus. We also putatively annotated and mapped the subcellular localization of 29 sulfoglycosphingolipids and 45 glycerophospholipids, and we confirmed lipid identities with tandem mass spectrometry. We demonstrated single-cell metabolomic profiling using rat alveolar macrophage cells incubated with different concentrations of the drug amiodarone, and we observed that the upregulation of phospholipid species and cholesterol is correlated with the accumulation of amiodarone

Meritev porušitvene napetosti ravninskega lipidnega dvosloja

magistrsko del

1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies

This volume presents the proceedings of the 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies (WC2015). The congress took place in Portorož, Slovenia, during the week of September 6th to 10th, 2015. The scientific part of the Congress covered different aspects of electroporation and related technologies and included the following main topics:   ·         Application of pulsed electric fields technology in food: challenges and opportunities ·         Electrical impedance measurement for assessment of electroporation yield ·         Electrochemistry and electroporation ·         Electroporation meets electrostimulation ·         Electrotechnologies for food and biomass treatment ·         Food and biotechnology applications ·         In vitro electroporation - basic mechanisms ·         Interfacial behaviour of lipid-assemblies, membranes and cells in electric fields ·         Irreversible electroporation in clinical use ·         Medical applications: electrochemotherapy ·         Medical applications: gene therapy ·         Non-electric field-based physical methods inducing cell poration and enhanced molecule transfer ·         Non-thermal plasmas for food safety, environmental applications and medical treatments ·         PEF for the food industry: fundamentals and applications ·         PEF proce ss integration - complex process chains and process combinations in the food industry ·         Predictable animal models ·         Pulsed electric fields and electroporation technologies in bioeconomy ·         Veterinary medical applications

Capstone HRM: dynamics and ambiguity in the workplace

Capstone HRM: Dynamics in the Workplace provides students, academics and practitioners with an alternative view of activities associated with managing people at work. Assuming readers have a sound understanding of 'best practice' human resource management (HRM) techniques; it seeks to speak to people fascinated by the puzzle posed by the real world of human resource management (HRM). HRM broadly refers to the activities associated with the management of the people who do the work of organizations, while strategic HRM assumes that HRM activities are integrated with strategic objectives, and improve organizational performance. Unfortunately, often HRM policies represent an intent rather than the actual practice of managing people. Capstone HRM: Dynamics in the Workplace grapples with these complexities, adopting a framework which captures the inter-relationships between national and international (macro) factors, organizational (meso) factors, and individual and group dynamics (micro) operating in the workplace.This framework highlights a number of themes common to the modern, dynamic workplace, including: International and national factors Globalization The contradictions and ambiguities of HRM policies and practices The desire to measure outcomes The embedded nature of ethics in HRM and SHRM, and its relationship to CSR The valuing of human and social capital

Beyond HR

11 page(s